Download or read book Preparation of Compounds Labeled with Tritium and Carbon 14 written by Rolf Voges and published by John Wiley & Sons. This book was released on 2009-03-12 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.
Download or read book Drug Discovery and Evaluation Methods in Clinical Pharmacology written by H.Gerhard Vogel and published by Springer Science & Business Media. This book was released on 2010-12-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Download or read book Modern Applications written by Frank Rösch and published by Walter de Gruyter GmbH & Co KG. This book was released on 2016-08-08 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear chemistry represents a vital field of basic and applied research. Modern applications cover, for example, fundamental aspects of energetics and high-sensitive, high-selective and non-destructive analytical technologies. Nuclear chemistry and radiopharmaceutical chemistry are increasingly used to bridge pharmaceutical and medical research with state-of-the-art non-invasive molecular diagnosis as well as with patient-individual treatment. While volume I on Introduction to Nuclear Chemistry describes the origin of unstable atoms and their pathways to stabilize, this volume II illustrates the spectrum of modern applications of nuclear and radiochemistry. In various chapters, leading scientists address - the measurement of radiation, - the dosimetric action of radioactive radiation and radiation safety - nuclear dating - elemental analysis by neutron activation, - radiation mass spectroscopy and chemicals speciation, - radiochemical separations, - applications of radiochemistry to life sciences, - the chemistry of radioelements: Tc and At, actinides and the transactinides - fundamentals of modern nuclear energy.
Download or read book TID written by and published by . This book was released on 1959 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ADME Enabling Technologies in Drug Design and Development written by Donglu Zhang and published by John Wiley & Sons. This book was released on 2012-04-13 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
Download or read book Principles Of Radiopharmacolgy written by Lelio G. Colombetti and published by CRC Press. This book was released on 2019-07-17 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1979, this book offers a full comprehensive guide to the applications and uses of radiopharmacology. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for radiologists and other practitioners in their respective fields.
Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1966 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bibliography of Mass Spectroscopy Literature for 1970 written by and published by . This book was released on 1972 with total page 900 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Isotopes for Medicine and the Life Sciences written by Institute of Medicine and published by National Academies Press. This book was released on 1995-01-27 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioactive isotopes and enriched stable isotopes are used widely in medicine, agriculture, industry, and science, where their application allows us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. Indeed, in many casesâ€"for example, biological tracersâ€"there is no alternative. In a stellar example of "technology transfer" that began before the term was popular, the Department of Energy (DOE) and its predecessors has supported the development and application of isotopes and their transfer to the private sector. The DOE is now at an important crossroads: Isotope production has suffered as support for DOE's laboratories has declined. In response to a DOE request, this book is an intensive examination of isotope production and availability, including the education and training of those who will be needed to sustain the flow of radioactive and stable materials from their sources to the laboratories and medical care facilities in which they are used. Chapters include an examination of enriched stable isotopes; reactor and accelerator-produced radionuclides; partnerships among industries, national laboratories, and universities; and national isotope policy.
Download or read book Journal of Research of the National Bureau of Standards written by United States. National Bureau of Standards and published by . This book was released on 1960 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Background information document proposed standards for radionuclides written by and published by . This book was released on 1983 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Paleoclimatology written by Gilles Ramstein and published by Springer Nature. This book was released on 2020-11-09 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume book provides a comprehensive, detailed understanding of paleoclimatology beginning by describing the “proxy data” from which quantitative climate parameters are reconstructed and finally by developing a comprehensive Earth system model able to simulate past climates of the Earth. It compiles contributions from specialists in each field who each have an in-depth knowledge of their particular area of expertise. The first volume is devoted to “Finding, dating and interpreting the evidence”. It describes the different geo-chronological technical methods used in paleoclimatology. Different fields of geosciences such as: stratigraphy, magnetism, dendrochronology, sedimentology, are drawn from and proxy reconstructions from ice sheets, terrestrial (speleothems, lakes, and vegetation) and oceanic data, are used to reconstruct the ancient climates of the Earth. The second volume, entitled “Investigation into ancient climates,” focuses on building comprehensive models of past climate evolution. The chapters are based on understanding the processes driving the evolution of each component of the Earth system (atmosphere, ocean, ice). This volume provides both an analytical understanding of each component using a hierarchy of models (from conceptual to very sophisticated 3D general circulation models) and a synthetic approach incorporating all of these components to explore the evolution of the Earth as a global system. As a whole this book provides the reader with a complete view of data reconstruction and modeling of the climate of the Earth from deep time to present day with even an excursion to include impacts on future climate.
Download or read book Oklahoma Conference Radioisotopes in Agriculture written by and published by . This book was released on 1960 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Energy Research Abstracts written by and published by . This book was released on 1986 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Isotopes and Radiation Technology written by and published by . This book was released on 1965 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Retinoids written by Michael B. Sporn and published by Academic Press. This book was released on 2012-12-02 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids, Volume 1 covers the chemistry and biology of retinoids, with an emphasis on the role of retinoids in nutrition and in vision. After briefly discussing the discovery and nomenclature of retinoids, this six-chapter volume describes the chemical and physical properties of natural and synthetic retinoids, as well as the retinoidal benzoic acid derivatives. The book goes on describing various reactions with radioisotopes for the synthesis of retinoids and related compounds. Considerable chapters explain the chemical, physical, and biological methodologies for separating and measuring retinoids. A discussion on the relationships between structure and activity of retinoids is included. The last chapter addresses the role of vitamin A in animal and human nutrition. This volume also discusses the metabolism of vitamin A in normal and disease states, as well as its interaction with hormones, micronutrients, drugs, and alcohol. This volume is an ideal source for nutritionists, clinicians, and researchers who are interested in the progressing field of retinoid research.
Download or read book Strategy and Methodology for Radioactive Waste Characterization written by International Atomic Energy Agency and published by IAEA. This book was released on 2007 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade significant progress has been achieved in the development of waste characterization and control procedures and equipment as a direct response to ever-increasing requirements for quality and reliability of information on waste characteristics. Failure in control procedures at any step can have important, adverse consequences and may result in producing waste packages which are not compliant with the waste acceptance criteria for disposal, thereby adversely impacting the repository. The information and guidance included in this publication corresponds to recent achievements and reflects the optimum approaches, thereby reducing the potential for error and enhancing the quality of the end product. -- Publisher's description.
