Download or read book Drug Discovery and Evaluation Methods in Clinical Pharmacology written by H.Gerhard Vogel and published by Springer Science & Business Media. This book was released on 2010-12-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1993 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Download or read book Index of Conference Proceedings written by British Library. Document Supply Centre and published by . This book was released on 2002 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Applications of Isotopically Labelled Compounds 1988 written by Thomas A. Baillie and published by Elsevier Publishing Company. This book was released on 1989 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Applications of Isotopically Labelled Compounds 1991 written by E. Buncel and published by Elsevier Publishing Company. This book was released on 1992 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds attracted some 400 scientists from over 20 countries. The scientific program consisted of three plenary lectures, 97 invited and contributed talks presented in 15 sessions on diverse topics, and 85 poster presentations. This proceedings volume covers the full texts of all the contributions, providing comprehensive, state-of-the-art information of interest to readers in chemistry, pharmacology, biochemistry and the medical sciences.

Download or read book Energy Research Abstracts written by and published by . This book was released on 1989 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Applications of Isotopically Labeled Compounds written by William P. Duncan and published by Elsevier Science & Technology. This book was released on 1983 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Applications of Isotopically Labeled Compounds 1985 written by Richard Robert Muccino and published by Elsevier Publishing Company. This book was released on 1986 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Methylxanthines written by Bertil B. Fredholm and published by Springer Science & Business Media. This book was released on 2010-09-22 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the present volume of the Handbook of Experimental Pharmacology well known experts describe the actions of different xanthines with a focus on caffeine and theophylline. A special chapter is devoted to theobromine, an active component of chocolate, the actions of which are less well characterized. This book also presents the pharmacology of one xanthine derivative, propentofylline, as an example of a xanthine that has gone through extensive development for a novel therapeutic area.

Download or read book The Cumulative Book Index written by and published by . This book was released on 1999 with total page 2520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Stable Isotope Analytical Techniques written by Pier A. de Groot and published by Elsevier. This book was released on 2004-10-27 with total page 1265 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Parent with price) Volume I contains subjective reviews, specialized and novel technique descriptions by guest authors. Part 1 includes contributions on purely analytical techniques and Part 2 includes matters such as development of mass spectrometers, stability of ion sources, standards and calibration, correction procedures and experimental methods to obtain isotopic fractionation factors.Volume II will be available in 2005.

Download or read book Cumulative Book Index written by and published by . This book was released on 1988 with total page 2056 pages. Available in PDF, EPUB and Kindle. Book excerpt: A world list of books in the English language.

Download or read book Synthesis and Applications of Isotopically Labelled Compounds written by Ulrich Pleiss and published by . This book was released on 2001-03-28 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This outstanding book covers the most recent advances in the production of stable and radioactive isotopes as well as in the synthesis, analysis and applications of isotopically labelled compounds. Written by internationally renowned contributors, it provides authoritative and wide-ranging coverage of significant growth areas including: * new methodologies in the production of isotopes * novel approaches to compounds labelled with isotopes of hydrogen, carbon and other stable, long-lived and short-lived radioactive isotopes * advances in the analysis of istopically labelled compounds * recent and future applications of isotopes in pharmaceutical research and development, in pharmacological and clinical sutdies and nuclear medicine, as well as in agricultural, nutritional and environmental research * recent applications of isotopes in investigating organic and bioorganic mechanisms and pathways * safety and regulations of handling isotopes This will be an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of compounds labelled with stable, long-lived or short-lived radioactive isotopes, in drug research and development, in clinical investigations and nuclear medicine, in agricultural research and development and environmental investigations, in the elucidation of biological and chemical pathways, handling radioisotopes, laboratory design and other areas.

Download or read book Index of Conference Proceedings Received written by British Library. Document Supply Centre and published by . This book was released on 1987 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index of Conference Proceedings Received written by British Library. Lending Division and published by . This book was released on 1983 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Isotope Production and Applications in the 21st Century written by Nigel R. Stevenson and published by World Scientific. This book was released on 2000 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third International Conference on Isotopes focused on the theme of ?Isotope Production and Applications in the 21st Century? and included presentations by several eminent experts in this field. The three central subjects ? Isotopes in Medicine, Industry and the Environment ? were supplemented by presentations on the latest developments in isotope production and synthesis, research into radiopharmaceuticals, applications in agriculture, analytical applications, radiocarbon dating, AMS and PET. Various views on the future directions for producers and users of isotopes were considered at this multi-disciplinary meeting.

Download or read book Modern Chromatographic Analysis Of Vitamins written by Andre P. De Leenheer and published by CRC Press. This book was released on 2000-04-18 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Third Edition collects and examines the tremendous proliferation of information on chromatographic analysis of fat and water soluble vitamins over the last decade. Extensively describes sample preparation and final measurement.