Download or read book Perspectives on Opportunities Toward a Hazard Free Bioprocessing Environment written by LJ. Elliott and published by . This book was released on 1990 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical research and commercial applications of biotechnologies are expanding rapidly. The increasing utilization of biotechnology is evident in the areas of clinical research, general medicine, agriculture, chemical synthesis, and waste disposal, to name only a few. In an effort to identify potential occupational health hazards during the early stages of this development, the National Institute for Occupational Safety and Health conducted industrial hygiene surveys at six companies involved in research and development of recombinant DNA (rDNA) techniques applicable to fermentation processes. During each visit potential worker exposures, engineering controls, work practices, and medical surveillance programs were assessed. Varying degrees of proficiency and sophistication were noted in all of the assessed areas. Three companies new to the field (less than ten years old) of industrial fermentation were less sophisticated in their approach to issues involving occupational safety and health than were companies with years of experience (20, 25, and 106 years) in such operations. The three less experienced companies had no operational protocols, conducted limited (if any) environmental monitoring for chemical and microbial hazards, did not conduct preventive maintenance, and had very limited medical surveillance programs. Two of these companies had not conducted any environmental monitoring of the fermentation or product extraction processes. Recommendations were made in the areas of preventive maintenance, environmental monitoring, medical surveillance, and improved containment during fermenter inoculation.
Download or read book Bioprocessing Safety written by Warren C. Hyer and published by ASTM International. This book was released on 1990 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biosafety in Industrial Biotechnology written by P. Hambleton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: As an industry, biotechnology may be likened to the Hymn Book, being both ancient and modern. Whereas activities such as baking, brewing, the fermenting of foods date from our earliest attempts to control and utilise the environment, the application of recombinant DNA technology is recognised as being at the forefront of novel industrial development. Perhaps because of its association with processing foodstuffs together with the benefits derived from applications in the early organic chemistry and pharmaceutical industries, biotechnology has been regarded as being inherently safe. Yet unlike other modern industries, such as chemical and nuclear, where regulation has followed from incidents or accidents, modern biotechnology has been subject to close scrutiny and regulation almost from its inception. The process of regulation itself is somewhat unusual in that it was initially self-imposed by the very scientists who developed the fundamental techniques of recombinant DNA technology. They recognised the signific ance of their development but were concerned of the effects on humans and the environment of uncontrolled application of the new, powerful technology. Concern about the possible consequences of genetic manipula tion has undoubtedly been the driving force behind the regulations that are now in place in many parts of the world and which are the subject of this book. Safety issues in the biotechnology industry can be categorised under three headings: worker, environmental and consumer (product) safety.
Download or read book Environmental Pollution Control written by and published by . This book was released on 1990 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Safety in Cell and Tissue Culture written by G. Stacey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now more than half a century since animal cells first came into regular use in the laboratory. Instances of laboratory acquired infection and con tamination of therapeutic products, derived from the use of animal cell cultures are rare. The use of animal cells, in addition to an established role in the production of vaccines and therapeutic proteins, has many new medical applications including gene therapy, tissue engineering and cell therapy. Furthermore, C;ldvances in molecular and cell biology are enabling rapid development and application of these technologies and the development of new and more sensitive methods, such as nucleic acid amplification, for the characterisation of cells and the detection of adven titious agents. However, it is clear that there is no room for complacency in this field and the recent expansion in the use of animal cells in the manufacture of medical products and the development of new biological assays for diagnostic and pharmaco-toxicological screening, underlines the need for vigilance regarding the correct and safe use of animal cells as substrates. This book is therefore very timely and should prove to be a highly valuable text, finding a wider audience beyond those with respon sibility for laboratory safety. The book guides the reader from fundamental cell biology issues and the establishment of new in vitro methods, through testing and validation of cell lines and on to issues in the use of animal cells in manufacturing processes.
Download or read book Government Reports Announcements Index written by and published by . This book was released on 1990 with total page 1002 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Putting Biotechnology to Work written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of the United States to sustain a dominant global position in biotechnology lies in maintaining its primacy in basic life-science research and developing a strong resource base for bioprocess engineering and bioproduct manufacturing. This book examines the status of bioprocessing and biotechnology in the United States; current bioprocess technology, products, and opportunities; and challenges of the future and what must be done to meet those challenges. It gives recommendations for action to provide suitable incentives to establish a national program in bioprocess-engineering research, development, education, and technology transfer.
Download or read book Advances in Sustainable Biomaterials written by Ajay Kumar and published by CRC Press. This book was released on 2024-10-28 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sustainable biomaterials are used as substitutions for traditional materials in aerospace, automotive, civil, mechanical, environmental engineering, medical, and other industries. This book presents the current knowledge and recent developments on the characterization and application of sustainable biomaterials with biomanufacturing 4.0 techniques. The book also describes the unique properties of various classes of sustainable biomaterials, making them highly suitable for many industrial applications. Advances in Sustainable Biomaterials: Bioprocessing 4.0, Characterizations, and Applications presents key chapters on smart biopolymer composites production and processing methods and provides a wide range of applications in a variety of fields such as medical, food, agriculture, electronics, manufacturing, and chemical engineering. The book features the most recent and detailed information on advancements in biopolymer biomaterials and emphasizes synthesis, characterization, modeling, manufacturing, and testing strategies. Written to be used as a resource guide on biomaterials and innovations, undergraduate and postgraduate students studying manufacturing and materials science will find this book very useful in addition to those working in mechanical engineering, biomedical engineering, manufacturing of pharmaceuticals, biotechnology, and electronics engineering fields. The book can also be used as additional classroom reading for an advanced course on biomaterials modeling and optimization.
Download or read book Industrialization of Biology written by National Research Council and published by National Academies Press. This book was released on 2015-06-29 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tremendous progress in biology over the last half century - from Watson and Crick's elucidation of the structure of DNA to today's astonishing, rapid progress in the field of synthetic biology - has positioned us for significant innovation in chemical production. New bio-based chemicals, improved public health through improved drugs and diagnostics, and biofuels that reduce our dependency on oil are all results of research and innovation in the biological sciences. In the past decade, we have witnessed major advances made possible by biotechnology in areas such as rapid, low-cost DNA sequencing, metabolic engineering, and high-throughput screening. The manufacturing of chemicals using biological synthesis and engineering could expand even faster. A proactive strategy - implemented through the development of a technical roadmap similar to those that enabled sustained growth in the semiconductor industry and our explorations of space - is needed if we are to realize the widespread benefits of accelerating the industrialization of biology. Industrialization of Biology presents such a roadmap to achieve key technical milestones for chemical manufacturing through biological routes. This report examines the technical, economic, and societal factors that limit the adoption of bioprocessing in the chemical industry today and which, if surmounted, would markedly accelerate the advanced manufacturing of chemicals via industrial biotechnology. Working at the interface of synthetic chemistry, metabolic engineering, molecular biology, and synthetic biology, Industrialization of Biology identifies key technical goals for next-generation chemical manufacturing, then identifies the gaps in knowledge, tools, techniques, and systems required to meet those goals, and targets and timelines for achieving them. This report also considers the skills necessary to accomplish the roadmap goals, and what training opportunities are required to produce the cadre of skilled scientists and engineers needed.
Download or read book Bioprocessing of Viral Vaccines written by Amine Kamen and published by CRC Press. This book was released on 2022-09-06 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on cell culture-produced viral vaccines to meet the needs of the rapidly expanding research and development in academia and industry in the field. This book introduces the basic principles of vaccination and the manufacturing of viral vaccines. Bioprocessing of Viral Vaccines, will provide an overview of the advanced strategies needed to respond to the challenges of new and established viral infection diseases. The first few chapters cover the basics of virology and immunology as essential concepts to understand the function and design of viral vaccines. The core of the content is dedicated to process development, including upstream processing and cell culture of viral vaccines, downstream processing, and extensive analytical technologies specific to viral vaccines. Advanced process analytical technologies (PAT) and Quality by Design (QbD) concepts are also introduced in the context of vaccine manufacturing. The case studies included cover inactivated, attenuated vaccines exemplified by influenza vaccines, sub-unit vaccines exemplified by Virus Like Particles (VLPs: HPV vaccines) and sub-unit vaccines (Flublock), vectored vaccines: adenoviruses and Vesicular stomatitis Virus (VSV) vectored vaccines, genomic vaccines (DNA and mRNA) vaccines as developed for COVID-19 response in particular and a review of COVID-19 vaccines approved or in advanced clinical trials. This book is aimed at graduate engineers and professionals in the fields of vaccinology, bioprocessing, and biomanufacturing of viral vaccines.
Download or read book The Prospect of Industry 5 0 in Biomanufacturing written by Pau Loke Show and published by CRC Press. This book was released on 2021-07-01 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to present the idea of Industry 5.0 in biomanufacturing and bioprocess engineering, both upstream and downstream. The Prospect of Industry 5.0 in Biomanufacturing details the latest technologies and how they can be used efficiently and explains process analysis from an engineering point of view. In addition, it covers applications and challenges. FEATURES Describes the previous Industrial Revolution, current Industry 4.0, and how new technologies will transition toward Industry 5.0 Explains how Industry 5.0 can be applied in biomanufacturing Demonstrates new technologies catered to Industry 5.0 Uses worked examples related to biological systems This book enables readers in industry and academia working in the biomanufacturing engineering sector to understand current trends and future directions in this field.
Download or read book Preparing for Future Products of Biotechnology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-07-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Between 1973 and 2016, the ways to manipulate DNA to endow new characteristics in an organism (that is, biotechnology) have advanced, enabling the development of products that were not previously possible. What will the likely future products of biotechnology be over the next 5â€"10 years? What scientific capabilities, tools, and/or expertise may be needed by the regulatory agencies to ensure they make efficient and sound evaluations of the likely future products of biotechnology? Preparing for Future Products of Biotechnology analyzes the future landscape of biotechnology products and seeks to inform forthcoming policy making. This report identifies potential new risks and frameworks for risk assessment and areas in which the risks or lack of risks relating to the products of biotechnology are well understood.
Download or read book Nanotechnology Applications in Agricultural and Bioprocess Engineering written by Megh R. Goyal and published by CRC Press. This book was released on 2022-06-16 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume looks at new research and advances in the use of nanotechnology applications in agricultural and bioprocess engineering. The first section deals with the impact of nanotechnology in agricultural engineering, looking at the role of nanomaterials in plant growth and nutrition. It goes on to discuss specific methods and processes in the development of food products, nutraceuticals, and therapeutics. This includes nanotechnological methods for iron fortification of dairy food, for processing and preservation of meat and meat products, for selective targeting of cancer, and more. The book then discusses the role of nanotechnology in bioprocessing, such as for biofuel production, for wastewater treatment, and as enzymatic nanoparticles for fabrication processes.
Download or read book Integrated Forest Biorefineries written by Lew Christopher and published by Royal Society of Chemistry. This book was released on 2012-09-30 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book describes how bioprocessing and biotechnology could enhance the value extracted from wood-based lignocellulosic fiber by employing both biochemical and thermochemical conversion processes. It documents recent accomplishments and suggests future prospects for research and development of integrated forest biorefineries (IFBR) as the path forward for the pulp, paper and other fiber-processing industries. This is the only book to cover this area of high economic, social, and environmental importance. It is aimed at industrialists and academics from diverse science and engineering backgrounds including chemical and biotechnology companies, governmental and professional bodies, and scholarly societies. The Editor and contributors are internationally recognized scientists and many are leaders in their respective fields. The book starts with an introductory overview of the current state of biorefining and a justification for future developments. The next four chapters deal with social, economic and environmental issues related to regulations, biomass production and supply, process modelling, and life cycle analysis. Subsequent chapters focus on the extraction of biochemicals from biomass and their potential utilization to add value to the IFBR prior to pulping. The book then presents, compares and evaluates two types of forest biorefineries based on kraft and organosolv pulping. Finally, the book assess the potential of waste biomass and streams, such paper mill sludge and black liquor, to serve as feedstock for biofuel production and value-added biomaterials through both the biochemical and thermochemical routes of biomass bioprocessing. The economics of the described IFBR processes and products, and their environmental impact, is a major focus in most of the chapters. Practical examples are presented where relevant and applicable.
Download or read book Process Intensification Technologies for Green Chemistry written by Kamelia Boodhoo and published by John Wiley & Sons. This book was released on 2013-01-03 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: The successful implementation of greener chemical processes relies not only on the development of more efficient catalysts for synthetic chemistry but also, and as importantly, on the development of reactor and separation technologies which can deliver enhanced processing performance in a safe, cost-effective and energy efficient manner. Process intensification has emerged as a promising field which can effectively tackle the challenges of significant process enhancement, whilst also offering the potential to diminish the environmental impact presented by the chemical industry. Following an introduction to process intensification and the principles of green chemistry, this book presents a number of intensified technologies which have been researched and developed, including case studies to illustrate their application to green chemical processes. Topics covered include: • Intensified reactor technologies: spinning disc reactors, microreactors, monolith reactors, oscillatory flow reactors, cavitational reactors • Combined reactor/separator systems: membrane reactors, reactive distillation, reactive extraction, reactive absorption • Membrane separations for green chemistry • Industry relevance of process intensification, including economics and environmental impact, opportunities for energy saving, and practical considerations for industrial implementation. Process Intensification for Green Chemistry is a valuable resource for practising engineers and chemists alike who are interested in applying intensified reactor and/or separator systems in a range of industries to achieve green chemistry principles.
Download or read book Scientific and Technical Aerospace Reports written by and published by . This book was released on 1977 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Waste Biorefinery written by Thallada Bhaskar and published by Elsevier. This book was released on 2018-04-13 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: Waste Biorefinery: Potential and Perspectives offers data-based information on the most cutting-edge processes for the utilisation of biogenic waste to produce biofuels, energy products, and biochemicals – a critical aspect of biorefinery. The book explores recent developments in biochemical and thermo-chemical methods of conversion and the potential generated by different kinds of biomass in more decentralized biorefineries. Additionally, the book discusses the move from 200 years of raw fossil materials to renewable resources and how this shift is accompanied by fundamental changes in industrial manufacturing technologies (from chemistry to biochemistry) and in logistics and manufacturing concepts (from petrochemical refineries to biorefineries). Waste Biorefinery: Potential and Perspectives designs concepts that enable modern biorefineries to utilize all types of biogenic wastes, and to integrate processes that convert byproduct streams to high-value products, achieving higher cost benefits. This book is an essential resource for researchers and students studying biomass, biorefineries, and biofuels/products/processes, as well as chemists, biochemical/chemical engineers, microbiologists, and biotechnologists working in industries and government agencies. Details the most advanced and innovative methods for biomass conversion Covers biochemical and thermo-chemical processes as well as product development Discusses the integration of technologies to produce bio-fuels, energy products, and biochemicals Illustrates specific applications in numerous case studies for reference and teaching purposes
