Download or read book Plant and Marine Derived Natural Product Research in Drug Discovery written by Noelia Duarte and published by Mdpi AG. This book was released on 2023-02-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: For centuries, nature has been an inspirational source for the discovery of drugs used in modern medicine. Nowadays, natural-based treatments continue to be employed for primary health care, particularly playing a significant role in folk medicine. In addition, we are currently observing an increasing use of natural-products-based supplements from botanical and marine sources, making their standardization and scientific validation a priority to guarantee the safety of these products. Natural products and/or synthetic derivatives using their novel structures have also been of utmost importance in drug discovery and development in several clinical areas. After a period of discreditation and reduced investment, we are now witnessing a renewed interest from the pharmaceutical industry and scientific community due to the urgent need to develop new drugs. This reprint comprises 11 original and 6 review articles dedicated to plant and marine natural products research, contributing to the scientific validation of their use and opening new perspectives in drug discovery

Download or read book Plant derived Natural Products written by Anne E. Osbourn and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Download or read book Bioactive Natural Products written by Goutam Brahmachari and published by World Scientific. This book was released on 2012 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Download or read book Marine Natural Products written by Hiromasa Kiyota and published by Springer. This book was released on 2010-11-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Natural Products written by Lixin Zhang and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Download or read book Studies in Natural Products Chemistry written by Ajai Prakash Gupta and published by Elsevier Inc. Chapters. This book was released on 2013-06-25 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a dreadful human disease, increasing with changing lifestyle, nutrition, and global warming. Its treatments do not have potent medicine as the currently available drugs results in severe side effects. Past activities in this area focused on the natural products derived from medicinal plants. According to the WHO, 80% of the world’s population primarily those from developing countries rely on plant-derived medicines for the health care. Over the past few decades, significant efforts have been made, jointly by pharmaceutical and academic institutions, to isolate and identify new marine-derived natural products. With the advancement of technology and methodology in this area, numerous new compounds have been isolated and several novel anticancer compounds are under clinical investigations. The ocean biomass, covering two-third of the earth, with huge unexplored natural product offers enormous scope and presents an effective alternative in natural product drug discovery. The uniqueness in oceanic mega-diversity is due to spatial as well as temporal competition along with unique habitat with extreme pressure, temperature, and saline conditions. As a result of this, marine organisms have adapted and evolved themselves successfully since centuries in these conditions by producing molecules which are unique in structures, biosynthesis, and function. This “chemical adaptations” is an excellent source of novel chemical entities which is absent in land-based organisms. The past decade has seen more than 10,000 compounds isolated from marine sources which have dramatically increased the number of preclinical anticancers drug under evaluation, and over 300 patents on bioactive natural products from marine sources were granted during this tenure. Efforts, in this direction, became more serious and focused with National Cancer Institute, USA taking a lead role. By collaborative interactions between pharmaceutical companies and research organization, numerous drug-like molecules with several of them having clinical and preclinical potential were discovered. Ecteinascidin-743/ET-743 from Caribbean tunicate and Didemnin and Aplidine from Aplidium albicans are some of the successful examples. Sterols and dietary fibers from seaweeds also hold immense potential. However, investigation of the marine floras chemical entities as drug-like molecule is still in its embryonic stage. The present chapter showcases the past research and reviews the baseline data for promoting further research in this field.

Download or read book Marine Biotechnology in the Twenty First Century written by National Research Council and published by National Academies Press. This book was released on 2002-05-29 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dramatic developments in understanding the fundamental underpinnings of life have provided exciting opportunities to make marine bioproducts an important part of the U.S. economy. Several marine based pharmaceuticals are under active commercial development, ecosystem health is high on the public's list of concerns, and aquaculture is providing an ever greater proportion of the seafood on our tables. Nevertheless, marine biotechnology has not yet caught the public's, or investor's, attention. Two workshops, held in October 1999 and November 2001 at the National Academies, were successful in highlighting new developments and opportunities in environmental and biomedical applications of marine biotechnology, and also in identifying factors that are impeding commercial exploitation of these products. This report includes a synthesis of the 2001 sessions addressing drug discovery and development, applications of genomics and proteomics to marine biotechnology, biomaterials and bioengineering, and public policy and essays contributed by the workshop speakers.

Download or read book Handbook on Drugs from Natural Sources written by H. Panda and published by ASIA PACIFIC BUSINESS PRESS Inc.. This book was released on 2010-10-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products have played an important role throughout the world in treating and preventing human diseases. Natural product medicines have come from various materials including terrestrial plants, terrestrial microorganisms, organisms etc. Historical experiences with plants as therapeutic tools have helped to introduce single chemical entries in modern medicine. About 40% of the drugs used are derived from natural sources. Most are pure substances which are isolated from various organisms & used directly or after chemical modification. Natural products will continue to be important in three areas of drug discovery: as targets for production by biotechnology as a source of new lead compounds of novel chemical structure and as the active ingredients of useful treatments derived from traditional systems. Biotechnology will contribute more new natural products for medicinal use. Plants provide a fertile source of natural products many of which are clinically important medicinal agents. Natural products have traditionally provided most of the drugs in use. Despite the achievements of synthetic chemistry and the advances towards rational drug design, natural products continue to be essential in providing medicinal compounds and as starting points for the development of synthetic analogues. With the increasing power of screening programs and the increasing interest in the reservoir of untested natural products, many future drug developments will be based, at least in part, on natural products. The major contents of the book are plant products produced in cell culture , application of genetic engineering to the production of pharmaceuticals , anti transpirants and plant growth regulators based , the potential and the problems of marine natural products, marine sterols, plants as a source of anti-inflammatory substances, anti hepatotoxic principles in oriental medicinal plants, immune stimulants of fungi and higher plants, amanita muscaria in medicinal chemistry, ergot alkaloids and their derivatives in medicinal chemistry and therapy, development of drugs from cannabinoids, etc. This book contains development of new drugs from plants, work on some Thai medicinal plants, plant growth based on Jasmonates, marine sterols, bleomycin and its derivatives, drugs from cannabinoids, bioactive compounds from nature, fungi and higher plants, biological active compounds from British Marine, microbial phytotoxins as herbicides and many more. This book will be very helpful to its readers, upcoming entrepreneurs, scientists, existing industries, technical institutions, druggist etc. TAGS Drugs from Natural Sources, Plants as Source of Drugs, Plant Based Drugs and Medicines, Drugs from Natural Products, Drugs from Plants, Natural Products, Natural Products in Drugs, Sources of Drugs, Drug from Medicinal Plants, Bioactive Compounds from Natural Sources, Biologically Active Compounds from British Marine Algae, Drugs from Natural Bio Sources, Natural Products as Sources of Drugs, Medicinal Natural Products, Plant Based Natural Products, Drugs of Natural Origin, Drugs from Cannabinoids, Plant Products Produced in Cell Culture, Herbicidal Compounds, Microbes and Microbial Phytotoxins as Herbicides, Chinese Traditional Medicine, Thai Medicinal Plants, Ompounds Derived from Hormones, Indigenous Medicinal Plants, Plants as Source of Anti-Inflammatory Substances, Bleomycin and its Derivatives, Antineoplastic Structure-Activity, Oriental Medicinal Plants, Immunostimulants of Fungi and Higher Plants, Acacia, Abrus Precatorius Linn, Babul, Acacia Catechu Willd, Chyranthes Aspera Linn, Adhatoda Vasica Nees, Allium Sativum Linn, Aloe Barbadensis Mill, Argemone Mexicana Linn, Neem, Asparagus Racemosus Willd, Azadirachta Indica, Boerhaavia Chinensis Aschers & Schweinf, Boswellia Serrata Roxb, Butea Frondosa, Butea Monosperma Taub, Cassia Fistula Linn, Cassia Tora Linn, Carica Papaya Linn, Evolvulus Alsinoides, Clitoria Ternatea Linn, Clerodendron Phlomidis Linn, Cuscuta Reflexa Roxbi, Glycyrrhiza Glabra, Gmelina Arborea Roxb, Morinda Tinctoria Roxb, Melia Azedarach Linn, Pterocarpus Santalinus, Raphanus Sativces, Viola Odorata, Ashawgandha, Withania Somnifera, Muli, Lal Chandan, Raktachandan, Bakain, Bakaanaanimb, Aakaashvalli, Shankhahuli, Talmuli, Chibud, Sweet Melon, Aparajit, Arni, Quall Grass, Sufaid Murgha, Lasun, Ghungehi, Khair, Adulsa, Arusha, NPCS, Niir, Process Technology Books, Business Consultancy, Business Consultant, Startup, Business Guidance, Business Guidance to Clients, Startup Ideas, Startup Project Plan, Business Start-Up, Business Plan for Startup Business, Great Opportunity for Startup, Small Start-Up Business Project, Best Small and Cottage Scale Industries, Startup India, Stand Up India, Small Scale Industries, New Small Scale Ideas for Thai Medicinal Plants, Natural Products in Drugs Business Ideas You Can Start on Your Own, Guide to Starting and Operating Small Business, Business Ideas for Drugs From Natural Sources, How to Start Drugs from Natural Sources Business, Start Your Own Drug from Medicinal Plants Business, Natural Drugs Business Plan, Business Plan for Natural Drugs, Small Scale Industries in India, Drugs from Cannabinoids Based Small Business Ideas in India, Small Scale Industry You Can Start on Your Own, Business Plan for Small Scale Industries, Profitable Small Scale Manufacturing, How to Start Small Business in India, Free Manufacturing Business Plans, Small and Medium Scale Manufacturing, Profitable Small Business Industries Ideas, Business Ideas for Startup

Download or read book Natural Product Chemistry for Drug Discovery written by Antony D. Buss and published by Royal Society of Chemistry. This book was released on 2010 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.

Download or read book Natural Compounds as Drugs Volume II written by Frank Petersen and published by Springer Science & Business Media. This book was released on 2008-07-29 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.

Download or read book Natural Products and Cancer Drug Discovery written by Frank E. Koehn and published by Springer Science & Business Media. This book was released on 2012-11-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Download or read book Drug Discovery and Development written by Ramarao Poduri and published by Springer Nature. This book was released on 2021-02-15 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the processes that are involved in the development of new drugs. The authors discuss the history, role of natural products and concept of receptor interactions with regard to the initial stages of drug discovery. In a single, highly readable volume, it outlines the basics of pharmacological screening, drug target identification, and genetics involved in early drug discovery. The final chapters introduce readers to stem therapeutics, pharmacokinetics, pharmacovigilance, and toxicological testing. Given its scope, the book will enable research scholars, professionals and young scientists to understand the key fundamentals of drug discovery, including stereochemistry, pharmacokinetics, clinical trials, statistics and toxicology.

Download or read book WHO Global Report on Traditional and Complementary Medicine 2019 written by World Health Organization and published by World Health Organization. This book was released on 2019-05-16 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report is structured in five parts: national framework for traditional and complementary medicine (T&CM); product regulation; practices and practitioners; the challenges faced by countries; and finally the country profiles. Apart from the section on practices and practitioners the report is consistent with the format of the report of the first global survey in order to provide a useful comparison. The section on practices and practitioners which covers providers education and health insurance is a new section incorporated to reflect the emerging trends in T&CM and to gather new information regarding these topics at a national level. All new information received has been incorporated into individual country profiles and data graphs. The report captures the three phases of progress made by Member States; that is before and after the first WHO Traditional Medicine Strategy (1999?2005) from the first global survey to the second global survey (2005?2012) and from the second survey to the most recent timeline (2012?2018).

Download or read book The Role of Natural Products in Drug Discovery written by J. Mulzer and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Download or read book Bioactive Natural products in Drug Discovery written by Joginder Singh and published by Springer Nature. This book was released on 2020-04-30 with total page 733 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Download or read book Handbook of Marine Natural Products written by Ernesto Fattorusso and published by Springer. This book was released on 2012-04-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Handbook of Marine Natural Products" takes a fresh approach to describing the major themes of research in this rapidly developing field. This two volume reference work begins with a section that provides a taxonomic survey of the secondary metabolites of diverse marine life including microbes, algae, and invertebrates. This is followed by a demonstration of the techniques and strategies employed in modern structure elucidation of complex natural products. The natural roles of marine natural products are then explored in a series of focused chapters which include the topics of symbiosis, anti-predation and antifouling, chemical interactions, and defence against UV stress. Various routes which facilitate the understanding of marine natural product biosynthesis are subsequently explained and these are followed by an extensive set of chapters on the biomedical potential of marine natural products. The latter portion of this section considers the technologies and scientific disciplines necessary for advancing bioactive marine natural product lead compounds into actual pharmaceuticals. The reference work finishes with a selection of chapters describing marine toxins and their impact on public health and seafood resources. Final thoughts presented at the end of the second volume focus on the future of this field of investigation and discovery research. This publication is presented as a reference handbook and general concepts are emphasized and illustrated with numerous interesting examples, graphical information, and a comprehensive index. "Handbook of Marine Natural Products" introduces students who are at advanced undergraduate and entry graduate student levels to this fascinating multidisciplinary field. It is an ideal desk companion for courses focusing on this contemporary area.

Download or read book Lead Molecules from Natural Products written by and published by Elsevier. This book was released on 2006-07-07 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lead Molecules from Natural Products: Discovery and New Trends provides the reader with a thorough overview of current discoveries and trends in Natural Products research. This book consists of 22 chapters from well known scientists all over the world, with topics ranging from Natural Product Chemistry and Phytochemistry in their most basic form, to Molecular Biology and in silico drug design. Contributors describe their own laboratory experiences, revealing their findings, the legal issues encountered.The chapters, all of equally high quality, summarize years of extensive research in each area, and provide insight in the new themes of natural product research. The information will help to predict promising leads, useful for physicians in the treatment of different diseases and disease manifestations.* Explains the effects of plant extracts on gene expression profiling. * Details medicinal plant research from around the world* Explores a variety of medicinal uses of plants from traditional remedies, to anti-cancer agents and anti-salmonella agents.