Download or read book Handbook of Eicosanoids 1987 written by A. L. Willis and published by CRC Press. This book was released on 2017-11-22 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building upon the extensive compilation of biochemical data featured in Volume I of the Handbook of Eicosanoids, the new Volume II describes the past, present, and potential future impact of eicosanoid research on new drug development. The reader is taken from a historical perspective through state-of-the-art basic concepts to extensive tabulation of molecular structures of compounds known to act via the eicosanoid system. Much emphasis is given to recent breakthroughs in the mechanism of action of anti-inflammatory corticosteroids and the development of receptor antagonists for prostaglandins and leukotrienes. There is also an introductory chapter that proposes areas that require further investigation and novel approaches using existing technology. This handbook will thus be invaluable for medicinal chemists, pharmacologists, and all those involved in basic research in the eicosanoid area. In addition, many parts of this handbook are suitable for use by university lecturers and students. There are 20 figures and 44 extensive tables as well as a bibliography containing more than 2,000 references that complement the text.

Download or read book Biology of Cellular Transducing Signals written by Jack Y. Vanderhoek and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intercellular communication in multicellular organisms enables cells to respond to environmental changes. Intercellular signal transduction transmitters include hormones, peptide growth factors, neurotransmitters as well as some lipid-soluble mediators. Once signalling molecules are bound to their cell surface receptors, one or more intracellular signals are generated which alter the Qehavior of the target cell. The IXth International Washington Spring Symposium at the George Washington University in Washington, D.C. was organized to assess the current status of the field of signal transduction processes and regulatory mechanisms. The symposium was held on May 8-'.2, 1989 and was attended by more than 1000 scientists from 30 countries. Most of the papers presented at the plenary sessions have been collected in this volume. The first section of this book details the action and regulation of receptors such as ,B-pdr.'nergic receptors and receptors for EGF, insulin, leukotrienes, phosphoinositides and prostaglandins. Section two focuses on the family of guanine nucleotide regulatory proteins (G proteins). These G proteins are known to mediate the coupling of receptor-mediated signals to several intracellular effector systems. Papers are presented describing the intracellular localization of G proteins, the utilization of G protein antibodies, the interaction of G proteins with tubulin and the involvement of G proteins in the regulation of ion channels, adenylate cy~lase and in the activation of neutrophils and T cells. In the third section, several papers describe the second messenger role of phosphoinositides as well as the regulation of phosphoinositide production.

Download or read book Index of Conference Proceedings Received written by British Library. Document Supply Centre and published by . This book was released on 1985 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1984 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index of Conference Proceedings Received written by British Library. Lending Division and published by . This book was released on 1985 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Therapeutic Control of Inflammatory Diseases written by Ivan Otterness and published by Lippincott Williams & Wilkins. This book was released on 1986 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Endothelium written by Michel Félétou and published by Morgan & Claypool Publishers. This book was released on 2011 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References

Download or read book Bronchial Asthma written by M. Eric Gershwin and published by Saunders. This book was released on 1986 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bollettino dell Istituto sieroterapico milanese written by Istituto sieroterapico milanese and published by . This book was released on 1986 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Immunopharmacology written by J. Hadden and published by Elsevier. This book was released on 2016-04-19 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunopharmacology documents the proceedings of the First International Conference on Immunopharmacology held in Brighton, England, in July 1980. The volume contains 60 papers organized into 10 parts. The papers in Part I examine the pharmacology of immunotherapeutic drugs and immunotoxicology. Part II presents studies on thymic hormones. Part III is devoted to immunopharmacologic approaches to diseases other than cancer. Part IV deals with mechanisms of chemotaxis degranulation and microbicidal action. Part V focuses on cancer immunopharmacology and immunotherapy while Part VI covers the mechanisms of inflammatory and allergic processes. Part VII takes up the immune testing of the actions of immunotherapeutic agents. Part VIII discusses prostaglandins and macrophage suppression. Part IX is devoted to selected topics such as mechanism of action of soluble immune response suppressor and new approaches to the therapy of allergic diseases. Part X presents discussions during the therapy communication sessions.

Download or read book Oral and Maxillofacial Infections written by Richard G. Topazian and published by Saunders. This book was released on 1994 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Abridged Index Medicus written by and published by . This book was released on 1984 with total page 906 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Immunopharmacology written by J. W. Hadden and published by Elsevier. This book was released on 2013-10-22 with total page 893 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second of two volumes covering the most recent developments in this new field. Like the previous volume, this book brings together the two fields of immunology and pharmacology, and offers a review format for advances in basic aspects, as well as an update in discussion format of therapy-related advances.

Download or read book Lipid Mediators written by Fiona M. Cunningham and published by . This book was released on 1994 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of lipid mediators from synthesis to inhibition. It addresses the immune system and its diseases from a pharmacological viewpoint and combines clinical aspects with basic science.

Download or read book New Trends in Allergy III written by Johannes Ring and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: The international symposium "New Trends in Allergy", held in Munich from July 13 to 15, 1990, brought together for the third time since 1980 some of the most experienced researchers working in the field of allergy. This volume comprises the papers presented at this meeting. All over the world, and not merely in the industrialized countries, allergy is becoming a cause of evermore serious diseases. In recent years, research in the field of allergy has provided numerous impor tant and fascinating results extending our knowledge considerably. Despite the new insights into basic mechanisms of allergic reactions, improved diagnostic methods, and new therapeutic approaches, how ever, many questions remain to be answered, including: Are allergies really increasing in frequency? If so, what are the reasons? Especially, does environmental pollution playa role? Which factors influence IgE synthesis? Can the IgE immune response be switched off? Does the nervous system interact with allergic reactions? If so, what are the mechanisms? Are new approaches in allergy prophylaxis and allergy therapy effi cient? What measures have proven useful and deserve to be employed in daily practice? In this volume, these questions and other current topics are dealt with. As each issue is covered by authors competent in the respective fields, the result is an extensive and critical review of the state of the art. Going through these papers, one comes to the conviction that allergy research is a multifacetted, explosively expanding, most stimulating field of work.

Download or read book Central Veterinary Conference Proceedings written by and published by . This book was released on 2002 with total page 1414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Polyunsaturated Fatty Acid Metabolism written by Graham C. Burdge and published by Elsevier. This book was released on 2018-05-04 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polyunsaturated Fatty Acid Metabolism explores a number of major roles of PUFA in the body, including its role as a component of cell membranes and how it provides substrates for the synthesis of lipid second messengers. Recent studies are unraveling the effect of interactions between diet and endocrine factors and genetic and epigenetic variation on the regulation of PUFA biosynthesis in animals. Together, these recent findings provide novel insights into the impact of differences in PUFA supply on health. This book captures these findings in a manner that marks the state-of-the-art, placing them in the wider context of PUFA metabolism and nutritional science. Users will find a comprehensive discussion on the topic that presents the contributions of leading researchers who combine their knowledge to create a cohesive academic resource for researchers, those involved in production, and health policymakers. - Provides a comprehensive view of polyunsaturated fatty acid metabolism - Describes underlying metabolism on lipids that include polyunsaturated fatty acids - Includes discussions on recent findings on the genetic and epigenetic regulation of polyunsaturated fatty acid metabolism