Download or read book Probing Mechanisms and Improving Management of Glaucoma Following Boston Keratoprosthesis Surgery written by Dominique Geoffrion and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Corneal blindness is a leading cause of visual impairment worldwide. The most common treatment is to replace the diseased cornea by standard corneal transplantation. In eyes at high risk of graft failure, the Boston keratoprosthesis type 1 (KPro) can be used to restore vision and is currently the most frequently used artificial cornea in the world. However, glaucoma is a well-known complication of KPro surgery and is the most important threat to vision in KPro-implanted eyes. This chronic disease is influenced by elevated intraocular pressure (IOP) and damages the optic nerve, leading to progressive vision loss. In KPro patients, glaucoma is highly prevalent and extremely challenging to manage, yet its exact cause remains unknown. The overall purpose of this work is to better understand the mechanisms and how to improve management of glaucoma after KPro implantation. The approaches used in this thesis include investigating one of the largest KPro patient cohorts in North America. The first objective was to identify risk factors for glaucoma development and progression after KPro. Multivariate logistic regression revealed that high preoperative IOP signals a higher risk for both glaucoma development and progression. Stromal and endothelial corneal disorders are less associated with glaucoma progression, while autoimmune and ocular surface diseases precipitate glaucoma development. Second, there is no objective evidence that indicates the best order for glaucoma surgeries and KPro implantation. By comparing medical and surgical management in KPro eyes with either preexisting or de novo glaucoma, we showed that glaucoma surgery may be performed before or at the time of KPro in eyes with preexisting glaucoma to limit progression without increasing complications. In eyes with de novo glaucoma, glaucoma surgery does not increase complications compared to medications. Third, among glaucoma surgery interventions, the two most frequently implanted glaucoma drainage devices were compared in KPro patients. Compared to the Ahmed valve, the Baerveldt implant is associated with lower failure rates, without increased postoperative complications. Fourth, even with aggressive management, many KPro patients suffer from progressive optic nerve damage, sometimes despite normal IOP. Inflammatory cytokines play an important role in glaucomatous optic neuropathy, but their role in KPro-associated glaucoma is still unknown. By analyzing tear fluid of KPro patients by multiplex bead immunoassay, we identified that cytokines TNF-a, IL-1b, FGF-basic, and IFN-g are elevated in KPro patients with glaucoma compared to those without. These cytokines correlate with optic nerve excavation and IOP. For the first time in humans, these results concord with the elevations of TNF-a and IL-1b documented in the mouse KPro model. Ocular surface inflammation may thus reflect the inflammatory processes that perpetuate glaucoma damage years after KPro surgery. Fifth, we determined that miniaturized mouse KPro implantation requires extensive practice to be used as a reproducible model of glaucoma post-KPro. KPro animal models with larger eyes and a full-thickness 360 degrees corneal excision should be prioritized to best validate human outcomes. In conclusion, glaucoma in KPro eyes is a long-lasting and multifactorial process. Most probable mechanisms combine IOP-independent inflammation mediated by TNF-a and IL-1b that prolong glaucoma damage, together with post-surgical angle closure elevating the IOP. Altogether, our results inform glaucoma risk profiling of transplant recipients, improvement of surgical management of KPro patients with glaucoma, and development of targeted treatments to minimize glaucomatous damage after KPro. Ultimately, this work has the potential to preserve the vision of thousands of patients who undergo KPro surgery every year worldwide, and to provide insight for the role of inflammation in other diseases involving neuronal damage"--

Download or read book Keratoprostheses and Artificial Corneas written by M. Soledad Cortina and published by Springer. This book was released on 2014-11-03 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the field of keratoprosthesis in detail and focuses specifically on the Boston type 1 keratoprosthesis (KPro), which is the device most widely used today. Extensive information is provided on all aspects of KPro surgery, from history and preoperative evaluation to surgical techniques and postoperative management of complications. Surgical videos are included that will aid both beginning and advanced corneal surgeons in mastering these procedures. In addition, essential basic science concepts relevant to keratoprosthesis surgery are explained and other keratoprostheses in use around the world are considered. A brief overview of integrating artificial corneas is provided and the future of keratoprosthesis is also discussed. The book is written by some of the most distinguished and renowned experts in the field.

Download or read book Aniridia written by Mohit Parekh and published by Springer. This book was released on 2015-08-25 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to highlight the latest findings in Aniridia research. Aniridia, meaning “without iris”, is a rare genetic disorder affecting vision, characterized by the incomplete formation of the iris (the coloured part of the eye that surrounds the black pupil). It may also cause other segments of the eye to be under-developed such as the optic nerve and the macula (the central part of the retina). Aniridia and associated conditions affect individuals differently. So while some affected people are partially sighted or blind, others may have near normal sight. Aniridia is congenital (present at birth) and is caused by a dysfunction of the PAX6 gene, situated on the 11th chromosome that causes the premature cessation of eye development. Aniridia affects between 1:40,000 to 1:100,000 people, and affects males and females equally. People with Aniridia may also experience secondary conditions such as Photophobia, Nystagmus, Glaucoma, Cataracts and Keratopathy.

Download or read book Principles and Practice of Vitreoretinal Surgery written by Narendran V and published by JP Medical Ltd. This book was released on 2014-05-30 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to the latest techniques in vitreoretinal surgery. Beginning with an introduction to the basics, each of the following chapters discusses surgical procedures for different retinal disorders. A complete section is dedicated to paediatric retinal surgery. Emerging techniques are also covered. This practical guide is an invaluable resource for both practising ophthalmic surgeons as well as trainees. More than 400 clinical photographs, diagrams and tables enhance learning. Key points Comprehensive guide to latest techniques in vitreoretinal surgery Covers numerous retinal disorders Paediatric retinal surgery covered Includes more than 400 clinical photographs, diagrams and tables

Download or read book Expert Techniques in Ophthalmic Surgery written by Parul Ichhpujani and published by Jaypee Brothers Medical Publishers. This book was released on 2019-06-30 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this comprehensive, 1032-pages text and atlas provides ophthalmic surgeons and trainees with the latest advances and techniques in their field. Divided into ten sections, the book begins with an overview of the basic principles of ophthalmic surgery. Each of the following sections is dedicated to surgical procedures for diseases and disorders in different parts of the eye. Surgical techniques are explained in a step by step format and each section is colour-coded for easy cross reference and navigation. Ethics and medico-legal issues are also discussed in depth. Authored by internationally recognised experts in ophthalmic surgery, this new edition has been fully revised and updated. Nearly 1000 clinical photographs, illustrations and tables further enhance the extensive text. Key points Comprehensive text and atlas providing latest advances and techniques in ophthalmic surgery Fully revised, second edition with nearly 1000 photographs, illustrations and tables Internationally recognised author team Previous edition (9789351525004) published in 2015

Download or read book Surgical Management of Childhood Glaucoma written by Alana L. Grajewski and published by Springer. This book was released on 2018-10-08 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide thoroughly covers the characteristics and presentations of childhood glaucoma, as well as all surgical options for treatment. Surgical Management of Childhood Glaucoma: Clinical Considerations and Techniques addresses a variety of surgical methods, ranging from angle surgery with recent modifications to cyclodestruction, reviewing each option’s particular set of advantages and disadvantages, and features illustrations and instructional videos of these techniques. Later chapters consider best-practices to providing surgery in developing countries, surgical considerations for patients with corneal opacities and cataracts, and the impact of glaucoma upon quality of life of pediatric patients. Written by leaders in the field of ophthalmology, this book offers readers an exceptional resource on the evaluation and surgical management of childhood glaucoma.

Download or read book Corneal Collagen Cross Linking written by Mazen M. Sinjab and published by Springer. This book was released on 2016-11-09 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of corneal collagen cross-linking (CXL), a major management modality for keratoconus and ectatic corneal disorders. All aspects are covered, including refractive and non-refractive surgery indications, models of application, safety, efficacy, performance, outcome measures, evidence of CXL, complications, contraindications, use in children, and controversies. The discussion reflects the considerable progress that has been made in understanding of the modality since its development in the late 1990s. Detailed attention is paid to new concepts, changing surgical techniques and indications, the latest evidence-based science and research, and the future of CXL. Guidance is also provided on the use of CXL in combination with other modalities, such as LASIK, PRK, intracorneal ring implantation and others. The text is accompanied by numerous high-quality color illustrations. Corneal Collagen Cross Linking will provide the reader with a sound grasp of the technique and its use and will hopefully also serve as a stimulus to further research and advances.

Download or read book Operative Dictations in Ophthalmology written by Eric D. Rosenberg and published by Springer Nature. This book was released on 2021-03-10 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely second edition expands upon the first edition, working to provide physicians with a comprehensive review of surgical cases within the field of ophthalmology. Extensive updates have been made to existing chapters, along with new chapters on hot topics in ophthalmology inserted throughout the existing text. Featuring important steps within each surgical case, indications for the procedure, possible complications, and a sample dictation – the review serves as both a preparation and debriefing for each surgeon, or surgeon in training, by improving comprehension time, cultivating surgical forethought, and refining post-operative dictations.

Download or read book Master Techniques in Ophthalmic Surgery written by Frederick Hampton Roy and published by JP Medical Ltd. This book was released on 2015-04-30 with total page 1185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Master Techniques in Ophthalmic Surgery covers all topics related to ophthalmic surgery in 149 chapters. This comprehensive book includes significant sections on various structures of the visual system, covering anterior chamber, choroid, conjunctiva, cornea, globe, iris and ciliary body, lacrimal system, lens, optical nerve, orbit, sclera and vitreous. The most extensive sections of this book concern the extraocular muscles, eyelids and retina, providing detailed information on multidisciplinary aspects. Master Techniques in Opthalmic Surgery is an essential reference for all practitioners, providing diagnoses and indications for surgery, surgical techniques, outcomes and references for a variety of ophthalmic conditions. Key Features Extensive coverage of every ophthalmic surgery technique over 1000 pages Each section covers part of the anatomical structure of the eye in detail 1116 full colour images Authored by renowned US ophthalmologist Frederick Hampton Roy

Download or read book Stem Cells and Biomaterials for Regenerative Medicine written by Marek J. Los and published by Academic Press. This book was released on 2018-11-07 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Biomaterials for Regenerative Medicine addresses the urgent need for a compact source of information on both the cellular and biomaterial aspects of regenerative medicine. By developing a mutual understanding between three separately functioning areas of science—medicine, the latest technology, and clinical economics—the volume encourages interdisciplinary relationships that will lead to solutions for the significant challenges faced by today's regenerative medicine. Users will find sections on the homeostatic balance created by apoptosis and proliferating tissue stem cells, the naturally regenerative capacities of various tissue types, the potential regenerative benefits of iPS-generation, various differentiation protocols, and more. Written in easily accessbile language, this volume is appropriate for any professional or medical staff looking to expand their knowledge with regard to stem cells and regenerative medicine. Arms readers with key information on tissue engineering, artificial organs and biomaterials, while using broadly accessible language Provides broad introduction to, and examples of, various types of stem cells, core concepts of regenerative medicine, biomaterials, nanotechnology and nanomaterials, somatic cell transdyferentiation, and more Edited and authored by researchers with expertise in regenerative medicine, (cancer) stem cells, biomaterials, genetics and nanomaterials

Download or read book Ocular Rigidity Biomechanics and Hydrodynamics of the Eye written by Ioannis Pallikaris and published by Springer Nature. This book was released on 2021-05-26 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the concept of ocular rigidity, the biomechanical properties and hydrodynamics of the human eye. The basics of anatomy and physiology are explored and the relevant data for the clinician are emphasized throughout the book. The engineering aspects as well as the clinical interpretation are presented to provide context. Ocular Rigidity, Biomechanics and Hydrodynamics of the Eye summarises recent evidence on ocular rigidity, but also provides a complete presentation of the data so far. The authors have recently worked on ocular rigidity corneal and globe biomechanics and hydrodynamics and the new, up-to-date data on the subject are highlighted in each chapter. The aim is to provide the framework or the understanding of these parameters and to determine their relevance in health and disease. This book will be an essential read for all practicing ophthalmologists looking to gain a more in-depth understanding of this interesting area of research particularly in refractive surgery and glaucoma.

Download or read book Practical Management of Pediatric Ocular Disorders and Strabismus written by Elias Traboulsi and published by Springer. This book was released on 2016-07-27 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: This case-based approach to the management of pediatric eye diseases and strabismus teaches the novice, as well as the experienced surgeon, how to conceptualize and analyze surgical planning to maximize patient outcomes, allowing readers to “get inside the head of the surgeon.” Individual cases with clear instructions and an abundance of color illustrations, presented by experts in the field, teach critical information one case at a time. Practical Management of Pediatric Ocular Disorders and Strabismus provides the key guiding principles of a traditional textbook in an easy-to-digest format. Each chapter of the text tackles a common or rare clinical situation and begins with the description of an illustrative case. The chapters are structured with sections on case description, differential diagnosis, management and outcomes with a list of possible complications and the approach to their management.

Download or read book Lacrimal Gland Tear Film and Dry Eye Syndromes written by David A. Sullivan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade a significant international research effort has been directed towards understanding the composition and regulation of the preocular tear film. This effort has been motivated by the recognition that the tear film plays an essential role in maintaining corneal and conjunctival integrity, protecting against microbial challenge and preserving visual acuity. In addition, research has been stimulated by the knowledge that alteration or deficiency of the tear film, which occurs in countless individuals throughout the world, may lead to desiccation of the ocular surface, ulceration and perforation of the cornea, an increased incidence of infectious disease, and potentially, pronounced visual disability and blindness. 7 To promote further progress in this field of vision research, the International Conference on the Lacrimal Gland, Tear Film and Dry Eye Syndromes: Basic Science and Clinical Relevance was held in the Southampton Princess Resort in Bermuda from November 14 to 17, 1992. This meeting was designed to assess critically the current knowledge and 'state of the art' research on the structure and function of lacrimal tissue and tears in both health and disease. The goal of this conference was to provide an international exchange of information that would be of value to basic scientists involved in eye research, to physicians in the ophthalmological community, and to pharmaceutical companies with an interest in the treatment of lacrimal gland, tear film or ocular surface disorders (e. g. Sjogren's syndrome).

Download or read book Handbook of Biomaterial Properties written by William Murphy and published by Springer. This book was released on 2016-06-11 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides tabular and text data relating to normal and diseased tissue materials and materials used in medical devices. Comprehensive and practical for students, researchers, engineers, and practicing physicians who use implants, this book considers the materials aspects of both implantable materials and natural tissues and fluids. Examples of materials and topics covered include titanium, elastomers, degradable biomaterials, composites, scaffold materials for tissue engineering, dental implants, sterilization effects on material properties, metallic alloys, and much more. Each chapter author considers the intrinsic and interactive properties of biomaterials, as well as their appropriate applications and historical contexts. Now in an updated second edition, this book also contains two new chapters on the cornea and on vocal folds, as well as updated insights, data, and citations for several chapters.

Download or read book Glaucoma Imaging written by Antonio Ferreras and published by Springer. This book was released on 2015-10-21 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas offers a truly comprehensive update on the use of imaging technologies for the diagnosis and follow-up of glaucoma. In addition to standard automated perimetry, gonioscopy, fundus photography, and stereophotography, other advanced, high-resolution methods for imaging the eye in glaucoma are explained in detail, including ultrasound biomicroscopy, confocal scanning laser ophthalmoscopy, scanning laser polarimetry, and spectral domain optical coherence tomography. The role of the various tests and the keys to optimizing their use in clinical practice are detailed with the aid of high-quality figures in order to enable the reader to achieve the best possible performance when applying these tools. The risk of developing visual disability and blindness as a consequence of glaucoma varies widely among affected individuals. Personalized testing strategies and tailored therapeutic interventions are required to effectively reduce visual impairment due to glaucoma. Glaucoma Imaging will assist residents, researchers, and clinicians in improving their ability to understand and integrate the information obtained using traditional techniques with the reports provided by computer-assisted image instruments.

Download or read book Albert and Jakobiec s Principles and Practice of Ophthalmology written by Daniel M. Albert and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keeping up to date with advances in comprehensive ophthalmology and in the ophthalmic sub-specialties is extremely difficult because of the accelerating rapidity with which new information and technology become available and the diminishing time and opportunity for practitioners and trainees to read and learn. The first edition of Albert and Jakobiec's Principles and Practice (1994) was conceived with the idea of utilizing an electronic, updated version in which the chapters were revised by the chapter authors on an annual or semi-annual basis, but the technology was not sufficiently advanced to achieve this goal. Subsequent editions (2000 and 2008) were organized by Saunders and the last published by Elsevier (of which Springer has obtained the complete rights to move forward with the 4th edition). For nearly three decades, this text has provided its readers with authoritative and comprehensive coverage of clinical ophthalmology, written and edited by a group of authors who represented a "Who's Who" in ophthalmology. By using Springer's Meteor platform, with its ability to allow authors and editors access to updating their chapters online annually/semi-annually, and with the recruitment of select chapter authors, this work's usefulness as the standard text in ophthalmology will be maintained and expanded upon by Springer. The 4th edition of this comprehensive and authoritative text is written by hundreds of the most distinguished authorities from around the world and edited by four leaders in the field, providing today's best answers to every question that arises in ophthalmology practice. Richly illustrated with thousands of high quality, full color, clinically-relevant images, Albert and Jakobiec's Principles and Practice of Ophthalmology, 4th Edition covers every scientific and clinical principle in ophthalmology, ensuring that the reader will always be able to find the guidance needed to diagnose and manage patients' ocular problems and meet today's standards of care. Written for practicing ophthalmologists and trainees, this book delivers in-depth guidance on new diagnostic approaches, operative techniques, and treatment options, as well as coherent explanations of new scientific concept and its clinical importance. The 4th edition will prove to be the source every practicing clinician needs to efficiently and confidently overcome any clinical challenge they may face. Updates include new chapters on anterior and posterior segment diseases, as well as chapters more focused on treatment, plus thousands of new, high-quality, color images and illustrations, updated references, and information on the most cutting-edge technology used by clinicians in their practices today. Additionally, readers will enjoy the same, user-friendly, full-color design they remember from the previous edition, complete with many at-a-glance summary tables, algorithms, boxes, and diagrams that allow the reader to locate the assistance needed more rapidly than ever. .

Download or read book Endophthalmitis written by Marlene L. Durand and published by Springer. This book was released on 2016-04-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endophthalmitis is a serious eye infection that can cause blindness if not promptly diagnosed and appropriately treated. The goals of this book are to provide the latest information about endophthalmitis and offer recommendations for diagnosis and treatment. Each chapter is written by experts in the field with the practicing clinician in mind. Several chapters focus on the major types of endophthalmitis such as postoperative, post-intravitreal injection, bleb-related, exogenous fungal, chronic, and endogenous endophthalmitis. Other chapters describe endophthalmitis in special populations such as diabetic or immunocompromised hosts or those with a glaucoma drainage device, keratoprosthesis, or other artificial implant. Also included are chapters that provide an overview of endophthalmitis as seen around the world, summarize current understanding of endophthalmitis pathogenesis, describe the latest microbiologic and molecular diagnostic techniques, and discuss emerging problems such as multidrug-resistant pathogens. A final chapter offers recommendations for ways to prevent this devastating eye infection.