Download or read book Principles of Molecular Diagnostics and Personalized Cancer Medicine written by Dongfeng Tan and published by Lippincott Williams & Wilkins. This book was released on 2012-12-07 with total page 2177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.
Download or read book Molecular Diagnostics written by Jan Trost Jorgensen and published by CRC Press. This book was released on 2019-05-08 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.
Download or read book Principles and Applications of Molecular Diagnostics written by Nader Rifai and published by Elsevier. This book was released on 2018-06-13 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Applications of Molecular Diagnostics serves as a comprehensive guide for clinical laboratory professionals applying molecular technology to clinical diagnosis. The first half of the book covers principles and analytical concepts in molecular diagnostics such as genomes and variants, nucleic acids isolation and amplification methods, and measurement techniques, circulating tumor cells, and plasma DNA; the second half presents clinical applications of molecular diagnostics in genetic disease, infectious disease, hematopoietic malignancies, solid tumors, prenatal diagnosis, pharmacogenetics, and identity testing. A thorough yet succinct guide to using molecular testing technology, Principles and Applications of Molecular Diagnostics is an essential resource for laboratory professionals, biologists, chemists, pharmaceutical and biotech researchers, and manufacturers of molecular diagnostics kits and instruments. Explains the principles and tools of molecular biology Describes standard and state-of-the-art molecular techniques for obtaining qualitative and quantitative results Provides a detailed description of current molecular applications used to solve diagnostics tasks
Download or read book Molecular Diagnostics in Cancer Patients written by Kamla Kant Shukla and published by Springer. This book was released on 2019-03-15 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Download or read book Introduction to Oncogenes and Molecular Cancer Medicine written by Dennis W. Ross and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing the physician with a solid understanding of molecular biology and its applications for the diagnosis and treatment of cancer, this book reviews the basic molecular and other principles of cancer medicine, including controls of cell growth and senescence, carcinogenesis, tumorogenesis, and epidemiology. The second part of the book gives clinical examples to demonstrate the basic science principles, including chapters on leukaemia, colon cancer, and breast cancer. A chapter on molecular diagnostics and screening plus a chapter on new molecular anti-cancer therapies allow readers an insight into current therapies as well as the future of molecular cancer medicine. A useful glossary defines new terminology at-a-glance. Written in a user-friendly, conversational format, this text will be welcomed by all physicians eager to sharpen their own understanding of molecular cancer medicine as well as to help them provide patients with balanced information on the advances and limitations of current treatment options.
Download or read book Diagnostic Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2023-10-27 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnostic Molecular Pathology: A Guide to Applied Molecular Testing, Second Edition assembles a group of experts to discuss the molecular basis and mechanisms of major human diseases and disease processes and how the molecular features of disease can be harnessed to develop practical molecular tests for disease detection, diagnosis and prognosis. The book explains how molecular tests are utilized in the treatment of patients in personalized medicine, highlights new technologies and approaches of applied molecular pathology, and discusses how this discovery-based research yields new and useful biomarkers and tests. As it is essential to stay up-to-date on new molecular diagnostics in this changing field, this book covers critically important areas in the practice of personalized medicine and reflects our understanding of the pathology, pathogenesis and pathophysiology of human disease. Includes new material on mass spectrometry for infectious diseases, microbiome, homology-directed repair for PARPi, whole genome sequencing for constitutional testing, and much more Provides insights on the value of the molecular test in comparison to traditional methods, which include speed, precision, sensitivity and clinical impacts for the patient Focuses on the menu of molecular diagnostic tests available in modern molecular pathology or clinical laboratories that can be applied to disease detection, diagnosis and classification in the clinical workup of a patient Explains how molecular tests are utilized to guide the treatment of patients in personalized medicine (guided therapies) and for the prognostication of disease
Download or read book Nucleic Acids as Molecular Diagnostics written by Andreas Keller and published by John Wiley & Sons. This book was released on 2015-01-12 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: By integrating technology, supporting infrastructure and efficient application, the all-in-one guide presents molecular diagnostics as an essential component of modern, personalized clinical practice. It considers all important aspects, from the hardware and software needed, to recent improvements in blood- and non-blood-based biomarker tests. Chapters on ethical challenges and a look at current trends and the latest innovations are also included. Bridging the gap between industry and academia, this is a highly useful resource for practitioners as well as for developers of modern, DNA- and RNA-based molecular diagnostics.
Download or read book Principles of Molecular Oncology written by Miguel H. Bronchud and published by Springer Science & Business Media. This book was released on 2003-12-03 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.
Download or read book Molecular Diagnostics in Cancer Patients written by Kamla Kant Shukla and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to bring together a broad variety of examples of the role of pharmacogenomics in current drug development, uncovering dynamic concentration-dependent drug responses on biological systems to understand pharmacodynamics responses in human cancer where genetic lesions serve as tumor markers and provide a basis for cancer diagnosis. The book describes methods and protocols applied in molecular diagnostics. It offers pathologists and researchers providing molecular diagnostic services an array of the most recent and readily accessible reference to compare methods and techniques. Highlights include the molecular diagnosis of genetic aberrations by quantitative polymerase reaction (qPCR), sequence-specific oligonucleotide arrays, next-generation sequencing (NGS), CGH arrays-and methodologies directed at the detection of epigenetic events, high-throughput nucleic acid and protein arrays, direct sequencing and FISH-based methodologies, currently used in the diagnosis of solid tumors. The book also includes an innovative line of treatment in relation to the molecular prognosis, diagnosis and pharmacogenomics in the actual practice of clinical findings at molecular levels. The book covers the applications of numerous genetic testing methodologies; in approximately the chronological order of discovery and high-throughput diagnosis using advanced genomic approaches to identify such genes, in the search for novel drug targets and/or key determinants of drug reactions. It also promotes a wider understanding of molecular diagnostics among physicians, medical students, and scientists in academics, industry and corporate world.
Download or read book Molecular Pathology and Diagnostics of Cancer written by Domenico Coppola and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
Download or read book Textbook of Personalized Medicine written by Kewal K. Jain and published by Humana Press. This book was released on 2015-03-17 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.
Download or read book Molecular Diagnostics written by William B. Coleman and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM contains ... "a companion eBook version of Molecular diagnostics : for the clinical laboratorian, Second edition ... for downloading and use in the reader's PC or PDA."--Page 4 of cover.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by Wiley-Blackwell. This book was released on 2023-05-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: HOLLAND-FREI CANCER MEDICINE The latest edition of the gold-standard in cancer science and clinical oncology references In the newly revised Tenth Edition of Holland-Frei Cancer Medicine, a team of distinguished researchers and practitioners delivers a comprehensive and up-to-date discussion of cancer science and clinical oncology practice. The book contains timely and indispensable information on epidemiology, etiology, cancer biology, immunology, prevention, screening, clinical presentation, pathology, imaging, and therapy. Grounded in a fundamental understanding of cancer biology, Holland-Frei Cancer Medicine combines scientific principles with clinical practice. It contains hundreds of full-color illustrations and photographs, tables, graphs, and algorithms that complement and enhance the complex topics discussed within the book. This book is an invaluable clinical tool that provides readers with overview boxes, additional references, and other pedagogic features designed to make the content easy to access and comprehend. Readers will also find: A translational and integrated approach throughout the book that combines cancer biology with cancer management A strong emphasis on multidisciplinary, research-driven patient care that improves outcomes and allows for the optimal use of all clinically appropriate therapies Discussions of the most current personalized cancer care, including molecular diagnostics and therapeutics Perfect for medical oncologists, radiation oncologists, and internists, Holland-Frei Cancer Medicine, Tenth Edition will also earn a place in the libraries of allied health professionals involved in the treatment of cancer patients.
Download or read book Molecular Pathology written by William B. Coleman and published by Academic Press. This book was released on 2009-02-10 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam Teaches from the perspective of “integrative systems biology, which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease Outlines the principles and practice of molecular pathology Explains the practice of “molecular medicine and the translational aspects of molecular pathology
Download or read book Principles of Molecular Pathology written by Anthony Killeen and published by Humana Press. This book was released on 2003-11-07 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anthony Killeen, MD, PhD, offers a comprehensive yet concise introduction to molecular pathology that encompasses both applied and theoretical knowledge. Writing in a very readable style, the author reviews the basic concepts of human molecular biology, explains the principles of the most commonly used analytical methods, and discusses the molecular principles that underlie both inherited diseases and acquired genetic abnormalities that lead to cancer. Using common viral infections as examples, the book applies these molecular methods to the detection of microbial pathogens. The growing importance of pharmacogenetics and identity testing in the clinical laboratory is also highlighted.
Download or read book Personalised Cancer Medicine written by Anne Kerr and published by . This book was released on 2021-02-23 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Molecular Basis of Human Cancer written by William B. Coleman and published by Humana. This book was released on 2018-12-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care. The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.
