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Book Preparation and Characterization of Cobalt II and Cobalt III Complexes

Download or read book Preparation and Characterization of Cobalt II and Cobalt III Complexes written by 陳彥彤 and published by . This book was released on 2012 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Synthesis and Characterization of Paramagnetic Cobalt III Complexes

Download or read book Synthesis and Characterization of Paramagnetic Cobalt III Complexes written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Cisplatin

    Cisplatin

    Book Details:
  • Author : Bernhard Lippert
  • Publisher : John Wiley & Sons
  • Release : 1999
  • ISBN : 9783906390208
  • Pages : 628 pages

Download or read book Cisplatin written by Bernhard Lippert and published by John Wiley & Sons. This book was released on 1999 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.

Book Preparation Characterization and Kinetic Studies on Cobalt III Complexes with a Sulfur Containing Flexible Linear Pentadentate Ligand

Download or read book Preparation Characterization and Kinetic Studies on Cobalt III Complexes with a Sulfur Containing Flexible Linear Pentadentate Ligand written by Thomas Andrew Jackman and published by . This book was released on 1976 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Preparation and Kinetic Studies of Some Halopentaamine Cobalt III Complexes

Download or read book Preparation and Kinetic Studies of Some Halopentaamine Cobalt III Complexes written by Martin Dale Alexander and published by . This book was released on 1964 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Synthesis and Characterization of Cobalt II Nickel II and Copper II Complexes with 3 3 bis p X benzoylacetoneiminato bis trimethylene amine Ligands

Download or read book Synthesis and Characterization of Cobalt II Nickel II and Copper II Complexes with 3 3 bis p X benzoylacetoneiminato bis trimethylene amine Ligands written by Yu-Ying Chen and published by . This book was released on 1979 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Preparation and Characterization of Pentadentate Schiff Base Cobalt II Complexes and Their Dioxygen Adducts

Download or read book Preparation and Characterization of Pentadentate Schiff Base Cobalt II Complexes and Their Dioxygen Adducts written by Ron Hayden Niswander and published by . This book was released on 1976 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Organotransition Metal Chemistry From Bonding to Catalysis

Download or read book Organotransition Metal Chemistry From Bonding to Catalysis written by John F. Hartwig and published by . This book was released on 2010-02-10 with total page 1172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on Collman et al.'s best-selling classic book, Principles and Applications of Organotransition Metal Chemistry, Hartwig's text consists of new or thoroughly updated and restructured chapters and provides an in-depth view into mechanism, reaction scope, and applications. It covers the most important developments in the field over the last twenty years with great clarity with a selective, but thorough and authoritative coverage of the fundamentals of organometallic chemistry, the elementary reactions of these complexes, and many catalytic processes occurring through organometallic intermediates, making this the Organotransition Metal Chemistry text for a new generation of scientists.

Book Synthesis and Characterization of Potassium Bis dipeptidato Cobalt III Complexes

Download or read book Synthesis and Characterization of Potassium Bis dipeptidato Cobalt III Complexes written by Anne Lamp and published by . This book was released on 1987 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book The Synthesis Characterization and Electronic Properties of Some Alkylaminofluorophosphine Complexes of Cobalt II Halides

Download or read book The Synthesis Characterization and Electronic Properties of Some Alkylaminofluorophosphine Complexes of Cobalt II Halides written by Thomas Edward Nowlin and published by . This book was released on 1971 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: