Download or read book Predicting the Complexity and Progression of the Gut Microbiome Using Temporal Data and Deep Learning written by Michael Wiest and published by . This book was released on 2019 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human microbiota exhibit a highly dynamic composition over the course of life and changes in the human gut microbiota have been associated with human health or disease. Reprogramming of the gut microbiota by interventions that counter these changes and promote long-lasting health has been an emerging topic in microbiome research. Predicting changes in the gut microbiome is therefore crucial for the nature and design of these interventions. Here, we report on a new method based on deep learning to forecast changes in the microbiome. We processed and analyzed nine time-course datasets of the human gut microbiome, identifying the main microorganisms present in these microbial communities at any given time. We then used an encoder-decoder neural network to train a model that successfully predicts the progression of the microbiome composition over time given only five time points of context data. Our results demonstrate the ability to predict the fate of the human gut microbiome into the future, providing the foundation for rational intervention design.
Download or read book Computational methods for microbiome analysis volume 2 written by Setubal and published by Frontiers Media SA. This book was released on 2023-01-04 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biomarkers of Human Aging written by Alexey Moskalev and published by . This book was released on 2019 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the "epigenetic clock," as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.
Download or read book Some Contributions to Deep Learning for Metagenomics written by Thanh Hai Nguyen and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metagenomic data from human microbiome is a novel source of data for improving diagnosis and prognosis in human diseases. However, to do a prediction based on individual bacteria abundance is a challenge, since the number of features is much bigger than the number of samples. Hence, we face the difficulties related to high dimensional data processing, as well as to the high complexity of heterogeneous data. Machine Learning has obtained great achievements on important metagenomics problems linked to OTU-clustering, binning, taxonomic assignment, etc. The contribution of this PhD thesis is multi-fold: 1) a feature selection framework for efficient heterogeneous biomedical signature extraction, and 2) a novel deep learning approach for predicting diseases using artificial image representations. The first contribution is an efficient feature selection approach based on visualization capabilities of Self-Organizing Maps for heterogeneous data fusion. The framework is efficient on a real and heterogeneous datasets containing metadata, genes of adipose tissue, and gut flora metagenomic data with a reasonable classification accuracy compared to the state-of-the-art methods. The second approach is a method to visualize metagenomic data using a simple fill-up method, and also various state-of-the-art dimensional reduction learning approaches. The new metagenomic data representation can be considered as synthetic images, and used as a novel data set for an efficient deep learning method such as Convolutional Neural Networks. The results show that the proposed methods either achieve the state-of-the-art predictive performance, or outperform it on public rich metagenomic benchmarks.
Download or read book Predictive Modeling of Human Microbiota and their Role in Health and Disease written by Hyun-Seob Song and published by Frontiers Media SA. This book was released on 2022-01-19 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Artificial Intelligence in Healthcare written by Adam Bohr and published by Academic Press. This book was released on 2020-06-21 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Artificial Intelligence (AI) in Healthcare is more than a comprehensive introduction to artificial intelligence as a tool in the generation and analysis of healthcare data. The book is split into two sections where the first section describes the current healthcare challenges and the rise of AI in this arena. The ten following chapters are written by specialists in each area, covering the whole healthcare ecosystem. First, the AI applications in drug design and drug development are presented followed by its applications in the field of cancer diagnostics, treatment and medical imaging. Subsequently, the application of AI in medical devices and surgery are covered as well as remote patient monitoring. Finally, the book dives into the topics of security, privacy, information sharing, health insurances and legal aspects of AI in healthcare. Highlights different data techniques in healthcare data analysis, including machine learning and data mining Illustrates different applications and challenges across the design, implementation and management of intelligent systems and healthcare data networks Includes applications and case studies across all areas of AI in healthcare data
Download or read book Microbiome and Machine Learning written by Isabel Moreno Indias and published by Frontiers Media SA. This book was released on 2022-08-02 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Proceedings of the Canadian Society of Civil Engineering Annual Conference 2022 written by Rishi Gupta and published by Springer Nature. This book was released on with total page 1270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Functional Metagenomics Tools and Applications written by Trevor C. Charles and published by Springer. This book was released on 2017-10-09 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the latest tools available for functional metagenomics research are described.This research enables scientists to directly access the genomes from diverse microbial genomes at one time and study these “metagenomes”. Using the modern tools of genome sequencing and cloning, researchers have now been able to harness this astounding metagenomic diversity to understand and exploit the diverse functions of microorganisms. Leading scientists from around the world demonstrate how these approaches have been applied in many different settings, including aquatic and terrestrial habitats, microbiomes, and many more environments. This is a highly informative and carefully presented book, providing microbiologists with a summary of the latest functional metagenomics literature on all specific habitats.
Download or read book Big Data Preprocessing written by Julián Luengo and published by Springer Nature. This book was released on 2020-03-16 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensible overview of Big Data Preprocessing, which includes a formal description of each problem. It also focuses on the most relevant proposed solutions. This book illustrates actual implementations of algorithms that helps the reader deal with these problems. This book stresses the gap that exists between big, raw data and the requirements of quality data that businesses are demanding. This is called Smart Data, and to achieve Smart Data the preprocessing is a key step, where the imperfections, integration tasks and other processes are carried out to eliminate superfluous information. The authors present the concept of Smart Data through data preprocessing in Big Data scenarios and connect it with the emerging paradigms of IoT and edge computing, where the end points generate Smart Data without completely relying on the cloud. Finally, this book provides some novel areas of study that are gathering a deeper attention on the Big Data preprocessing. Specifically, it considers the relation with Deep Learning (as of a technique that also relies in large volumes of data), the difficulty of finding the appropriate selection and concatenation of preprocessing techniques applied and some other open problems. Practitioners and data scientists who work in this field, and want to introduce themselves to preprocessing in large data volume scenarios will want to purchase this book. Researchers that work in this field, who want to know which algorithms are currently implemented to help their investigations, may also be interested in this book.
Download or read book The Human Microbiome Diet and Health written by Food Forum and published by National Academies Press. This book was released on 2013-02-27 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.
Download or read book Flood Forecasting Using Machine Learning Methods written by Fi-John Chang and published by MDPI. This book was released on 2019-02-28 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowadays, the degree and scale of flood hazards has been massively increasing as a result of the changing climate, and large-scale floods jeopardize lives and properties, causing great economic losses, in the inundation-prone areas of the world. Early flood warning systems are promising countermeasures against flood hazards and losses. A collaborative assessment according to multiple disciplines, comprising hydrology, remote sensing, and meteorology, of the magnitude and impacts of flood hazards on inundation areas significantly contributes to model the integrity and precision of flood forecasting. Methodologically oriented countermeasures against flood hazards may involve the forecasting of reservoir inflows, river flows, tropical cyclone tracks, and flooding at different lead times and/or scales. Analyses of impacts, risks, uncertainty, resilience, and scenarios coupled with policy-oriented suggestions will give information for flood hazard mitigation. Emerging advances in computing technologies coupled with big-data mining have boosted data-driven applications, among which Machine Learning technology, with its flexibility and scalability in pattern extraction, has modernized not only scientific thinking but also predictive applications. This book explores recent Machine Learning advances on flood forecast and management in a timely manner and presents interdisciplinary approaches to modelling the complexity of flood hazards-related issues, with contributions to integrative solutions from a local, regional or global perspective.
Download or read book Data Science for Economics and Finance written by Sergio Consoli and published by Springer Nature. This book was released on 2021 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book covers the use of data science, including advanced machine learning, big data analytics, Semantic Web technologies, natural language processing, social media analysis, time series analysis, among others, for applications in economics and finance. In addition, it shows some successful applications of advanced data science solutions used to extract new knowledge from data in order to improve economic forecasting models. The book starts with an introduction on the use of data science technologies in economics and finance and is followed by thirteen chapters showing success stories of the application of specific data science methodologies, touching on particular topics related to novel big data sources and technologies for economic analysis (e.g. social media and news); big data models leveraging on supervised/unsupervised (deep) machine learning; natural language processing to build economic and financial indicators; and forecasting and nowcasting of economic variables through time series analysis. This book is relevant to all stakeholders involved in digital and data-intensive research in economics and finance, helping them to understand the main opportunities and challenges, become familiar with the latest methodological findings, and learn how to use and evaluate the performances of novel tools and frameworks. It primarily targets data scientists and business analysts exploiting data science technologies, and it will also be a useful resource to research students in disciplines and courses related to these topics. Overall, readers will learn modern and effective data science solutions to create tangible innovations for economic and financial applications.
Download or read book Supervised Sequence Labelling with Recurrent Neural Networks written by Alex Graves and published by Springer. This book was released on 2012-02-06 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supervised sequence labelling is a vital area of machine learning, encompassing tasks such as speech, handwriting and gesture recognition, protein secondary structure prediction and part-of-speech tagging. Recurrent neural networks are powerful sequence learning tools—robust to input noise and distortion, able to exploit long-range contextual information—that would seem ideally suited to such problems. However their role in large-scale sequence labelling systems has so far been auxiliary. The goal of this book is a complete framework for classifying and transcribing sequential data with recurrent neural networks only. Three main innovations are introduced in order to realise this goal. Firstly, the connectionist temporal classification output layer allows the framework to be trained with unsegmented target sequences, such as phoneme-level speech transcriptions; this is in contrast to previous connectionist approaches, which were dependent on error-prone prior segmentation. Secondly, multidimensional recurrent neural networks extend the framework in a natural way to data with more than one spatio-temporal dimension, such as images and videos. Thirdly, the use of hierarchical subsampling makes it feasible to apply the framework to very large or high resolution sequences, such as raw audio or video. Experimental validation is provided by state-of-the-art results in speech and handwriting recognition.
Download or read book Gut Microbiota Brain Axis in Enteric and Central Neuronal Functions in Health and Neuropsychiatric Disorders written by Francesca Ronchi and published by Frontiers Media SA. This book was released on 2022-06-28 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Dr. Kasper is co-founder of Symbiotix Biotherapeutics. The other Topic Editors declare no competing interests with regards to the Research Topic theme.
Download or read book Role of Microbiome in Disease Diagnostics and Therapeutics written by Nar Singh Chauhan and published by Frontiers Media SA. This book was released on 2022-10-07 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microbiome Analysis written by Robert G. Beiko and published by . This book was released on 2018 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
