Download or read book Progress in the Chemistry of Organic Natural Products 122 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2023-07-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights some recent developments on plants used widely as botanical dietary supplements and herbal medicines, especially in terms of knowledge of the chemical types and diverse biological activities of their constituents, as well as laboratory approaches for their quality control and taxonomic identification. In the first chapter, the biologically active secondary metabolites are described of selected botanicals that have a wide current use in the United States, with recent information provided also on their in vitro and in vivo biological activities. The second chapter constitutes an updated survey of the different chromatographic, spectroscopic, and metabolomics techniques that can be utilized for the quality control of botanical products. The penultimate chapter covers different nomenclatural systems that are of use for the taxonomic identification of source plants used in botanical products. Finally, deoxyribonucleic acid molecular barcoding techniques for the identification for plants used as dietary supplements are covered.

Download or read book Progress in the Chemistry of Organic Natural Products written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer imprint ever since the series was founded in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Download or read book Progress in the Chemistry of Organic Natural Products 112 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2020-12-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first chapter describes the oldest method of communication between living systems in Nature, the chemical language. Plants, due to their lack of mobility, have developed the most sophisticated way of chemical communication. Despite that many examples involve this chemical communication process - allelopathy, there is still a lack of information about specific allelochemicals released into the environment, their purpose, as well as in-depth studies on the chemistry underground. These findings are critical to gain a better understanding of the role of these compounds and open up a wide range of possibilities and applications, especially in agriculture and phytomedicine. The most relevant aspects regarding the chemical language of plants, namely, kind of allelochemicals have been investigated, as well as their releasing mechanisms and their purpose, are described in this chapter. The second chapter is focused on the natural products obtained from Hypericum L., a genus of the family Hypericaceae within the dicotyledones. Hypericum has been valued for its important biological and chemical properties and its use in the treatment of depression and as an antibacterial has been well documented in primary literature and ethnobotanical reports. The present contribution gives a comprehensive summary of the chemical constituents and biological effects of this genus. A comprehensive account of the chemical constituents including phloroglucinol derivatives, xanthones, dianthrones, and flavonoids is included. These compounds show a diverse range of biological activities that include antimicrobial, cytotoxic, antidepressant-like, and antinociceptive effects. The third chapter addresses microtubule stabilizers, which are a mainstay in the treatment of many solid cancers and are often used in combination with molecularly targeted anticancer agents and immunotherapeutics. The taccalonolides are a unique class of such microtubule stabilizers isolated from plants of Tacca species that circumvent clinically relevant mechanisms of drug resistance. Although initial reports suggested that the microtubule stabilizing activity of the taccalonolides is independent of direct tubulin binding, additional studies have found that potent C-22,23 epoxidated taccalonolides covalently bind the Aspartate 226 residue of β-tubulin and that this interaction is critical for their microtubule stabilizing activity. Some taccalonolides have demonstrated in vivo antitumor efficacy in drug-resistant tumor models with exquisite potency and long-lasting antitumor efficacy as a result of their irreversible target engagement. The recent identification of a site on the taccalonolide scaffold that is amenable to modification has provided evidence of the specificity of the taccalonolide-tubulin interaction and the opportunity to further optimize the targeted delivery of the taccalonolides to further improve their anticancer efficacy and potential for clinical development.

Download or read book Progress in the Chemistry of Organic Natural Products 110 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2019-10-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book summarizes important aspects of cheminformatics that are relevant for natural product research. It highlights cheminformatics tools that help to match natural products with their respective biological targets or off-targets, and discusses the potential and limitations of this approach.

Download or read book Progress in the Chemistry of Organic Natural Products 113 written by A Douglas Kinghorn and published by Springer Nature. This book was released on 2021-04-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, chemical studies are described mainly from literature reports appearing since 2000, inclusive of investigations performed by the present authors, on the diversity in secondary metabolites of Ligularia growing in the Hengduan Mountains area of China, focusing on eremophilane sesquiterpenoids and other metabolites. More than 100 Ligularia species and their related genera in the plant family Senecioneae plants (Cremanthodium, Cacalia, Senecio, and others) grow in East Asia. For many years, researchers have studied the chemical constituents of these plants, and terpenoids, flavonoids, steroids, alkaloids, and aromatic compounds have been isolated. Among these, in particular, numerous sesquiterpenoids were reported. Within this book terpenoids and aromatic compounds (total 1049), both previously unknown and known, are presented. Finally, genetic studies and synthesis investigations are briefly reviewed.

Download or read book Progress in the Chemistry of Organic Natural Products 111 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2020-02-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first chapter in volume 111 summarizes research on the sesterterpenoids, which are known as a relatively small group of natural products. However, they express a variety of simple to complicated chemical structures. This chapter focuses on the chemical structures of sesterterpenoids and how their structures are synthesized in Nature. The second chapter is devoted to marine-derived fungi, which play an important role in the search for structurally unique secondary metabolites, some of which show promising pharmacological activities that make them useful leads for drug discovery. Marine natural product research in China in general has made enormous progress in the last two decades as described in this chapter on fungal metabolites. This contribution covers 613 new natural products reported from 2001 to 2017 from marine-derived fungi obtained from algae, sponges, corals, and other marine organisms from Chinese waters.

Download or read book Progress in the Chemistry of Organic Natural Products 105 written by A. Douglas Kinghorn and published by Springer. This book was released on 2017-02-13 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution reviews the occurrence of xanthine alkaloids in the plant kingdom and the elucidation of the caffeine biosynthesis pathway, providing details of the N-methyltransferases, belonging to the motif B' methyltransferase family which catalyze three steps in the four step pathway leading from xanthosine to caffeine. The second contribution in this book provides a background on the molecule and related compounds and update knowledge on the most recent advances in Iboga alkaloids. The third contribution presents a comprehensive analysis of frequently occurring errors with respect to 13C NMR spectroscopic data and proposes a straightforward protocol to eliminate a high percentage of the most obvious errors.

Download or read book Progress in the Chemistry of Organic Natural Products 118 written by A. Douglas Kinghorn and published by Springer Nature. This book was released on 2022-04-13 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume consists of four chapters that cover a structurally diverse range of naturally occurring compounds. Chapter 1 delves into the chemistry of pyrogallols and their oxidized products, the hydroxy-o-quinones, including their role in cycloaddition reactions in the chemical synthesis of several fungal metabolites. Chapter 2 provides an in-depth description of the constituents of agarwood essential oil and smoke samples that are used in the perfumery industry, with an emphasis on the sesquiterpenoid and chromones constituents so far known. Chapter 3 discusses the defensive chemical ecology of two North American newt species that both produce tetrodotoxin, a well-known neurotoxin that causes paralysis and death in metazoans by disrupting electrical signals in the nerves and muscles. Chapter 4 discusses the limonoids and triterpenoids from the genus Walsura of the plant family Meliaceae, of which a number of species are utilized in several southeastern Asian countries in systems of folk medicine.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: A.A. Leslie Gunatilaka: Triterpenoid Quinonemethides and Related Compounds (Celastroloids). - P. Walser-Volken and Ch. Tamm: The Spirostaphylotrichins and Related Microbial Metabolites. The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products written by Bernhard Kräutler and published by Springer Science & Business Media. This book was released on 2009-10-13 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority to provide an up-to-date review of the topic in question.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products 85 written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products 88 written by W. Herz and published by Springer Science & Business Media. This book was released on 2007-04-05 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products written by E. Fattorusso and published by Springer Science & Business Media. This book was released on 1997-09-30 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products written by A. Andersen and published by Springer Science & Business Media. This book was released on 1997-05-28 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Download or read book Progress in the Chemistry of Organic Natural Products Vol 94 written by A. Douglas Kinghorn and published by Springer Science & Business Media. This book was released on 2011-08-12 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three reviews cover the advances in the chemistry and biology of withanolides over the last 16 years, review the chemistry and biology of the rocaglamide-type derivatives and related compounds, with emphasis on their structural diversity, biosynthesis, pharmacological significance and total synthesis, and summarize the extensive chemistry and biology studies on a natural product, which have resulted in a novel therapy approved worldwide.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products written by M.T. Davies-Coleman and published by Springer Science & Business Media. This book was released on 1998-06-30 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Download or read book Fortschritte der Chemie organischer Naturstoffe Progress in the Chemistry of Organic Natural Products written by T. Fukai and published by Springer Science & Business Media. This book was released on 1997-12-17 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Leguminosae is an economically important family in the Dicotyledonae with many cultivated species, e. g., beans and peas. The family also contains many well-known medicinal plants. It is composed of 17,000 or more species that constitute nearly one twelfth of the world's flowering plants (1). Traditionally the family has been divided into three subfamilies, Caesalpinioideae, Mimosoideae and Papilionoi deae, which are sometimes recognized as separate families Caesalpinia ceae, Mimosaceae and Papilionaceae. The International Code of Botanical Nomenclature permits alternative nomenclatures, the family names being replaced by Fabaceae, Fabales and Faboideae, and this usage will be common (2). Licorice (liquorice, kanzoh in Japanese, gancao in Chinese) is the name applied to the roots and stolons of some Glycyrrhiza species (Fabaceae) and has been used by human beings for at least 4000 years. The earliest written reference to the use of licorice is contained in the Codex Hammurabi dating from 2100 B. C., and the subsequent history in the West has been described in the earlier reviews (3-6). In the Far East, references to the effectiveness of licorice are contained in the "Shen Nong Ben Cao Jing," the first Chinese dispensatory whose original anonymous volumes probably appeared by the end of the third century (7, 8)."