Download or read book Ehlers Danlos Syndrome A Multidisciplinary Approach written by J.W.G. Jacobs and published by IOS Press. This book was released on 2018-08-14 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generalized hypermobility has been known since ancient times, and a clinical description of Ehlers-Danlos syndrome (EDS) is said to have first been recorded by Hippocrates in 400 BC. Hypermobility syndromes occur frequently, but the wide spectrum of possible symptoms, coupled with a relative lack of awareness and recognition, are the reason that they are frequently not recognized, or remain undiagnosed. This book is an international, multidisciplinary guide to hypermobility syndromes, and EDS in particular. It aims to create better awareness of hypermobility syndromes among health professionals, including medical specialists, and to be a guide to the management of such syndromes for patients and practitioners. It is intended for use in daily clinical practice rather than as a reference book for research or the latest developments, and has been written to be understandable for any healthcare worker or educated patient without compromise to the scientific content. The book is organized as follows: chapters on classifications and genetics are followed by chapters on individual types, organ (system) manifestations and complications, and finally ethics and therapeutic strategies, with an appendix on surgery and the precautions which should attend it. A special effort has been made to take account of the perspective of the patient; two of the editors have EDS. The book will be of interest to patients with hypermobility syndromes and their families, as well as to all those healthcare practitioners who may encounter such syndromes in the course of their work.
Download or read book Cystogenesis written by Jong Hoon Park and published by Springer. This book was released on 2016-10-12 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.
Download or read book Every Tool s a Hammer written by Adam Savage and published by Atria Books. This book was released on 2020-10-27 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this New York Times bestselling “imperative how-to for creativity” (Nick Offerman), Adam Savage—star of Discovery Channel’s Mythbusters—shares his golden rules of creativity, from finding inspiration to following through and successfully making your idea a reality. Every Tool’s a Hammer is a chronicle of my life as a maker. It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and breaking, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the friction in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.
Download or read book Relationships Among the Brain the Digestive System and Eating Behavior written by Institute of Medicine and published by National Academies Press. This book was released on 2015-02-27 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: On July 9-10, 2014, the Institute of Medicine's Food Forum hosted a public workshop to explore emerging and rapidly developing research on relationships among the brain, the digestive system, and eating behavior. Drawing on expertise from the fields of nutrition and food science, animal and human physiology and behavior, and psychology and psychiatry as well as related fields, the purpose of the workshop was to (1) review current knowledge on the relationship between the brain and eating behavior, explore the interaction between the brain and the digestive system, and consider what is known about the brain's role in eating patterns and consumer choice; (2) evaluate current methods used to determine the impact of food on brain activity and eating behavior; and (3) identify gaps in knowledge and articulate a theoretical framework for future research. Relationships among the Brain, the Digestive System, and Eating Behavior summarizes the presentations and discussion of the workshop.
Download or read book Pediatric Nephrology written by Ellis D. Avner and published by Springer Science & Business Media. This book was released on 2009-08-20 with total page 2059 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here is an extensive update of Pediatric Nephrology, which has become the standard reference text in the field. It is global in perspective and reflects the international group of editors, who are well-recognized experts in pediatric nephrology. Within this text, the development of kidney structure and function is followed by detailed and comprehensive chapters on all childhood kidney diseases.
Download or read book Handbook of Clinical Obstetrics written by E. Albert Reece, MD, PhD, MBA and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this quick reference handbook for obstetricians and gynecologists and primary care physicians is designed to complement the parent textbook Clinical Obstetrics: The Fetus & Mother The third edition of Clinical Obstetrics: The Fetus & Mother is unique in that it gives in-depth attention to the two patients – fetus and mother, with special coverage of each patient. Clinical Obstetrics thoroughly reviews the biology, pathology, and clinical management of disorders affecting both the fetus and the mother. Clinical Obstetrics: The Fetus & Mother - Handbook provides the practising physician with succinct, clinically focused information in an easily retrievable format that facilitates diagnosis, evaluation, and treatment. When you need fast answers to specific questions, you can turn with confidence to this streamlined, updated reference.
Download or read book Living with a Wild God written by Barbara Ehrenreich and published by Twelve. This book was released on 2014-04-08 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the New York Times bestselling author of Nickel and Dimed comes a brave, frank, and exquisitely written memoir that will change the way you see the world. Barbara Ehrenreich is one of the most important thinkers of our time. Educated as a scientist, she is an author, journalist, activist, and advocate for social justice. In Living With a Wild God, she recounts her quest-beginning in childhood-to find ""the Truth"" about the universe and everything else: What's really going on? Why are we here? In middle age, she rediscovered the journal she had kept during her tumultuous adolescence, which records an event so strange, so cataclysmic, that she had never, in all the intervening years, written or spoken about it to anyone. It was the kind of event that people call a ""mystical experience""-and, to a steadfast atheist and rationalist, nothing less than shattering. In Living With a Wild God, Ehrenreich reconstructs her childhood mission, bringing an older woman's wry and erudite perspective to a young girl's impassioned obsession with the questions that, at one point or another, torment us all. The result is both deeply personal and cosmically sweeping-a searing memoir and a profound reflection on science, religion, and the human condition. With her signature combination of intellectual rigor and uninhibited imagination, Ehrenreich offers a true literary achievement-a work that has the power not only to entertain but amaze.
Download or read book Elements of Fiction Writing Scene Structure written by Jack Bickham and published by Penguin. This book was released on 1999-03-15 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Craft your fiction with scene-by-scene flow, logic and readability. An imprisoned man receives an unexpected caller, after which "everything changed..." And the reader is hooked. But whether or not readers will stay on for the entire wild ride will depend on how well the writer structures the story, scene by scene. This book is your game plan for success. Using dozens of examples from his own work - including Dropshot,Tiebreaker and other popular novels - Jack M. Bickham will guide you in building a sturdy framework for your novel, whatever its form or length. You'll learn how to: • "worry" your readers into following your story to the end • prolong your main character's struggle while moving the story ahead • juggle cause and effect to serve your story action As you work on crafting compelling scenes that move the reader, moment by moment, toward the story's resolution, you'll see why... • believable fiction must make more sense than real life • every scene should end in disaster • some scenes should be condensed, and others built big Whatever your story, this book can help you arrive at a happy ending in the company of satisfied readers.
Download or read book The Android s Dream written by John Scalzi and published by Tor Books. This book was released on 2007-04-01 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: From New York Times bestseller and Hugo Award-winner John Scalzi, a wild-and-woolly caper novel of interstellar diplomacy A human diplomat creates an interstellar incident when he kills an alien diplomat in a most . . . unusual . . . way. To avoid war, Earth's government must find an equally unusual object: a type of sheep ("The Android's Dream"), used in the alien race's coronation ceremony. To find the sheep, the government turns to Harry Creek, ex-cop, war hero and hacker extraordinare, who, with the help of a childhood friend turned artificial intelligence, scours the earth looking for the rare creature. But there are others with plans for the sheep as well. Mercenaries employed by the military. Adherents of a secret religion based on the writings of a 21st century SF author. And alien races, eager to start a revolution on their home world and a war on Earth. To keep our planet from being enslaved, Harry will have to pull off a grand diplomatic coup, a gambit that will take him from the halls of power to the lava-strewn battlefields of alien worlds. There's only one chance to get it right, to save the life of the sheep—and to protect the future of humanity. Other Tor Books The Android’s Dream Agent to the Stars Your Hate Mail Will Be Graded Fuzzy Nation Redshirts 1. Lock In 2. Head On The Interdepency Sequence 1. The Collapsing Empire 2. The Consuming Fire Old Man's War Series 1. Old Man’s War 2. The Ghost Brigades 3. The Last Colony 4. Zoe’s Tale 5. The Human Division 6. The End of All Things At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Download or read book Primer on Transplantation written by American Society of Transplantation and published by John Wiley & Sons. This book was released on 2011-03-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: immunobiology pharmacology donor management infectious complications pediatric transplantation general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: Interactive Multiple-Choice Questions for each chapter Figures from the book as Powerpoints for downloading All chapters online
Download or read book The First Five Pages written by Noah Lukeman and published by Oxford University Press, USA. This book was released on 2010-02-11 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Language, literature and biography.
Download or read book Blueprints Obstetrics and Gynecology written by Tamara Callahan and published by LWW. This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Wolters Kluwers is dedicated to providing quality content. This is a reprint of the Seventh Edition, corrected to address typographical errors identified by reviewers. Clinical high-yield content covers what you need to know for the USMLE, shelf exam, and your Obstetrics & Gynecology rotation This best-selling Blueprints title is an ideal resource for the obstetrics and gynecology rotation and board preparation. This is the perfect companion for quick study breaks during rotation downtime, with concise chapters that appeal to students who want a review of key concepts, research, and therapies in today's practice. Blueprints are also utilized by students in physician assistant, nurse practitioner, and osteopathic programs, as well as residents preparing for USMLE Step 3. Features include: Expanded coverage of topics, evidence-based research, therapies, and the latest changes in the management of cervical dysplasia and cervical cancer screening, abnormal uterine bleeding, hypertension in pregnancy, cervical insufficiency, prenatal diagnosis, and preterm labor. Updates on the latest techniques in contraception, sterilization, and hormone replacement, as well as current treatment options for uterine fibroids and ovarian cysts. Updated tables and figures that improve student's assimilation and retention of information. Case-based clinical vignette questions at the end of each chapter help you review the material and prepare for exams. New and updated board-style questions, with full explanations of both correct and incorrect options, increase understanding.
Download or read book More Than a Body written by Lexie Kite and published by Houghton Mifflin. This book was released on 2020-12-29 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drs. Lindsay and Lexie Kite know firsthand how hard filtering out media influence is when it comes to self-image. Both struggled as young women to overcome the expectations of body size and shape, but were able to learn to love, appreciate, and reclaim their own bodies, eventually earning their PhDs in body image resilience. The twin sisters founded the nonprofit Beauty Redefined and have made it their mission to help other women see themselves without societal expectations distorting their self-perception. More than a Body is a self-help book focused on going beyond body positivity, showing how a mindset focused on appearance sets women up for insecurities and self-judgement. In this book, they offer an action plan for readers to combat that mindset, and instead learn how the body can be "an instrument, not an ornament," with practical, actionable steps to take when consuming media, exercising, practicing self-reflection and self-compassion, and finding a purpose in life.
Download or read book Pediatric Hepatology and Liver Transplantation written by Lorenzo D'Antiga and published by Springer. This book was released on 2019-04-29 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.
Download or read book Stardust Dads written by Josephine C. George and published by iUniverse. This book was released on 2008-10-17 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: The e-mail Danny and Allison read on their new computer in 1996 looks no different from the millions of others received by Web users around the world, with one glaring exception--it was sent by their dads who died during the 1970s. While residing in the afterworld at an amenity-laden paradise called Midway Manor, guitar-strumming Mickey Parks and piano-playing Lloyd Wallace monitor and manipulate the lives of their adult children on earth from the mid-'70s through the 1990s. Tampering with the facility's sophisticated computer, the dads thrust Mickey's daughter Allison and Lloyd's son Danny into a passionate but sometimes stormy relationship-a relationship steeped in Danny's heavy drinking and entangled in the often-zany world of men's adventure magazine publishing. After carefully implementing a plan to send their son and daughter a gift of knowledge that could enrich their lives forever, the dads' brief contact is cut short. They are banished to another destination in the afterworld, but not before they impart indisputable proof of life after death--and unwittingly put Danny's and Allison's earthbound lives on the line.
Download or read book Pediatric Neurology written by Tena Rosser and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Neurology for the Oral Boards: A Case-Based Review is the first pediatric neurology review book written specifically for neurology residents preparing for the oral boards. The book presents sixty cases with discussions structured according to the neurology oral boards format: localization of neurologic findings; differential diagnosis and most likely diagnosis; diagnostic workup; and patient management. The cases will help readers lay a foundation of knowledge in pediatric neurology and develop an organized approach to clinical decision-making. An introduction explains in detail what to expect on the examination and gives helpful hints on preparing for and taking the exam.
