Download or read book Photoacoustic and Thermoacoustic Tomography written by Geng Ku and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoacoustic tomography (PAT), as well as thermoacoustic tomography (TAT), utilize electromagnetic radiation in its visible, near infrared, microwave, and radiofrequency forms, respectively, to induce acoustic waves in biological tissues for imaging purposes. Combining the advantages of both the high image contrast that results from electromagnetic absorption and the high resolution of ultrasound imaging, these new imaging modalities could be the next successful imaging techniques in biomedical applications. Basic research on PAT and TAT, and the relevant physics, is presented in Chapter I. In Chapter II, we investigate the imaging mechanisms of TAT in terms of signal generation, propagation and detection. We present a theoretical analysis as well as simulations of such imaging characteristics as contrast and resolution, accompanied by experimental results from phantom and tissue samples. In Chapter III, we discuss the further application of TAT to the imaging of biological tissues. The microwave absorption difference in normal and cancerous breast tissues, as well as its influence on thermoacoustic wave generation and the resulting transducer response, is investigated over a wide range of electromagnetic frequencies and depths of tumor locations. In Chapter IV, we describe the mechanism of PAT and the algorithm used for image reconstruction. Because of the broad bandwidth of the laser-induced ultrasonic waves and the limited bandwidth of the single transducer, multiple ultrasonic transducers, each with a different central frequency, are employed for simultaneous detection. Chapter V further demonstrates PAT's ability to image vascular structures in biological tissue based on blood's strong light absorption capability. The photoacoustic images of rat brain tumors in this study clearly reveal the angiogenesis that is associated with tumors. In ChapterVI, we report on further developing PAT to image deeply embedded optical heterogeneity in biological tissues. The improved imaging ability is attributed to better penetration by NIR light, the use of the optical contrast agent ICG (indocyanine green) and a new detection scheme of a circular scanning configuration. Deep penetrating PAT, which is based on a tissue's intrinsic contrast using laser light of 532um [mu] green light and1.06 um [mu] near infrared light, is also presented.
Download or read book Handbook of Mathematical Methods in Imaging written by Otmar Scherzer and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 1626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Mathematical Methods in Imaging provides a comprehensive treatment of the mathematical techniques used in imaging science. The material is grouped into two central themes, namely, Inverse Problems (Algorithmic Reconstruction) and Signal and Image Processing. Each section within the themes covers applications (modeling), mathematics, numerical methods (using a case example) and open questions. Written by experts in the area, the presentation is mathematically rigorous. The entries are cross-referenced for easy navigation through connected topics. Available in both print and electronic forms, the handbook is enhanced by more than 150 illustrations and an extended bibliography. It will benefit students, scientists and researchers in applied mathematics. Engineers and computer scientists working in imaging will also find this handbook useful.
Download or read book Photoacoustic Imaging and Spectroscopy written by Lihong V. Wang and published by CRC Press. This book was released on 2017-12-19 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoacoustics promises to revolutionize medical imaging and may well make as dramatic a contribution to modern medicine as the discovery of the x-ray itself once did. Combining electromagnetic and ultrasonic waves synergistically, photoacoustics can provide deep speckle-free imaging with high electromagnetic contrast at high ultrasonic resolution and without any health risk. While photoacoustic imaging is probably the fastest growing biomedical imaging technology, this book is the first comprehensive volume in this emerging field covering both the physics and the remarkable noninvasive applications that are changing diagnostic medicine. Bringing together the leading pioneers in this field to write about their own work, Photoacoustic Imaging and Spectroscopy is the first to provide a full account of the latest research and developing applications in the area of biomedical photoacoustics. Photoacoustics can provide functional sensing of physiological parameters such as the oxygen saturation of hemoglobin. It can also provide high-contrast functional imaging of angiogenesis and hypermetabolism in tumors in vivo. Discussing these remarkable noninvasive applications and so much more, this reference is essential reading for all researchers in medical imaging and those clinicians working at the cutting-edge of modern biotechnology to develop diagnostic techniques that can save many lives and just as importantly do no harm.
Download or read book Microwave induced thermoacoustic imaging photoacoustic imaging written by Huan Qin and published by Frontiers Media SA. This book was released on 2023-02-13 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mathematical Modeling in Biomedical Imaging II written by Habib Ammari and published by Springer. This book was released on 2011-09-15 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reports on recent mathematical and computational advances in optical, ultrasound, and opto-acoustic tomographies. It outlines the state-of-the-art and future directions in these fields and provides readers with the most recently developed mathematical and computational tools. It is particularly suitable for researchers and graduate students in applied mathematics and biomedical engineering.
Download or read book Biomedical Optics written by Lihong V. Wang and published by John Wiley & Sons. This book was released on 2012-09-26 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized. A solutions manual is available for instructors; to obtain a copy please email the editorial department at [email protected].
Download or read book Photoacoustic Tomography PAT written by Xueding Wang and published by MDPI. This book was released on 2021-02-17 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoacoustic (or optoacoustic) imaging, including photoacoustic tomography (PAT) and photoacoustic microscopy (PAM), is an emerging imaging modality with great clinical potential. PAI’s deep tissue penetration and fine spatial resolution also hold great promise for visualizing physiology and pathology at the molecular level. PAI combines optical contrast with ultrasonic resolution, and is capable of imaging at depths of up to 7 cm with a real-time scalable spatial resolution of 10 to 500 µm. PAI has demonstrated applications in brain imaging and cancer imaging, such as breast cancer, prostate cancer, ovarian cancer etc. This Special Issue focuses on the novel technological developments and pre-clinical and clinical biomedical applications of PAI. Topics include but are not limited to: brain imaging; cancer imaging; image reconstruction; quantitative imaging; light source and delivery for PAI; photoacoustic detectors; nanoparticles designed for PAI; photoacoustic molecular imaging; photoacoustic spectroscopy.
Download or read book Photoacoustic Tomography written by Huabei Jiang and published by CRC Press. This book was released on 2018-09-03 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of photoacoustic tomography (PAT) emerged in the mid-1990s, and the field of PAT is now rapidly moving forward. Presenting the research of a well-respected pioneer and leading expert, Photoacoustic Tomography is a first-of-its-kind book covering the underlying principles and practical applications of PAT in a systematic manner. Written in a tutorial format, the text: Addresses the fundamentals of PAT, the theory on photoacoustic effect, image reconstruction methods, and instrumentation Details advanced methods for quantitative PAT, which allow the recovery of tissue optical absorption coefficient and/or acoustic properties Explores the development of several image-enhancing schemes, including both software and hardware approaches Examines array-based PAT systems that are the foundation for the realization of 2-D, 3-D, and 4-D PAT Discusses photoacoustic microscopy (PAM) and combinations of PAT/PAM with other imaging methods Considers contrast-agents-based molecular PAT, with both nontargeted and cell receptor–targeted methods Describes clinical applications and animal studies in breast cancer detection, osteoarthritis diagnosis, seizure localization, intravascular imaging, and image-guided cancer therapy Photoacoustic Tomography is an essential reference for graduate students, researchers, industry professionals, and those who wish to enter this exciting field.
