Download or read book Pt Platinum written by Gary J.K. Acres and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like most supplement volumes of the platinum-group metal series,Platinum Suppl. Vol. A 1 has been written by an international team of specialists. It comprises technological data of all six platinum-group metals and their technically relevant alloys and compounds. The volume starts with a review on the recovery of the platinum-group metals (23 pages); the next 42 pages are devoted to processes for separating and refining the PGM in order to obtain metals of high purity. The electrodeposition of the PGM and their alloys is treated on 26 pages.The by far most extensive section deals with PGMand their alloys and compounds in catalysis. After a historicalsurvey and alist of important reviewson PGMcatalysis,the catalytic properties of the metals are treated in a general way, followed by unsupported metals and alloys including preparation of catalysts and their reactions in various industrial processes. The role of supported metals and alloys is described in asimilar manner. This isfollowed byan extensive description of the preparation and the reactions of PGM compounds with various nonmetals and their catalytically active role in a number of industrial processes (226 pages). The last chapter (21 pages) is a compilation of data on the medical use of cytostatic platinum compounds. Gelnhausen, December 1985 Kurt Swars IX Table of Contents Page Technology ofthe Platinum-Group Metals. ............................... 1 1 Review on the Recovery ofthe Platinum-Group Metals . 1.1 Historical Perspective , , , . Period of Discovery, 1750 to 1820 , , . First Industrial Period 1820 to 1900 , , , .
Download or read book Chemistry and Properties of Biomolecular Systems written by E. Rizzarelli and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiple Bonds between Metal Atoms written by F. Albert Cotton and published by Springer Science & Business Media. This book was released on 2006-07-31 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides historical perspective as well as current data Abundantly illustrated with figures redrawn from literature data Covers all pertinent theory and physical chemistry Catalytic and chemotherapeutic applications are included
Download or read book Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy written by Marino Nicolini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 813 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Fifth International Symposium, held in Abano Terme (Padova), italy, June 29-July 2, 1987
Download or read book Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy written by Stephen B. Howell and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Download or read book Inorganic Electrochemistry written by Piero Zanello and published by Royal Society of Chemistry. This book was released on 2003 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book bridges the gap between undergraduate and research-level electrochemistry books, as an introduction to electrochemical applications within inorganic chemistry.
Download or read book Platinum Blues written by William Deverell and published by ECW Press. This book was released on 2003-10-03 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this “fast-paced, wickedly funny” legal thriller, a small-town lawyer’s case against a Los Angeles record label turns into a deadly media circus (Publishers Weekly). Living in the Northern California town of Foolsgold, widowed lawyer Oliver Gulliver is headed for a midlife crisis. It doesn’t help that his eighteen-year-old daughter Elora has fallen in love with alcoholic former rock star C.C. Gilley. But then C.C. quits drinking and gets to work on a comeback album. Things actually seem to be looking up—until C.C.’s car is stolen, with his priceless demo tape inside. In no time at all, another band is all over the radio with C.C.’s song, and Oliver finds himself in Los Angeles working the biggest case of his life—suing a billion-dollar record company for plagiarism. But even as Oliver discovers his talent for charming the public, he finds out how nasty the music industry can get. When the stakes skyrocket from plagiarism to murder, Oliver will have to try C.C.’s case like his life depends on it—because it does. “Reeling off witty turns of phrase and uncanny plot twists, Deverell offers wonderfully sardonic takes on the worlds of music, law, Hollywood, Southern California and fatherhood--just for starters.” —Publishers Weekly
Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1975 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electron Spin Resonance written by M. C. R. Symons and published by Royal Society of Chemistry. This book was released on 1987 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Download or read book Cisplatin written by Bernhard Lippert and published by John Wiley & Sons. This book was released on 1999 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.
Download or read book Metal Containing Polymeric Systems written by John E. Sheats and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on metal-containing polymers began in the early 1960's when several workers found that vinyl ferrocene and other vinylic transition metal u -com plexes would undergo polymerization under the same conditions as conventional organic monomers to form high polymers which incorporated a potentially reactive metal as an integral part of the polymer structures. Some of these materials could act as semi-conducters and pos sessed one or two dimensional conductivity. Thus appli cations in electronics could be visualized immediately. Other workers found that reactions used to make simple metal chelates could be used to prepare polymers if the ligands were designed properly. As interest in homo geneous catalysts developed in the late 60's and early 70's, several investigators began binding homogeneous catalysts onto polymers, where the advantage of homo geneous catalysis - known reaction mechanisms and the advantage of heterogeneous catalysis - simplicity and ease of recovery of catalysts could both be obtained. Indeed the polymer matrix itself often enhanced the selectivity of the catalyst.
Download or read book Inorganic Biochemistry written by H A O Hill and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.
Download or read book Soviet Journal of Coordination Chemistry written by and published by . This book was released on 1993 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transition Metal Complexes as Drugs and Chemotherapeutic Agents written by N. Farrell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate. This timeliness has not diminished during the gestation and final publica tion of the manuscript. The introduction contains an explanation of the layout and approach to the book, which I wrote as an overall survey of the wide variety of biological properties of metal complexes. Hopefully, the reader will see the parallels in mechanisms and behavior, even in different organisms. The writing was considerably helped by the enthusiasm and confidence (totally unearned on my part) in the project of Professor Brian James and lowe him my special thanks. I also owe a great debt of gratitude to my colleagues, and especially to Eucler Paniago, of the Universidade Federal de Minas Gerais, for their comprehension and for the initial leave of absence which allowed me to begin the project. To those who read some or all of the manuscript and made suggestions, Bernhard Lippert, Kirsten Skov, and Tom Tritton, as well as the editor's reviewer I am also grateful. As usual, the final responsibility for errors or otherwise rests with the author.
Download or read book Advances in Inorganic Chemistry written by and published by Elsevier. This book was released on 1999-11-11 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state. This acclaimed serial features reviews written by experts in the area and is an indispensable reference for advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.
Download or read book Bioactive Polymeric Systems written by Charles G. Gebelein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast array of libraries in the world bear mute witness to the truth of the 3000-year-old observation of King Solomon who stated " ... of making many books there is no end, and much study is a weariness of the flesh." Yet books are an essential written record of our lives and the progress of science and humanity. Here is another book to add to this huge collection, but, hopefully, not just another collection of pages, but rather a book with a specific purpose to aid in alleviating the "weariness of the flesh" that could arise from much studying of other journals and books in order to obtain the basic information contained herein. This book is about polymeric materials and biological activity, as the title notes. Polymeric materials, in the broad view taken here, would include not only synthetic polymers (e.g., polyethylene, polyvinyl chloride, polyesters, polyamides, etc.), but also the natural macromolecules (e.g., proteins, nucleic acids, polysaccharides) which compose natural tissues in humans, animals and plants. In the broad sense used here, biological activity is any type of such action whether it be in medication, pest control, plant-growth regu lation, and so on. In short, this book attempts to consider, briefly, the use of any type of polymeric material system with essentially any kind of biological activity.
