Download or read book Photoproduction of Vitamin D3 and Activation into 1a 25 Dihydroxyvitamin D3 in Human Epiderman Keratinocytes Dermal Fibroblasts and Other Cells written by Katleen Vantieghem and published by Leuven University Press. This book was released on 2006 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Effects of 1 25 Dihydroxyvitamin D3 and Analogues on UVB irradiated Human Keratinocytes written by Petra De Haes and published by Leuven University Press. This book was released on 2004 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a Ph.D. dissertation. The skin serves as a protective interface between the body and the noxious environment. Ultraviolet (UV) radiation is one of the most important sources of environmental stress, inducing photochemical changes in the skin that may lead to sunburn, premature skin aging and skin cancer. The skin and UV also play a leading part in the vitamin D endocrine system. When UVB photons strike the epidermis, their energy can be used for the synthesis of vitamin D3. Furthermore, the skin is one of the direct target issues for vitamin D3 action. The close interplay between UV and vitamin D3 production in the skin evokes the possibility of mutual interactions. Contents: Introduction, Aims and Scopes of the Study, Materials and Methods, 1,25D3 Inhibits UVB-Induced Apoptosis and IL-6 Production in Human Keratinocytes, 1,25D3 Protects Human Keratinocytes Against UVB-Induced Damage, Two 14-EPI Analogues of 1,25D3 Protect Human Keratinocytes Against Different UVB Effects, Molecular Pathways Involved in the Anti-Apoptotic Effect of 1,25D3 in Human Keratinocytes, General Discussion and Perspectives.
Download or read book Cardiac Contractility Ca2 Handling in Mouse Models of Type II Diabetes written by An Van Den Bergh and published by Leuven University Press. This book was released on 2006-12 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Expression and Function of a Serotoninergic System in the Rat Anterior Pituitary written by Anna-Pia Papageorgiou and published by Leuven University Press. This book was released on 2006-12 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Axon Growth Injury and Regeneration in the Fly Brain written by Maarten Leyssen and published by Leuven University Press. This book was released on 2006 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nitric Oxide and Cytochrome P450 Signaling in Experimental Pulmonary Hypertension written by Peter Pokreisz and published by Leuven University Press. This book was released on 2006 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book In Vitro and in Vivo Analysis of the Role of PEX 19 P Farnesylation and PEX 14P Phosphorylation in Peroxisome Biogenesis written by Ilse Vastiau and published by Leuven University Press. This book was released on 2006-12 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Sunlight Vitamin D and Skin Cancer written by Jörg Reichrath and published by Springer Nature. This book was released on 2020-09-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third edition is a comprehensive and updated overview of positive and negative effects of UV-exposure, with a focus on Vitamin D and skin cancer. Researchers, oncologists,and students will be provided with the most significant and timely information related to topics such as the epidemiology of skin cancer, the immune system and skin cancer, ultraviolet damage, DNA repair and Vitamin D in Nonmelanoma skin cancer and malignant melanoma. There have been a number of new, scientific findings in this fast moving field that necessitated a thoroughly updated and revised edition including new Vitamin D metabolites and skin cancer, new findings on the beneficial effects of UV and solar UV and skin cancer, adverse effects of sun protection and sunscreens, sun exposure and mortality, and more. The book will summarize essential, up-to-date information for every clinician or scientist interested in how to balance the positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.
Download or read book The Roles of Vitamin D in Cutaneous Wound Healing written by Jing Q. Tay and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1981 with total page 960 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vitamin D written by Michael F. Holick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nutrition and Health series of books has as an overriding mission to provide health professionals with texts that are considered essential because each includes: a synthesis of the state of the science; timely, in-depth reviews by the leading researchers in their respective fields; extensive, up-to-date fully annotated reference lists; a detailed index; relevant tables and figures; identification of paradigm shifts and the consequences; of information between chapters, but targeted, inter-chapter refer virtually no overlap rals, suggestions of areas for future research; and balanced, data-driven answers to patient questions that are based on the totality of evidence rather than the findings of any single study. The series volumes are not the outcome of a symposium. Rather, each editor has the potential to examine a chosen area with a broad perspective, both in subject matter as well as in the choice of chapter authors. The international perspective, especially with regard to public health initiatives, is emphasized where appropriate. The editors, whose training is both research and practice oriented, have the opportunity to develop a primary objective for their book, define the scope and focus, and then invite the leading authori ties from around the world to be part of their initiative. The authors are encouraged to provide an overview of the field, discuss their own research, and relate the research de findings to potential human health consequences.
Download or read book On the Role of Vitamin D Receptor Alternative Splicing in Human Keratinocytes written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that Vitamin D essential for proper regeneration of epidermal barrier and immunomodulation. The active form of vitamin D, calcitriol (1,25(OH)2D3) thought the binding to vitamin D nuclear receptor (VDR), modulates expression of hundreds of genes. In an additions activity of VDR could be regulated on various levels. Here we presenting our preliminary results concerning effects of VDR expression, alternative splicing, expression of coactivator RXR on the activity of 1,25(OH)2D3 in human keratinocytes (HaCaT, A431 and primary cells). At least three splicing variants of VDR receptor mRNA were expressed in human keratinocyte cells, and its expression was modulated by 1,25(OH)2D3. Interestingly, keratinocytes cell lines used in the study differ in the patter of expressed VDR isoforms, which could at least partially explain observed various response to 1,25(OH)D3. Next it was shown, that overexpression of VDR splicing variants (VDR1 or VDR3) in keratinocytes had a modulatory effect on VDR signalling including delayed translocation of VDR to the nucleus and partial selectivity in target genes. The translocation of VDR1 and VDR3 was observed live by using fusion constructs of VDR isoform with green fluorescent protein (GFP). On the other hand, attenuation of VDR expression by RNAi resulted in downregulation of classic VDR targets in keratinocytes, however some phenotypic changes including induction of differentiation by 1,25(OH)2D3 were not full diminished what suggested involvement of alternative pathways. Thus, we are planning to investigate non geneomic pathways activated by vitamin D.Summarising, our preliminary results suggest that alternative splicing of VDR may modulate response of keratinocytes to 1,25(OH)2D3 and could be essential regulatory factor in maintenance of epidermal barrier and skin physiology.
Download or read book Principles and Practice of Endocrinology and Metabolism written by Kenneth L. Becker and published by Lippincott Williams & Wilkins. This book was released on 2001 with total page 2500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established as the foremost text in the field, Principles and Practice of Endocrinology and Metabolism is now in its thoroughly revised, updated Third Edition. This practical, clinically relevant, and comprehensive text covers the entire field of endocrinology and metabolism, including the diffuse endocrine system; morphology and physiology; diagnosis and treatment of endocrine diseases; endocrinology of the female; hormones and cancer; and much more. The Third Edition contains new chapters reflecting the latest advances and features expanded coverage of genetics and the endocrinology of sepsis. More than 1,400 illustrations complement the text. A drug formulary appears at the back of the book.
Download or read book Studies on the Mechanism of 1 25 dihydroxyvitamin D3 Action on Keratinocytes as They Progress from the Normal to the Malignant Phenotype written by Michael Sebag and published by . This book was released on 1996 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: "1,25-dihydroxyvitaminD$ sb3$ (1,25(OH)$ sb2$D$ sb3$) is anti-proliferative and pro-differentiative in a variety of cell types, including human keratinocytes. Exposure of cultured normal human keratinocytes to 1,25(OH)$ sb2$D$ sb3$ markedly reduces ($ sp3$H) thymidine incorporation and cell number and arrests these cells in the G1/G0 phase of the cell cycle. Calcium and 1,25(OH)$ sb2$D$ sb3$ act in concert to modulate the expression of two important cell-cycle associated genes, c-fos and p53, and of markers of keratinocyte differentiation. In contrast, inhibition of cell growth and of the cell cycle associated oncogene, c-myc, in the malignant keratinocyte cell line, HPK1Aras, requires 10 to 100 fold higher concentrations of 1,25(OH)$ sb2$D$ sb3$ than do the immortal non-malignant human keratinocyte cell line, HPK1A. Cell cycle analysis also reveals that 10-100 fold higher concentrations of 1,25(OH)$ sb2$D$ sb3$ are required to induce cell cycle arrest in HPK1Aras cells as compared to HPK1A cells. Analysis of the vitamin D receptor (VDR) from these two cell lines reveals identical sizes, numbers, and ligand binding characteristics. Furthermore, the sequence of the DNA binding domain of this receptor is unchanged in the vitamin D resistant HPK1Aras cells. Gel mobility shift assays using extracts from both cell lines reveals that the complexes formed by HPK1Aras nuclear extracts in the presence of a vitamin D DNA response element (VDRE) probe contain VDR but not its dimerization partner, the retinoic acid X receptor (RXR). In contrast, HPK1A nuclear extracts form complexes that contain both VDR and RXR. Overexpressing wild type RXR$ alpha$ in HPK1Aras cells results in VDRE-binding complexes containing VDR/RXR heterodimers. However, the sequence of the RXR$ alpha$ is unchanged in HPK1Aras cells and its expression in both cell lines is the same. Western blot analysis of RXR$ alpha$ from ras transformed keratinocytes suggests that its post-translational modification is" --
Download or read book Hormonal Signaling in Biology and Medicine written by Gerald Litwack and published by Academic Press. This book was released on 2019-10-24 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal for biochemists, pharmacologists, biologists and students. - Serves as a valuable desk reference for researchers - Provides information on the structure of a given hormone, its receptor(s), and the pathways that become activated - Includes extensive citations to the literature that will enable the reader to dig more deeply into the effects of a given hormone
Download or read book Bone and Mineral Research written by Johannes N. M. Heersche and published by . This book was released on 1990 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone and Mineral Research.
Download or read book Vitamin D written by Anthony W. Norman and published by de Gruyter. This book was released on 1994 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proceedings of the May-June 1994 workshop comprise technical papers in: chemistry of vitamin D, structure/function studies of vitamin D steroids, vitamin D binding protein, vitamin D hydroxylases--biochemistry and regulation, vitamin D metabolism and catabolism, receptors for 1,25(OH)2D3, gene regulation, rapid actions of vitamin D steroids, calbindins D--function and gene regulation--calcium transport, cell differentiation, cancer, immunology, dermatology, neurosciences, renal osteodystrophy, bone and cartilage, miscellaneous biological actions of vitamin D metabolites and analogs, assays for vitamin D steroids, nutrition, osteoporosis, neonatology and pregnancy, gerontology, other basic science topics, and other clinical topics. Annotation copyright by Book News, Inc., Portland, OR
