Download or read book Profilometry for Diffuse Optical Tomography Breast Imaging System written by Long Xie and published by . This book was released on 2013 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Diffuse Optical Tomography System Combined with X ray Mammography for Improved Breast Cancer Detection written by Thomas John Brukilacchio and published by . This book was released on 2003 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central thesis of this dissertation states that optical imaging of diffuse tissues must be combined in co-registration with a recognized gold standard of mammographic screening, i.e. X-ray mammography, to gain wide acceptance in the clinical environment. This multi-modality imaging approach promises to overcome the deficiencies of both imaging modalities by drawing on the strengths of each. Functional and structural image contrast would be provided by optical and high-resolution structural contrast by X-ray. Furthermore, the structural information provided by X-ray could be used to improve the optical image reconstruction by providing boundary information and soft constraints for weakly correlated structural contrast. Ultimately, image-processing techniques could be developed to provide the radiologist with a three-dimensional image indicative of both optical and X-ray contrast that would provide much greater information content than either modality alone.

Download or read book Parallel rapid diffuse optical tomography of breast written by and published by . This book was released on 2002 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last year we have experimentally and computationally investigated rapid acquisition and analysis of informationally dense diffuse optical data sets in the parallel plate compressed breast geometry. We have developed and tested a 3-dimensional image reconstruction algorithm for the diffusive wave inverse problem that runs on a parallel computer cluster. This code uses a finite difference method in the forward calculation, a novel Integro-Differential equation, previously developed by this group, in the reconstruction. There has been a significant improvement in our instrumentation and measurement capabilities. A hybrid RF/CW diffuse optical tomography (DOT) system measures limited number of frequency-domain reemission data and significantly larger continuous wave transmission data by a lens coupled CCD simultaneously. The wavelength of the light source is optically switched from 690, 750, 786 and 830 nm and then its position is switched among 45 different positions on the compression plate. The instrument and reconstruction algorithm performance have been tested using small silicone tissue phantoms as a tumor of various size and optical properties suspended into the liquid tissue phantom. The study of the effect of boundary between the matching fluid and breast has been initiated by building and taking measurements from tissue phantoms with breast shape, embedded with small objects with higher absorption or scattering.

Download or read book Diffuse Optical Tomography written by Ruixin Jiang and published by . This book was released on 2012 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse Optical Tomography has drawn more and more interests in the biomedical field over the recent couple of decades due to its ability to noninvasively recover not only tissue structural information but also functional and molecular properties. The contrasts that optical parameters could demonstrate in DOT are usually higher than those of the conventional methods. Based on these contrasts, different approaches had been developed applying DOT for imaging, and so far lots of efforts were spent on detecting breast cancer by imaging tissue absorption and scattering coefficients as well as hemoglobin concentration and oxygen saturation level. In this work, we tried to expand the ability of DOT in breast cancer detection by introducing Phase-contrast diffuse optical tomography (PCDOT). PCDOT uses near-infrared diffusing light to non-invasively reconstruct tissue refractive index (RI) distribution. RI depends on the tissue's physical and chemical properties and previous study revealed that it might serve as a promising imaging parameter in breast cancer detection. We've first developed a 2-step method to improve the PCDOT image both qualitatively and quantitatively at single-wavelength; then we've introduced a multispectral PCDOT algorithm to more efficiently reconstruct RI simultaneously with other tissue functional parameters and attempted to improve this algorithm by different structural regularization methods.

Download or read book Optical Tomography and Spectroscopy of Tissue VII written by Britton Chance and published by SPIE-International Society for Optical Engineering. This book was released on 2007 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory/Algorithm/Modeling; Instrumentation and Technology I; Fluorescence Imaging/Spectroscopy (algorithm/model/tomography); Fluorescence Imaging/Image Reconstruction (Experimental); Instrumentation and Technology II; Fluorescence Imaging Technology I; Fluorescence Imaging Technology II; Fluorescence Imaging Technology III; Network for Translational Research in Optical Imaging: Breast Cancer Diffuse Optical Imaging; Breast II - Instrumentation & New Analysis Method; Breast III - Clinical Study; Pre-Clinical/Animal; Instrumentation and Technology III; Clinical/Human Subject Studies.

Download or read book Multi spectral and Fluorescence Diffuse Optical Tomography of Breast Cancer written by Alper Corlu and published by . This book was released on 2007 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Spatially dense Multi spectral Frequency domain Diffuse Optical Tomography of Breast Cancer written by Han Yong Ban and published by . This book was released on 2015 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography (DOT) employs near-infrared light to image the concentration of chromophores and cell organelles in tissue and thereby providing access to functional parameters that can differentiate cancerous from normal tissues. This thesis describes research at the bench and in the clinic that explores and identifies the potential of DOT breast cancer imaging. The bench and clinic instrumentation differ but share important features: they utilize a very large, spatially dense, set of source-detector pairs (10 7) for imaging in the parallel-plate geometry.

Download or read book Diffuse Optical Tomography with Multiple Priors written by Ang Li and published by . This book was released on 2005 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: In human tissue, the propagation of near-infrared light beyond a depth of 0.5-cm can be modeled as diffusive photons migrating through randomly distributed particles. The exiting photon measurements are highly sensitive to the variation of hemoglobin content and sensitive to water and adipose content. These enable dynamic, noninvasive quantification of the distribution of tissue physiology. In the past two decades, evolving from the development of pulse oximetry, laser Doppler blood-flowmetry, and near infrared spectroscopy, Diffuse Optical Tomography (DOT) has emerged as a newly established functional imaging modality.

