Download or read book Primary Progressive Multiple Sclerosis written by Nancy J. Holland and published by Diamedica. This book was released on 2009-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary progressive multiple sclerosis (PPMS) affects approximately 10% of the MS population, and is characterized by a steady decline in function, without relapses. This book is geared to the wide variety of physical and emotional issues of people with PPMS and their families. It explains the nature and characteristics of the disease, as well as comprehensive multidisciplinary management.
Download or read book Primary Progressive Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin ical trials have excluded PPMS patients on two counts. Clinical worsening devel ops slowly in PPMS and may not be recognized during the course of a 2-or 3-year trial even in untreated control patients. This factor alone adds to the potential for a type 2 error or, at the very least, inflates the sample size and duration of the trial. In addition, there is mounting evidence that progressive axonal degeneration and neuronal loss (rather than active, recurrent inflammation) may be important components of the pathology in this form of the disease. Although contemporary trials are evaluating whether PPMS patients may benefit from treatment with the ~-interferons and glatiramer acetate, preliminary, uncontrolled clinical experi ence suggests that the results may not be dramatic.
Download or read book Neuroinflammation written by Alireza Minagar and published by Elsevier. This book was released on 2010-12-17 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, and brain trauma as well as meningitis and contributes to the generation of pain. We are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage through tolerance to modulation and repair. This book discusses some of the more common neuro-inflammatory diseases. Topics covered include multiple sclerosis, optic neuritis and Susac syndrome. Comprehensive review of the latest developments in neuroinflammation Includes contributions from leading authorities
Download or read book Multiple Sclerosis written by Institute of Medicine and published by National Academies Press. This book was released on 2001-08-10 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is a chronic and often disabling disease of the nervous system, affecting about 1 million people worldwide. Even though it has been known for over a hundred years, no cause or cure has yet been discovered-but now there is hope. New therapies have been shown to slow the disease progress in some patients, and the pace of discoveries about the cellular machinery of the brain and spinal cord has accelerated. This book presents a comprehensive overview of multiple sclerosis today, as researchers seek to understand its processes, develop therapies that will slow or halt the disease and perhaps repair damage, offer relief for specific symptoms, and improve the abilities of MS patients to function in their daily lives. The panel reviews existing knowledge and identifies key research questions, focusing on: Research strategies that have the greatest potential to understand the biological mechanisms of recovery and to translate findings into specific strategies for therapy. How people adapt to MS and the research needed to improve the lives of people with MS. Management of disease symptoms (cognitive impairment, depression, spasticity, vision problems, and others). The committee also discusses ways to build and financially support the MS research enterprise, including a look at challenges inherent in designing clinical trials. This book will be important to MS researchers, research funders, health care advocates for MS research and treatment, and interested patients and their families.
Download or read book Case Studies in Multiple Sclerosis written by Paul S. Giacomini and published by Springer. This book was released on 2016-10-06 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is a collection of clinical narratives that underscore the heterogeneous and unpredictable presentation of multiple sclerosis (MS) and give real-world clinical context to recent drug developments. This accessible and concise publication is intended to be used by a wide range of medical professionals, from specialist neurologists to medical trainees with an interest in neurology. An ideal clinical resource, Case Studies in Multiple Sclerosis provides an evidence-based discussion of each case, with an aim to enhance effective diagnosis and treatment of patients with MS and MS-related conditions.
Download or read book Neuroimmune Diseases written by Hiroshi Mitoma and published by Springer. This book was released on 2019-08-13 with total page 822 pages. Available in PDF, EPUB and Kindle. Book excerpt: A translational overview of neuroimmune diseases for neuroscientists and clinicians that clarifies the pathological mechanisms underlying neuroimmune diseases and builds a comprehensive bridge between the latest research findings and their clinical implications in daily practice. The material is presented in two steps. The first section comprises a review of the pathogenic actions of immune cells in brain diseases. Here the authors discuss the mechanisms through which immune cells disrupt the functions of nerve cells. The second section explores the ways in which the brain becomes dysfunctional due to impaired nerve cell function. Based on pathogenesis, diagnostic and therapeutic strategies are discussed for each clinical category. The book will be invaluable for use in clinical practice of neuroimmune diseases
Download or read book Living with Progressive Multiple Sclerosis written by June Halper, MSN, ANP, FAAN and published by Demos Medical Publishing. This book was released on 2007-10-19 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the National Multiple Sclerosis Society, 15% of MS patients are diagnosed with the progressive form of the disease and experience symptoms such as tremor, poor coordination, difficulty walking, and other problems from the start. While an additional 50%, of those diagnosed with relapsing-remitting MS, will develop progressive MS within 10 years. Living with Multiple Sclerosis: Overcoming the Challenges, 2nd Edition is written for people who have been diagnosed with the progressive form of multiple sclerosis. It focuses on the newest advances in managing worsening symptoms and offers hope to MS patients facing the future. This concise and practical overview educates patients about diagnosis, disease-modifying therapies, managing difficult symptoms, and coping strategies. Other topics include: Top Ten Questions about Progressive MS Can Progressive MS be Treated? Vocational and Legal Issues A Glimpse into the Future This encouraging and informative book will be a welcome addition to any patient, healthcare professional, or institutional library.
Download or read book The Molecular and Clinical Pathology of Neurodegenerative Disease written by Patrick A. Lewis and published by Academic Press. This book was released on 2018-11-16 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models
Download or read book White Matter Diseases written by Massimo Filippi and published by Springer Nature. This book was released on 2020-02-13 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.
Download or read book Atlas of Clinical Neurology E Book written by G. David Perkin and published by Elsevier Health Sciences. This book was released on 2010-10-13 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Clinical Neurology, by David Perkin, Douglas C. Miller, Russell Lane, Maneesh C. Patel, and Fred H. Hochberg, delivers the most powerful, clinically oriented image collection of any reference in your specialty - to help you accurately diagnose any condition you see in practice! Approximately 2,000 large, high-quality images – 1,000 in full color - capture the characteristic physical examination and imaging findings of every type of neurological disorder. All of the diagnostic imaging studies have been updated to reflect the dramatic advances in neuroimaging. Updates throughout include a brand-new chapter on myopathies and myasthenia, expanded coverage of epilepsy, and an entire chapter devoted to extrapyramidal disorders. The result is the ultimate diagnostic resource in neurology! Find a perfect match for your clinical findings with the aid of the most powerful, clinically oriented image collection found in any neurology atlas: 2,000 illustrations, 1,000 in full color! Interpret the findings from the latest neuroimaging techniques with the aid of thoroughly updated images representing the most recent advances. Effectively overcome difficult diagnostic challenges with a brand-new chapter on myopathies and myasthenia, expanded coverage of epilepsy, and an entire chapter devoted to extrapyramidal disorders.
Download or read book The Multiple Sclerosis Manifesto written by Julie Stachowiak, PhD and published by Demos Medical Publishing. This book was released on 2009-12-22 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: An empowering guide for increasing your quality of life, navigating challenges, and embracing opportunities Julie Stachowiak, PhD is the About.com Guide to Multiple Sclerosis. As an epidemiologist who is also a person living with MS, Julie has an in-depthunderstanding about the scientific developments around MS and the personal side of living with a chronic illness. In the Multiple Sclerosis Manifesto, Julie shows you how to create your own personal MS manifesto and provides practical tools and reassurance to help you ìget betterî in your life, from optimizing medical care and managing symptoms, to strengthening relationships, dealing with emotions, and embracing activism. Committed to making the hard parts easier and the good parts last longer, Julie show you how to figure out what you need, identify opportunities, understand challenges, and get your needs met. With the Multiple Sclerosis Manifesto, youíll know how to: Create your personal mission statement Protect yourself by learning more about medications you are currently taking or considering to take Determine what you want in a doctor and how to evaluate the doctor you have Celebrate your successesóand why itís essential that you do Make disclosing your MS status to friends, family and others easier Find a support group
Download or read book Neurodegeneration in Multiple Sclerosis written by M. Filippi and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Download or read book Multiple Sclerosis For Dummies written by Rosalind Kalb and published by John Wiley & Sons. This book was released on 2011-02-25 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Being diagnosed with multiple sclerosis (MS) doesn’t have to mean your life is over. Everyone’s MS is different and no one can predict exactly what yours will be like. The fact is, lots of people live their lives with MS without making a full-time job of it. MS for Dummies gives you easy to access, easy to understand information about what happens with MS—what kinds of symptoms it can cause, how it can affect your life at home and at work, what you can do to feel and function up to snuff, and how you can protect yourself and your family against the long-term unpredictability of the disease. You'll learn: Why some people get MS and others don’t How to make treatment and lifestyle choices that work for you What qualities to look for in a neurologist and in the rest of your healthcare team How to manage fatigue, walking problems, and visual changes Why the road to diagnosis can be full of twists and turns How to understand the pros and cons of alternative medicine Why and how to talk to your kids about MS How to find stress management strategies that work for you Your rights under the Americans with Disabilities Act Complete with listings of valuable resources such as other books, Web sites, and community agencies and organizations that you can tap for information or assistance, MS for Dummies will tell you everything you need to know in order to make educated choices and comfortable decisions about life with MS.
Download or read book Multiple Sclerosis written by Ian S. Zagon and published by . This book was released on 2017 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optical Coherence Tomography in Multiple Sclerosis written by Axel Petzold and published by Springer. This book was released on 2015-08-28 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives a clinical context to optical coherence tomography (OCT) findings, while considering the differential diagnosis and providing patient management guidance. Relevant anatomical and technical aspects are discussed, followed by a pragmatic illustration of the use of OCT for the clinical spectrum of multiple sclerosis and optic neuritis, and finishing with information on monitoring ocular side effects of recently approved disease-modifying treatments in multiple sclerosis. Optical Coherence Tomography in Multiple Sclerosis: Clinical Applications is aimed at clinical neurologists working with patients suffering from MS and general neurologists who see patients with visual symptoms in their daily practice. Ophthalmologists sharing clinical responsibilities with neurologists for patients under disease-modifying treatments will also find the book of interest.
Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.
Download or read book Handbook of Sleep Disorders in Medical Conditions written by Josee Savard and published by Academic Press. This book was released on 2019-03-14 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Sleep Disorders in Medical Conditions reviews the current knowledge on the nature and manifestations of sleep disorders associated with a variety of common medical conditions, including epilepsy, traumatic brain injury and dementia. It also provides clinical guidelines on how to assess and treat them with pharmacological and non-pharmacological interventions. Although the general principles of sleep medicine may be applied to some extent to patients with comorbid medical conditions, this book makes the case that an adaptive approach is warranted when considering the particularities of each condition. In addition, clinicians must also be cautious when prescribing sleep medications as some pharmacological agents are known to exacerbate symptoms associated with the medical condition, such as cognitive deficits (i.e. difficulties with memory and attention) in cancer patients experiencing chemo brain, or in persons with neurologic conditions (e.g. mild cognitive impairment, dementia, stroke, brain injury). A differential approach to evaluating and treating sleep is thus warranted. Presents a general overview on assessing and treating sleep disorders that are applicable to a diverse set of patients Provides a comprehensive, up-to-date review of the literature on the prevalence and manifestations of sleep problems related to specific medical conditions Includes practical information regarding special considerations for the assessment and treatment of sleep issues in specific medical conditions
