Download or read book Progress in Drug Research written by JUCKER and published by Birkhäuser. This book was released on 2013-03-07 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the first years of the existence of this series of monographs, during the so-called "Golden Age" of drug research, the majority of the pa pers published were mainly concerned with the traditional domains of drug research, namely chemistry, pharmacology, toxicology and pre clinical investigations. The series' aim was to give coverage to impor tant areas of research, to introduce new active substances with thera peutic potential and to call attention to unsolved problems. This objective has not changed. The table of contents of the present volume makes evident, however, that the search for new medicines has become increasingly complex, and additional, new disciplines have entered the research arena. The series now includes reviews on bio chemical, biological, immunological, physiological and medicinal aspects of drug research. Researchers actively engaged in the various scientific fields forming the entity of drug research can benefit from the wealth of knowledge and experience of the respective authors, and will be assisted in their endeavour to discover new pharmaceutical agents. Those simply wanting to keep abreast of new developments in the complex, multi-discipline science can turn to the "Progress in Drug Research" volumes as an almost encyclopaedic source of information without having to consult the innumerable original publications. Volume 33 contains 13 reviews, a subject index, an index for the close to 400 articles published in the series so far, and an author and titles index for all 33 volumes.

Download or read book Progress in Drug Research written by Richard M. Eglen and published by Birkhäuser. This book was released on 2012-12-06 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the contents: · C. Brater and M. D. Murray: The effects of NSAIDs on the kidney · G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs · M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms · S.P. Gupta: Studies on cardiovascular drugs · G. Polak: Antifungal chemotherapy: An everlasting battle · O. Valdenaire: New insights into the bioamine receptor family.

Download or read book Progress in Drug Research written by Hao Wu and published by Birkhäuser. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.

Download or read book Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques written by Ernst Jucker and published by Birkhäuser. This book was released on 2013-03-07 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 47 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with inotropic steroids, with chemokines and their involvement in a wide range of inflam matory diseases, with the subclassification and nomenclature of ul- and Uz-adrenoceptors, with Chinese traditional medicine, with drug targets in the molecular pathogenesis of asthma, with cytokines and their therapeutic application in immunosuppression and immunostimulation, with alter native medicine and with the potential use of calcium blockers in psy chiatry. These reviews and the quotations of original articles provide the reader with valuable information on several new developments in the world-wide search for new and better medicines. In 1959, when the Editor started this series of monographs, it was his intention to help disseminate informa tion on the vast and fast growing domain of drug research. Already at that time,it was not possible to follow the major individual publications in this field, and the reader was thereby provided with a tool to keep abreast of the latest developments and trends. This goal remained unchanged over the last 37 years, and I believe that the reviews in PDR are useful to the non-specialist who can obtain an overview of a particular field of drug research in a relatively short time.

Download or read book Progress in Drug Research written by Ernst Jucker and published by Birkhäuser. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nikolaus Seiler, Benoit Duranton and Francis Raul: The polyamine oxidase inactivator MDL 72527.- Zhi Hong and Craig E. Cameron: Pleiotropic mechanisms of ribavirin antiviral activities.- Jie Hong Hu and Charles Krieger: Protein phosphorylation networks in motor neuron death.- James O. Schenk: The functioning neuronal transporter for dopamine: kinetic mechanisms and effects of amphetamines, cocaine and methylphenidate.- Laszlo Prokai: Central nervous system effects of thyrotropin-releasing hormone and ist analogues: opportunities and perspectives for drug discovery and development.- David F. Horrobin: A new category of psychotropic drugs: neuroactive lipids as exemplified by ethyl eicosapentaenoate (E-E).- Suprabhat Ray, Reema Rastogi and Atul Kumar: Current status of estrogen receptors.

