EBookClubs

Read Books & Download eBooks Full Online

EBookClubs

Read Books & Download eBooks Full Online

Book Human Herpesviruses

    Book Details:
  • Author : Ann Arvin
  • Publisher : Cambridge University Press
  • Release : 2007-08-16
  • ISBN : 1139461648
  • Pages : 1325 pages

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Book Temporal Regulation of Herpes Simplex Virus Type 1 Gene Expression

Download or read book Temporal Regulation of Herpes Simplex Virus Type 1 Gene Expression written by Ramon Rivera-Gonzalez and published by . This book was released on 1994 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Chromatin and Coactivators in Herpes Simplex Virus Type 1 Gene Regulation

Download or read book Chromatin and Coactivators in Herpes Simplex Virus Type 1 Gene Regulation written by Sebla Bulent Kutluay and published by . This book was released on 2009 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Regulation of Herpes Simplex Virus Type 1 Gene Expression by the Transcription Factor Early Growth Response 1

Download or read book Regulation of Herpes Simplex Virus Type 1 Gene Expression by the Transcription Factor Early Growth Response 1 written by Gautam Reddy Bedadala and published by . This book was released on 2010 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Studies on the Structure  Function  and Regulation of Expression of the Latency associated Transcript of Herpes Simplex Virus Type 1

Download or read book Studies on the Structure Function and Regulation of Expression of the Latency associated Transcript of Herpes Simplex Virus Type 1 written by Michael James Farrell and published by . This book was released on 1993 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Identification of Cellular Factors Involved in the Regulation of Herpes Simplex Virus Type 1 Late Gene Expression

Download or read book Identification of Cellular Factors Involved in the Regulation of Herpes Simplex Virus Type 1 Late Gene Expression written by Matthew David Petroski and published by . This book was released on 1999 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Characterization and Regulation of Herpes Simplex Type One Gene Expression in Productive and Latent Infections

Download or read book Characterization and Regulation of Herpes Simplex Type One Gene Expression in Productive and Latent Infections written by William Michael Flanagan and published by . This book was released on 1989 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book The Role of Herpes Simplex Virus Type 1 Regulatory Protein Infected Cell Protein 27  ICP27  in Viral Gene Expression Regulation

Download or read book The Role of Herpes Simplex Virus Type 1 Regulatory Protein Infected Cell Protein 27 ICP27 in Viral Gene Expression Regulation written by Jenny Q. Dai-Ju and published by . This book was released on 2007 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The association of ICP27 with general transcription factors TFIID-TBP suggested that ICP27 interacts with the pre-initiation complex. ChIP assays further confirmed that ICP27 binds to the initiation complex at 5 h post-infection. These lines of evidence imply that ICP27 may have a role in viral gene transcription initiation.

Book Herpes Simplex Virus Type 1

Download or read book Herpes Simplex Virus Type 1 written by Kari Lynn Roberts and published by . This book was released on 2011 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes simplex virus type 1 (HSV-1) replicates in the nucleus and buds through the nuclear membrane to access the cytosol and complete the maturation process. The HSV-1 protein pUL31, along with its binding partner, pUL34, has been previously shown to be required for nucleocapsids to successfully bud through the nuclear membrane. pUL31 is also required for efficient viral DNA synthesis and packaging. After the HSV-1 exits the nucleus, the capsid acquires several accessory proteins (tegument) and finally a mature envelope by budding into vesicles of the trans-Golgi network (TGN). These virion-laden vesicles traffic toward the cell periphery and through cortical actin until ultimately the virion is secreted upon fusion of the TGN vesicle with the plasma membrane. The data presented here reveals new roles for pUL31, as cells infected with a UL31-null virus were delayed for viral gene expression as well as activation of NF[kappa]B and c-Jun N-terminal kinase (JNK) in multiple cell lines. At least one representative from each kinetic class of viral genes was examined at various times post infection. The protein expression defects were not caused by a failure to enter cells, was not rescued by ICP27 expressed in trans and correlated with NF[kappa]B activation. The data shows that these defects were not observed in the absence of the pUL31 binding partner, pUL34, and that while most pUL31 is expressed at late times post infection, low levels are detectable as early as 2 hours post infection. Data presented in this work also demonstrates a role for the actin motor myosin Va in the secretion of HSV-1 virions. Expression of two isoforms of dominant negative myosin Va (DN-myoVa) decreased virion secretion by 5075% as well as significantly decreased surface expression of viral glycoproteins B, M and D. DN-myoVa colocalized with TGN markers and the conformation of native myosin Va in infected cells was altered by 4 hours post infection. These data suggest that myosin Va is involved in the egress of virion-laden TGN vesicles as they transit through cortical actin toward the plasma membrane.

Book The Epstein Barr Virus

    Book Details:
  • Author : M. A. Epstein
  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • ISBN : 3642672361
  • Pages : 467 pages

Download or read book The Epstein Barr Virus written by M. A. Epstein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Epstein-Barr virus was discovered 15 years ago. Since that time an immense body of information has been accumu lated on this agent which has come to assume great signifi cance in many different fields of biological science. Thus, the virus has very special relevance in human medicine and oncology, in tumor virology, in immunology, and in mole cular virology, since it is the cause of infectious mononu cleosis and also the first human cancer virus, etiologically related to endemic Burkitt's lymphoma and probably to nasopharyngeal carcinoma. In addition, continuous human lymphoid cell lines initiated and maintained by the transform ing function of the virus genome provide a laboratory tool with wide and ever-growing applications. Innumerable papers on the Epstein-Barr virus have ap peared over recent years and reports of work with this agent now constitute a veritable flood. The present book provides the first and only comprehensive, authoritative over-view of all aspects of the virus by authors who have been the original and major contributors in their particular disciplines. A complete and up-to-date survey of this unique and important agent is thus provided which should be of great interest to experts, teachers, and students engaged in cancer research, virology, immunology, molecular biology, epide miology, and cell culture. Where topics have been dealt with from more than one of these viewpoints, some inevitable overlap and duplication has resulted; although this has been kept to a minimum, it has been retained in some places because of positive usefulness.