Download or read book Polymeric Nanoparticles and Microspheres written by P. Guiot and published by CRC Press. This book was released on 2018-01-18 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributors were asked to emphasize their own experience with nanoparticles or microspheres. They were also encouraged to provide aspects normally not stipulated in specialized reviews. The objective was to produce a book which although written by specialists, presented a subject which could be easily understood by people in different fields of life sciences. Another goal was to set up a condensed work covering many aspects of nanoparticles and microspheres. That is the reason why, although mainly dealing with synthetic drug carriers, the first chapter is related to preparation and physicochemical properties of nanoparticles constructed from natural polymers. This is followed by two chapters involving the application of polymeric drug carriers in cancer therapy. The second chapter extensively describes in vitro and in vivo behaviour of purely synthetic nanoparticles. As ub the case of liposomes, a problem can be that some particles are preferentially taken up by the reticuloendothelial system. Magnetic drug carriers provide a partial answer to this problem since their tropism can be managed by an external magnet. The third chapter is entirely devoted to this aspect. A brief but original application of nanoparticles is given in the fourth chapter by reviewing their use in ocular therapy. Finally, two general applications of polymeric microspheres are discussed in chapters 5 and 6.
Download or read book Smart Drug Delivery System written by Ali Demir Sezer and published by BoD – Books on Demand. This book was released on 2016-02-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Download or read book Polymer Nanoparticles for Nanomedicines written by Christine Vauthier and published by Springer. This book was released on 2017-01-07 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.
Download or read book Polymeric Nanoparticles and Microospheres written by P. Guiot and published by . This book was released on 1986 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticulate drug delivery systems based on gelatin and albumin. Biodegradable polymeric nanoparticles as drug carrier for antitumor. Biomedical appllications of magnetic drug carriers in cancer chemotherapy. Ocular theraphy with nanoparticles. Microcapsules and microspheres for embolization and chemoembolization. Colloidal particles as radiodignostic agents.
Download or read book Polymers in Drug Delivery written by Ijeoma F. Uchegbu and published by CRC Press. This book was released on 2006-05-19 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Together, the nano explosion and the genomic revolution are ushering in a new frontier in drug delivery. In recent years we've seen how polymers can play a crucial role in controlling the rate of drug release, enhancing solubility and uptake, and limiting degradation and toxicity. In the very near future, they may well be used to deliver gene thera
Download or read book Silk based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Download or read book Handbook of Ultrasonics and Sonochemistry written by Muthupandian Ashokkumar and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microspheres and Microcapsules in Biotechnology written by Guanghui Ma and published by CRC Press. This book was released on 2013-01-29 with total page 539 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microspheres and microcapsules have very broad applications in various fields, especially in those of biotechnology and biopharmaceuticals, as targeting drug-delivery carriers, separation media for protein, peptide, DNA, and so forth. It is a big challenge to design and prepare microspheres and microcapsules of different sizes and structures from v
Download or read book Engineering Polymer Systems for Improved Drug Delivery written by Rebecca A. Bader and published by John Wiley & Sons. This book was released on 2014-01-17 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers have played a critical role in the rational design and application of drug delivery systems that increase the efficacy and reduce the toxicity of new and conventional therapeutics. Beginning with an introduction to the fundamentals of drug delivery, Engineering Polymer Systems for Improved Drug Delivery explores traditional drug delivery techniques as well as emerging advanced drug delivery techniques. By reviewing many types of polymeric drug delivery systems, and including key points, worked examples and homework problems, this book will serve as a guide to for specialists and non-specialists as well as a graduate level text for drug delivery courses.
Download or read book Single Organic Nanoparticles written by Hiroshi Masuhara and published by Springer Science & Business Media. This book was released on 2003 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Introduction.- I Preparation of Nanoparticles.- 2 Reprecipitation Method for Organic Nanocrystals.- 3 Laser Ablation Method for Organic Nanoparticles.- 4 Synthesis of Functionalized Polymer Particles.- 5 Synthesis of Photosensitive Dendrimer Molecules.- II Spectroscopy and Manipulation.- 6 Electrodynamic Trap of Single Microparticles.- 7 Lasing Spectroscopy of Single Microspheres.- 8 Microspectroscopy of Single Nanoparticles.- 9 Force Measurement for a Single Nanoparticle.- 10 Laser Manipulation of Single Nanoparticles.- III Theory of Optical Interactions.- 11 Optical Spectrum of a Confined Exciton in a Sphere: A Prototype of Advanced Analyses.- 12 Optical Manipulation of Single Nanoparticles Under a Resonance Condition.- 13 Low-Dimensional Eexcitons in Aromatic Nanoparticles.- IV Physics and Chemistry of Nanoparticles.- 14 Optical Properties of Polymer Nanocrystals.- 15 Photophysics of Capped Nanocrystals and Molecular J-Aggregates.- 16 Near-field Microspectroscopy and Microprocessing of Individual Perylene Microcrystals.- 17 Photochemical Dynamics of Fullerene Nanoparticles.- 18 Structural Relaxation of Dendrimers and Polymer Nanoparticles with Single Chromophores.- 19 Photophysical Properties of Semiconductor Nanocrystals.- 20 Electronic States of Chemically Modified CdS Nanoparticles.- V Physics and Chemistry of Liquid Droplets.- 21 Photoredox Chemistry of Single Microdroplets in Water.- 22 Raman Spectroscopy of a Single Microdroplet.- 23 Picoliter Droplets for Single-Particle and Single-Molecule Imaging.- 24 Auto-Oscillated Vibration of Single Oil Droplets.- VI Materials Application and Future Perspective.- 25 Photon-Force Controlled Molecular Assembling in Solution.- 26 Spectroscopic Analysis of Single Microparticles Under Solution-Flow Conditions.- 27 Stimulus-Responsive Polymer Nanoparticles.- 28 Photonic Band Properties of Ordered Nanoparticle Layers.- 29 Particle-Based Optical Devices.
Download or read book Nanotechnology in Functional Foods written by Shakeel Ahmed and published by John Wiley & Sons. This book was released on 2022-07-28 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: NANOTECHNOLOGY IN FUNCTIONAL FOODS The broad applicability of bioactive delivery systems for improving food quality, safety, and human health will make this book a valuable resource for a wide range of readers in industry, research, and academia. Functional foods is an emerging trend in the food industry, whose potential value is determined by whether they are safe with respect to consumer health. Nanotechnology in Functional Foods was written to help the reader better understand the benefits and concerns associated with these foods. In addition to giving an overview of the current state-of-the-art in functional foods, different aspects of the advanced research being conducted on their extraction, synthesis, analysis, and biological effects are presented. Besides focusing on several synthesis techniques, the book also discusses the application of nanoparticles in nutrient delivery and pharmaceuticals, such as nano-emulsions, solid lipid nanoparticles, and polymeric nanoparticles; their properties and interactions with other food components and their impact on the human body; the consumer acceptance and diversification of these nutrients. Moreover, new trends are discussed concerning the application of artificial intelligence in screening various components of functional foods. Audience The book will be central to food scientists, materials scientists, biotechnologists, medicinal chemists, pharmacists, and medical professionals. Tanima Bhattacharya, PhD, is a formulation scientist, who completed her Doctoral degree in Food Processing & Nutrition Science from the Indian Institute of Engineering Science and Technology, Shibpur, West Bengal, India and gained overseas post-doctoral experience from the College of Chemistry and Chemical Engineering Hubei University of China. She has published several scientific research articles in international peer-reviewed journals, and her research interests include the fabrication of biocompatible nanostructures and studying their properties and applications in the area of food science, technology, and biomedical sciences. Shakeel Ahmed, PhD, is an assistant professor of Chemistry at the Higher Education Department, Government of Jammu and Kashmir, India. His PhD degree in Chemistry is from Jamia Millia Islamia, A Central University, New Delhi. He has published several research publications in the area of green nanomaterials and biopolymers for various applications including biomedical, packaging, and water treatment. He has published more than 20 books in the area of nanomaterials and green materials.
Download or read book Single Chain Polymer Nanoparticles written by José A. Pomposo and published by John Wiley & Sons. This book was released on 2017-08-18 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first book on this important and emerging topic presents an overview of the very latest results obtained in single-chain polymer nanoparticles obtained by folding synthetic single polymer chains, painting a complete picture from synthesis via characterization to everyday applications. The initial chapters describe the synthetics methods as well as the molecular simulation of these nanoparticles, while subsequent chapters discuss the analytical techniques that are applied to characterize them, including size and structural characterization as well as scattering techniques. The final chapters are then devoted to the practical applications in nanomedicine, sensing, catalysis and several other uses, concluding with a look at the future for such nanoparticles. Essential reading for polymer and materials scientists, materials engineers, biochemists as well as environmental chemists.
Download or read book Nanoparticle Reinforced Polymers written by Ana María Díez-Pascual and published by MDPI. This book was released on 2019-07-23 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, a collection of 12 original contributions and 4 reviews, provides a selection of the most recent advances in the preparation, characterization, and applications of polymeric nanocomposites comprising nanoparticles. The concept of nanoparticle-reinforced polymers came about three decades ago, following the outstanding discovery of fullerenes and carbon nanotubes. One of the main ideas behind this approach is to improve the matrix mechanical performance. The nanoparticles exhibit higher specific surface area, surface energy, and density compared to microparticles and, hence, lower nanofiller concentrations are needed to attain properties comparable to, or even better than, those obtained by conventional microfiller loadings, which facilitates processing and minimizes the increase in composite weight. The addition of nanoparticles into different polymer matrices opens up an important research area in the field of composite materials. Moreover, many different types of inorganic nanoparticles, such as quantum dots, metal oxides, and ceramic and metallic nanoparticles, have been incorporated into polymers for their application in a wide range of fields, ranging from medicine to photovoltaics, packaging, and structural applications.
Download or read book Peptide and Protein Delivery written by Chris Van Der Walle and published by Academic Press. This book was released on 2011-05-12 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Download or read book Microspheres Medical and Biological Applications 1988 written by Alan Rembaum and published by CRC Press. This book was released on 2017-11-22 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have previously described the syntheses of both magnetic and nonmagnetic polymeric microspheres, and we have reported their application in removal of neuroblastoma cells from normal cells in bone marrow, in the separation of red blood cells, and the separation of human B and T lymphocytes. In the present study, we describe a series of hydrophilic microspheres consisting of (1) poly-HEMA and (2) a copolymer sequence of HEMA-acrolein microspheres.
Download or read book Rational Design on Controlled Release Ion exchange Polymeric Microspheres and Polymer lipid Hybrid Nanoparticles for the Delivery of Water soluble Drugs Through a Multidisciplinary Approach written by Yongqiang Li and published by . This book was released on 2008 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sulfopropyl dextran sulfate (SP-DS) microspheres and polymer-lipid hybrid nanoparticles (PLN) for the delivery of water-soluble anticancer drugs and P-glycoprotein inhibitors were developed by our group recently and demonstrated effectiveness in local chemotherapy. To optimize the delivery performance of these particulate systems, particularly PLN, an integrated multidisciplinary approach was developed, based on an in-depth understanding of drug-excipient interactions, internal structure, drug loading and release mechanisms, and application of advanced modeling/optimization techniques. An artificial neural networks (ANN) simulator capable of formulation optimization and drug release prediction was developed. In vitro drug release kinetics of SP-DS microspheres, with various drug loading and in different release media, were predicted by ANN. The effects of independent variables on drug release were evaluated. Good modeling performance suggested that ANN is a useful tool to predict drug release from ion-exchange microspheres. In summary, this thesis demonstrates that an integrated multidisciplinary strategy ranging from preformulation to formulation to optimization is suitable for the rational design of SP-DS microspheres and PLN with desired properties. Based upon the optimized drug-polymer-lipid interactions, PLN with high drug loading capacity (36%, w/w) and sustained release without initial burst release were achieved. VRP remained amorphous and was molecularly dispersed within PLN. H-bonding contributed to the miscibility between the VRP-DS complex and DA. Drug release from PLN was mainly controlled by diffusion and ion-exchange processes. Drug loading capacity and particle size of PLN depend on the formulation factors of the weight ratio of drug to lipid and concentrations of surfactants applied. A three-factor spherical composite experimental design was used to map the cause-and-effect relationship. PLN with high drug loading efficiency (92%) and small particle size (100 nm) were predicted by ANN and confirmed by experiment. The roles of various factors on the properties of PLN were also investigated. To further improve the performance of PLN, drug-polymer-lipid interactions were characterized theoretically and experimentally using verapamil hydrochloride (VRP) as a model drug and dextran sulfate sodium (DS) as a counter-ion polymer. VRP-DS complexation followed a stoichiometric rule and solid-state transformation of VRP were observed. Dodecanoic acid (DA) was identified as the lead lipid carrier material.
Download or read book Polymer and Polymer Hybrid Nanoparticles written by Stanislav Rangelov and published by CRC Press. This book was released on 2013-08-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric and hybrid nanoparticles have received increased scientific interest in terms of basic research as well as commercial applications, promising a variety of uses for nanostructures in fields including bionanotechnology and medicine. Condensing the relevant research into a comprehensive reference, Polymer and Polymer-Hybrid Nanoparticles: From Synthesis to Biomedical Applications covers an array of topics from synthetic procedures and macromolecular design to possible biomedical applications of nanoparticles and materials based on original and unique polymers. The book presents a well-rounded picture of objects ranging from simple polymeric micelles to complex hybrid polymer-based nanostructures, detailing synthetic procedures, techniques for characterization and analysis, properties, and behavior in selective solvents and dispersions. Each chapter contains background and introductory information, summarizing generalities on the nanosystems being discussed. The chapters also describe representative works of experts and provide in-depth, focused discussions. The authors present current knowledge on the following topics: Designed synthesis of functional polymers Construction of block copolymer micellar and nonmicellar self-assembled structures Construction of organic–organic hybrid nanosized particles Construction of organic–inorganic hybrid nanoparticles and nanoassemblies The final chapter addresses biological applications of polymeric nanoparticles, including delivery of low-molecular-weight drugs, macromolecular drugs, imaging and diagnostics, and photodynamic therapy. Summarizing important developments in the field, the authors condense relevant research into a comprehensive resource.
