Download or read book Peptides in Oncology written by and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peptides in Oncology III written by K. Höffken and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interference with protein-mediated intra- and intercellular pathways has become a major goal of preclinical and clinical research. A, rapidly increasing numBer of peptides are known to be responsible for endo-, para-and autocrine sig nal transduction. These peptides and their receptors have been studied with regard to their cell growth stimulatory ac tion and their impact on differentiation. In parallel, peptide antagonists are being investigated in terms of their potential role in preclinical and clinical application. Thus, biotherapy might improve the clinical outcome of patients with tumors that respond to the respective hormonal manipulation. Among the numerous peptides of interest somatostatin (somatotropin release inhibitory factor) and the luteinizing hormone releasing hormone (LH-RH) have been the topic of intensive research during recent years. In this third vol ume of peptides in oncology, experts in the field exten sively review and update the mechanisms of action of so matostatin and LH -RH -analogues in oncology. Somatostatin and its various short-and long-acting ana logues have the unique feature of suppressing and inhibit ing a wide range of cellular processes including cell prolif eration. Receptors for these peptides which belong to the family of neuropeptides or neurotransmitters, are widely distributed, a feature which is not in keeping with the gen eral view of a growth hormone regulatory system. LH -RH analogues play an established role in curative (adjuvant) and palliative treatment of hormone sensitive tumors."
Download or read book Delivery Of Protein And Peptide Drugs In Cancer written by Vladimir P Torchilin and published by World Scientific. This book was released on 2006-04-05 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading scientists in the field of delivery of protein and peptide drugs to tumors for cancer therapy, this important book provides a broad introduction to the field, with discussion by key experts on the physiological barriers for protein and peptide drugs in tumors, and the different approaches to stabilization of these drugs in biological surroundings, as well as their enhanced delivery to tumors and inside cancer cells.This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, physiology, experimental and clinical oncology and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting as well as in a more specialized topics of using protein and peptide drugs for tumor therapy.Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences.
Download or read book Peptides in Oncology III written by K. Höffken and published by Springer. This book was released on 1999-11-12 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peptide Based Cancer Vaccines written by W. Martin Kast and published by CRC Press. This book was released on 2000-10-01 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of peptide based cancer vaccines has evolved tremendously in the last decade of this century. The exploration on how to apply the peptide knowledge for vaccination purposes began when it was demonstrated that these peptides after being mixed into adjuvants actually induced T cell responses that could prevent virus infections and tumor gro
Download or read book Radionuclide Peptide Cancer Therapy written by Marco Chinol and published by CRC Press. This book was released on 2016-04-19 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering lower toxicity and higher accuracy than conventional therapies, this source offers illustrative coverage of this new method to treat tumors associated with brain, breast, lung, and neuroendocrine cancers. Accompanied by a CD offering color images, radiolabeling procedures, and tips on radiopharmceutical administration, this source will off
Download or read book Peptides in Oncology written by Klaus Höffken and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Peptides in Oncology I written by K. Höffken and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal treatment of malignant diseases has been used for quite some years now, and progress in this field is still being made at a steady pace. The detection of new endocrine feed back loops and the availability of new classes of hormonal agents made hormonal intervention with predictable outcome possible. Besides the intellectual challenge of modulating the hormone system, an important aspect of recent research on hormones and cancer is the reduction of treatment-related morbidity achieved with the new hormonal strategies. Thus, controlled intervention in the hypothalamic-gonadotropic axis is increasingly apt to replace surgical removal of the relevant glands, i. e. , the pituitary gland or the gonads. In the same way as, for example, aromatase inhibitors are being used as a substitute for adrenalectomy. The concept that secretion of hypothalamic gonadotropin releasing hormone (GnRH), pituitary gonadotropins, and sex steroids are regulated via negative and positive feedback loops is based on the pioneering work of Hohlweg and Harris some 40 years ago. In 1971, a breakthrough was achieved with the isolation, structural analysis, and synthesis of the luteinizing hormone releasing hormone (LH-RH), or GnRH as it is now more appropriately termed, since it provokes the secretion of both gonadotropins, LH and FSH, and since then the progress made in this area of research has been remarkable. Both ago nists and antagonists of LH-RH have been synthesized and extensively studied in preclinical and clinical settings.
Download or read book Peptidomics of Cancer Derived Enzyme Products written by and published by Academic Press. This book was released on 2017-10-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptidomics of Cancer-Derived Enzyme Products, Volume 42, the latest in The Enzymes series, is ideal for researchers in biochemistry, molecular and cell biology, pharmacology, and cancer, with this volume featuring high-caliber, thematic articles on the topic of peptidomics of cancer-derived enzyme products. Specific chapters cover Circulating peptidome and tumor-resident proteolysis, Colon tumor secretopeptidome, Chemoenzymatic method for glycomics, Human plasma peptidome for pancreatic cancer, Lipoproteomics and quantitative proteomics, Salivaomics: Protein markers/extracellular RNA/DNA in saliva, and Enzyme-responsive vectors for cancer therapy.
Download or read book Peptides and Non Peptides of Oncologic and Neuroendocrine Relevance written by E.E. Müller and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the ability of a series of endocrine-derived compounds, i.e. CHRH, LHRH, somatostatin, anti-androgens, and aromatase inhibitors to exert a direct anti-neoplastic activity or to potentiate the activity of traditional chemotherapeutic agents on neuroendocrine and solid tumors. In addition, a new class of potent GH-releasers, GSHs/Ghrelin, endowed with important endocrine and extra-endcocrine action, is presented. Therefore, in addition to traditional chemotherapy, characterized by high toxicity and non-selective action on tumoral cells, the reader can find a new approach with more selective, less cytotoxic endocrine derived compounds.
Download or read book Multifunctional Theranostic Nanomedicines in Cancer written by Malay K. Das and published by Academic Press. This book was released on 2021-03-16 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Theranostic Nanomedicines in Cancer focuses on new trends, applications, and the significance of novel multifunctional nanotheranostics in cancer imaging for diagnosis and treatment. Cancer nanotechnology offers new opportunities for cancer diagnosis and treatment. Multifunctional nanoparticles harboring various functions—including targeting, imaging, and therapy—have been intensively studied with the goal of overcoming the limitations of conventional cancer diagnosis and therapy. Thus theranostic nanomedicines have emerged in recent years to provide an efficient and safer alternative in cancer management. This book covers polymer-based therapies, lipid-based therapies, inorganic particle-based therapies, photo-related therapies, radiotherapies, chemotherapies, and surgeries. Multifunctional Theranostic Nanomedicines in Cancer offers an indispensable guide for researchers in academia, industry, and clinical settings; it is also ideal for postgraduate students; and formulation scientists working on cancer. Provides a comprehensive resource of recent scientific progress and novel applications of theranostic nanomedicines Discusses treatment options from a pharmaceutical sciences perspective Includes translational science and targeted CNS cancer treatment
Download or read book Unravelling Cancer Signaling Pathways A Multidisciplinary Approach written by Kakoli Bose and published by Springer Nature. This book was released on 2019-11-25 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unravelling the intricate cell signalling networks and their significance in cancer poses major intellectual challenge. Keeping this in mind, the book aims at understanding the mechanism of action of different proteins and their complexes in the cancer signalling pathways. Hence, the proposed book that comprises 20 chapters provides a comprehensive introduction on cell signalling, its alterations in cancer, molecules that have been popular targets as well as the ones that are emerging as targets. In addition, it discusses different forms of therapy that are coming up for its treatment. Other than that, a major portion of the book is focused on studying different disciplines at the interface of biology and other areas of science that are being used to understand cancer biology in depth.
Download or read book Monoclonal Antibody and Peptide Targeted Radiotherapy of Cancer written by Raymond M. Reilly and published by John Wiley & Sons. This book was released on 2010-12-28 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncology Book of 2011, British Medical Association's Medical Book Awards Awarded first prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.
Download or read book Peptides in Oncology II written by K. Höffken and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second of two volumes presents the state of the art in somatostatin analogues and bombesin antagonists in neoplastic diseases. It provides a detailed description of mechanisms of action and the present clinical relevance of these new approaches in cancer treatment. Each chapter has been prepared by an expert active in the respective experimental and/or clinical field so that the reader is assured of obtaining the latest information on the topic.
Download or read book Somatostatin Analogues written by Alicja Hubalewska-Dydejczyk and published by John Wiley & Sons. This book was released on 2015-06-11 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring chapters from specialists in endocrinology, physiology, pathology, and nuclear medicine, this book provides a multidisciplinary approach to a wide variety of issues concerning somatostatin and its analogues. The book: Provides the most up-to-date coverage of somatostatin analog use in diagnostic and therapy Integrating the specialties of endocrinology, physiology, pathology, and nuclear medicine, providing the multidisciplinary approach to the topic Focuses on future applications, novel compounds, and areas for further research Covers topics by authors who are renowned experts and researchers in the field
Download or read book Encyclopedic Reference of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2001-10-15 with total page 1017 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid and focused information about topics of cancer research for the clinical and basic scientist, students and informed laymen. It will be readily accessible, both electronically and in print, such that it will be of value to both the scientific community and the public.
Download or read book The NPY Family of Peptides in Immune Disorders Inflammation Angiogenesis and Cancer written by Zofia Zukowska and published by Springer Science & Business Media. This book was released on 2006-01-17 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research indicates that the immune system and inflammatory reactions are governed and regulated by powerful neuronal mediators derived from the central and peripheral nervous system. The NPY family of peptides is a diverse group of neuropeptides that acts via multiple receptors, Y1-Y5, which are widespread not only in neurons but also in a variety of non-neural and immune cells. These peptides have been known as important regulators of many essential systems, such as blood pressure and cardiac function, food consumption and energy homeostasis. However, in recent years, they have also become recognized for their role as potent modulators of cell growth and immune functions with broad implications in chronic inflammatory diseases, cancer and angiogenesis. In this book, experts in the field analyze recent evidence supporting the role of NPY family of peptides in regulation of the immune/inflammatory system with special reference to its medical and therapeutic implications.
