Download or read book Prescriptions for Working Statisticians written by Albert Madansky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first course in statistics, no matter how "good" or "long" it is, typically covers inferential procedures which are valid only if a number of preconditions are satisfied by the data. For example, students are taught about regression procedures valid only if the true residuals are independent, homoscedastic, and normally distributed. But they do not learn how to check for indepen dence, homoscedasticity, or normality, and certainly do not learn how to adjust their data and/or model so that these assumptions are met. To help this student out! I designed a second course, containing a collec tion of statistical diagnostics and prescriptions necessary for the applied statistician so that he can deal with the realities of inference from data, and not merely with the kind of classroom problems where all the data satisfy the assumptions associated with the technique to be taught. At the same time I realized that I was writing a book for a wider audience, namely all those away from the classroom whose formal statistics education ended with such a course and who apply statistical techniques to data.
Download or read book Statistical Thinking for Non Statisticians in Drug Regulation written by Richard Kay and published by John Wiley & Sons. This book was released on 2014-10-23 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Thinking for Non-Statisticians in Drug Regulation, Second Edition, is a need-to-know guide to understanding statistical methodology, statistical data and results within drug development and clinical trials. It provides non-statisticians working in the pharmaceutical and medical device industries with an accessible introduction to the knowledge they need when working with statistical information and communicating with statisticians. It covers the statistical aspects of design, conduct, analysis and presentation of data from clinical trials in drug regulation and improves the ability to read, understand and critically appraise statistical methodology in papers and reports. As such, it is directly concerned with the day-to-day practice and the regulatory requirements of drug development and clinical trials. Fully conversant with current regulatory requirements, this second edition includes five new chapters covering Bayesian statistics, adaptive designs, observational studies, methods for safety analysis and monitoring and statistics for diagnosis. Authored by a respected lecturer and consultant to the pharmaceutical industry, Statistical Thinking for Non-Statisticians in Drug Regulation is an ideal guide for physicians, clinical research scientists, managers and associates, data managers, medical writers, regulatory personnel and for all non-statisticians working and learning within the pharmaceutical industry.
Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.
Download or read book Probability for Statisticians written by Galen R. Shorack and published by Springer Science & Business Media. This book was released on 2006-05-02 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: The choice of examples used in this text clearly illustrate its use for a one-year graduate course. The material to be presented in the classroom constitutes a little more than half the text, while the rest of the text provides background, offers different routes that could be pursued in the classroom, as well as additional material that is appropriate for self-study. Of particular interest is a presentation of the major central limit theorems via Steins method either prior to or alternative to a characteristic function presentation. Additionally, there is considerable emphasis placed on the quantile function as well as the distribution function, with both the bootstrap and trimming presented. The section on martingales covers censored data martingales.
Download or read book Recent Studies on Risk Analysis and Statistical Modeling written by Teresa A. Oliveira and published by Springer. This book was released on 2018-08-22 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the latest developments in the field of risk analysis (RA). Statistical methodologies have long-since been employed as crucial decision support tools in RA. Thus, in the context of this new century, characterized by a variety of daily risks - from security to health risks - the importance of exploring theoretical and applied issues connecting RA and statistical modeling (SM) is self-evident. In addition to discussing the latest methodological advances in these areas, the book explores applications in a broad range of settings, such as medicine, biology, insurance, pharmacology and agriculture, while also fostering applications in newly emerging areas. This book is intended for graduate students as well as quantitative researchers in the area of RA.
Download or read book Statistical Thinking for Non Statisticians in Drug Regulation written by Richard Kay and published by John Wiley & Sons. This book was released on 2022-11-29 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: STATISTICAL THINKING FOR NON-STATISTICIANS IN DRUG REGULATION Statistical methods in the pharmaceutical industry are accepted as a key element in the design and analysis of clinical studies. Increasingly, the medical and scientific community are aligning with the regulatory authorities and recognizing that correct statistical methodology is essential as the basis for valid conclusions. In order for those correct and robust methods to be successfully employed there needs to be effective communication across disciplines at all stages of the planning, conducting, analyzing and reporting of clinical studies associated with the development and evaluation of new drugs and devices. Statistical Thinking for Non-Statisticians in Drug Regulation provides a comprehensive in-depth guide to statistical methodology for pharmaceutical industry professionals, including physicians, investigators, medical science liaisons, clinical research scientists, medical writers, regulatory personnel, statistical programmers, senior data managers and those working in pharmacovigilance. The author’s years of experience and up-to-date familiarity with pharmaceutical regulations and statistical practice within the wider clinical community make this an essential guide for the those working in and with the industry. The third edition of Statistical Thinking for Non-Statisticians in Drug Regulation includes: A detailed new chapter on Estimands in line with the 2019 Addendum to ICH E9 Major new sections on topics including Combining Hierarchical Testing and Alpha Adjustment, Biosimilars, Restricted Mean Survival Time, Composite Endpoints and Cumulative Incidence Functions, Adjusting for Cross-Over in Oncology, Inverse Propensity Score Weighting, and Network Meta-Analysis Updated coverage of many existing topics to reflect new and revised guidance from regulatory authorities and author experience Statistical Thinking for Non-Statisticians in Drug Regulation is a valuable guide for pharmaceutical and medical device industry professionals, as well as statisticians joining the pharmaceutical industry and students and teachers of drug development.
