Download or read book Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development written by and published by Elsevier. This book was released on 2022-12-02 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Application of Supercritical Fluid Chromatography for Pharmaceutical Research and Development provides a valuable “go-to reference for many difficult-to-solve challenges using pertinent chromatographic theory, first-hand case studies, and examples provided from academic and industry experts. This text also enables professors teaching an analytical instrumental course to introduce and instruct students about one of the most sustainable and powerful separation methods currently available. While the text has broad applicability across industrial sectors, it focuses primarily on application in the pharmaceutical industry. The book is designed to allow readers to align current HPLC/UHPLC capabilities with SFC as an orthogonal tool for project specific methods in the pharmaceutical industry. It highlights where SFC falls on the spectrum of useful chromatographic tools for routine and challenging separative methods. Experienced HPLC users who are interested in developing knowledge in orthogonal separation techniques, as well as newcomers to the field of separation science, will find this text particularly useful. Chapters address where SFC may fit the analytical needs of the pharmaceutical industry and alert the readers as to where the technique will not fit. Readers will gain an understanding of how and where SFC may be applied and adapted more routinely across the pharmaceutical industry as a ‘green’ way of undertaking separation opportunities and challenges. Areas within the pharmaceutical industry include early drug discovery, process chemistry, and late stage development and manufacturing. Describes approaches to SFC column and mobile phase selection for method development for both analytical and preparative tasks Gives practical examples of how analytical SFC enables the monitoring of synthetic reactions including unstable intermediates, chiral and achiral polar reactants and products across small and large modalities Provides need-focused case studies for pharmaceutical analysts, process chemists, and contract chemistry facilities that can benefit from monitoring or purifying polar intermediates, mutagenic impurities, nitrosamines and other reaction by-products including excipients and metabolites

Download or read book Supercritical Fluid Chromatography written by Gregory K. Webster and published by CRC Press. This book was released on 2014-02-04 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical chemists in the pharmaceutical industry are always looking for more-efficient techniques to meet the analytical challenges of today’s pharmaceutical industry. One technique that has made steady advances in pharmaceutical analysis is supercritical fluid chromatography (SFC). SFC is meeting the chromatography needs of the industry by providing efficient and selective testing capabilities on the analytical and preparative scale. The supercritical fluid mobile phase, consisting mainly of CO2, facilitates cost reduction costs and helps the industry in meeting green chemistry standards. This book provides a comprehensive overview of the use of SFC in pharmaceutical analysis. Supercritical Fluid Chromatography reviews the use of SFC in drug-discovery applications and describes its application in drug development. When a drug is developed and brought to market, it is tested many times for impurities and degradants, enantiomeric purity, and analytical and preparative isolations—it is tested during discovery and development and for under-regulated and unregulated methodologies. The book describes the use of SFC for each of these applications and discusses more in-depth topics, such as the use of SFC in mass spectrometric and polarographic detection. The book also sheds light on the role of SFC in drug development from natural products and the advancement of SFC with new technologies and its use in pilot-scale operations as a chromatographic technique.

Download or read book Supercritical Fluid Chromatography written by Gérard Rossé and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-17 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercritical Fluid Chromatography (SFC) provides a timely overview of SFC application areas which were unimaginable just a decade ago. This two-volume series opens with an overview of the history and expectant future of SFC and continues with recent applications in the pharmaceutical industry and other fascinating areas of science. SFC has found its place in the pharmaceutical industry with an increasing body of applications for chiral and achiral molecules in both the research and development phases of the drug discovery process. As illustrated in this two-volume series, the current interest in SFC extends well beyond the pharmaceutical industry. Chapters encompassing applications for polar and non-polar mixtures of importance are covering widely disparate areas in substance abuse, natural products including cannabinoids, bioactive lipids, flavor and fragrance. With its broad balance and coverage, this two-volume book constitutes a unique educational platform to students and scientists for many years to come. The major objective of this book editions is to inspire and stimulate readers to continue exploring the possibilities of exploiting supercritical fluids as a particular media for analysis, purifications and synthesis

Download or read book Modern Supercritical Fluid Chromatography written by Larry M. Miller and published by John Wiley & Sons. This book was released on 2019-11-06 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains why modern supercritical fluid chromatography (SFC) is the leading "green" analytical and purification separations technology. Modern supercritical fluid chromatography (SFC) is the leading method used to analyze and purify chiral and achiral chemical compounds, many of which are pharmaceuticals, pharmaceutical candidates, and natural products including cannabis-related compounds. This book covers current SFC instrumentation as it relates to greater robustness, better reproducibility, and increased analytical sensitivity. Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases covers the history, instrumentation, method development and applications of SFC. The authors provided readers with an overview of analytical and preparative SFC equipment, stationary phases, and mobile phase choices. Topics covered include: Milestones of Supercritical Fluid Chromatography; Physical Properties of Supercritical Fluids; Instrumentation for SFC; Detection in SFC; Achiral SFC Method Development; Chiral SFC Method Development; and Preparative Scale SFC. The book also includes highlights of modern applications of SFC in the final chapters—namely pharmaceuticals, consumer products, foods, polymers, petroleum-related mixtures, and cannabis—and discusses the future of SFC. Provides a clear explanation of the physical and chemical properties of supercritical fluids, which gives the reader a better understanding of the basis for improved performance in SFC compared to HPLC and GC Describes the advantages of SFC as a green alternative to HPLC and GC for the analysis of both polar, water-soluble, and non-polar analytes Details both achiral and chiral SFC method development, including modifiers, additives, the impact of temperature and pressure, and stationary phase choices Details why SFC is the premier modern preparative chromatographic technique used to purify components of mixtures for subsequent uses, both from performance and economic perspectives Covers numerous detectors, with an emphasis on SFC-MS, SFC-UV, and SFC-ELSD (evaporative light scattering detection) Describes the application of SFC to numerous high-value application areas Modern Supercritical Fluid Chromatography: Carbon Dioxide Containing Mobile Phases will be of great interest to professionals, students, and professors involved in analytical, bioanalytical, separations science, medicinal, petroleum, and environmental chemistries. It will also appeal to pharmaceutical scientists, natural-product scientists, food and consumer-products scientists, chemical engineers, and managers in these areas.

Download or read book Supercritical Fluid Chromatography written by Gérard Rossé and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-12-17 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercritical Fluid Chromatography (SFC) provides a timely overview of SFC application areas which were unimaginable just a decade ago. This two-volume series opens with an overview of the history and expectant future of SFC and continues with recent applications in the pharmaceutical industry and other fascinating areas of science. SFC has found its place in the pharmaceutical industry with an increasing body of applications for chiral and achiral molecules in both the research and development phases of the drug discovery process. As illustrated in this two-volume series, the current interest in SFC extends well beyond the pharmaceutical industry. Chapters encompassing applications for polar and non-polar mixtures of importance are covering widely disparate areas in substance abuse, natural products including cannabinoids, bioactive lipids, flavor and fragrance. With its broad balance and coverage, this two-volume book constitutes a unique educational platform to students and scientists for many years to come. The major objective of this book editions is to inspire and stimulate readers to continue exploring the possibilities of exploiting supercritical fluids as a particular media for analysis, purifications and synthesis

Download or read book Packed Column SFC written by T A Berger and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Packed Column SFC is the third title to be published in this series and has been produced as a result of the dramatic re-emergence, in the last three years, of packed column instrumentation. This has led to a redefinition of the technique and an urgent need for a practical guide that deals with its subtleties. This book fulfils that need and deals exclusively with packed column SFC. It places the emphasis on understanding the underlying chemistry in order to perform rapid, systematic optimizations and provides many practical tips to help the new user avoid problems unique to SFC. It also proposes a detailed scheme for method development and provides lists of prioritized guidelines. The book clears up some of the confusion that surrounds the analytical use of supercritical fluids and assists the user in understanding the power and utility of this technique. Detailed chapters cover the most promising new application areas for packed column SFC, which are often overlooked in the mainstream chromatography literature. Like the other books in this popular series, Packed Column SFC will prove an invaluable guide and is essential reading for graduates, postgraduates and researchers with interests in pharmaceuticals, agricultural chemistry, small polar drug molecules, chiral analysis, environmental chemistry, and chromatography/instrumentation.

Download or read book Supercritical Fluid Chromatography written by Colin F. Poole and published by Elsevier. This book was released on 2017-02-16 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in SFC in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and are underappreciated. Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in SFC and how it should be implemented in laboratory science. Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique and introduces SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at an advanced level. Edited and authored by world-leading chromatography experts Provides comprehensive coverage of SFC in a single source Extensive referencing facilitates identification of key research developments More than 200 figures and tables aid in the retention of key concepts

Download or read book Supercritical Fluid Technology for Drug Product Development written by Peter York and published by CRC Press. This book was released on 2004-03-23 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical prod

Download or read book Practical Supercritical Fluid Chromatography and Extraction written by Thomas Caudell and published by CRC Press. This book was released on 1999-03-08 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the fundamental and practical aspects of supercritical fluid chromatography (SFC) and extraction. It discusses packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.

Download or read book Practical Supercritical Fluid Chromatography and Extraction written by Thomas Caudell and published by Routledge. This book was released on 2018-05-08 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of fundamental as well as practical aspects of supercritical fluid chromatography and extraction. It addresses topics such as: packed columns in SFC; detection in SFC; supercritical fluid chromatography/mass spectroscopy; and evaporative light scattering detection in SFC.

Download or read book Analysis with Supercritical Fluids Extraction and Chromatography written by Bernd Wenclawiak and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of supercritical fluids in analytical chemistry is still grow ing. More and more analysts are discovering the favorable advan tages for a number of applications. Especially supercritical fluid extraction (SFE) has attracted a lot of interest in recent years due to its simplicity. Supercritical fluid chromatography (SFC) has become better established and the development of this technique has been accelerated by the many applications with capillary col umns which have been published in the literature. At first SFC equipment was based on instruments commonly used for liquid chromatography, and the first commercial in struments were derived from this technology. However, capillary columns can be much more easily interfaced to gas chromatogra phy equipment especially to the detectors commonly used for Oc. Many stationary phases both for packed micro columns and capillary columns have been designed for SFC purposes extending this technology to LC and OC. The most common fluid applied in SFC and SFE is carbon dioxide. The advantages of supercritical CO , such as having dif 2 fusivity like a gas and solvating power depending on temperature and pressure, are also valid for other fluids and modified fluids. Both properties are valuable for sample extraction and extraction selectivity.

Download or read book Handbook of Advanced Chromatography Mass Spectrometry Techniques written by Michal Holcapek and published by Elsevier. This book was released on 2017-09-07 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Advanced Chromatography /Mass Spectrometry Techniques is a compendium of new and advanced analytical techniques that have been developed in recent years for analysis of all types of molecules in a variety of complex matrices, from foods to fuel to pharmaceuticals and more. Focusing on areas that are becoming widely used or growing rapidly, this is a comprehensive volume that describes both theoretical and practical aspects of advanced methods for analysis. Written by authors who have published the foundational works in the field, the chapters have an emphasis on lipids, but reach a broader audience by including advanced analytical techniques applied to a variety of fields. Handbook of Advanced Chromatography / Mass Spectrometry Techniques is the ideal reference for those just entering the analytical fields covered, but also for those experienced analysts who want a combination of an overview of the techniques plus specific and pragmatic details not often covered in journal reports. The authors provide, in one source, a synthesis of knowledge that is scattered across a multitude of literature articles. The combination of pragmatic hints and tips with theoretical concepts and demonstrated applications provides both breadth and depth to produce a valuable and enduring reference manual. It is well suited for advanced analytical instrumentation students as well as for analysts seeking additional knowledge or a deeper understanding of familiar techniques. Includes UHPLC, HILIC, nano-liquid chromatographic separations, two-dimensional LC-MS (LCxLC), multiple parallel MS, 2D-GC (GCxGC) methodologies for lipids analysis, and more Contains both practical and theoretical knowledge, providing core understanding for implementing modern chromatographic and mass spectrometric techniques Presents chapters on the most popular and fastest-growing new techniques being implemented in diverse areas of research

Download or read book Supercritical Fluid Extraction and its Use in Chromatographic Sample Preparation written by S.A. Westwood and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: by Professor D. E. Games, Mass Spectrometry Research Unit, University College of Swansea Sample preparation can be viewed as occupying a Cinderella role in analytical science. However, the quality of sample preparation plays a key role in high In the past decade, there has been quality analysis and deserves higher stature. considerable interest in the use of supercritical fluid extraction (SFE) as an alternative to conventional procedures for the preparation of samples for ana lysis. The driving force for this development is the need for automated, sim pler, faster, non-destructive and selective methods for extraction, preferably using non-toxic extraction media which are easily disposed of. Utilization of supercritical fluids for extraction fulfils these requirements because of their unique physical chemical properties and usually low toxicity. Selectivity can be achieved by suitable selection of pressure (density), temperature and modi fier conditions which enable solvating power to be varied. The high diffusivity of supercritical fluids provides rapid sample penetration and extraction. Use of fluids with low critical temperatures enables extraction to be conducted under mild thermal conditions ensuring that thermally labile compounds do not decompose. The technique can be used off-line, and the extracts analysed by appropriate techniques, or it can be used on-line, by coupling with a variety of chromatographic techniques. These can then, if necessary, be coupled fur ther with spectroscopic techniques, such as Fourier transform infrared, ultra violet or mass spectrometry, to provide specific identification or structural information.

Download or read book The Essence of Chromatography written by C. F. Poole and published by Elsevier. This book was released on 2003 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: General concepts in column chromatography -- The column in gas chromatography -- Instrumental aspects of gas chromatography -- The column in liquid chromatography -- Instrumental aspects of liquid chromatography -- Thin-layer chromatography -- Supercritical fluid chromatography -- Capillary-electromigration separation techniques -- Spectroscopic detectors for identification and quantification -- Separation of stereoisomers -- Laboratory-scale preparative chromatography.

Download or read book Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring written by Melissa N. Dunkle and published by John Wiley & Sons. This book was released on 2020-09-01 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough introduction to environmental monitoring in the oil and gas industry Analytical Techniques in the Oil and Gas Industry for Environmental Monitoring examines the analytical side of the oil and gas industry as it also provides an overall introduction to the industry. You’ll discover how oil and natural gas are sourced, refined, and processed. You can learn about what’s produced from oil and natural gas, and why evaluating these sourced resources is important. The book discusses the conventional analyses for oil and natural gas feeds, along with their limitations. It offers detailed descriptions of advanced analytical techniques that are commercially available, plus explanations of gas and oil industry equipment and instrumentation. You’ll find technique descriptions supplemented with a list of references as well as with real-life application examples. With this book as a reference, you can prepare to apply specific analytical methods in your organization’s lab environment. Analytical Techniques can also serve as your comprehensive resource on key techniques in the characterization of oil and gas samples, within both refinery and environmental contexts. Understand of the scope of oil and gas industry techniques available Consider the benefits and limitations of each available process Prepare for applying analytical techniques in your lab See real examples and a list of references for each technique Read descriptions of off-line analytics, as well as on-line and process applications As a chemist, engineer, instructor, or student, this book will also expand your awareness of the role these techniques have in environmental monitoring and environmental impact assessments.

Download or read book Supercritical Fluid Chromatography with Patked Columns written by Klaus Anton and published by CRC Press. This book was released on 1997-09-19 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the analytical to industrial preparative scale, this work provides a praxis-oriented overview of packed column supercritical fluid chromatography. It discusses and evaluates established applications and techniques, up-to-date and promising developments, and commercial instrumentation devices for use in industry. The book also reveals possibilities for problem solving and future innovations.

Download or read book Supercritical Fluid Extraction written by Larry T. Taylor and published by Wiley-Interscience. This book was released on 1996-03-13 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: By encouraging a deliberate, systematic approach to supercritical fluid extraction (SFE) methods and techniques, this book enables scientists and technicians to avoid disappointing results and erroneous conclusions and develop reliable guidelines for using this versatile technology.