Download or read book Phenotypic Variations In Animal Morphogenesis written by Dimitri Fabrèges and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Variability is an intrinsic characteristic of biological systems, essential for evolution and embryogenesis.Considered as noise for centuries, it is only recently that the stochasticity of biological processes has began to be systematically explored.The present thesis addresses the following questions: What is a normal development?What is the extent and role of variability in developmental robustness and resilience?We tackle these issues in rabbit (Oryctolagus cuniculus) and sea urchin (Paracentrotus lividus and Sphaerechinus granularis).We also aimed to quantify determinism and stochasticity of developmental variability by means of sea urchin twins and cloned rabbits.Variations in cell behaviors were investigated through reconstruction of cell lineage from 3D+time imaging.We showed that sea urchin twins can follow three different developmental paths never observed in normal embryo, before converging to normal looking blastula.Moreover, comparisons between and within pairs of twins revealed that phenotype and survival depend on individual history alone.Our quantitative observation of twin pairs raises question opening a future line of research: are twins robust or resilient?Rabbit preimplantation development was explored with five digital specimens (three wild-types and two clones) from the 32-cell stage to hatching.We showed that inner and outer asymmetric divisions regulate the variation of inner cell number and may control inner cell mass size.In addition, the variation of inner cell number in clones is higher than outer cells which seems to be directly correlated to their cell death ratio.Our current hypothesis is that the potential to lead to viable clones requires plasticity of donor's epigenetic state.This work is expected to ground concepts and methods for a quantitative exploration and further multilevel modeling of morphogenetic processes.
Download or read book Evolutionary Developmental Biology written by Laura Nuno de la Rosa and published by Springer. This book was released on 2020-11-15 with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work provides an comprehensive and easily accessible source of information on numerous aspects of Evolutionary Developmental Biology. The work provides an extended overview on the current state of the art of this interdisciplinary and dynamic scientific field. The work is organized in thematic sections, referring to the specific requirements and interests in each section in far detail. “Evolutionary Developmental Biology – A Reference Guide” is intended to provide a resource of knowledge for researchers engaged in evolutionary biology, developmental biology, theoretical biology, philosophy of sciences and history of biology.
Download or read book Developmental Instability written by Michal Polak and published by Oxford University Press, USA. This book was released on 2003 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of developmental instability has generated a large amount of controversy recently, mostly because of fierce disagreement over the genetic basis of fluctuating asymmetry and its role in mate selection. This book is a timely and innovative critical evaluation of a burgeoning field. The book explores the premise that complex organismal, ecological and evolutionary processes can be understood as emergent properties of the "epigenetic machine," that is, the mechanisms fundamental to all organisms responsible for building and organizing phenotypes from information translated from DNA.
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Vogel and Motulsky s Human Genetics written by Michael Speicher and published by Springer Science & Business Media. This book was released on 2009-11-26 with total page 1006 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of this classical reference book can once again be relied upon to present a cohesive and up-to-date exposition of all aspects of human and medical genetics. Human genetics has become one of the main basic sciences in medicine, and molecular genetics is increasingly becoming a major part of this field. This new edition integrates a wealth of new information - mainly describing the influence of the "molecular revolution" - including the principles of epigenetic processes which together create the phenotype of a human being. Other revisions are an improved layout, sub-division into a larger number of chapters, as well as two-colour print throughout for ease of reference, and many of the figures are now in full colour. For graduates and those already working in medical genetics.
Download or read book Epigenetics written by Benedikt Hallgrimsson Ph.D. and published by Univ of California Press. This book was released on 2011-04-11 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illuminating the processes and patterns that link genotype to phenotype, epigenetics seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.
Download or read book Epigenetic Inheritance and Evolution written by Eva Jablonka and published by Oxford University Press, USA. This book was released on 1995 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does the inheritance of acquired characteristics play a significant role in evolution? In this book, Eva Jablonka and Marion J. Lamb attempt to answer that question with an original, provocative exploration of the nature and origin of hereditary variations. Starting with a historical account of Lamarck's ideas and the reasons they have fallen in disrepute, the authors go on to challenge the prevailing assumption that all heritable variation is random and the result of variation in DNA base sequences. They also detail recent breakthroughs in our understanding of the molecular mechanisms underlying inheritance--including several pathways not envisioned by classical population genetics--and argue that these advances need to be more fully incorporated into mainstream evolutionary theory. Throughout, the book offers a new look at the evidence for and against the hereditability of environmentally induced changes, and addresses timely questions about the importance of non-Mendelian inheritance. A glossary and extensive list of references round out the book. Urging a reconsideration of the present DNA-centric view prevalent in the field, Epigentic Inheritance and Evolution will make fascinating and important reading for students and researchers in evolution, genetics, ecology, molecular biology, developmental biology, and the history and philosophy of science.
Download or read book Phenotypic Integration written by Massimo Pigliucci and published by Oxford University Press, USA. This book was released on 2004 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interface of evolution and development has attracted the attention of evolutionary and developmental biologists, geneticists, and organismal biologists. Pigliucci (ecology, evolutionary biology, University of Tennessee) and Preston (botany, Standford University) bring together work by experts in the field of phenotype integration, shedding ligh.
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Morphogenesis and Evolution written by Keith Stewart Thomson and published by Oxford University Press, USA. This book was released on 1988 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1. Introduction. 2. Theory, Reduction, and Hierarchy. 3. Development: Pattern and Process. 4. Early Pattern Formation. 5. Example: Early Pattern Formation in Amphibia. 6. Later Pattern Formation: Morphogenesis. 7. Some General Properties of Morphogenetic Systems. 8. Patterns of Evolution. 9. Morphogenesis and Evolution.
Download or read book Morphogenesis and Evolution written by Keith Stewart Thomson and published by Oxford University Press. This book was released on 1988-09-01 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today developmental and evolutionary biologists are focussing renewed attention on the developmental process--those genetic and cellular factors that influence variation in individual body shape or metabolism--in an attempt to better understand how evolutionary trends and patterns within individuals might be limited and controlled. In this important work, the author reviews the classical literature on embryology, morphogenesis, and paleontology, and presents recent genetic and molecular studies on development. The result is a unique perspective on a set of problems of fundamental importance to developmental and evolutionary biologists.
Download or read book Mechanisms of Morphogenesis written by Jamie A. Davies and published by Academic Press. This book was released on 2013-02-18 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, Mechanisms of Morphogenesis, second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. By combining hard data with computer modeling, Mechanisms of Morphogenesis, second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future Includes over 200 four-color figures Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries Covers experimental techniques as a guide to the reader Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems
Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil and published by Academic Press. This book was released on 2021-08-21 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field
Download or read book Essential Fungal Genetics written by David Moore and published by Springer Science & Business Media. This book was released on 2007-06-14 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most genetics textbooks deal adequately with plant and animal genetics, but tend to neglect fungi. The authors have produced a book that will compensate for this imbalance. This book discusses the genetics of fungi in a way that is attractive and challenging, succinct yet comprehensive, sensitive to commercial and applied aspects, yet also theoretical, dealing with their genetics from molecules to individuals to population. This short text will be an ideal supplement to the established basic genetics texts or can be used as the sole text for an advanced course devoted to fungal genetics.
Download or read book Morphogenesis written by Paul Bourgine and published by Springer Science & Business Media. This book was released on 2010-10-28 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the relations between the shape of a system of cities and that of fish school? Which events should happen in a cell in order that it participates to one of the finger of our hands? How to interpret the shape of a sand dune? This collective book written for the non-specialist addresses these questions and more generally, the fundamental issue of the emergence of forms and patterns in physical and living systems. It is a single book gathering the different aspects of morphogenesis and approaches developed in different disciplines on shape and pattern formation. Relying on the seminal works of D’Arcy Thompson, Alan Turing and René Thom, it confronts major examples like plant growth and shape, intra-cellular organization, evolution of living forms or motifs generated by crystals. A book essential to understand universal principles at work in the shapes and patterns surrounding us but also to avoid spurious analogies.
Download or read book Vogel and Motulsky s Human Genetics written by Friedrich Vogel and published by Springer Science & Business Media. This book was released on 1997 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides information on the molecular basis of human genetics and outlines the principles of other epigenetic processes which together create the phenotype of a human being. This work also discusses the molecular basis for the concepts, methods and results in fields such as population genetics.
Download or read book Tempo and Mode in Evolution written by for the National Academy of Sciences and published by National Academies Press. This book was released on 1995-02-09 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since George Gaylord Simpson published Tempo and Mode in Evolution in 1944, discoveries in paleontology and genetics have abounded. This volume brings together the findings and insights of today's leading experts in the study of evolution, including Ayala, W. Ford Doolittle, and Stephen Jay Gould. The volume examines early cellular evolution, explores changes in the tempo of evolution between the Precambrian and Phanerozoic periods, and reconstructs the Cambrian evolutionary burst. Long-neglected despite Darwin's interest in it, species extinction is discussed in detail. Although the absence of data kept Simpson from exploring human evolution in his book, the current volume covers morphological and genetic changes in human populations, contradicting the popular claim that all modern humans descend from a single woman. This book discusses the role of molecular clocks, the results of evolution in 12 populations of Escherichia coli propagated for 10,000 generations, a physical map of Drosophila chromosomes, and evidence for "hitchhiking" by mutations.