Download or read book Probability and Statistical Inference written by J.G. Kalbfleisch and published by Springer Science & Business Media. This book was released on 1985 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: A carefully written text, suitable as an introductory course for second or third year students. The main scope of the text guides students towards a critical understanding and handling of data sets together with the ensuing testing of hypotheses. This approach distinguishes it from many other texts using statistical decision theory as their underlying philosophy. This volume covers concepts from probability theory, backed by numerous problems with selected answers.
Download or read book Pharmaceutical Statistics Using SAS written by Alex Dmitrienko, Ph.D. and published by SAS Institute. This book was released on 2007-02-07 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces a range of data analysis problems encountered in drug development and illustrates them using case studies from actual pre-clinical experiments and clinical studies. Includes a discussion of methodological issues, practical advice from subject matter experts, and review of relevant regulatory guidelines.
Download or read book Engineering Biostatistics written by Brani Vidakovic and published by John Wiley & Sons. This book was released on 2017-11-06 with total page 995 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a one-stop resource for engineers learning biostatistics using MATLAB® and WinBUGS Through its scope and depth of coverage, this book addresses the needs of the vibrant and rapidly growing bio-oriented engineering fields while implementing software packages that are familiar to engineers. The book is heavily oriented to computation and hands-on approaches so readers understand each step of the programming. Another dimension of this book is in parallel coverage of both Bayesian and frequentist approaches to statistical inference. It avoids taking sides on the classical vs. Bayesian paradigms, and many examples in this book are solved using both methods. The results are then compared and commented upon. Readers have the choice of MATLAB® for classical data analysis and WinBUGS/OpenBUGS for Bayesian data analysis. Every chapter starts with a box highlighting what is covered in that chapter and ends with exercises, a list of software scripts, datasets, and references. Engineering Biostatistics: An Introduction using MATLAB® and WinBUGS also includes: parallel coverage of classical and Bayesian approaches, where appropriate substantial coverage of Bayesian approaches to statistical inference material that has been classroom-tested in an introductory statistics course in bioengineering over several years exercises at the end of each chapter and an accompanying website with full solutions and hints to some exercises, as well as additional materials and examples Engineering Biostatistics: An Introduction using MATLAB® and WinBUGS can serve as a textbook for introductory-to-intermediate applied statistics courses, as well as a useful reference for engineers interested in biostatistical approaches.
Download or read book Regression Analysis written by Ashish Sen and published by Springer Science & Business Media. This book was released on 1997-04-01 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date, rigorous, and lucid treatment of the theory, methods, and applications of regression analysis, and thus ideally suited for those interested in the theory as well as those whose interests lie primarily with applications. It is further enhanced through real-life examples drawn from many disciplines, showing the difficulties typically encountered in the practice of regression analysis. Consequently, this book provides a sound foundation in the theory of this important subject.
Download or read book Perspectives on Promotion and Database Marketing written by Robert C. Blattberg and published by World Scientific. This book was released on 2010 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative marketing as a discipline started around the mid 60's and has been dominated by only a handful of individuals. Robert Blattberg is one of them and has been a leader in setting a research agenda for this discipline. The collection of articles in this book along with commentary by some of his doctoral students is a magnificent testament to the genius of Robert Blattberg. The chapters in this book are organized into six parts. The first part, titled ?Early Bob?, traces research which he completed during the first decade after he joined University of Chicago. The second part is titled ?Statistical Bob?. This part comprises papers that Robert wrote in characterizing the response of consumers to dealing. The third part is titled ?Promotional Bob?, and covers roughly a ten-year stretch from 1987 to 1996. The fourth part titled ?Big Bob?, describes Robert's contribution to and impact on marketing practice. The fifth part is titled ?Direct Bob?, and focuses on what customer level data should be gathered, how they should be organized, linked and analyzed, and what metrics should be used to assess customer value. The sixth and final part titled ?Micro-Macro Bob?, is not genre or area specific as much as an illustration of Robert's overall research interests in marketing-mix modeling.
Download or read book Introduction to Graphical Modelling written by David Edwards and published by Springer Science & Business Media. This book was released on 2000-06-15 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: A useful introduction to this topic for both students and researchers, with an emphasis on applications and practicalities rather than on a formal development. It is based on the popular software package for graphical modelling, MIM, freely available for downloading from the Internet. Following a description of some of the basic ideas of graphical modelling, subsequent chapters describe particular families of models, including log-linear models, Gaussian models, and models for mixed discrete and continuous variables. Further chapters cover hypothesis testing and model selection. Chapters 7 and 8 are new to this second edition and describe the use of directed, chain, and other graphs, complete with a summary of recent work on causal inference.
Download or read book Measurement Theory for Engineers written by Ilya Gertsbakh and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Well written textbook on industrial applications of Statistical Measurement Theory. It deals with the principal issues of measurement theory, is concise and intelligibly written, and to a wide extent self-contained. Difficult theoretical issues are separated from the mainstream presentation. Each topic starts with an informal introduction followed by an example, the rigorous problem formulation, solution method, and a detailed numerical solution. Chapter are concluded with a set of exercises of increasing difficulty, mostly with solutions. Knowledge of calculus and fundamental probability and statistics is assumed.
Download or read book Statistics Done Wrong written by Alex Reinhart and published by No Starch Press. This book was released on 2015-03-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific progress depends on good research, and good research needs good statistics. But statistical analysis is tricky to get right, even for the best and brightest of us. You'd be surprised how many scientists are doing it wrong. Statistics Done Wrong is a pithy, essential guide to statistical blunders in modern science that will show you how to keep your research blunder-free. You'll examine embarrassing errors and omissions in recent research, learn about the misconceptions and scientific politics that allow these mistakes to happen, and begin your quest to reform the way you and your peers do statistics. You'll find advice on: –Asking the right question, designing the right experiment, choosing the right statistical analysis, and sticking to the plan –How to think about p values, significance, insignificance, confidence intervals, and regression –Choosing the right sample size and avoiding false positives –Reporting your analysis and publishing your data and source code –Procedures to follow, precautions to take, and analytical software that can help Scientists: Read this concise, powerful guide to help you produce statistically sound research. Statisticians: Give this book to everyone you know. The first step toward statistics done right is Statistics Done Wrong.
Download or read book Data Mining written by John Wang and published by IGI Global. This book was released on 2003-01-01 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: "An overview of the multidisciplinary field of data mining, this book focuses specifically on new methodologies and case studies. Included are case studies written by 44 leading scientists and talented young scholars from seven different countries. Topics covered include data mining based on rough sets, the impact of missing data, and mining free text for structure. In addition, the four basic mining operations supported by numerous mining techniques are addressed: predictive model creation supported by supervised induction techniques; link analysis supported by association discovery and sequence discovery techniques; DB segmentation supported by clustering techniques; and deviation detection supported by statistical techniques."
Download or read book A First Course in Probability Models and Statistical Inference written by James H.C. Creighton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 743 pages. Available in PDF, EPUB and Kindle. Book excerpt: Welcome to new territory: A course in probability models and statistical inference. The concept of probability is not new to you of course. You've encountered it since childhood in games of chance-card games, for example, or games with dice or coins. And you know about the "90% chance of rain" from weather reports. But once you get beyond simple expressions of probability into more subtle analysis, it's new territory. And very foreign territory it is. You must have encountered reports of statistical results in voter sur veys, opinion polls, and other such studies, but how are conclusions from those studies obtained? How can you interview just a few voters the day before an election and still determine fairly closely how HUN DREDS of THOUSANDS of voters will vote? That's statistics. You'll find it very interesting during this first course to see how a properly designed statistical study can achieve so much knowledge from such drastically incomplete information. It really is possible-statistics works! But HOW does it work? By the end of this course you'll have understood that and much more. Welcome to the enchanted forest.
Download or read book Applying and Interpreting Statistics written by Glen McPherson and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basis, application, and interpretation of statistics, and presents a wide range of univariate and multivariate statistical methodology. The Second Edition retains the unique feature of being written from the users' perspective; it connects statistical models and methods to investigative questions and background information, and connects statistical results with interpretations in plain English. In keeping with this approach, methods are grouped by usage rather than by commonality of statistical methodology.
