Download or read book Principles of Quantitative Living Systems Science written by James R. Simms and published by Springer Science & Business Media. This book was released on 2005-12-02 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1978, when the book Living Systems was published, it contained the prediction that the sciences that were concerned with the biological and social sciences would, in the future, be stated as rigorously as the “hard sciences” that study such nonliving phenomena as temperature, distance, and the interaction of chemical elements. Principles of Quantitative Living Systems Science, the first of a planned series of three books, begins an attempt to fulfill that prediction. The view that living things are similar to other parts of the physical world, differing only in their complexity, was explicitly stated in the early years of the twentieth century by the biologist Ludwig von Bertalanffy. His ideas could not be published until the end of the war in Europe in the 1940s. Von Bertalanffy was strongly opposed to vitalism, the theory current among biologists at the time that life could only be explained by recourse to a “vital principle” or God. He c- sidered living things to be a part of the natural order, “systems” like atoms and molecules and planetary systems. Systems were described as being made up of a number of interrelated and interdependent parts, but because of the interrelations, the total system became more than the sum of those parts. These ideas led to the development of systems movements, in both Europe and the United States, that included not only biologists but scientists in other fields as well. Systems societies were formed on both continents.
Download or read book Principles of Systems Science written by George E. Mobus and published by Springer. This book was released on 2014-11-11 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pioneering text provides a comprehensive introduction to systems structure, function, and modeling as applied in all fields of science and engineering. Systems understanding is increasingly recognized as a key to a more holistic education and greater problem solving skills, and is also reflected in the trend toward interdisciplinary approaches to research on complex phenomena. While the concepts and components of systems science will continue to be distributed throughout the various disciplines, undergraduate degree programs in systems science are also being developed, including at the authors’ own institutions. However, the subject is approached, systems science as a basis for understanding the components and drivers of phenomena at all scales should be viewed with the same importance as a traditional liberal arts education. Principles of Systems Science contains many graphs, illustrations, side bars, examples, and problems to enhance understanding. From basic principles of organization, complexity, abstract representations, and behavior (dynamics) to deeper aspects such as the relations between information, knowledge, computation, and system control, to higher order aspects such as auto-organization, emergence and evolution, the book provides an integrated perspective on the comprehensive nature of systems. It ends with practical aspects such as systems analysis, computer modeling, and systems engineering that demonstrate how the knowledge of systems can be used to solve problems in the real world. Each chapter is broken into parts beginning with qualitative descriptions that stand alone for students who have taken intermediate algebra. The second part presents quantitative descriptions that are based on pre-calculus and advanced algebra, providing a more formal treatment for students who have the necessary mathematical background. Numerous examples of systems from every realm of life, including the physical and biological sciences, humanities, social sciences, engineering, pre-med and pre-law, are based on the fundamental systems concepts of boundaries, components as subsystems, processes as flows of materials, energy, and messages, work accomplished, functions performed, hierarchical structures, and more. Understanding these basics enables further understanding both of how systems endure and how they may become increasingly complex and exhibit new properties or characteristics. Serves as a textbook for teaching systems fundamentals in any discipline or for use in an introductory course in systems science degree programs Addresses a wide range of audiences with different levels of mathematical sophistication Includes open-ended questions in special boxes intended to stimulate integrated thinking and class discussion Describes numerous examples of systems in science and society Captures the trend towards interdisciplinary research and problem solving
Download or read book Living Systems written by James Grier Miller and published by McGraw-Hill Companies. This book was released on 1978 with total page 1172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Biology Dynamics of Living Systems written by Noriko Hiroi and published by Frontiers Media SA. This book was released on 2017-07-24 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the emergence of Systems Biology, there is a greater realization that the whole behavior of a living system may not be simply described as the sum of its elements. To represent a living system using mathematical principles, practical quantities with units are required. Quantities are not only the bridge between mathematical description and biological observations; they often stand as essential elements similar to genome information in genetics. This important realization has greatly rejuvenated research in the area of Quantitative Biology. Because of the increased need for precise quantification, a new era of technological development has opened. For example, spatio-temporal high-resolution imaging enables us to track single molecule behavior in vivo. Clever artificial control of experimental conditions and molecular structures has expanded the variety of quantities that can be directly measured. In addition, improved computational power and novel algorithms for analyzing theoretical models have made it possible to investigate complex biological phenomena. This research topic is organized on two aspects of technological advances which are the backbone of Quantitative Biology: (i) visualization of biomolecules, their dynamics and function, and (ii) generic technologies of model optimization and numeric integration. We have also included articles highlighting the need for new quantitative approaches to solve some of the long-standing cell biology questions. In the first section on visualizing biomolecules, four cutting-edge techniques are presented. Ichimura et al. provide a review of quantum dots including their basic characteristics and their applications (for example, single particle tracking). Horisawa discusses a quick and stable labeling technique using click chemistry with distinct advantages compared to fluorescent protein tags. The relatively small physical size, stability of covalent bond and simple metabolic labeling procedures in living cells provides this type of technology a potential to allow long-term imaging with least interference to protein function. Obien et al. review strategies to control microelectrodes for detecting neuronal activity and discuss techniques for higher resolution and quality of recordings using monolithic integration with on-chip circuitry. Finally, the original research article by Amariei et al. describes the oscillatory behavior of metabolites in bacteria. They describe a new method to visualize the periodic dynamics of metabolites in large scale cultures populations. These four articles contribute to the development of quantitative methods visualizing diverse targets: proteins, electrical signals and metabolites. In the second section of the topic, we have included articles on the development of computational tools to fully harness the potential of quantitative measurements through either calculation based on specific model or validation of the model itself. Kimura et al. introduce optimization procedures to search for parameters in a quantitative model that can reproduce experimental data. They present four examples: transcriptional regulation, bacterial chemotaxis, morphogenesis of tissues and organs, and cell cycle regulation. The original research article by Sumiyoshi et al. presents a general methodology to accelerate stochastic simulation efforts. They introduce a method to achieve 130 times faster computation of stochastic models by applying GPGPU. The strength of such accelerated numerical calculation are sometimes underestimated in biology; faster simulation enables multiple runs and in turn improved accuracy of numerical calculation which may change the final conclusion of modeling study. This also highlights the need to carefully assess simulation results and estimations using computational tools.
Download or read book General Systems Theory written by Yi Lin and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: As suggested by the title of this book, I will present a collection of coherently related applications and a theoretical development of a general systems theory. Hopefully, this book will invite all readers to sample an exciting and challenging (even fun!) piece of interdisciplinary research, that has characterized the scientific and technological achievements of the twentieth century. And, I hope that many of them will be motivated to do additional reading and to contribute to topics along the lines described in the following pages. Since the applications in this volume range through many scientific disciplines, from sociology to atomic physics, from Einstein’s relativity theory to Dirac’s quan tum mechanics, from optimization theory to unreasonable effectiveness of mathe matics to foundations of mathematical modeling, from general systems theory to Schwartz’s distributions, special care has been given to write each application in a language appropriate to that field. That is, mathematical symbols and abstractions are used at different levels so that readers in various fields will find it possible to read. Also, because of the wide range of applications, each chapter has been written so that, in general, there is no need to reference a different chapter in order to understand a specific application. At the same time, if a reader has the desire to go through the entire book without skipping any chapter, it is strongly suggested to refer back to Chapters 2 and 3 as often as possible.
Download or read book Quantitative Physiology written by Shangbin Chen and published by Springer Nature. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics
Download or read book Facets of Systems Science written by George J. Klir and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has a rather strange history. It began in spring 1989, thirteen years after our Systems Science Department at SUNY-Binghamton was established, when I was asked by a group of students in our doctoral program to have a meeting with them. The spokesman of the group, Cliff Joslyn, opened our meeting by stating its purpose. I can closely paraphrase what he said: "We called this meeting to discuss with you, as Chairman of the Department, a fundamental problem with our systems science curriculum. In general, we consider it a good curriculum: we learn a lot of concepts, principles, and methodological tools, mathematical, computational, heu ristic, which are fundamental to understanding and dealing with systems. And, yet, we learn virtually nothing about systems science itself. What is systems science? What are its historical roots? What are its aims? Where does it stand and where is it likely to go? These are pressing questions to us. After all, aren't we supposed to carry the systems science flag after we graduate from this program? We feel that a broad introductory course to systems science is urgently needed in the curriculum. Do you agree with this assessment?" The answer was obvious and, yet, not easy to give: "I agree, of course, but I do not see how the situation could be alleviated in the foreseeable future.
Download or read book Quantitative Elements of General Biology written by Ivan V. Maly and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph sketches out a broad spectrum of problems (from evolution and metabolism to morphogenesis and biogeographical dynamics) whose solution has been impacted by mathematical models. Each of the selected examples has led to the recognition and set direction to further study of certain fundamental but unintuitive properties of biological systems, such as the making and breaking of specific symmetries that underlie morphogenesis. Whether they are long-established or only recently accepted, these models are selected for being thought-provoking and illuminating both the achievements and the gaps in our current understanding of the given area of biology. The selection of models is also meant to bring to the fore the existing degree of unity in the quantitative approach to diverse general-biological questions and in the systems-level properties that are discovered across the levels of biological organization. It is the thesis of this book that further cultivation of such unity is a way forward as we progress toward a general theory of living matter. This is an ideal book for students (in the broadest sense) of biology who wish to learn from this attempt to present the exemplary models, their methodological lessons, and the outline of a unified theory of living matter that is now beginning to emerge. In addition to a doctoral student preparing for quantitative biology research, this reader could also be an interdisciplinary scientist transitioning to biology. The latter for example, a physicist or an engineer may be comfortable with the mathematical apparatus and prepared to quickly enter the intended area of work, but desires a broader foundation in biology from the quantitative perspective.
Download or read book Physical Models of Living Systems written by Philip Nelson and published by Macmillan Higher Education. This book was released on 2014-12-20 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for intermediate-level undergraduates pursuing any science or engineering major, Physical Models of Living Systems helps students develop many of the competencies that form the basis of the new MCAT2015. The only prerequisite is first-year physics. With the more advanced "Track-2" sections at the end of each chapter, the book can be used in graduate-level courses as well.
Download or read book A Guide to Systems Research written by Mary C. Edson and published by Springer. This book was released on 2016-12-15 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide is designed for systems researchers – emerging and seasoned – searching for holistic approaches of inquiry into complexity, which the Systems Sciences provide. The authors share insight into the foundations of research that are not only systematic in terms of rigor, but systemic in perspective, analysis, design, development, implementation, reporting, and evaluation. This guide also explores researcher competencies necessary to conduct sound systems research. Researchers using this guide will gain understanding of what distinguishes systems research from other types of research and why it is important in research today.
Download or read book Understanding Complexity written by Gillian Ragsdell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peter A. Coming Palo Alto, CA November, 2000 This volwne represents a distillation of the plenary sessions at a unique millenniwn year event -a World Congress of the Systems Sciences in conjunction with the 44th annual meeting of the International Society for the Systems Sciences (ISSS). The overall theme of the conference was "Understanding Complexity in the New Millenniwn. " Held at Ryerson Polytechnic University in Toronto, Canada, from July 16-22,2000, the conference included some 350 participants from over 30 countries, many of whom were representatives of the 21 organizations and groups that co-hosted this landmark event. Each of these co-host organizations/groups also presented a segment of the program, including a plenary speech. In addition, the conference featured a nwnber of distinguished "keynote" speeches related to the three daily World Congress themes: (1) The Evolution of Complex Systems, (2) The Dynamics of Complex Systems, and (3) Human Systems in the 21st Century. There were also seven special plenary-level symposia on a range of timely topics, including: "The Art and Science of Forecasting in the Age of Global Wanning"; "Capitalism in the New Millenniwn: The Challenge of Sustainability"; "The Future of the Systems Sciences"; "Global Issues in the New Millenniwn"; "Resources and the Environment in the New Millenniwn"; "The Lessons of Y2K"; and "Can There be a Reconciliation Between Science and Religion?" Included in this special commemorative volume is a cross-section of these presentations.
Download or read book Quantitative Elements of General Biology written by Ivan Maly and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph sketches out a broad spectrum of problems (from evolution and metabolism to morphogenesis and biogeographical dynamics) whose solution has been impacted by mathematical models. Each of the selected examples has led to the recognition-and set direction to further study-of certain fundamental but unintuitive properties of biological systems, such as the making and breaking of specific symmetries that underlie morphogenesis. Whether they are long-established or only recently accepted, these models are selected for being thought-provoking and illuminating both the achievements and the gaps in our current understanding of the given area of biology. The selection of models is also meant to bring to the fore the existing degree of unity in the quantitative approach to diverse general-biological questions and in the systems-level properties that are discovered across the levels of biological organization. It is the thesis of this book that further cultivation of such unity is a way forward as we progress toward a general theory of living matter. This is an ideal book for students (in the broadest sense) of biology who wish to learn from this attempt to present the exemplary models, their methodological lessons, and the outline of a unified theory of living matter that is now beginning to emerge. In addition to a doctoral student preparing for quantitative biology research, this reader could also be an interdisciplinary scientist transitioning to biology. The latter-for example, a physicist or an engineer-may be comfortable with the mathematical apparatus and prepared to quickly enter the intended area of work, but desires a broader foundation in biology from the quantitative perspective.
Download or read book Intelligent Robotic Systems written by Witold Jacak and published by Springer Science & Business Media. This book was released on 2005-12-27 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is a comprehensive presentation of methodology for the design and synthesis of an intelligent complex robotic system, connecting formal tools from discrete system theory, artificial intelligence, neural network, and fuzzy logic. The necessary methods for solving real time action planning, coordination and control problems are described. A notable chapter presents a new approach to intelligent robotic agent control acting in a realworld environment based on a lifelong learning approach combining cognitive and reactive capabilities. Another key feature is the homogeneous description of all solutions and methods based on system theory formalism.
Download or read book The Systems View of Life written by Fritjof Capra and published by Cambridge University Press. This book was released on 2014-04-10 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past thirty years, a new systemic conception of life has emerged at the forefront of science. New emphasis has been given to complexity, networks, and patterns of organisation, leading to a novel kind of 'systemic' thinking. This volume integrates the ideas, models, and theories underlying the systems view of life into a single coherent framework. Taking a broad sweep through history and across scientific disciplines, the authors examine the appearance of key concepts such as autopoiesis, dissipative structures, social networks, and a systemic understanding of evolution. The implications of the systems view of life for health care, management, and our global ecological and economic crises are also discussed. Written primarily for undergraduates, it is also essential reading for graduate students and researchers interested in understanding the new systemic conception of life and its implications for a broad range of professions - from economics and politics to medicine, psychology and law.
Download or read book Holistic Darwinism written by Peter Corning and published by University of Chicago Press. This book was released on 2010-08-15 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, evolutionary theorists have come to recognize that the reductionist, individualist, gene-centered approach to evolution cannot sufficiently account for the emergence of complex biological systems over time. Peter A. Corning has been at the forefront of a new generation of complexity theorists who have been working to reshape the foundations of evolutionary theory. Well known for his Synergism Hypothesis—a theory of complexity in evolution that assigns a key causal role to various forms of functional synergy—Corning puts this theory into a much broader framework in Holistic Darwinism, addressing many of the issues and concepts associated with the evolution of complex systems. Corning's paradigm embraces and integrates many related theoretical developments of recent years, from multilevel selection theory to niche construction theory, gene-culture coevolution theory, and theories of self-organization. Offering new approaches to thermodynamics, information theory, and economic analysis, Corning suggests how all of these domains can be brought firmly within what he characterizes as a post–neo-Darwinian evolutionary synthesis.
Download or read book Modeling Biological Systems written by James W Haefner and published by . This book was released on 1996-07-01 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Laws in Biological Chemistry written by Svante Arrhenius and published by Legare Street Press. This book was released on 2023-07-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking work that explores the fundamental principles governing chemical reactions in biological systems, and their implications for our understanding of life itself. Essential reading for anyone interested in the interface between chemistry and biology. This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work is in the "public domain in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant.