Download or read book Anatomical Realistic Phantom Measurement by the Generation III Optical and Magnetic Resonance Breast Imaging System written by Li Lin and published by . This book was released on 2013 with total page 53 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book New Approaches to Higher Resolution Imaging in Diffuse Optical Tomography written by Ari Goldberg and published by . This book was released on 2004 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Time Resolved and Spectroscopic Three Dimensional Optical Breast Tomography written by and published by . This book was released on 2009 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of the research project, "Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography," was to develop a safe and affordable breast cancer detection modality that uses noninvasive near-infrared (NIR) light for imaging and diagnosing tumors in human breast with high resolution and specificity. In order to realize that goal three different approaches were developed. These are Optical Tomography using Independent Component Analysis (OPTICA), Round Trip Matrix (RTM) approach, and Center of Intensity Time Gated Imaging (CITGI). OPTICA is the most developed of these approaches. It has been demonstrated that OPTICA can detect, obtain the threedimensional location information and cross-section images of small absorbing, scattering, and fluorescent targets in model media, and tumor(s) in realistic model breast with considerable accuracy. Further accomplishments include development of a forward model for determining the backscattered polarized light intensity distribution, and initial development of a technique to determine scattering coefficient, absorption coefficient, and anisotropy factor (g) of breast tissue specimens. Besides detection and localization of tumors in breast, these results may have potential applications in optical biopsy, and lumpectomy. The graduate student supported by the project received his Ph. D., adding another scientist to the ongoing fight against breast cancer.

Download or read book Advances in Optical Biopsy and Optical Mammography written by Robert R. Alfano and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes papers presented at a two-day conference in New York in 1997 on optical biopsy and optical mammography. Topics covered include near-infrared imaging methods such as time-resolved and nonlinear optical imaging, frequency-domain imaging, optical coherence tomography and biopsy, multiphoton excitation confocal microscopy, flourescence lifetime imaging and spectroscopy, spectral diagnosis, and applications of light-based techniques to investigate cancers. Presentations also address physiological markers, such as increased vascularity and changes in blood oxygenation, that may indicate the onset of cancer, in addition to the importance of understanding physiological and pathological factors that may influence optical diagnosis.

Download or read book Optical breast imaging written by Ven and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book System Optimization and Iterative Image Reconstruction in Photoacoustic Computed Tomography for Breast Imaging written by Yang Lou (Biomedical engineer) and published by . This book was released on 2017 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoacoustic computed tomography(PACT), also known as optoacoustic tomography (OAT), is an emerging imaging technique that has developed rapidly in recent years. The combination of the high optical contrast and the high acoustic resolution of this hybrid imaging technique makes it a promising candidate for human breast imaging, where conventional imaging techniques including X-ray mammography, B-mode ultrasound, and MRI suffer from low contrast, low specificity for certain breast types, and additional risks related to ionizing radiation. Though significant works have been done to push the frontier of PACT breast imaging, it is still challenging to successfully build a PACT breast imaging system and apply it to wide clinical use because of various practical reasons. First, computer simulation studies are often conducted to guide imaging system designs, but the numerical phantoms employed in most previous works consist of simple geometries and do not reflect the true anatomical structures within the breast. Therefore the effectiveness of such simulation-guided PACT system in clinical experiments will be compromised. Second, it is challenging to design a system to simultaneously illuminate the entire breast with limited laser power. Some heuristic designs have been proposed where the illumination is non-stationary during the imaging procedure, but the impact of employing such a design has not been carefully studied. Third, current PACT imaging systems are often optimized with respect to physical measures such as resolution or signal-to-noise ratio (SNR). It would be desirable to establish an assessing framework where the detectability of breast tumor can be directly quantified, therefore the images produced by such optimized imaging systems are not only visually appealing, but most informative in terms of the tumor detection task. Fourth, when imaging a large three-dimensional (3D) object such as the breast, iterative reconstruction algorithms are often utilized to alleviate the need to collect densely sampled measurement data hence a long scanning time. However, the heavy computation burden associated with iterative algorithms largely hinders its application in PACT breast imaging. This dissertation is dedicated to address these aforementioned problems in PACT breast imaging. A method that generates anatomically realistic numerical breast phantoms is first proposed to facilitate computer simulation studies in PACT. The non-stationary illumination designs for PACT breast imaging are then systematically investigated in terms of its impact on reconstructed images. We then apply signal detection theory to assess different system designs to demonstrate how an objective, task-based measure can be established for PACT breast imaging. To address theslow computation time of iterative algorithms for PACT imaging, we propose an acceleration method that employs an approximated but much faster adjoint operator during iterations, which can reduce the computation time by a factor of six without significantly compromising image quality. Finally, some clinical results are presented to demonstrate that the PACT breast imaging can resolve most major and fine vascular structures within the breast, along with some pathological biomarkers that may indicate tumor development.

Download or read book Breast Lesion Detection Using Diffuse Optical Imaging written by Anaïs Leproux and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical imaging is een beeldvormende techniek waarbij dieper gelegen weefsels zichtbaar worden gemaakt met behulp van licht. De techniek wordt onder andere gebruikt bij het opsporen van borstkanker. Borsttumoren kunnen dan optisch gelokaliseerd worden door te kijken naar verhoogde absorptie en verstrooiing van licht in tumorweefsel, wat veroorzaakt wordt door lokale verschillen in hemoglobine- en waterconcentraties. Een probleem is vaak dat de resolutie van de beelden vrij laag is. Bovendien zijn afwijkingen in de borst soms minder goed waarneembaar door het relatief geringe contrast tussen tumorweefsel en gewone klieren. Anaïs Leproux onderzocht verschillende manieren om de beeldvorming van borstweefsel te verbeteren om zo borstkanker sneller en beter op te kunnen sporen.

Download or read book Photons Plus Ultrasound written by and published by . This book was released on 2004 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optics Letters written by and published by . This book was released on 2003 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: