Download or read book Programmed Cell Death and Cardiovascular Disease written by Zhi Qi and published by Frontiers Media SA. This book was released on 2022-09-12 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Apoptosis in Cardiac Biology written by Heribert Schunkert and published by Springer Science & Business Media. This book was released on 2007-06-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis or programmed cell death is increasingly considered to be a major factor in the development and progression of cardiovascular disease. In patients with heart failure the activation of apoptosis may result in the loss of irreplaceable cardiac myocytes promoting the clinical course of the syndrome. Moreover, in the coronary arteries inflammation and apoptosis may weaken critical structures of the vessel wall leading to plaque rupture and, subsequently, to myocardial infarction. Given these deleterious consequences, it seems almost paradoxical that programmed cell death is an active process that, if initiated under physiological circumstances, is essential for both coordinated tissue growth or destruction of malignant cells. Apoptosis in Cardiac Biology, written by a team of internationally renowned researchers, gives a timely synopsis of basic mechanisms, cellular and structural targets and, finally, clinical implications of programmed cell death in the heart. The expert authors of this volume give concise overviews on general and cell-specific aspects of programmed cell death in cardiac myocytes and fibroblasts, as well as in vascular smooth muscle and endothelial cells. Furthermore, novel therapeutic options arising from the outstanding pathophysiological significance of cardiac apoptosis are presented. This comprehensive review of Apoptosis in Cardiac Biology will be of interest to both clinicians and basic researchers who are active in the fields of cardiology and atherosclerosis.
Download or read book Cardiac Hypertrophy and Failure written by Bernard Swynghedauw and published by . This book was released on 1990 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac insufficiency, a major cause of premature mortality, is a key focus of medical and pharmaceutical research. This book aims to bring clinicians and researchers up-to-date on recent biophysical, cellular physiological and molecular biological developments and their clinical applications.
Download or read book Apoptosis in Health and Disease written by Jr., Robert R. Ruffolo and published by CRC Press. This book was released on 2000-09-15 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation
Download or read book Cytokines Novel Cell Death Models and Pathways in Cardiovascular Diseases written by Yuli Huang and published by Frontiers Media SA. This book was released on 2023-09-26 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokines are soluble proteins secreted by a wide variety of cells in the body, playing crucial roles in many physiological responses and are involved in the pathophysiology of cardiovascular diseases (CVDs). Recently, there is great progress in discoveries that some novel cytokines, including secreted frizzled-related proteins (SFRPs), adiponectin, and C1q/TNF-Related Proteins (CTRPs), can perform a protective effect in cardiometabolic diseases, heart failure and coronary heart disease. However, the mechanisms underlying the molecular and pathophysiological actions of these cytokines in CVDs are still vague. Novel mechanisms of cell death including pyroptosis, autophagy, ferroptosis, cuproptosis, and PANoptosis have been considered novel therapeutic targets for CVDs. Some cytokines have been shown to regulate the cell death pathway in the incidence and development of CVDs. Further investigations are needed to understand the link between these novel cytokines and novel cell death models and pathways in CVDs.
Download or read book Programmed Cell Death written by Mark Paul Mattson and published by . This book was released on 2001 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides the most recent insight into how abnormalities in the regulation of cell death lead to a variety of diseases. Each chapter in this book is written by an internationally recognized expert on the role of aberrant cell death in the pathogenesis of a particular disease. In addition to various types of cancer and neurodegenerative disorders, this book covers diseases ranging from arthritis to cardiovascular disease to diabetes. The chapters each integrate information obtained from patients with data obtained in experimental models of the disease to arrive at an emerging view of the pathogenic mechanisms of the disease. Applications of this fundamental knowledge to prevention and treatment of the diseases are considered. When taken together with http://www.elsevier.nl/locate/isbn/0444504931Programmed Cell Death, Volume 1, this title will provide graduate students, postdocs and senior investigators in an array of biomedical disciplines invaluable resource for their pursuit of the causes and cures of many different human diseases.
Download or read book Mitochondria and Their Role in Cardiovascular Disease written by José Marín-García and published by Springer Science & Business Media. This book was released on 2012-11-19 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades, due to dramatic advances in molecular and cell biology, biochemistry, and genetics, our view on mitochondria as a relatively static cellular powerhouse has changed radically. We now know that these organelles play a critical role in the normal and in the damaged heart. Written by Dr. José Marín-García, Director of the Molecular Cardiology and Neuromuscular Institute, Mitochondria and Their Role in Cardiovascular Disease brings readers up- to-date on the many significant advances in the field of mitochondrial cardiovascular medicine. The book begins with a general introduction to mitochondria, followed by laboratory methods to study the structure and function of the organelle, regulation of replication and biogenesis, and the mechanisms and functional consequences of mitophagia and mitochondrial dynamics. Subsequent chapters deal with mitochondrial oxidative stress and the role that the organelle plays in cell signaling and cell death. Discussions will be undertaken on the biochemistry of mitochondrial cell signaling, including the nature of the proteins engaged in these processes, many of them only recently discovered. Later chapters examine the role of mitochondria and mitochondrial abnormalities in cardiovascular diseases, including their diagnosis, therapeutic options currently available, animal models of mitochondrial disease, and new frontiers in mitochondria cardiovascular medicine, including areas of research that are relatively new or developing, such as proteomics, next generation sequencing, and systems biology.
Download or read book Cardiomyocytes Active Players in Cardiac Disease written by Klaus-Dieter Schlüter and published by Springer. This book was released on 2016-06-28 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.
Download or read book Molecular Defects in Cardiovascular Disease written by Naranjan S. Dhalla and published by Springer Science & Business Media. This book was released on 2011-08-09 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Defects in Cardiovascular Disease provides an in-depth discussion of the molecular mechanisms underlying the genesis of cardiovascular defects and the implications this has on current and emerging targeted therapeutics. Divided into three sections, this book covers the scientific foundations of our present understanding as well as the array of clinical manifestations and their treatment. The first section covers Molecular Mechanisms of Heart Disease, with discussion of the development of cardiovascular dysfunction. The remaining two sections provide a more clinical focus. The second, Cardiac Hypertrophy and Heart Failure deals with metabolic derangements, Ca2+ handling, and subcellular remodeling. It illustrates the wide variety of molecular defects which may serve as targets associated with the transition from cardiac hypertrophy to advanced heart failure. The third section, Hypertension and Diabetes, provides molecular rationale for the pathogenesis of hypertension and diabetic cardiomyopathy, as well as highlighting the importance of hormones toward this end. A necessary resource for clinicians and researchers, this book elucidates the experimental basis of the practice of cardiology. It is the culmination of our advances in the understanding of cardiovascular molecular biology and a blueprint for the efficacious use of targeted therapies.
Download or read book Blood Oxidant Ties The Evolving Concepts in Myocardial Injury and Cardiovascular Disease written by Bashir Matata and published by Bentham Science Publishers. This book was released on 2023-07-18 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood Oxidant Ties: The Evolving Concepts in Myocardial Injury and Cardiovascular Disease is an update on the recent advances in the development of antioxidant-based therapies. It starts with an overview of the mechanisms underlying the genesis of oxidative stress, summarizing the link between oxidative stress and a number of cardiovascular conditions. This is followed by an explanation of how oxidative stress interacts with lipid metabolism and the placental environment. Three chapters on the role of antioxidant-based therapy for cardiovascular diseases round up the book. Key Features - Outlines several cell-signaling pathways that are modulated by the interplay between reducing and oxidizing agents (redox status) and gene expression in the cardiovascular disease process - Brings information about maternal programming environment in the placenta - Covers development of novel nanotechnology-based antioxidant delivery systems for effective drug delivery - Includes references for further reading The book is aimed at a broad readership of scientific and medical professionals involved in research on cardiovascular diseases, pathophysiology, pharmacy, pharmaceutical science and life sciences. It also serves as a reference for scholars who want to understand the complex biochemical mechanisms of antioxidant agents.
Download or read book Cardiomyocytes in Health and Disease written by Chandrasekharan C. Kartha and published by Springer Nature. This book was released on 2021-09-13 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.
Download or read book Cell Death written by Tobias Ntuli and published by BoD – Books on Demand. This book was released on 2015-12-16 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of selected and relevant research, concerning the developments within the Cell Death field of study. Each contribution comes as a separate chapter complete in itself but directly related to the books topics and objectives. The target audience comprises scholars and specialists in the field.
Download or read book Reactive Oxygen Species ROS Nanoparticles and Endoplasmic Reticulum ER Stress Induced Cell Death Mechanisms written by Loutfy H. Madkour and published by Academic Press. This book was released on 2020-06-27 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment
Download or read book Modulation of Oxidative Stress in Heart Disease written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-10 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions.
Download or read book Apoptosis Genes written by James W. Wilson and published by Springer. This book was released on 2012-12-16 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This useful work presents a current overview of key genes involved in the control of apoptosis research together with thoughts on future prospects and clinical applications. While there are several books written on apoptosis, this one deals specifically with its regulation.
Download or read book Biochemistry of Apoptosis and Autophagy written by Lorrie A. Kirshenbaum and published by Springer Nature. This book was released on 2021-11-29 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.
Download or read book Mechanisms of Cell Death written by Zahra Zakeri and published by . This book was released on 1999 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics
