Download or read book Poor Nutrition Leading to Potential Clinically Relevant Pathologies written by Aida Zarfeshani and published by . This book was released on 2016 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increasingly prevalent 'Western style' diet is typified by an excessive intake of high caloric foods with little or poor nutritional value. Notably, the branched-chain amino acids (BCAAs) and free fatty acids (FFAs) micronutrients have been linked with diet induced progression of metabolic syndrome. Branched-chain amino acids concentrations are increased in the plasma of obese and type 2 diabetes mellitus (T2DM) patients and may be potential inducers of initial hyperglycemia and insulin resistance (IR). Specifically, the BCAA leucine (leu) has been highlighted as potentially significant for stimulating the secretion of insulin and promoting IR as a consequence. However, seemingly contradictory evidence suggests that leu may also be protective against the development of IR and T2DM. By examining the molecular mechanism underpinning the effects of leu on hepatic glucose metabolism (the central physiological mediator of systemic glucose homeostasis) I have arrived at a potentially parsimonious explanation allowing for a reconciliation of the many disparate observations about leu that exist in this literature. Specifically, leu supplementation is initially linked with a beneficial hepatic sequestration of 'circulating‘ glucose. However, this results in a consequential hepatic accumulation of triglycerides (TGs), through the activation of the glucose transporter solute carrier family 2 (SLC2A2), its transcriptional factor forkhead box A2 (FOXA2) and downstream genes. Thus, as a consequence of persistent dietary intake, the resulting metabolic ̳trade-off‘ in which enhanced glucose uptake in the shorter term leads to elevated TGs in the longer term, could account for the pathological appearance of intra-hepatic fat droplets and progression of fatty liver disease that is often associated with IR and metabolic syndrome. Notably, my studies link leu supplementation with intracellular signalling through the key metabolic regulator myostatin (MSTN) and the associated AMP-kinase (AMPK). There is a growing body of evidence that MSTN activity enhances systemic insulin sensitivity and prevents obesity. Further, I have identified a strong epigenetic component to this regulation and specifically, identify miR-143, miR-92b* and miR-335 as instrumental to the leu-dependent induction of hepatic MSTN, SLC2A2 and FOXA2. I have also explored the molecular basis of hepatic metabolic shifts resulting from free fatty acid (palmitate) supplementation. Multiple clinical studies identify palmitate as likely the primary FFA contributing to obesity driven by dietary excess. Again MSTN dependent signalling is found to be central to these responses, as are specific miRNA species, and in particular miR-335. A key terminal effector in this signalling cascade is the hepatokine fetuin A (FetA), which is linked pathologically with clinical obesity and promotes peripheral IR by reducing insulin sensitivity. My in vitro work establishes a mechanistic link between FFA supplementation and hepatokine induction, a central element of which is the epigenetic regulation of MSTN. To further test the validity of these latter observations and in an attempt to translate these lab bench observations to the clinical setting, I have also explored these pathways in the context of pre and post bariatric surgery. Currently the clinical intervention of last resort for morbid obesity, bariatric surgery encompasses a range of surgical procedures designed to lower dietary intake. Whilst each surgical approach results in similar levels of initial weight loss, the longer term outcomes would seem to vary particularly with regard to the remission of metabolic syndrome and associated complications. The current consensus from prospective studies of post surgery T2DM remission suggest that gastric bypass (GBP) is superior to other modalities such as sleeve gastrectomy (SG), However, relatively little is known about the mechanistic basis of the metabolic shifts resulting from these types of surgery, although FetA hepatokine expression has been described as a possible biomarker of efficacy. I have defined a specific set of circulating miRNAs for which post-surgery expression is strongly correlated with both decreased body mass index (BMI) and glycated hemoglobin (HbA1c) level, but only following GBP and not SG. Of these, miRNA-355 is one of the principal regualtors of MSTN that I had identified in vitro in the context of MSTN dependent FetA expression following palmitate supplementation, suggesting that epigenetically regulated hepatokine expression may indeed be of clinical significance to the physiological changes initiated by GBP surgery at least. It remains to be seen why similar changes are not observed with SG, but clearly implies mechanistic differences in the biological responses initiated by the different surgical approaches. Collectively, the work presented herein illustrates the centrality of epigenetic regulation and of the MSTN-dependent signalling axis in underpining pivotal metabolic shifts invoked by two distinct micronutrient stimuli (BCAA and FFA), each of which is linked with deleterious consequences of dietary excess. Further, the relevance of these findings to understanding the observed features of metabolic syndrome is encouraged by the first steps that have been taken to recapitulate the initial in vitro observations in the context of clinical patients.