Download or read book Progress in Drug Research written by Bijoy Kundu and published by Birkhäuser. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Progress in Drug Research written by Pushkar N. Kaul and published by Birkhäuser. This book was released on 2012-12-06 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Progress in Drug Research written by and published by Birkhäuser. This book was released on 2012-12-06 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis C virus (HCV) was first identified in 1989 as the etiologic agent of non-A, non-B hepatitis [1] and is currently recognized as the leading cause of chronic liver disease worldwide. In contrast to hepatitis B virus infection, in which only about 5% of adult infections become chronic, more than 80% of HCV-infected patients develop chronic hepatitis. Moreover, 20-50% of those persistently infected with HCV will develop liver cirrhosis and hepatocellu lar carcinoma (HCC) [2]. It is estimated that there are 10,000 deaths in the USA per year due to chronic liver failure or HCC [3]. In addition, HCV dis 25-50% of all liver transplants in US centers, and the ease is responsible for recurrence of HCV infection following liver transplantation is universal [4]. Typically, HCV disease emerges after a 10-20 year period during which symp toms, if they exist at all, are mild and non-specific. Although the prevalence varies greatly among different countries, it has been estimated that up to 170 million people (3% of the world's population), are infected with HCV [5]. A recent study in the USA found that 65% of all HCV-infected persons are 30 to 49 years old [6].

Download or read book The Role of NIH in Drug Development Innovation and Its Impact on Patient Access written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-27 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: To explore the role of the National Institutes of Health (NIH) in innovative drug development and its impact on patient access, the Board on Health Care Services and the Board on Health Sciences Policy of the National Academies jointly hosted a public workshop on July 24â€"25, 2019, in Washington, DC. Workshop speakers and participants discussed the ways in which federal investments in biomedical research are translated into innovative therapies and considered approaches to ensure that the public has affordable access to the resulting new drugs. This publication summarizes the presentations and discussions from the workshop.

Download or read book Progress in Drug Research written by Ernst M. Jucker and published by Birkhäuser. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jay A. Glasel: Drugs, the human genome, and individual-based medicine.- Vera M. Kolb: Herbal medicine of Wisconsin Indians.- Paul L. Skatrud: The impact of multiple drug resistance (MDR) proteins on chemotherapy and drug discovery.- John W. Ford, Edward B. Stevens, J. Mark Treherne, Jeremy Packer and Mark Bushfield: Potassium channels: Gene family, therapeutic relevance, high-throughput screening technologies and drug discovery.- David T. Wong and Frank P. Bymaster: Dual serotonin and noradrenaline uptake inhibitor class of antidepressants - Potential for greater efficacy of just hype?.- Satya P. Gupta: Advances in QSAR studies of HIV-1 reverse transcriptase inhibitors.

Download or read book Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques written by JUCKER and published by Birkhäuser. This book was released on 2013-03-08 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 36 of "Progress in Drug Research" contains 5 articles and the various indexes which facilitate its use and establish the connec tion with the previous volumes. While all articles deal with some of the topical aspects of drug research, the contribution by Robert R. Ruffolo et al. on "Drug receptors and control of the cardiovas cular system: Recent advances" is indeed in its own right a mono graphic presentation of this important domain. The remaining four reviews provide an overview of the work in volved in the search for new and better medicines, with a focus on chemical, pharmacological, toxicological, biological, biochemical and molecular modeling studies. In the 31 years this series has existed, the Editor has enjoyed the help and advice of many colleagues. Readers, the authors of the in dividual articles, and, last but not least, the reviewers have all con tributed greatly to the success of PDR. Although many comments received have been favorable, it is nevertheless necessary to analyze and to reconsider the current position and the direction of such a series. So far, it has been the Editor's aim to help spread informa tion on the vast domain of drug research, and to provide the reader with a tool helping him or her to keep abreast of the latest develop ments and trends.

Download or read book Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques written by George deStevens and published by Birkhäuser. This book was released on 2013-11-11 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contents: V. Zingel, C. Leschke and W. Schunack: Developments in research on histamine (H1) receptor agonists / P.D. Hoeprich: Antifungal chemotherapy / G. de Stevens: The diversity of heterocyclic compounds and their biological activities / R.M. Schultz: Newer antifolate compounds in cancer therapy / P.K. Mehrotra, S. Batra and A.P. Bhadun: Non-steroidal agents for regulation of the menstrual cycle / A.K. Saxena and M. Saxena: Developments in anti-convulsant drugs

Download or read book Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques written by E. Jucker and published by Birkhäuser. This book was released on 2013-03-08 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 41 of "Progress in Orug Research" contains eight reviews and the various indexes which facilitate its use and establish the con nection with the previous volumes. The articles in this volume deal with teratogenesis; nephrotoxicity; bacterial resistance to P. lactam antibiotics; eradication of diseases by vaccination; chirality and drug design; endogenous digitalis-like factors; erythropoietin; and sero tonin (5HT)-antagonists. 3 All these articles give an excellent overview of the respective fields of research. In the 33 years that POR has existed, the Editor has enjoyed the valu able help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. So far, it has been the Editors intention to help disseminate informa tion on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in POR are useful to the non-specialists, who can obtain an overview of a particular field of research in a relatively short time. The specialist readers of POR will appreciate the reviews' comprehensive bibliographies, and, in addition, they may even get fresh impulses for their own research.

Download or read book Progress in Drug Research Fortschritte der Arzneimittelforschung Progr s des recherches pharmaceutiques written by and published by Birkhäuser. This book was released on 2012-12-06 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 43 of «Progress in Drug Research» contains five reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with high cholesterol blood levels and other dyslipidemias; search of ideal antihypertensive drugs; the natural PQlyamines and the immune system; biologically active quinazolones and with production and action of interferons. In the 35 years the PDR has existed, the Editor has enjoyed the valuable help and advice of many colleagues. Readers, the authors of the reviews, and last but not least, the reviewers have all contributed greatly to the success of this series. Although the comments received so far have generally been favorable, it is nevertheless necessary to analyze and to reassess the current position and the future direction of such a review series. So far, it has been the Editors intention to help disseminate information on the vast domain of drug research, and to provide the reader with a tool with which to keep abreast of the latest developments and trends. The reviews in PDR are useful to the non-specialist, who can obtain an overview of a particular field of drug research in a relatively short time. The specialist readers of PDR will appreciate the reviews' comprehensive bibliographies, and, in addition, they may even get fresh impulses for their own research. Finally, the readers can use the 43 volumes of PDR as an encyclopedic source of information.

Download or read book Progress in drug research 50 1998 written by Ernst Jucker and published by Springer Science & Business Media. This book was released on 1998 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Drug Research is a prestigious book series (founded in 1959) which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmalogical research. Each volume contains fully cross-referencing indexes which link the volumes together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines. Volume 50 in the series includes: P.N. Kaul: Drug discovery: Past, present and future M. Rohmer: Isoprenoid biosynthesis via the mevalonate -- independent route, a novel target for antibacterial drugs G. Edwards and A.H. Weston: Endothelium, -derived hyperpolarizing factor -- a critical appraisal R.W. Rockhold: Glutamatic involvement in psychomotor stimulant action J.M. Colacino and K.A. Staschke: The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection T.D. Johnson: Polyamines and cerebral ischemia

Download or read book Progress in Drug Research 56 written by and published by Birkhäuser. This book was released on 2012-12-06 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded in 1959 by its current Editor, the series has moved from its initial focus on medicinal chemistry to a much wider scope. Today it encompasses all fields concerned with the development of new therapeutic drugs and the elucidation of their mechanisms of action, reflecting the increasingly complex nature of modern drug research. Invited authors present their biological, chemical, biochemical, physiological, immunological, pharmaceutical, toxicological, pharmacological and clinical expertise in carefully written reviews and provide the newcomer and the specialist alike with an up-to-date comprehensive list of prime references. Each volume of Progress in Drug Research contains fully cross-referencing indices which link the books together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.

Download or read book Progress in drug research 49 1997 written by Ernst Jucker and published by Springer Science & Business Media. This book was released on 1997 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the contents: A- C. Brater and M. D. Murray: The effects of NSAIDs on the kidney A- G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs A- M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms A- S.P. Gupta: Studies on cardiovascular drugs A- G. Polak: Antifungal chemotherapy: An everlasting battle A- O. Valdenaire: New insights into the bioamine receptor family