Download or read book Peripheral Nerve Regeneration written by Ana Colette Maurício and published by BoD – Books on Demand. This book was released on 2017-05-31 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.
Download or read book Peripheral Nerve Regeneration From Surgery to New Therapeutic Approaches Including Biomaterials and Cell Based Therapies Development written by and published by . This book was released on 19?? with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peripheral Nerve Regeneration written by Giovanna Gambarotta and published by Frontiers Media SA. This book was released on 2019-12-24 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modern Concepts of Peripheral Nerve Repair written by Kirsten Haastert-Talini and published by Springer. This book was released on 2017-06-19 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on posttraumatic repair and reconstruction of peripheral nerves. Written by internationally respected specialists, it provides an overview of the challenges and the latest advances in diagnosis and treatment of traumatic peripheral nerve injuries. It presents an outline of state-of the-art procedures from diagnostics, including newest imaging techniques, over conventional and alternative surgical approaches to clinical follow-up and rehabilitation, including the latest concepts to improve functional recovery. The purely clinical topics are preceded by neuroanatomical principles and neurobiological events related to peripheral nerve transection injuries and followed by an outlook on current experimental developments in the area of biomaterials for artificial nerve grafts and peripheral nerve tissue engineering. Peripheral nerve injuries not only affect the nerve tissue at the site of injury, but also target tissue and parts of the central nervous system. They often have dramatic consequences for patients, including loss of sensory and motor functions combined with paresthesia or pain, and a reduced quality of life and ability to work. An adequate understanding of the procedures for proper decision-making and reconstructing peripheral nerves is therefore essential to ensure optimized functional recovery.
Download or read book Tissue Engineering of the Peripheral Nerve Biomaterials and Physical Therapy written by and published by Academic Press. This book was released on 2013-10-01 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of International Review of Neurobiology brings together cutting-edge research on tissue engineering of the peripheral nerve. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery. This volume covers the cutting-edge research on tissue engineering of the peripheral nerve
Download or read book Peripheral Nerve Tissue Engineering and Regeneration written by James B. Phillips and published by Springer. This book was released on 2022-05-26 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.
Download or read book Mesenchymal Stem Cells written by Phuc Van Pham and published by BoD – Books on Demand. This book was released on 2017-11-29 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal Stem Cells: Isolation, Characterization, and Applications thoroughly presents the isolation, characterization, and some applications of mesenchymal stem cells in the clinic. The book has two parts: "Isolation and Characterization" and "Clinical Perspectives and Applications." In Part I, the subsequent chapters introduce some techniques in isolation, characterization, and purification of mesenchymal stem cells in different tissues. In Part II, some applications of mesenchymal stem cells in the popular diseases, which include cartilage regeneration, spinal cord injury, and osteoarthritis, are discussed. This book provides a succinct yet comprehensive overview of mesenchymal stem cells for advanced students, graduate students, and researchers.
Download or read book Principles of Regenerative Medicine written by Anthony Atala and published by Academic Press. This book was released on 2010-12-16 with total page 1202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs
Download or read book Cells and Biomaterials for Intervertebral Disc Regeneration written by Sibylle Grad and published by Springer Nature. This book was released on 2022-06-01 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration
Download or read book Peripheral Nerve Tissue Engineering and Regeneration written by James Phillips and published by Springer. This book was released on 2022-07-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.
Download or read book Cells and Biomaterials for Intervertebral Disc Regeneration written by Sibylle Grad and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disorders related to the intervertebral disc (IVD) are common causes of morbidity and of severe life quality deterioration. IVD degeneration, although in many cases asymptomatic, is often the origin of painful neck and back diseases. In Western societies IVD related pain and disability account for enormous health care costs as a result of work absenteeism and thus lost production, disability benefits, medical and insurance expenses. Although only a small percentage of patients with disc disorders finally will undergo surgery, spinal surgery has been one of the fastest growing disciplines in the musculoskeletal field in recent years. Nevertheless, current treatment options are still a matter of controversial discussion. In particular, they hardly can restore normal spine biomechanics and prevent degeneration of adjacent tissues. While degeneration affects all areas of the IVD, the most constant and noticeable changes occur in the gel-like central part, the nucleus pulposus (NP). Recent emphasis has therefore been put in biological ways to regenerate the NP; however, there are a number of obstacles to overcome, considering the exceptional biological and biomechanical environment of this tissue. Different biological approaches such as molecular, gene, and cell based therapies have been investigated and have shown promising results in both in vitro and in vivo studies. Nonetheless, considerable hurdles still exist in their application for IVD regeneration in human patients. The choice of the cells and the choice of the cell carrier suitable for implantation pose major challenges for research and development activities. This lecture recapitulates the basics of IVD structure, function, and degeneration mechanisms. The first part reviews the recent progress in the field of disc and stem cell based regenerative approaches. In the second part, most appropriate biomaterials that have been evaluated as cell or molecule carrier to cope with degenerative disc disease are outlined. The potential and limitations of cell- and biomaterial-based treatment strategies and perspectives for future clinical applications are discussed. Table of Contents: Cell Therapy for Nucleus Pulposus Regeneration / Recent Advances in Biomaterial Based Tissue Engineering for Intervertebral Disc Regeneration
Download or read book Cellular Biological Approaches to Treating Peripheral Nerve Injuries written by P. J. Kingham and published by . This book was released on 2015-05-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functional recovery after peripheral nerve injury is poor, and it has become clear that surgical reconstruction should be combined with novel therapies which address the problems of the limited rate and quantity of axonal regeneration, neuronal cell death and target organ atrophy. There is significant scope for the application of cellular and biological approaches towards peripheral nerve repair. This special topics issue begins with an introduction to the importance of Schwann cell-axon interactions which is followed by a series of papers highlighting the exciting therapeutic potential of various cell types including skin, adipose, bone marrow and hair follicle-derived adult stem cells, induced pluripotent stem cells and olfactory ensheathing cells. Another biological approach, the use of chondroitinase to overcome nerve scarring, is also described. Finally, noninvasive imaging methods, which will be necessary to determine the efficacy of these novel treatments, are reviewed. The publication will be of interest to a large number of interdisciplinary scientists including cell biologists, biomaterials scientists and chemists as well as surgeons who are involved in translational research aimed at improving the treatment of peripheral nerve injury.
Download or read book Indwelling Neural Implants written by William M. Reichert and published by CRC Press. This book was released on 2007-12-17 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Download or read book Advances in Nanostructured Materials and Nanopatterning Technologies written by Vincenzo Guarino and published by Elsevier. This book was released on 2020-02-11 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nanostructured Materials and Nanopatterning Technologies: Applications for Healthcare, Environment and Energy demonstrates how to apply micro- and nanofabrication and bioextrusion based systems for cell printing, electrophoretic deposition, antimicrobial applications, and nanoparticles technologies for use in a range of green industry sectors, with an emphasis on emerging applications. Details strategies to design and realize smart nanostructured/patterned substrates for healthcare and energy and environmental applications Enables the preparation, characterization and fundamental understanding of nanostructured materials for promising applications in health, environmental and energy related sectors Provides a broader view of the context around existing projects and techniques, including discussions on potential new routes for fabrication
Download or read book Nerve Surgery written by Susan E. Mackinnon and published by Georg Thieme Verlag. This book was released on 2015-04-15 with total page 1464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Representing the treatment and management philosophy of Dr. Susan Mackinnon, Nerve Surgery provides extensive coverage of innovative surgical options as well as guidance on the management of complicated compression neuropathies. In addition to detailed information on tried-and-true as well as cutting-edge surgical techniques, it contains chapters on the basic principles of nerve surgery, such as "Anatomy and Physiology for the Peripheral Nerve Surgeon" and "Evaluation of the Patient with Nerve Injury or Nerve Compression." Key Features: More than 850 compelling full-color figures and photographs demonstrate key concepts Videos narrated by Dr. Mackinnon are available online Coverage of important conditions that can be treated non-operatively, such as neurogenic thoracic outlet syndrome and multilevel compression neuropathy Strategies and secondary procedures for failed nerve surgeries Dr. Mackinnon provides tips on how she manages complicated pain problems This book is a core reference for all plastic surgeons, neurosurgeons, orthopedic surgeons, hand surgeons, residents, and allied health specialists treating patients with nerve injuries.
Download or read book Peripheral Nerve Disorders and Treatment written by Hande Turker and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathies are one of the main neurological problems in everyday life, and they still have many partially understood parts and unknowns both for physicians and patients. Many systemic conditions may exist within them and therefore they may be difficult to treat. In this book we provide current knowledge concerning neuropathies, which we believe you will find interesting. The subject ‘’neuropathies’’ comprises a number of topics, and each and every one could be the subject of a textbook. On the other hand, this book was never designed as one. This book should be read without prejudgment because the content may not be compatible with general but repeated assumptions and guidelines. However, I believe that the book may be an inspiration for many young investigators as well. It contains current approaches and knowledge and we sincerely believe and hope that it will answer your queries regarding new perspectives about neuropathy in general.
Download or read book Surgical Disorders of the Peripheral Nerves written by Rolfe Birch and published by Springer Science & Business Media. This book was released on 2011-01-21 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the highly praised first edition of Surgical Disorders of the Peripheral Nerves was published in 1998, greater understanding of the the molecular and cellular events which underlie the response of nerves to injury, regeneration and neuropathic pain has been achieved. This second edition has been fully updated in line with new clinical knowledge, and also incorporates the extensive study of thousands of surgical case studies spanning repairs of the supraclavicular plexus in the adult, the birth lesion of the brachial plexus,compound nerve injury and iatrogenous injury. Beginning with the fundamentals of the anatomy and function of the peripheral nervous system, and working its way through various types of injury, operative methods, the regeneration and recovery of nerves, surgical reconstruction, pain, and rehabilitation, this eloquently written work provides the reader with the solid understanding required to successfully perform surgery on the peripheral nervous system. Dr Shelagh Smith, joined by Dr Ravi Knight, has rewritten the chapter Electrodiagnosis. Professor Tara Renton has written a new chapter on injuries to the trigeminal nerve in maxilla-facial and dental work. The drawings, by Mr Philip Wilson, are new. Most of the 700 illustrations are also new. This thorough and authoritative look at the surgical treatment of the peripheral nerves is fully illustrated throughout with exquisite line diagrams and clear, instructive photographs.
