Download or read book Principles and Methods for the Assessment of Risk from Essential Trace Elements written by Inter-Organization Programme for the Sound Management of Chemicals and published by World Health Organization. This book was released on 2002-02 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: The risk assessment approach described in this monograph applies only to essential trace elements (ETEs) involved in human health and not to non-essential elements. The purpose of this monograph is to provide the scientific principles that support the concept of an acceptable range of oral intake (AROI) which uses a homeostatic model for determining the range of dietary intakes for essential trace elements (ETEs) that meet the nutritional requirements of a healthy population and avoid excess intakes. To facilitate comparisons AROIs are discussed in relation to other risk assessment approaches. Although it includes examples this monograph is not a compendium of assessments on ETEs nor is it a textbook detailing the scientific basis of risk assessment of the derivation of dietary reference intakes. Described in the book is the process of risk assessment which begins with the selection of the database for a particular ETE. A weight-of-evidence approach is then used for hazard identification selecting relevant end-point of deficient and excess exposures. Next the probability of risk and the severity of various effects are quantified and critical effects are selected. The AROI is then established by balancing end-points of comparable health significance. At this time the exposure assessment is conducted. Finally a risk characterization enumerating the strengths and weaknesses of the databases is performed integrating the AROI and exposure assessment. ... The amount of work which is entailed in these volumes is very great and the low cost does not reflect the time of experts travelling nor even the hours expended UN staff in Geneva... This well informed book with its predecessors in the series is essential reading for biologists chemists and medical professionals concerned with essential trace elements. - The International Journal of Environmental Studies

Download or read book Diet and Health written by National Research Council and published by National Academies Press. This book was released on 1989-01-01 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diet and Health examines the many complex issues concerning diet and its role in increasing or decreasing the risk of chronic disease. It proposes dietary recommendations for reducing the risk of the major diseases and causes of death today: atherosclerotic cardiovascular diseases (including heart attack and stroke), cancer, high blood pressure, obesity, osteoporosis, diabetes mellitus, liver disease, and dental caries.

Download or read book Trace Elements in Soils written by Peter Hooda and published by John Wiley & Sons. This book was released on 2010-04-13 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trace elements occur naturally in soils and some are essential nutrients for plant growth as well as human and animal health. However, at elevated levels, all trace elements become potentially toxic. Anthropogenic input of trace elements into the natural environment therefore poses a range of ecological and health problems. As a result of their persistence and potential toxicity, trace elements continue to receive widespread scientific and legislative attention. Trace Elements in Soils reviews the latest research in the field, providing a comprehensive overview of the chemistry, analysis, fate and regulation of trace elements in soils, as well as remediation strategies for contaminated soil. The book is divided into four sections: • Basic principles, processes, sampling and analytical aspects: presents an overview including general soil chemistry, soil sampling, analysis, fractionation and speciation. • Long-term issues, impacts and predictive modelling: reviews major sources of metal inputs, the impact on soil ecology, trace element deficient soils and chemical speciation modelling. • Bioavailability, risk assessment and remediation: discusses bioavailability, regulatory limits and cleanup technology for contaminated soils including phytoremediation and trace element immobilization. • Characteristics and behaviour of individual elements Written as an authoritative guide for scientists working in soil science, geochemistry, environmental science and analytical chemistry, the book is also a valuable resource for professionals involved in land management, environmental planning, protection and regulation.

Download or read book Principles and Methods for the Assessment of Risk from Essential Trace Elements written by WHO and published by World Health Organization. This book was released on 2002-02-01 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: The risk assessment approach described in this monograph applies only to essential trace elements (ETEs) involved in human health and not to non-essential elements. The purpose of this monograph is to provide the scientific principles that support the concept of an acceptable range of oral intake (AROI) which uses a homeostatic model for determining the range of dietary intakes for essential trace elements (ETEs) that meet the nutritional requirements of a healthy population and avoid excess intakes. To facilitate comparisons AROIs are discussed in relation to other risk assessment approaches. Although it includes examples this monograph is not a compendium of assessments on ETEs nor is it a textbook detailing the scientific basis of risk assessment of the derivation of dietary reference intakes. Described in the book is the process of risk assessment which begins with the selection of the database for a particular ETE. A weight-of-evidence approach is then used for hazard identification selecting relevant end-point of deficient and excess exposures. Next the probability of risk and the severity of various effects are quantified and critical effects are selected. The AROI is then established by balancing end-points of comparable health significance. At this time the exposure assessment is conducted. Finally a risk characterization enumerating the strengths and weaknesses of the databases is performed integrating the AROI and exposure assessment. ... The amount of work which is entailed in these volumes is very great and the low cost does not reflect the time of experts travelling nor even the hours expended UN staff in Geneva... This well informed book with its predecessors in the series is essential reading for biologists chemists and medical professionals concerned with essential trace elements. - The International Journal of Environmental Studies

Download or read book Risk Evaluation of Essential Trace Elements Essential Versus Toxic Levels of Intake written by Jan Alexander and published by . This book was released on 1995 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: On cover: Food.

Download or read book Essential Metals in Medicine Therapeutic Use and Toxicity of Metal Ions in the Clinic written by Peggy L. Carver and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Download or read book Issue Paper on the Human Health Effects of Metals written by and published by . This book was released on 2004 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Origins of Life written by Vlado Valkovic and published by CRC Press. This book was released on 2021-11-10 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary purpose of this book is to prepare the ground for coordinated efforts aiming to answer the question: where and when life originated. The appearance of life involves three successive stages: i) the formation of chemical elements and their combination to simple molecules, which is the concern of physicists; ii) the evolution of organized complexity in biomolecules and their reactions, which falls within the field of chemistry; iii) the onset of Darwinian evolution after the appearance of the first cell-like structure, which is studied by biologists. This book focuses on the first two steps of this process with chapters exploring topics such as chemical element abundances; galaxies, galactic magnetic fields and cosmic rays; galactic chemical evolution. Key Features: Contains extensive lists of reference and additional reading. Includes new hypotheses concerning the origin of life. Combines consideration from nuclear physics, astrophysics, astro- and geochemistry. Despite its interdisciplinary nature, this book remains accessible to nonexperts, and would be a valuable companion for both experts and laypeople.

Download or read book Introduction to Medical Geology written by C. B. Dissanayake and published by Springer Science & Business Media. This book was released on 2009-09-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over two billion people live in tropical lands. Most of them live in intimate contact with the immediate geological environment, obtaining their food and water directly from it. The unique geochemistry of these tropical environments have a marked influence on their health, giving rise to diseases that affect millions of people. The origin of these diseases is geologic as exemplified by dental and skeletal fluorosis, iodine deficiency disorders, trace element imbalances to name a few. This book, one of the first of its kind, serves as an excellent introduction to the emerging discipline of Medical Geology.

Download or read book The Development of DRIs 1994 2004 written by Institute of Medicine and published by National Academies Press. This book was released on 2008-03-12 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: In what ways can the process for developing Dietary Reference Intakes (DRIs) be enhanced? The workshop entitled "The Development of DRIs 1994-2004: Lessons Learned and New Challenges" offered a valuable window into the issues and challenges inherent in the development of nutrient reference values. The dialogue-carried out under the auspices of the Institute of Medicine (IOM), Food and Nutrition Board (hereafter referred to jointly as the IOM)-was enriched by the 10 years of experience in deriving the expanded set of values known as the DRIs, plus the decades of experience that grounded the earlier Recommended Dietary Allowances for the United States and the Recommended Nutrient Intakes for Canada. The lessons learned and the knowledge gained will guide decisions about the next phase of the DRIs. To paraphrase one participant, we are now asking better questions. In 2006, the IOM, with support from the United States and Canadian governments, undertook an effort to synthesize the research needs identified during the 10 years of DRI development. While the workshop summarized here was predicated on the fact that the development of DRIs is improved by better data, its focus was different. Its goals were to examine the framework and conceptual underpinnings for developing DRIs and to identify issues important for enhancing the process of DRI development. The workshop was designed to use the existing framework for DRI development as a basis for the discussions and to consider the components of the framework in sequence. Consideration of the pros and cons of the current conceptual underpinnings of the framework opened the workshop, followed by the general "road map" for decision making and the needed scientific criteria. Next, the challenges associated with providing guidance for users were explored. The Development of DRIs 1994-2004: Lessons Learned and New Challenges: Workshop Summary explains an array of issues germane to the future process for developing DRIs, including strategies for updating and revising existing DRIs and opportunities for stakeholder input.

Download or read book Principles for Modelling Dose response for the Risk Assessment of Chemicals written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."

Download or read book Handbook on the Toxicology of Metals Volume I General Considerations written by Gunnar F. Nordberg and published by Academic Press. This book was released on 2021-11-30 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health. Contains peer-reviewed chapters that deal with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and the transformation of metals in the environment Covers the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Provides critical information on the properties, use, biological monitoring, dose-response relationships, diagnosis, treatment and prevention of metallic elements and compounds

Download or read book Sustainable Agriculture Reviews 52 written by Eric Lichtfouse and published by Springer Nature. This book was released on 2021-08-02 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents advanced knowledge and techniques to improve food quality, such as organic farming, fertilization using waste, reducing arsenic in food, soil restoration, forage production in arid regions and weed control. Agriculture is actually facing two major challenges, feeding an ever-growing population and providing safe food in the context of pollution, climate change and the future circular economy.

Download or read book Endocrine Toxicology written by J. Charles Eldridge and published by CRC Press. This book was released on 2016-04-19 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by international experts in academia, chemical manufacturing, government research laboratories, regulatory agencies, and private consulting, this guide explores the potentially damaging influence of environmental agents on the endocrine system. It examines endocrine toxicology's increased importance in environmental safety issues

Download or read book A Little Less Arctic written by Steven H. Ferguson and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Arctic Canada, Hudson Bay is a site of great exploration history, aboriginal culture, and a vast marine wilderness supporting large populations of marine mammals and birds. These include some of the most iconic Arctic animals like beluga, narwhal, bowhead whales, and polar bears. Due to the challenges of conducting field research in this region, some of the mysteries of where these animals move, and how they are able to survive in such seemingly inhospitable, ice-choked habitats are just now being unlocked. For example, are polar bears being replaced by killer whales? This new information could not be more salient, as the Hudson Bay Region is undergoing rapid environmental change due to global warming, as well as increased pressures from industrial development interests. A Little Less Arctic brings together some of the world’s leading Arctic scientists to present the current state of knowledge on the physical and biological characteristics of Hudson Bay.

Download or read book Handbook on the Toxicology of Metals written by Monica Nordberg and published by Elsevier. This book was released on 2011-04-28 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more

Download or read book Best Practice Guide on the Control of Iron and Manganese in Water Supply written by Adam Postawa and published by IWA Publishing. This book was released on 2013-08-14 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Best Practice Guide on the Control of Iron and Manganese in Water Supply is one of a series produced by the International Water Association’s Specialist Group on Metals and Related Substances in Drinking Water. Iron and manganese are often found in soft upland water sources associated with natural organic matter and are also commonly found in the groundwater abstracted from confined and unconfined aquifers. The presence of iron and manganese in water is one of the most frequent reasons for customers’ complaint due to aesthetic issues (yellow, brown and black or stains on laundry and plumbing fixtures). These two metals can be removed fairly readily by physico-chemical treatment. The municipal treatment systems deployed derive benefit from their larger scale, particularly in relation to control, but the processes used are less suitable for the numerous small supplies that are the most common water supplies throughout Europe, especially in rural areas. One important source of iron in drinking water is from old corroded cast-iron water mains, historically the material used most commonly in supply networks. Replacement and refurbishment is very expensive and the major challenge is how best to prioritize available expenditure. The purpose for this Best Practice Guide on the Control of Iron and Manganese in Water Supply is to give readers the broad view of a problem based on state-of-the-art compilation of the range of scientific, engineering, regulatory and operational issues concerned with the control of iron and manganese in drinking water. The Guide is of interest to water utility practitioners, health agencies and policy makers, as well as students on civil engineering and environmental engineering courses. Authors: Dr Adam Postawa, AGH University of Science and Technology, Faculty of Geology, Geophysics and Environment Protection, Krakow, Poland and Dr Colin R Hayes, University of Swansea, UK, Chair of IWA Specialist Group on Metals and Related Substances in Drinking Water.