Download or read book Photoacoustic Tomography written by Minghua Xu and published by CRC PressI Llc. This book was released on 2014-09-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Image Reconstruction in Photoacoustic Computed Tomography with Acoustically Heterogeneous Media written by Chao Huang and published by . This book was released on 2014 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoacoustic computed tomography (PACT), also known as optoacoustic or thermoacoustic tomography, is a rapidly emerging hybrid imaging modality that combines optical image contrast with ultrasound detection. The majority of currently available PACT image reconstruction algorithms are based on idealized imaging models that assume a lossless and acoustically homogeneous medium. However, in many applications of PACT these assumptions are violated and the induced photoacoustic (PA) wavefields are scattered and absorbed as they propagate to the receiving transducers. In those applications of PACT, the reconstructed images can contain significant distortions and artifacts if the inhomogeneous acoustic properties of the object are not accounted for in the reconstruction algorithm. In this dissertation, we develop and investigate a full-wave approach to iterative image reconstruction in PACT with acoustically heterogeneous lossy media. A key contribution of this work is the establishment of a discrete imaging model that is based on the exact PA wave equation and a procedure to implement an associated matched discrete forward and backprojection operator pair, which permits application of a variety of modern iterative image reconstruction algorithms that can mitigate the effects of noise, data incompleteness and model errors. Another key contribution is the development of an optimization approach to joint reconstruction (JR) of absorbed optical energy density and speed of sound in PACT, which is utilized to investigate the numerical properties of the JR problem and its feasibility in practice. We also develop a TR-based methodology to compensate for heterogeneous acoustic attenuation that obeys a frequency power law. In addition, we propose a image reconstruction methodology for transcranial PACT that employs detailed subject-specific descriptions of the acoustic properties of the skull to mitigate skull-induced distortions in the reconstructed image.
Download or read book LED Based Photoacoustic Imaging written by Mithun Kuniyil Ajith Singh and published by Springer Nature. This book was released on 2020-04-07 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.
Download or read book Dual modality Thermoacoustic and Photoacoustic Imaging written by Manojit Pramanik and published by . This book was released on 2010 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis of early breast cancer is the key to survival. The combined contrasts from thermoacoustic and photoacoustic tomography (TAT and PAT) can potentially predict early stage breast cancer. We have designed and engineered a breast imaging system integrating both thermoacoustic and photoacoustic imaging techniques to achieve dual-contrast (microwave and light absorption), non-ionizing, low-cost, high-resolution, three-dimensional breast imaging. We have also developed a novel concept of using a negative acoustic lens to increase the acceptance angle of an unfocused large-area ultrasonic transducer (detector), leading to more than twofold improvement of the tangential resolution in both TAT and PAT when the object is far from the scanning center. A contrast agent could be greatly beneficial for early cancer diagnosis using TAT/PAT, because the early stage intrinsic contrast can be low. We have developed a carbon nanotube-based contrast agent for both TAT and PAT. In comparison with deionized water, single-walled carbon nanotubes (SWNTs) exhibited more than twofold signal enhancement for TAT at 3 GHz, and in comparison with blood, they exhibited more than sixfold signal enhancement for PAT at 1064 nm wavelength. Using PAT in conjunction with an intradermal injection of SWNTs, we also showed the feasibility of noninvasive in vivo sentinel lymph node imaging in a rat model. We have also developed and demonstrated molecular photoacoustic imaging using unique "soft-type" colloidal gold nanobeacons (GNBs) in the near-infrared region. GNBs represent a novel class of stable, colloidal gold nanoparticles, incorporating small metallic gold nanoparticles that can clear from the body when the particles are metabolically disrupted. We have also imaged the sentinel lymph node using different sizes of GNBs, showing that size plays an important role in their in vivo behavior and uptake to the lymph nodes. In addition to providing diagnostic imaging, TAT and PAT can be used in therapy for real-time temperature monitoring with high spatial resolution and high temperature sensitivity, which are both needed for safe and efficient thermotherapy. Using a tissue phantom, these noninvasive methods have been demonstrated to have a high temperature sensitivity of 0.15 0C at 2 s temporal resolution (20 signal averages).
Download or read book Thermoacoustic Tomography written by JIANG and published by IOP Publishing Limited. This book was released on 2020-03-23 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind to cover the underlying principles and biomedical applications of thermoacoustic tomography (TAT). Written in a tutorial format, it describes the fundamentals of TAT; details advanced approaches for quantitative TAT; explores the development of several image enhancing schemes including both software and hardware approaches; examines array-based TAT systems; considers high-resolution TAT approaches and combinations of TAT with other imaging methods; addresses contrast agent-based molecular TAT; and discusses clinical applications and animal studies in the areas of brain, breast, joint, thyroid, liver and vascular imaging. It is a valuable resource for students, academics, and industry specialists, including biomedical engineers, electrical engineers, physicists and mathematicians.
Download or read book Laser Optoacoustics written by Vitaliĭ Ėduardovich Gusev and published by American Institute of Physics. This book was released on 1993 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Market: Researchers in optoacoustics, laser interactions with fluids and solids, and nondestructive evaluation by laser ultrasonics. Written by two of the world's recognized authorities in this rapidly growing discipline, this volume offers an in-depth description of new techniques for non-contact ultrasonic measurement based on the use of laser optics.
Download or read book The Radiative Transfer Equation in Photoacoustic Imaging written by Lee Patrolia and published by . This book was released on 2013 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photoacoustic tomography is a rapidly developing medical imaging technique that combines optical and ultrasound imaging to exploit the high contrast and high resolution of the respective individual modalities. Mathematically, photoacoustic tomography is divided into two steps. In the first step, one solves an inverse problem for the wave equation to determine how tissue absorbs light as a result of a boundary illumination. The second step is generally modeled by either diffusion or transport equations, and involves recovering the optical properties of the region being imaged. In this paper we, we provide an overview of mathematical progress in photoacoustic and thermoacoustic tomography, as well as inverse problems for the radiative transfer equation. We then address quantitative photoacoustic tomography modeled by the radiative transfer equation, and in particular, we show that the absorption coefficient in the stationary transport equation can be recovered given certain internal information about the solution. Our new result will consider the variable index of refraction case, which will correspond to an inverse transport problem on a Riemannian manifold with internal data and a known metric. We will prove a stability estimate for a functional of the absorption coefficient of the medium by finding a singular decomposition for the distribution kernel of the measurement operator. Finally, we will use this estimate to recover the desired absorption properties.
Download or read book Nanoscale Science and Technology written by Robert Kelsall and published by John Wiley & Sons. This book was released on 2005-11-01 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology is a vital new area of research and development addressing the control, modification and fabrication of materials, structures and devices with nanometre precision and the synthesis of such structures into systems of micro- and macroscopic dimensions. Future applications of nanoscale science and technology include motors smaller than the diameter of a human hair and single-celled organisms programmed to fabricate materials with nanometer precision. Miniaturisation has revolutionised the semiconductor industry by making possible inexpensive integrated electronic circuits comprised of devices and wires with sub-micrometer dimensions. These integrated circuits are now ubiquitous, controlling everything from cars to toasters. The next level of miniaturisation, beyond sub-micrometer dimensions into nanoscale dimensions (invisible to the unaided human eye) is a booming area of research and development. This is a very hot area of research with large amounts of venture capital and government funding being invested worldwide, as such Nanoscale Science and Technology has a broad appeal based upon an interdisciplinary approach, covering aspects of physics, chemistry, biology, materials science and electronic engineering. Kelsall et al present a coherent approach to nanoscale sciences, which will be invaluable to graduate level students and researchers and practising engineers and product designers.
Download or read book Optical Imaging in Human Disease and Biological Research written by Xunbin Wei and published by Springer Nature. This book was released on 2021-05-29 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book introduces readers to the basic principle of optical imaging technologies. Focusing on human disease diagnostics using optical imaging methods, it provides essential information for researchers in various fields and discusses the latest trends in optical imaging. In recent decades, there has been a huge increase in imaging technologies and their applications in human diseases diagnostics, including magnetic resonance imaging, x-ray computed tomography, and nuclear tomographic imaging. This book promotes further developments to extend optical imaging to a wider range of disease diagnostics. It is a valuable resource for researchers and students in the field of biomedical optics, as well as for clinicians.
