Download or read book Perspectives in Receptor Research written by Dario Giardina and published by Elsevier. This book was released on 1996-06-07 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perspectives in Receptor Research

Download or read book Perspectives in steriod receptor research written by and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Perspectives in Steroid Receptor Research written by Francesco Bresciani and published by Raven Press (ID). This book was released on 1980 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Perspectives in Steroid Receptor Research written by Francesco Bresciani and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nuclear Receptors written by Mostafa Z. Badr and published by Springer Nature. This book was released on 2021-09-28 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear receptors are ligand activated transcription factors that control numerous biological functions. Consequently, altering activity of these receptors is proposed, and indeed documented, to affect many physiological and pathological conditions in experimental animals and humans. Thus, nuclear receptors have become a major target in the effort to treat numerous diseases. This book will shed light on and emphasize intricate processes involved in designing as well as discovering physiological and pharmacological modulators of these important proteins. World-renowned scientists will share with the reader their professional expertise and extensive experience acquired through decades working with nuclear receptors. Chapters address the various means and consequences of modulating nuclear receptor activity will be presented and discussed. These modulators cover a wide span of moieties ranging from synthetic chemicals to natural products. In addition, the classification of these chemicals ranges from pan agonists to selective agonists and inverse agonists to antagonists. They also include proteolytic means to obliterate the receptor in the event that modulating its activity through canonical pharmacological agents becomes less effective and/or less desirable due to anticipated or experienced toxicities. Modulation of receptor activity may also take place in the absence of a ligand or through manipulating the structure of the receptor itself by controlling posttranslational events.

Download or read book From Structure to Signalosomes New Perspectives About Membrane Receptors and Channels written by Yi Ma and published by Frontiers Media SA. This book was released on 2019-09-19 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Estrogen Receptor and Breast Cancer written by Xiaoting Zhang and published by Humana Press. This book was released on 2019-11-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.

Download or read book Drug Discovery and Development written by Omboon Vallisuta and published by BoD – Books on Demand. This book was released on 2015-06-03 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. The following 5 sections cover diverse chapter topics in drug discovery: Natural Products as Sources of Leading Molecules in Drug Discovery; Oncology and Drug Discovery; Receptors Involvement in Drug Discovery; Management and Development of Drugs against Infectious Diseases; Advanced Methodology.

Download or read book Sigma Receptors Their Role in Disease and as Therapeutic Targets written by Sylvia B. Smith and published by Springer. This book was released on 2017-03-16 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

Download or read book G Protein Coupled Receptors Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: G-Protein-Coupled Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about G-Protein-Coupled Receptors. The editors have built G-Protein-Coupled Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about G-Protein-Coupled Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of G-Protein-Coupled Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Methods in Receptor Research written by Melvin Blecher and published by . This book was released on 1976 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Sigma Receptors written by Rae R. Matsumoto and published by Springer Science & Business Media. This book was released on 2007-02-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.

Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1342 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Download or read book Physics of Biological Action and Perception written by Mark L. Latash and published by Academic Press. This book was released on 2019-09-05 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physics of Biological Action and Perception helps researchers interested in exploring biological motor control from a physics or alternative viewpoint perspective. The book introduces the idea of parametric control as a distinguishing feature of living systems. Sections cover how the CNS creates stable percepts based on fuzzy and continuously changing signals from numerous receptors and the variable processes related to ongoing actions. The author also develops the idea of control with referent coordinates to stability of salient variables in fields typically united under the label of "cognition." Examples of this include communication (how the gist of a message is preserved despite variability of phrases), thought processes (how one can solve a mental problem via different logical routes), and playing chess (how one selects an optimal move given a position on the board). The book is written for researchers, instructors, clinicians and other professionals in all the fields related to biological movement and perception. Presents a unifying theory of motor control based on physics Encompasses action, perception and cognition Discusses referent coordinates, kinesthetic perception and stability of actions Identifies the importance of the CNS over computational brain function

Download or read book D1 D2 Dopamine Receptor Interactions written by John L. Waddington and published by . This book was released on 1993 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents up-to-date comprehensive reviews of neuroscience research and theory on the fundamental interactions between the D1 and D2 dopamine receptor subtypes at numerous levels of investigation-from molecular biology and neuroanatomy, through electrophysiology, to the psychopharmacology of multiple forms of behavior, putative clinical significance, and therapeutic potential. This volume seeks to stand as a reference source on the evolution of the concept of D1: D2 interactions, on their substrates and psychopharmacological roles and, in such a continually evolving field, to look to the future. The Neuroscience Perspectives series aims to provide an all-round view of a current topic of great interest in neuroscience from the biochemical, pharmacological, and physiological standpoints together with the potential therapeutic applications. * SPECIAL FEATURES: * This is the ninth in Neuroscience Perspectives. * A Volume in Neuroscience Perspectives following series aim of providing all-round view of a current topic of great interest in Neuroscience from the biochemical, pharmacological and physiological standpoints together with the potential therapeutic applications. * The brain dopamine receptor has been the subject of intense interest for the past ten years owing to its involvement in motor and psychotic conditions. It is the target for the development of potential new drugs for eg. Schizophrenia and Parkinsons Diseases. Two subtypes of receptor have been found (D1 and D2). This book, edited by a respected expert in the field, examines the history of the topic, biochemistry, molecular biology and mode of interaction of the subtypes, and the therapeutic potential of the scientific discoveries, in the format of Neuroscience Perspectives. An issue of Nature in October 1990 led with the reported discovery of a D3 receptor. The implications of this for future research will be discussed in the final chapter.

Download or read book Reproductive and Developmental Toxicology written by Kenneth S . Korach and published by CRC Press. This book was released on 1998-03-27 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti