Download or read book Photofonctionnalisation et modification de surface du titane en implantologie written by Astrid Colnat and published by . This book was released on 2018 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Surface Modification of Titanium for Biomaterial Applications written by Kyo-Han Kim and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book starts with concepts of bone, its structure, remodelling, materials for implants and implant testing methods. Calcium phosphate ceramics and need for titanium surface modification are detailed in the initial chapters. Surface modification techniques include plasma spraying, sol-gel, biomimetic, electrochemical, laser, sputtering and ion-implantation methods. Chapters 5 to 19 deal with these modification techniques. Chapters 20-22 deal with less-common methods titanium nitride coating, protein modification, diamond like carbon coating and ultraviolet treatment. Substituting the apatite lattice with other cations like silicon, magnesium, sodium, carbon, etc is provided. The chapters involving these techniques begin with a small introduction about that technique and go on to explain the underlying principles, methodology and properties of the coats. According to the authors, the book gives a complete overview of almost all the surface modification techniques known, as applied to titanium biomaterials.

Download or read book Effects of Surface Modified Titanium Implants on Osseointegration in Irradiated Bone written by Junyuan Li and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effects of Surface-modified Titanium Implants on Osseointegration in Irradiated Bone" by Junyuan, Li, 黎俊媛, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Radiotherapy is a common treatment for head and neck cancers. However, it compromises bone healing. Titanium implanthas been shown to be a predictable method for replacing missing teeth. Clinical studies revealed that implant failure rate in irradiated regionwas high. Many studies showed that modifications of implant surface could enhance implant osseointegration by improving cell attachment, cell growth and bone formation. Nevertheless, there were few studies investigating the effect of implant surface modification on osseointegration in irradiated bone. In the first experiment, the effect of fluoride-modified (FM) titanium surface on irradiated osteoblast attachment was assessed. The morphology and chemical composition of FM surface was assessed by SEM, AFM and XPS. Osteoblasts received 0Gy, 2Gy, 4Gy, 6Gy, 8Gy, 10Gy radiation. Cell number, fluorescence intensity and cell area of irradiated osteoblasts were assessed. The number of osteoblasts onFM surface was fewer than those on NF surface after 0Gy, 2Gy, 8Gy and 10Gy radiation. Cell area of osteoblasts on FM surface was less at 2Gy radiation but larger at 6Gy radiation than on NF surface. The fluorescence intensity of osteoblasts was also higher on NF surface than on FM surface after receiving 0Gy, 2Gy, 4Gy, 10Gy radiation. In the second experiment, an animal model was established to study the effect of radiation on osseointegration. Rabbits were divided into 15Gy and 30Gy radiation groups. Only the left leg was exposed to radiation, and the right leg was protected from radiation. Totally, 24 implants were inserted. Implant stability quotient (ISQ), bone volume to total volume (BV/TV), bone-to-implant contact (BIC), and bone growth rate were measured. After 15Gy and 30Gy of radiation, ISQ and BV/TV were significantly reduced. At week 3, 15Gy radiation group displayed slower bone growth rate comparing with the control side. Fluorochrome results showed that the 30Gy radiation side had a significantly slower apposition of new bone.In addition, BIC on30Gy radiation side was notablypoorer than that on 15Gy radiation side and on 30Gy control side. Based on the animal model, the third experiment investigated effects of calcium phosphate nanocrystals on implant osseointegration in irradiated bone. Titanium implants treated with nano-scale calcium phosphate (CaP) crystals served as the test group while ones with dual acid-etching only served as the control group. The left leg of rabbits received 15Gy radiation and implants were placed in the irradiated leg. Significant higher ISQ was detected in the nano-CaP group at week 12. The bone growth rate in nano-CaP group was more than doubled than the control group at both week 6 and week 9. The fourth experiment evaluated artifacts on micro-CT images caused by titanium dental implant. Implants were assigned into four groups: (1) implant only; (2) implant with covering screw; (3) implant with resin embedding; and (4) implant with covering screw and resin embedding. Each implant was scanned by micro-CT at 3 angulations. Implant angulation was the most determining factor followed by resin embedding. Minimal metallic artifacts were obtainedin non-embedded implants with its axis paralleling to X-ray. DOI: 10.5353/th_b5312315 Subjects: Osseointegration Dental implants

Download or read book L tat de surface du titane et de ses alliages en implantologie written by Ayham Mousa and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Le succès de l'implant dentaire en titane est basé sur leur ostéointegration osseuse qui est conditionné par le contact entre l'os et la surface de l'implant. Les excellentes propriétés de surface confèrent au titane pur et à ses alliages une très bonne résistance à la corrosion, ainsi qu'une excellente biocompatibilité. Cependant, ces propriétés peuvent être modifiées en fonction du traitement de surface appliqué pendant le processus de fabrication de l'implant. Un nombre très important d'études a été réalisé afin d'améliorer les propriétés de surface du titane, ainsi, de nombreux procédés de traitement de surface ont été développés et appliqués sur la surfaces des implants dentaire, permettant d'améliorer leur ostéointégration. Dans ce travail, nous avons détaillé les différents procédés de traitement de surface utilisés par l'industrie implantaire. Souvent un ou plusieurs traitements sont appliqués afin d'obtenir l'état de surface souhaité. Nous avons donc souhaité comparer l'état de surface d'implants dentaires des marques différentes vendues en France.La comparaison de l'état de surface des implants commercialisés a permis de mettre en évidence des différences entre ces implants, et l'absence d'une norme indépendante reconnue pour les états de surface des implants dentaires. Nous avons aussi noté l'absence d'un contrôle de qualité indépendant vis-à-vis des fabricants. L'avenir de l'implantologie dentaire devrait viser à développer des surfaces avec une topographie et une composition chimique contrôlée et normalisée. Cette approche permettra de mieux comprendre les interactions entre les tissus et les cellules de l'organisme avec les surfaces d'implantaires.

Download or read book Fonctionnalisation de la Surface Du Titane Pour Les Implants Dentaires written by Sabin Issa and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this thesis is to create new nanostructured surfaces with bioactive coatings and to study theirs physicochemical properties in order to develop better dental implants designs and promote their osseointegration. This functionalization was performed in two steps; starting by the nanostructuration of TiO2 surface by anodisation to create reactive sites on the edges of titanium nanotubes which acts as points of “attachment" to bioactive coatings. The second step was the surface chemical modification by coating the nanostructured surface with bioactive coatings of calcium phosphate (CaP) and strontium doped calcium phosphate (Sr.CaP). This coating was performed by pulsed electrodeposition. The physicochemical characterization by XPS, SEM and IR showed that doping with Sr promotes a non-apatitic compound similar to DCPD or DCPA (Dicalcium Phosphate Dihydrate or Anhydrous), while undoped CaP coating looks like an amorphous apatite-like compound ACP. The addition of strontium has the double advantage of optimizing the cellular multiplication and of giving an inorganic phase with bio-performance better than apatitic compounds. We also evaluated the adsorption proprieties of these functionalized surfaces by investigating the adsorption of proteins (BSA). This adsorption was performed onto tblank nanotubes, nanotubes coated with CaP and Sr doped CaP and evaluated according to deposition time and to the pH value of the solution that affect both protein and surface charge. The kinetic and structural evaluation reveals different adsorption geometries according to pH and adsorption time and also according to the chemical nature of surface. Such results of protein adsorption and conformation may form a database to understand and control protein activities and reactions with living body when used for dental implants system.

Download or read book Surface Modification of Titanium Alloy Implants written by Martin Browne and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book New Bioactive Surfaces for Titanium Implants written by Laëtitia Salou and published by . This book was released on 2015 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocompatible and corrosion resistant regarding biological fluids, titanium is still an inert material: it does not participate actively at the tissue-integration around the implant. Surface modification of titanium at nanoscale can promote cell adhesion and differentiation by modulate genes expression due to a phenomenon of mechano-transduction. In this thesis, we have focused on the development, the characterization and the direct application of our nanostructured surface of medical devices. First of all, our study focused on the preparation and physicochemical characterization. After obtaining reproducible surfaces on small samples, our research has focused on the biological characterization of the surface. In-vivo studies conducted in rabbits have allowed us to show similar biomechanical attachment and good osseointegration of the nanostructured surface compared to commonly used surfaces on the market. The application of this new surface on more complex titanium implant such as tracheal prosthesis, has allowed us to observe delamination phenomenon of the nanostructure layer. Therefore, our research was oriented towards the problem of mechanical strength of the surface with the realization of nano scratch test and tribology. A topic in the zeitgeist, as a new EU regulation for medical devices which incorporate nanomaterials will take effect in 2017. To conclude, this work enable to propose a nanosurface with promising results of tissues integration required for medical device.

Download or read book Implants dentaires written by Jérémy Abitbol and published by . This book was released on 2008 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Les implants dentaires intraosseux en titane représentent à l’heure actuelle l’approche thérapeutique la plus novatrice en dentisterie. Ceux-ci ont subi au cours des vingt dernières années, une évolution importante au niveau de leur forme, mais surtout au niveau de leur état de surface. Celui-ci a évolué: il peut être usiné, sablé, mordancé, recouvert d’hydroxyapatite en vue d’optimiser le déroulement des événements cellulaires qui permettent à l’implant d’être ostéointégré. Plus récemment, d’autres voies de recherche ont été explorées afin d’améliorer la vitesse d’ostéointégration. Elles concernent essentiellement des modifications biologiques de la surface par incorporation de molécules bioactives. La surface d’échantillons titane a été fonctionnalisée par greffage d’un film mince de polymère biodégradable pour y inclure une protéine. L’étude de la surface par spectroscopie infra-rouge a permis de vérifier la présence des espèces greffées. Les résultats expérimentaux montrent que le traitement de silanisation de la surface est nécessaire pour assurer un greffage optimal du polymère. Le film mince chargé en protéine résiste à une immersion dans de l’eau sous champ d’ultrasons. L’utilisation de substance d’induction osseuse à la surface des implants dentaires s’annonce un moyen très prometteur pour optimiser un recrutement cellulaire plus adapté et plus rapide qui mène à l’ostéointégration. Un tel implant serait «biomimétique» c’est-à-dire capable d’induire la différentiation de cellules appropriées.

Download or read book Surface Modification of Titanium Substrates with Polymer Brushes to Control Cell Adhesion for Bioapplications written by Jenny E. Raynor and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Modification of the surface chemistry of materials used as implants in biomedical applications affords the ability to control cell adhesion, prevent inflammation and enhance integration with the host. Titanium and its alloys are strong and lightweight thereby making them desirable for applications such as hip and knee replacements, dental implants, and cardiac pacemaker implants. However, the lifetime of these implants is often limited by poor incorporation into the surrounding bone which results in loosening and wear. In order to overcome these limitations we have studied the modification of titanium substrates with a self-assembled monolayer that can be used to perform surface-initiated atom transfer radical polymerization (SI-ATRP) of a monomer to afford polymer brushes that effectively prevent the adhesion of cells. In addition, the polymer brushes afford the ability to tether a peptide sequence. Specific peptides containing adhesion sequences have been tethered to the polymer brushes. The resulting surfaces promote cell adhesion and osteoblast differentiation, thereby increasing bone tissue formation around the implant resulting in better incorporation of the implant.

Download or read book Surface Modification Strategies for Antimicrobial Titanium Implant Materials with Enhanced Osseointegration written by Kennedy Omoniala and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Electrochemical Surface Modification of Titanium Based Material with Detonation Nanodiamonds for Implant Applications written by Afnan Qurban Shaikh and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Designing Multi Scale Functionalities in 3D Printed Titanium and Tantalum Metal Implants Toward Early Stage Osseointegration written by Indranath Mitra and published by . This book was released on 2021 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, advanced materials research in implantable metallic devices for bone tissue engineering has significantly influenced orthopedic and dental applications. However, these devices' practical usage still has several challenges concomitant to acquiring and retaining biological fixation at the implant site. An important goal of current biomaterials research is to induce and accelerate bone tissue growth around the implants. In addition to rapid wound healing at the surgery site, these implants must have adequate biomechanical characteristics. This dissertation elaborates on investigating the effect of developing surface charge on Titania (TiO2) nanotubes and assessed it's in vitro and in vivo early-stage osseointegration. Growing TiO2 nanotubes on commercially pure titanium led to the introduction of bioactivity in an otherwise bioinert material via physical anchoring surface for the bone tissue to bond. Surface charge enhances makes the surfaces more hydrophilic and better suited for cellular interactions. We have further explored the effect of compositional modifications through alloying titanium (Ti) with tantalum (Ta) to induce bioactivity. Comparisons among porous and dense Ti-Ta with and without surface modification through TiO2 nanotubes were drawn to assess the variation in cellular interactions and in vivo early-stage bone regeneration.Our results indicate a stored charge of 37.15 ℗ł 14 mC/cm2 for TNT surfaces. Histomorphometric analyses show ~40% increase in mineralized bone formation around the TNT-P implants than the TNTs at 5 weeks, indicative of accelerated bone remodeling cycle. We have shown comparable performance of porous Ta and surface-modified porous Ti64 implants towards early-stage osseointegration at 5 weeks post-implantation through seamless bone-material interlocking. However, a continued and extended efficacy of porous Ta is found in terms of higher osteoid formation at 12 weeks post-surgery. Alloying Ta with Ti during additive fabrication resulted in an overall decrease in elastic modulus of Ti (Ti: 110GPa, 25Ta: 63℗ł 5.5 GPa), helping circumvent any mechanical instability that can arise from a very high mismatch in modulus. Consequently, porous Ti-Ta alloys exhibited increased osseous tissue formation at the implant-bone interface (70% trabecular bone formation in rabbit femur), providing evidence of the superior biological performance of the material towards early-stage bone healing.

Download or read book Titanium Implants with Modified Surface for Rapid Osseointegration written by Denisa-Alexandra Florea and published by . This book was released on 2016-04-23 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Nanostructural and Electrical Surface Properties on the Osteogenic Potential of Titanium Implants written by Rolando Arturo Gittens Ibacache and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dental and orthopaedic implants are currently the solutions of choice for teeth and joint replacements with success rates continually improving, but they still have undesirable failure rates in patients who are compromised by disease or age, and who in many cases are the ones most in need. The success of titanium (Ti) implants depends on their ability to osseointegrate with the surrounding bone and this, in turn, is greatly dependent on the surface characteristics of the device. Advancements in surface analysis and surface modification techniques have improved the biological performance of metallic implants by mimicking the hierarchical structure of bone associated with regular bone remodeling. In this process, damaged bone is resorbed by osteoclasts, which produce resorption lacunae containing high microroughness generated after mineral dissolution under the ruffled border, as well as superimposed nanoscale features created by the collagen fibers left at the surface. Indeed, increasing Ti surface roughness at the micro and sub-microscale level has been shown to increase osteoblast differentiation in vitro, increase bone-to-implant contact in vivo, and accelerate healing times clinically. Recently, the clinical application of surface nanomodification of implants has been evaluated. Still, most clinically-available devices remain smooth at the nanoscale and fundamental questions remain to be elucidated about the effect of nanoroughness on the initial response of osteoblast lineage cells. \r : Another property that could be used to control osteoblast development and the process of osseointegration is the electrical surface charge of implants. The presence of endogenous electrical signals in bone has been implicated in the processes of bone remodeling and repair. The existence of these native signals has prompted the use of external electrical stimulation to enhance bone growth in cases of fractures with delayed union or nonunion, with several in vitro and in vivo reports confirming its beneficial effects on bone formation. However, the use of electrical stimulation on Ti implants to enhance osseointegration is less understood, in part because of the lack of in vitro models that truly represent the in vivo environment. In addition, an aspect that has not been thoroughly examined is the electrical implication of implant corrosion and its effect on the surrounding tissue. Implants are exposed to extreme conditions in the body such as high pH during inflammation, and cyclic loads. These circumstances may lead to corrosion events that generate large electrochemical currents and potentials, and may cause abnormal cell and tissue responses that could be partly responsible for complications such as aseptic loosening of implants. \r : Consequently, Ti implants with tailored surface characteristics such as nanotopography and electrical polarization, could promote bone healing and osseointegration to ensure successful outcomes for patients by mimicking the biological environment of bone without the use of systemic drugs. The objective of this thesis is to understand how surface nanostructural and electrical characteristics of Ti and Ti alloy surfaces may affect osteoblast lineage cell response in vitro for normal tissue regeneration and repair. Our central hypothesis is that combined micro/nanostructured surfaces, as well as direct stimulation of Ti surfaces with fixed direct current (DC) potentials, can enhance osteoblast differentiation.

Download or read book Effects of Surface modified Titanium Implants on Osseointegration in Irradiated Bone written by 黎俊媛 and published by . This book was released on 2013 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: