Download or read book The Benzodiazepines Crisis written by John Peppin and published by Oxford University Press. This book was released on 2020-10-01 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed decades ago to treat a legitimate medical need, benzodiazepines promisingly displaced less-effective and less-safe drugs, though prescribing has since exceeded their intended use and outpaced the available data. The current situation is characterized by excessive prescribing and extended utilization beyond good therapeutic practice. Evidence indicates that prolonged use of benzodiazepines causes a wide range of adverse reactions, and withdrawal can be particularly challenging. Misused, abused, diverted, and counterfeited, benzodiazepines have serious potential for substance use disorder, and are among the leading causes of drug-related overdose deaths. The Benzodiazepines Crisis sounds the alarm against the overuse of benzodiazepines, presenting an updated, evidence-based overview of this class of drugs and their negative consequences. Bringing together years of research, clinical expertise, and scientific evidence, this book aims to address a perceived lag between evidence and action in order to call for rational and dramatically reduced usage of benzodiazepines.

Download or read book Translocator Protein TSPO written by Giovanni Natile and published by MDPI. This book was released on 2018-03-05 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS

Download or read book The Benzodiazepine Receptor written by Walter Erhard Müller and published by Cambridge University Press. This book was released on 1987-12-10 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Benzodiazepines are the most commonly used psychotropic drugs, prescribed for their action as tranquillizers, hypnotics and anti-epileptics. They act in the brain by binding to specific, highly selective recognition sites, the benzodiazepine receptors. This book, first published in 1987, summarises our knowledge of these receptors for a student and professional audience and is divided into two sections. In the first part, the general properties of the receptors and their involvement in the mechanisms of action of benzodiazepines are described. The second part discusses the function of the receptors and concludes that the system represents a novel neuronal system for the fine adjustment of brain function or for auxiliary function if the other neuronal systems fail owing to pathological defects.

Download or read book Sleep and Sleep Disorders written by Malcolm Lader and published by Springer Science & Business Media. This book was released on 2009-11-06 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many recent discoveries in both laboratory and clinical settings have greatly increased our understanding of sleep medicine and the relevant psychopharmacology. This timely book serves to present updated information about the neuropsychopharmacology of sleep as this field enters mainstream psychiatry, neurology and medicine This volume has assembled articles that summarize and review carefully, a chosen selection of the latest discoveries concerning sleep medicine, sleep physiology and sleep pharmacology. Outstanding contributions have been sought from acknowledged experts in their respective fields. The goal of the volume is to present the more recent developments and advances in the fields of sleep and neuropsychopharmacology, as well as to provide a context for considering them both in depth and from multidisciplinary perspectives. This volume brings together the collective expertise of clinicians and basic researchers who represent a range of interests in neuroscience, neuropharmacology, sleep physiology, and biological rhythms. Presenting a thoughtful balance of basic experimental and clinical facts and viewpoints, this book will serve as a foundation for understanding, and ultimately treating, sleep disorders.

Download or read book Naturally Occurring Benzodiazepines written by Ivan Izquierdo and published by CRC Press. This book was released on 1993-01-01 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: An exploration of benzodiazepines (BZDs), including the widely-used drug Valium, which have been in wide circulation in clinical practice since the 1960s as sedatives, antidepressants, hypnotics and anticonvulsants. It reveals research results with naturally-occurring BZDs in plants and animals.

Download or read book Peripheral Benzodiazepine Receptors written by Eva Giesen-Crouse and published by Academic Press. This book was released on 1993-05-05 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences. Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas. Although peripheral type benzodiazepne recognition sites have been demonstrated in the brain and peripheral organs of various species for more than 10 years, the exact physiological function or pharmacological effects have not yet been established. Peripheral benzodiazepine literature is so overwhelming that the novice may find it virtually impossible to form a clear idea about the diverse findings. This volume, dedicated exclusively to pBR and their natural and synthetic ligands, puts the available data into perspective. A truly interdisciplinary approach has brought neuroscientists, cardiologists, endocrinologists, and immunologists together to work on the description of pBR-mediated effects. The chemistry, biochemistry, and molecular biology of the pBR receptor and its ligands are reviewed, their pharmacological usefulness is conjectured, and thus a true overview of the field is provided. * SPECIAL FEATURES * This volume follows the Neuroscience Perspectives brief of providing a historical background, pharmacological, biochemical and physiological aspects of research and therapeutic potential, of its chosen topic. * The peripheral benzodiazepine recognition site has been recognised for more than ten years, but the exact physiological and pharmacological effects have not yet been established.

Download or read book Handbook of Sleep Disorders in Medical Conditions written by Josee Savard and published by Academic Press. This book was released on 2019-03-14 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Sleep Disorders in Medical Conditions reviews the current knowledge on the nature and manifestations of sleep disorders associated with a variety of common medical conditions, including epilepsy, traumatic brain injury and dementia. It also provides clinical guidelines on how to assess and treat them with pharmacological and non-pharmacological interventions. Although the general principles of sleep medicine may be applied to some extent to patients with comorbid medical conditions, this book makes the case that an adaptive approach is warranted when considering the particularities of each condition. In addition, clinicians must also be cautious when prescribing sleep medications as some pharmacological agents are known to exacerbate symptoms associated with the medical condition, such as cognitive deficits (i.e. difficulties with memory and attention) in cancer patients experiencing chemo brain, or in persons with neurologic conditions (e.g. mild cognitive impairment, dementia, stroke, brain injury). A differential approach to evaluating and treating sleep is thus warranted. - 2020 PROSE Awards - Winner: Category: Textbook/Medicine and Clinical Science: Association of American Publishers - Presents a general overview on assessing and treating sleep disorders that are applicable to a diverse set of patients - Provides a comprehensive, up-to-date review of the literature on the prevalence and manifestations of sleep problems related to specific medical conditions - Includes practical information regarding special considerations for the assessment and treatment of sleep issues in specific medical conditions - 2020 PROSE Award Subject Winner in Textbook/Medicine and Clinical Science (Association of American Publishers)

Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.

Download or read book Clinical Psychopharmacology written by Prakash B. Behere and published by Springer. This book was released on 2018-10-31 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides practical information on how to use various psychotropic drugs in clinical practice, focusing on their mechanisms of action on receptors and enzymes in the brain. Divided into 11 chapters, it covers all main drug classes, with a dedicated chapter each on special populations and upcoming drugs. All the drugs discussed are presented in the same design format in order to facilitate rapid access to information. Specifically, each drug is individually divided into sections - its history and introduction, classification, pharmacological action, doses, drug interactions, indications, side effects and special populations. Only the essential facts about each drug have been included, so as to make the content concise and to avoid dilution of important information. To aid with review, key points are summarized at the end of each chapter.

Download or read book Seminars in Addiction Psychiatry written by Ed Day and published by Cambridge University Press. This book was released on 2021-11-04 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive coverage of the theory, practical understanding and management of the psychiatric aspects of drug and alcohol use and dependence.

Download or read book Benzodiazepine Receptor Inverse Agonists written by Martin Sarter and published by Wiley-Liss. This book was released on 1995-01-23 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive overview of the biochemical, pharmacological and behavioral research on benzodiazepine receptor (BZR) inverse agonists. Emphasis is given to psychopharmacological potential (including cognitive and motivational enhancement) andtreatment applications (ethanol-antagonism, movement disorders, head injury). The book contains black-and-white illustrations.

Download or read book Encephalopathy and Nitrogen Metabolism in Liver Failure written by E. Anthony Jones and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encephalopathy and Nitrogen Metabolism in Liver Failure contains research reports and state-of-the-art reviews that were presented at the 11th International Symposium on Hepatic Encephalopathy and Nitrogen Metabolism in relation to liver disease, that was held in Amsterdam, The Netherlands from 30 May to 1 June, 2002. Themes covered include the metabolism of ammonia and amino acids in relation to liver disease, the assessment of hepatic encephalopathy (HE), minimal HE, animal models of HE, neuropsychiatric dysfunction in patients with chronic liver disease, the pathogenesis of HE, the astrocyte in liver disease, acute liver failure and cerebral edema, treatment of HE and artificial liver support systems. This volume provides an indispensable source of important new research findings and ideas for clinicians and biomedical scientists working in the field of HE and nitrogen metabolism in relation to liver disease.

Download or read book Peripheral Benzodiazepine Receptors in Prostate and Prostatic Tumors written by Jan Alenfall and published by . This book was released on 1995 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Radiopharmaceuticals and Brain Pathophysiology Studied with Pet and Spect written by M. Diksic and published by CRC Press. This book was released on 1990-11-30 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers three major areas essential to in vivo biochemical studies with PET and SPECT: synthesis of radiopharmaceuticals, biological modeling, and clinical applications. The book emphasizes advances in the synthesis of radiopharmaceuticals used in PET and SPECT studies of brain flow and oxidatative metabolism, in addition to biological modeling. The most widely used 2-deoxyglucose/2-fluorodeoxyglucose models are discussed, as well as models used in the quantitation of brain receptors. Other topics include a possible model for converting 6-[18F] fluorodopa images into the quantitative rate of dopamine synthesis, evaluations of technetium- and iodine-labeled blood flow tracers, and possibilities for using SPECT to measure other pathophysiological variables. This book will be a valuable reference source to students and specialists interested in these in vivo measurements.

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Download or read book Neurosteroids written by Etienne-Emile Baulieu and published by Springer Science & Business Media. This book was released on 1999-07-23 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.

Download or read book Molecular Steroidogenesis written by Mitsuhiro Okamoto and published by . This book was released on 2000 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: