Download or read book Principles and Methods of Immunotoxicology written by Jacques Descotes and published by Elsevier. This book was released on 2004-10-14 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.
Download or read book Immunotoxicology of Drugs and Chemicals Principles and methods of immunotoxicology written by Jacques Descotes and published by Elsevier Science Serials. This book was released on 2004 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third thoroughly revised edition, written by a renowned expert in this rapidly expanding field, is a welcome and timely publication in the field of experimental and clinical immunotoxicology. Immunotoxicology is a young, but rapidly expanding area of toxicology. Since the second edition of this book was published in 1988, an increasing amount of data has resulted in the publication of many articles and reviews. This book covers the many general facets of current immunotoxicology - clinical, experimental, mechanistic and regulatory aspects, including a chapter on the immune system giving toxicologists unfamiliar with immunology the opportunity to acquire the minimal knowledge necessary to conduct and interpret immunotoxicity studies. A comprehensive chapter on adverse effects in relation to immunotoxicity is included in order to predict and understand the toxic effects of drugs and other chemicals in living beings. An effort is made to answer one of the perhaps most confusing issues confronting the student of immunotoxicology namely the identification of what constitutes an immunotoxic response and what does not. Researchers from different disciplines have shown interest in this new field, and presented results of their work on immunotoxicological issues from extremely varied perspectives. As a bridging discipline between immunology and toxicology, immunotoxicology is genuinely multidisciplinary, reflected in this excellent book.
Download or read book Principles and Methods of Toxicology Fifth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2007-09-25 with total page 2304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanisms. While the vastness of the field and the rapid accumulation of data may preclude the possibility of absorbing and retaining more than a fraction of the available information, a solid understanding of the underlying principles is essential. Extensively revised and updated with four new chapters and an expanded glossary, this fifth edition of the classic text, Principles and Methods of Toxicology provides comprehensive coverage in a manageable and accessible format. New topics include 'toxicopanomics', plant and animal poisons, information resources, and non-animal testing alternatives. Emphasizing the cornerstones of toxicology-people differ, dose matters, and things change, the book begins with a review of the history of toxicology and followed by an explanation of basic toxicological principles, agents that cause toxicity, target organ toxicity, and toxicological testing methods including many of the test protocols required to meet regulatory needs worldwide. The book examines each method or procedure from the standpoint of technique and interpretation of data and discusses problems and pitfalls that may be associated with each. The addition of several new authors allow for a broader and more diverse treatment of the ever-changing and expanding field of toxicology. Maintaining the high-quality information and organizational framework that made the previous editions so successful, Principles and Methods of Toxicology, Fifth Edition continues to be a valuable resource for the advanced practitioner as well as the new disciple of toxicology.
Download or read book Principles and Methods of Toxicology written by A. Wallace Hayes and published by Lippincott Williams & Wilkins. This book was released on 1984-01 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hefty and authoritative, the new edition of this reference and text (suitable for graduate level teaching) contains 37 contributed chapters arranged in sections on principles, agents, and methods of toxicology. They provide a state-of-the-art exposition of information related to the task of identifying whether or not a causal relationship exists between specific doses of a chemical and an alleged adverse effect. Current testing procedures, guidelines on data interpretation, and areas of current controversy are covered; new chapters in this edition expand coverage of epidemiology, exposure assessment, and repeat dosing. Editor Hayes is an executive in charge of product integrity at The Gillette Company; contributors are from companies and institutions all over the US. c. Book News Inc.
Download or read book Principles of Immunopharmacology written by Frans P. Nijkamp and published by Springer Science & Business Media. This book was released on 2011-09-01 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a unique support in gaining essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book, covering a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts. The second section on immunodiagnostics has been further expanded to describe widely used molecular techniques and is followed by a systematic coverage of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. This third edition continues the unique format dealing with four related topics in a single volume, obviating the need to refer to several different textbooks. New aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition.
Download or read book Principles and Methods of Toxicology written by A. Wallace Hayes and published by . This book was released on 1995 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles of Toxicology Testing written by Frank A. Barile and published by CRC Press. This book was released on 2007-07-23 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v
Download or read book Principles and Methods of Toxicology student Edition written by A. W. Hayes and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book History of Immunotoxicology written by Jacques Descotes and published by Academic Press. This book was released on 2017-10-01 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: History of Immunotoxicology offers the first book-length exploration of the development and importance of the field of immunotoxicology. Toxicology is evolving with the identification of new toxic hazards and the marketing of new chemicals. As preventive measures are implemented to reduce risks, including banning of chemicals or applications of one given chemical, current toxicologists may not be aware of the actual toxicity potential of chemicals when marketing or used in the past. Knowledge of what has occurred before can help to give context and understanding of current and future debates. Although immunotoxicology is one of the youngest areas of toxicology – its origin dates back to approximately half a century – a number of significant adverse effects and safety issues have been described, which deserve a historical perspective. History of Immunotoxicology describes the adverse health effects involving the immune system, hypersensitivity and autoimmunity. It also explores new avenues of research and immunotoxicity evaluation, as well as regulatory aspects of immunotoxicology, and the withdrawal/banning from the market of several approved drugs and chemicals due to their immunotoxic effects. Clinical manifestations of immunotoxicity, such as anaphylaxis, opportunistic infections, lymphomas, cytokine storm, and immunotherapy will be addressed. Finally, the book considers how the recent past can provide insights on the future practice of immunotoxicology. This book will be of interest to students and researchers in government, industry, and academia who have an interest in immunotoxicology. Examines the development of immunotoxicology Provides context to current debates about actual toxicity potential of chemicals Covers major developments and areas of immunotoxicology
Download or read book Principles and Methods for Assessing Direct Immunotoxicity Associated with Exposure to Chemicals written by World Health Organization and published by . This book was released on 1996 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to general strategies and specific methods for testing the immunotoxicity of chemicals in animal models and humans. Addressed to those seeking a basic introduction to the field as well as specialist researchers the book takes its focus from growing concern in scientific and public communities about the capacity of environmental agents to disrupt normal immune functions and thus increase susceptibility to tumours and infectious diseases. Compounds known to adversely affect the immune system are numerous and include drugs pesticides solvents halogenated and aromatic hydrocarbons and metals. The book draws on considerable recent progress in understanding the immunological consequences of chemical insults as well as increasingly sophisticated methodologies for assessing such effects. Close to 1000 references are included in this authoritative guide. The book opens with a detailed basic introduction to immunotoxicology. An extensive explanation of the function histophysiology and pathophysiology of the immune system emphasizes features that can aid the understanding and interpretation of the pathological changes caused by immunotoxic insults. Chapter two on the health impact of selected immunotoxic agents gives illustrative examples for some 30 chemicals that have been shown to exert immunotoxic effects in laboratory animals and for an additional seven groups of chemicals known to disturb immune functions in humans. For each brief discussions illustrate the chemical's distinct immunosuppressive properties and the mechanisms by which it exerts its toxic effects on the immune system. Chapter three provides detailed descriptions of a number of tests used in a tiered approach to the assessment of immunotoxicity. Against this background specific nonfunctional and functional tests for the assessment of immunotoxicology in experimental animals are presented and explained in full detail. Information on individual tests includes an explanation of why the test is important the types of data it can yield and exactly how it should be performed. Also included are sections offering advice on assessments in non-rodent species in vitro approaches and approaches using biomarkers in epidemiological studies and monitoring. The chapter concludes with a discussion of good laboratory practices for immunotoxicology studies and procedures for the validation of tests. Chapter five explains the much more complicated procedures needed to assess immunotoxicity in humans. An explanation of general questions to be considered when designing epidemiological studies is followed by presentation of three recommended testing schemes proposed by WHO and other agencies for preliminary evaluation of individuals exposed to immunotoxicants. Specific assays for assessing immune status are also described. The final chapter outlines a step-by-step process of risk assessment specific to the evaluation of potentially immunotoxic chemicals.
Download or read book Hayes Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Download or read book Principles and Methods of Toxicology written by A Wallace Hayes and published by CRC Press. This book was released on 2001-01-11 with total page 1912 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fourth edition, this core text and standard reference in toxicology has once again been updated to incorporate the latest testing procedures and address new challenges faced by toxicologists. The author brings together more than 70 distinguished investigators to detail current testing procedures, offer guidelines on data interpretation and highlight major areas of controversy. The book deals with the methods of toxicology, as well as principles and agents. New chapters on exposure assessment and epidemiology for toxicologists have been added. The reader will find an in-depth look at the principles underlying toxicology, such as absorption, distribution, metabolism and excretion, as well as topics dealing with pharmacokinetics. Principles and Methods of Toxicology, Fourth Edition allows the working toxicologist, whether a senior professional or graduate student, to understand and use basic experiments in toxicology.
Download or read book Hayes Principles and Methods of Toxicology Sixth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Download or read book TOXICOLOGY PRINCIPLES AND METHODS SECOND REVISED EDITION written by M. A. Subramaniam and published by Mjp Publisher. This book was released on 2021-07 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of toxicants-their route of entry, their absorption, distribution, eliminationand transformation, and their dynamics within organisms and the environment-havebeen clearly dealt with in this book. It provides a concise, well-balanced and technicalintroduction to toxicology with focus on the basic principles and concepts. It wouldprove to be a complete study unit for new entrants to this field.
Download or read book Principles and Methods of Toxicology 1 2 written by and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Immunotoxicology written by P. W. Mullen and published by . This book was released on 2014-08-15 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles and Methods of Toxicology written by AW Hayes (Ed) and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
