Download or read book Pharmacokinetics of Anticancer Agents in Humans written by Matthew M. Ames and published by Elsevier Publishing Company. This book was released on 1983 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetics of Anticancer Agents in Humans written by MM Ames (Ed) and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by Michelle A. Rudek and published by Springer Science & Business Media. This book was released on 2014-01-10 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Cancer Clinical Pharmacology written by Jan H. M. Schellens and published by Oxford University Press. This book was released on 2005-05-05 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book considers both the theory and practice of clinical pharmacology where it is relevant to cancer treatment. It covers the basics of clinical pharmacology in oncology and cancer therapeutics, discussing the specific classes of anti-cancer agents in detail. Edited and written by a mix of generalist cancer clinical pharmacologists and sub-specialists within this area, the book allows the reader to develop both general clinical pharmacology skills and specialist knowledge for particular cancer chemotherapy agents.
Download or read book A Clinician s Guide to Chemotherapy Pharmacokinetics and Pharmacodynamics written by Louise B. Grochow and published by Lippincott Williams & Wilkins. This book was released on 1998 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anticancer Drugs written by Garth Powis and published by Pergamon. This book was released on 1994 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a review of the metabolism of anticancer drugs, this text emphasizes the relation of metabolism to the therapeutic and toxic effects of anticancer drugs. It aims to facilitate an understanding of how a drug is transformed into active metabolites or inactive products to be excreted.
Download or read book Clinical Pharmacokinetics and Pharmacodynamics of Anticancer Agents written by Laurentius Joannes Cornelis van Warmerdam and published by . This book was released on 1995 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Clinical Pharmacology of Novel Anticancer Agents Bioanalysis Clinical Pharmacokinetics Mass Balance Studies written by and published by . This book was released on 2016 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phase I and Clinical Pharmacokinetic Studies of Anticancer Agents written by Michael R. Grever and published by . This book was released on 1988 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drinking Water and Health Volume 8 written by National Research Council and published by National Academies Press. This book was released on 1987-02-01 with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacokinetics, the study of the movement of chemicals within the body, is a vital tool in assessing the risk of exposure to environmental chemicals. This bookâ€"a collection of papers authored by experts in academia, industry, and governmentâ€"reviews the progress of the risk-assessment process and discusses the role of pharmacokinetic principles in evaluating risk. In addition, the authors discuss software packages used to analyze data and to build models simulating biological phenomena. A summary chapter provides a view of trends in pharmacokinetic modeling and notes some prospective fields of study.
Download or read book Handbook of Anticancer Pharmacokinetics and Pharmacodynamics written by William Figg and published by Humana Press. This book was released on 2004-03-26 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading investigators synthesize the entire laboratory and clinical process of developing anticancer drugs to create a single indispensable reference that covers all the steps from the identification of cancer-specific targets to phase III clinical trials. These expert authors provide their best guidance on a wide variety of issues, including clinical trial design, preclinical screening, and the development and validation of bioanalytic methods. The chapters on identifying agents to test in phase III trials and on trial design for the approval of new anticancer agents offer a unique roadmap for moving an agent to NDA submission.
Download or read book The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease written by Bharat B. Aggarwal and published by Springer Science & Business Media. This book was released on 2007-08-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.
Download or read book Influence of Formulation on Pharmacokinetics of Anticancer Drugs written by Waleed Mohammed Al-Shakhaa and published by . This book was released on 1996 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this study the use of HPMA copolymer to deliver Doxorubicin (DOX) has resulted in a favorable modification of the pharmacokinetic behaviour of DOX. This study has attempted to demonstrate whether the efficacy of PK1 is enhanced as a result of enhanced permeability and retention (EPR) or whether it is due to altered pharrnacokinetics and drug exposure parameters using two different models of murine tumour. The two models were MAC15A, which is poorly differentiated and poorly vascularised and MAC26 which is well differentiated and well vascularised. This study has shown that the method used for extraction of DOX and PK1 from plasma and tumour was valid with acceptable sensitivity. Evaluation of this method showed both acceptable extraction efficiencies and good reproducibility for extraction of PK1 and DOX from plasma. Preliminary pharmacokinetic work on both PK1 and DOX showed different pharmacokinetic profiles with both compounds. Pharmacokinetic parameters obtained from the data showed a higher AUC for PK1 in plasma of NMRI mice compared to that for DOX with slightly longer half life in the case of PKI . On other hand, there was a small amount of free DOX released from PKI in plasma in the case of MAC15A tumour model but there was no free DOX from PKI seen in the case of MAC26 tumour model. Analysis of plasma samples showed that PKI was still detectable at the 72h time point. The most interesting points in this study were the tumour drug levels and the associated pharmacokinetic parameters. Analysis of samples obtained from both MAC15A and MAC26 tumours showed very high levels of PK1 and free DOX released from PK1 within the tumours compared with DOX 10 mg/kg (iv). In general, AUC of PK1 and released DOX following a single 490 mg/kg which equates to 40mg/kg of DOX was very high when compared with free DOX and....
Download or read book Anticancer Drug Toxicity written by Hans-Peter Lipp and published by CRC Press. This book was released on 1999-04-13 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Containing the latest findings on the toxicity of a wide range of chemotherapeutic agents, this up-to-the-minute reference offers expert analyses on the pharmacokinetic-pharmacodynamic and pharmacokinetic-toxicodynamic relationships of anticancer compounds. Anticancer Drug Toxicity explores therapeutic drug monitoring (TDM) as a method of maximizing the efficacy, and minimizing the dangers, of chemotherapy presents a vast amount of clinical pharmacokinetic data on cytostatic drugs offers a comprehensive classification of toxicity patterns associated with the use of cytotoxic drugs analyzes the pharmacokinetics of alkylating agents, platinum compounds, anthracyclines, antimetabolites, semisynthetic podophyllotoxin- and camptothecin derivatives, mitotic inhibitors, and other cytotoxic agents highlights the pharmacogenetics of 6-mercaptopurine and its clinical significance explicates toxicity in relation to the lungs, kidneys, heart, and gonads examines disorders caused by asparaginase preparations reviews types of secondary malignancy such as leukemias, ovarian cancer, testicular cancer, breast cancer, secondary solid neoplasias, and Hodgkin's disease clarifies the understanding of toxicity as a crucial element in supportive management of cancer therapy and more! An enormously practical guide for everyday clinical practice, as well as a source of inspiration for further research in the field, Anticancer Drug Toxicity is an invaluable reference for clinical and medical oncologists; hospital, industrial, and clinical pharmacologists and pharmacists; toxicologists; pharmaceutical chemists; radiologists; and graduate and medical school students in these disciplines.
Download or read book The Analysis and Pharmacokinetics of Some Anticancer Drugs written by Lo-Yin Lin and published by . This book was released on 1980 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular Pharmacokinetics of Anticancer Drugs written by Hagar Katzir and published by . This book was released on 2008 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