Download or read book Front of Package Nutrition Rating Systems and Symbols written by Institute of Medicine and published by National Academies Press. This book was released on 2012-01-30 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, tremendous growth has occurred in the use of nutrition symbols and rating systems designed to summarize key nutritional aspects and characteristics of food products. These symbols and the systems that underlie them have become known as front-of-package (FOP) nutrition rating systems and symbols, even though the symbols themselves can be found anywhere on the front of a food package or on a retail shelf tag. Though not regulated and inconsistent in format, content, and criteria, FOP systems and symbols have the potential to provide useful guidance to consumers as well as maximize effectiveness. As a result, Congress directed the Centers for Disease Control and Prevention (CDC) to undertake a study with the Institute of Medicine (IOM) to examine and provide recommendations regarding FOP nutrition rating systems and symbols. The study was completed in two phases. Phase I focused primarily on the nutrition criteria underlying FOP systems. Phase II builds on the results of Phase I while focusing on aspects related to consumer understanding and behavior related to the development of a standardized FOP system. Front-of-Package Nutrition Rating Systems and Symbols focuses on Phase II of the study. The report addresses the potential benefits of a single, standardized front-label food guidance system regulated by the Food and Drug Administration, assesses which icons are most effective with consumer audiences, and considers the systems/icons that best promote health and how to maximize their use.

Download or read book Sustainable healthy diets written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2019-10-15 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considering the detrimental environmental impact of current food systems, and the concerns raised about their sustainability, there is an urgent need to promote diets that are healthy and have low environmental impacts. These diets also need to be socio-culturally acceptable and economically accessible for all. Acknowledging the existence of diverging views on the concepts of sustainable diets and healthy diets, countries have requested guidance from the Food and Agriculture Organization of the United Nations (FAO) and the World Health Organization (WHO) on what constitutes sustainable healthy diets. These guiding principles take a holistic approach to diets; they consider international nutrition recommendations; the environmental cost of food production and consumption; and the adaptability to local social, cultural and economic contexts. This publication aims to support the efforts of countries as they work to transform food systems to deliver on sustainable healthy diets, contributing to the achievement of the SDGs at country level, especially Goals 1 (No Poverty), 2 (Zero Hunger), 3 (Good Health and Well-Being), 4 (Quality Education), 5 (Gender Equality) and 12 (Responsible Consumption and Production) and 13 (Climate Action).

Download or read book Pocket Book of Hospital Care for Children written by World Health Organization and published by World Health Organization. This book was released on 2013 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pocket Book is for use by doctors nurses and other health workers who are responsible for the care of young children at the first level referral hospitals. This second edition is based on evidence from several WHO updated and published clinical guidelines. It is for use in both inpatient and outpatient care in small hospitals with basic laboratory facilities and essential medicines. In some settings these guidelines can be used in any facilities where sick children are admitted for inpatient care. The Pocket Book is one of a series of documents and tools that support the Integrated Managem.

Download or read book Disease related Malnutrition written by Rebecca J. Stratton and published by CABI. This book was released on 2003-01-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease-related malnutrition is a global public health problem. The consequences of disease-related malnutrition are numerous, and include shorter survival rates, lower functional capacity, longer hospital stays, greater complication rates, and higher prescription rates. Nutritional support, in the form of oral nutritional supplements or tube feeding, has proven to lead to an improvement in patient outcome. This book is unique in that it draws together the results of numerous different studies that demonstrate the benefits of nutritional support and provides an evidence base for it. It also discusses the causes, consequences, and prevalence of disease-related malnutrition, and provides insights into the best possible use of enteral nutritional support.

Download or read book The Role of Nutrition in Maintaining Health in the Nation s Elderly written by Institute of Medicine and published by National Academies Press. This book was released on 2000-06-09 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malnutrition and obesity are both common among Americans over age 65. There are also a host of other medical conditions from which older people and other Medicare beneficiaries suffer that could be improved with appropriate nutritional intervention. Despite that, access to a nutrition professional is very limited. Do nutrition services benefit older people in terms of morbidity, mortality, or quality of life? Which health professionals are best qualified to provide such services? What would be the cost to Medicare of such services? Would the cost be offset by reduced illness in this population? This book addresses these questions, provides recommendations for nutrition services for the elderly, and considers how the coverage policy should be approached and practiced. The book discusses the role of nutrition therapy in the management of a number of diseases. It also examines what the elderly receive in the way of nutrition services along the continuum of care settings and addresses the areas of expertise needed by health professionals to provide appropriate nutrition services and therapy.

Download or read book Disease Control Priorities Third Edition Volume 8 written by Donald A. P. Bundy and published by World Bank Publications. This book was released on 2017-11-20 with total page 977 pages. Available in PDF, EPUB and Kindle. Book excerpt: More children born today will survive to adulthood than at any time in history. It is now time to emphasize health and development in middle childhood and adolescence--developmental phases that are critical to health in adulthood and the next generation. Child and Adolescent Health and Development explores the benefits that accrue from sustained and targeted interventions across the first two decades of life. The volume outlines the investment case for effective, costed, and scalable interventions for low-resource settings, emphasizing the cross-sectoral role of education. This evidence base can guide policy makers in prioritizing actions to promote survival, health, cognition, and physical growth throughout childhood and adolescence.

Download or read book Brain Metabolic Crossroads in Severe Mental Disorders Focus on Metabolic Syndrome written by Virginio Salvi and published by Frontiers Media SA. This book was released on 2019-10-23 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Providing Healthy and Safe Foods As We Age written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-29 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.

Download or read book Disease Control Priorities in Developing Countries written by Dean T. Jamison and published by World Bank Publications. This book was released on 2006-04-02 with total page 1449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on careful analysis of burden of disease and the costs ofinterventions, this second edition of 'Disease Control Priorities in Developing Countries, 2nd edition' highlights achievable priorities; measures progresstoward providing efficient, equitable care; promotes cost-effectiveinterventions to targeted populations; and encourages integrated effortsto optimize health. Nearly 500 experts - scientists, epidemiologists, health economists,academicians, and public health practitioners - from around the worldcontributed to the data sources and methodologies, and identifiedchallenges and priorities, resulting in this integrated, comprehensivereference volume on the state of health in developing countries.

Download or read book Nutrition in Critical Care written by Peter Faber and published by Cambridge University Press. This book was released on 2014-03-06 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive and practical guidance for managing the nutritional requirements of critically ill patients and thereby improving prognosis.

Download or read book Disease Control Priorities Third Edition Volume 2 written by Robert Black and published by World Bank Publications. This book was released on 2016-04-11 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evaluation of reproductive, maternal, newborn, and child health (RMNCH) by the Disease Control Priorities, Third Edition (DCP3) focuses on maternal conditions, childhood illness, and malnutrition. Specifically, the chapters address acute illness and undernutrition in children, principally under age 5. It also covers maternal mortality, morbidity, stillbirth, and influences to pregnancy and pre-pregnancy. Volume 3 focuses on developments since the publication of DCP2 and will also include the transition to older childhood, in particular, the overlap and commonality with the child development volume. The DCP3 evaluation of these conditions produced three key findings: 1. There is significant difficulty in measuring the burden of key conditions such as unintended pregnancy, unsafe abortion, nonsexually transmitted infections, infertility, and violence against women. 2. Investments in the continuum of care can have significant returns for improved and equitable access, health, poverty, and health systems. 3. There is a large difference in how RMNCH conditions affect different income groups; investments in RMNCH can lessen the disparity in terms of both health and financial risk.

Download or read book Nutrition and Cardiovascular Disease written by Elaine B. Feldman and published by Prentice Hall. This book was released on 1976 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Disease and Mortality in Sub Saharan Africa written by Dean T. Jamison and published by World Bank Publications. This book was released on 2006-01-01 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current data and trends in morbidity and mortality for the sub-Saharan Region as presented in this new edition reflect the heavy toll that HIV/AIDS has had on health indicators, leading to either a stalling or reversal of the gains made, not just for communicable disorders, but for cancers, as well as mental and neurological disorders.

Download or read book The State of Food Security and Nutrition in the World 2018 written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2018-09-14 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: New evidence this year corroborates the rise in world hunger observed in this report last year, sending a warning that more action is needed if we aspire to end world hunger and malnutrition in all its forms by 2030. Updated estimates show the number of people who suffer from hunger has been growing over the past three years, returning to prevailing levels from almost a decade ago. Although progress continues to be made in reducing child stunting, over 22 percent of children under five years of age are still affected. Other forms of malnutrition are also growing: adult obesity continues to increase in countries irrespective of their income levels, and many countries are coping with multiple forms of malnutrition at the same time – overweight and obesity, as well as anaemia in women, and child stunting and wasting.

Download or read book Protein Calorie Malnutrition written by Robert Olson and published by Academic Press. This book was released on 2012-12-02 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein-Calorie Malnutrition reviews the state of knowledge of metabolic phenomena in the syndromes embraced by the general term protein-calorie malnutrition (PCM), and places this new knowledge in perspective with the traditional descriptions of kwashiorkar and marasmus. The clarification it provides constitutes a benchmark for design of future programs of prevention, therapy, rehabilitation, research, or teaching. Highly noteworthy are the new advances in amino acid and protein metabolism; the enlightening evidence concerning lysine and carnitine; the evidences of derangements or deficiencies of the broad spectrum of nutrients from carbohydrates to vitamins and minerals; and the implications of these for recovery and therapy. This book includes papers on the following: the impact of age on amino acid requirements; the mechanisms of adaptation to low-protein intakes; the metabolic consequences of essential amino acid deficiency in higher animals; carbohydrate metabolism; vitamin deficiencies associated with PCM; and mineral metabolism in PCM. Other studies deal with the effects of malnutrition on endocrine function; liver function in PCM; the synergistic interaction of malnutrition and infection; and the treatment and prevention of PCM.

Download or read book Nutrition in the Prevention and Treatment of Disease written by Ann M. Coulston and published by Academic Press. This book was released on 2017-04-28 with total page 1075 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition in the Prevention and Treatment of Disease, Fourth Edition, is a compilation of current knowledge in clinical nutrition and an overview of the rationale and science base of its application to practice in the prevention and treatment of disease. In its fourth edition, this text continues the tradition of incorporating new discoveries and methods related to this important area of research Generating and analyzing data that summarize dietary intake and its association with disease are valuable tasks in treating disease and developing disease prevention strategies. Well-founded medical nutrition therapies can minimize disease development and related complications. Providing scientifically sound, creative, and effective nutrition interventions is both challenging and rewarding. Two new chapters on metabolomics and translational research, which have come to be used in nutrition research in recent years. The new areas of study are discussed with the perspective that the application of the scientific method is by definition an evolutionary process. A new chapter on Genetics and Diabetes which reviews the latest research on causal genetic variants and biological mechanisms responsible for the disease, and explores potential interactions with environmental factors such as diet and lifestyle. Includes all major "omics" – the exposome, metabolomics, genomics, and the gut microbiome. Expands the microbiota portions to reflect complexity of diet on gut microbial ecology, metabolism and health