Download or read book Patterning the Drosophila Embryonic Central Nervous System written by Jocelyn Ann McDonald and published by . This book was released on 1998 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Generation of Cellular Pattern and Fate in the Drosophila Embryonic Central Nervous System written by James Benjamin Skeath and published by . This book was released on 1993 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Dorsoventral Patterning of the Drosophila Embryonic Central Nervous System written by Guoyan Zhao and published by . This book was released on 2003 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Developmental Neuroscience Patterning and Cell Type Specification in the Developing CNS and PNS written by J. Benito-Sipos and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 45 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Developmental Neuroscience Patterning and Cell Type Specification in the Developing CNS and PNS written by P.A. Kuert and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Morphology and Gene Expression Patterning of Primary and Secondary Neurons in the Drosophila Brain written by Diana Amy Shy and published by . This book was released on 2009 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Development in Drosophila melanogaster written by Gerhard Martin Technau and published by Springer Science & Business Media. This book was released on 2009-01-08 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.
Download or read book Analysis of Axon Guidance in the Embryonic Central Nervous System of Drosophila Melanogaster written by Vicki L. McGovern and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The goal of developmental neurobiology is to understand how a complex nervous system is wired. During development of the central nervous system (CNS) neural connections are assembled in a highly stereotyped fashion. How do axons find their targets with such accuracy? We know that axon migration is direct by attractive and repulsive guidance cues located in the extracellular environment. While many guidance molecules have been identified, we are only just beginning to understand the mechanisms of axon guidance. In order to identify additional genes involved in axon guidance and CNS development we performed a misexpression screen. Using P-elements and the UAS/GAL4 system, transcription of endogenous genes was induced in the embryonic CNS. Misexpression phenotypes were then identified immunohistochemically with two monoclonal antibodies: BP102, a general axon marker, and 1D4, which labels a subset of axon pathways. Over 4100 individual P-element insertion lines were screened. Twenty-five insertions corresponding to 18 genes resulted in misexpression phenotypes. Genes involved in axon guidance, embryonic patterning, and cell cycle regulation were identified. Several transcription factors that have not been previously implicated in CNS development were isolated and characterized as well. The identification of these transcription factors is intriguing since little is known about the transcriptional regulation of axon guidance genes. Additionally, we have studied the regulation of the previously identified guidance molecule Commissureless (Comm). Comm is necessary for proper axon guidance at the CNS midline of the Drosophila embryo. In the absence of Comm, commissural axons fail to cross the midline and instead make ispilateral projections on their respective sides of the midline. Using mosaic analysis, we have identified a cell autonomous neuronal requirement for Comm. Clones containing mutant alleles of comm formed commissural projections at a statistically significant reduced frequency when compared to wild type clones. This result suggests that regulation of Comm expression in neurons is critical for Comm's function in axon guidance at the CNS midline. These studies have both advanced the understanding of the regulation of Comm, and have identified new potential regulators of guidance molecules.
Download or read book The Development of Drosophila Melanogaster written by Michael Bate and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
Download or read book Biology of Drosophila written by Milislav Demerec and published by CSHL Press. This book was released on 1994 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference.
Download or read book Comprehensive Developmental Neuroscience Patterning and Cell Type Specification in the Developing CNS and PNS written by T. Stork and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 59 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Patterning sensory axon projections in the Drosophila embryonic nervous system written by Louise Matilda Christie Block and published by . This book was released on 2001 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetic Mechanisms Regulating the Spatiotemporal Modulation of Proliferation Rate and Mode in Neural Progenitors and Daughter Cells during Embryonic CNS Development written by Behzad Yaghmaeian Salmani and published by Linköping University Electronic Press. This book was released on 2018-05-09 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central nervous system (CNS) is a hallmark feature of animals with a bilateral symmetry: bilateria and can be sub-divided into the brain and nerve cord. One of the prominent properties of the CNS across bilateria is the discernible expansion of its anterior part (brain) compared with the posterior one (nerve cord). This evolutionarily conserved feature could be attributed to four major developmental agencies: First, the existence of more anterior progenitors. Second, anterior progenitors are more proliferative. Third, anterior daughter cells, generated by the progenitors, are more proliferative. Forth, fewer cells are removed by programmed cell death (PCD) anteriorly. My thesis has addressed these issues, and uncovered both biological principles and genetic regulatory networks that promote these A-P differences. I have used the Drosophila and mouse embryonic CNSs as model systems. Regarding the 1st issue, while the brain indeed contains more progenitors, my studies demonstrate that this only partly explains the anterior expansion. Indeed, with regard to the 2nd issue, my studies, on both the Drosophila and mouse CNS, demonstrate that anterior progenitors divide more extensively. Concerning the 3rd issue, in Drosophila we identified a gradient of daughter proliferation along the AP axis of the developing CNS with brain daughter cells being more proliferative. Specifically, in the brain, progenitors divide to generate a series of daughter cells that divide once (Type I), to generate two neurons or glia. In contrast, in the nerve cord, progenitors switch during later stages, from first generating dividing daughters to subsequently generating daughters that directly differentiate (Type 0). Hence, nerve cord progenitors undergo a programmed Type I->0 proliferation switch. In the Drosophila posterior CNS, this switch occurs earlier and is more prevalent, contributing to the generation of smaller lineages in the posterior regions. Similar to Drosophila, in the mouse brain we also found that progenitor and daughter cell proliferation was elevated and extended into later developmental stages, when compared to the spinal cord. DNA-labeling experiments revealed faster cycling cells in the brain when compared to the nerve cord, in both Drosophila and mouse. In both Drosophila and mouse, we found that the suppression of progenitor and daughter proliferation in the nerve cord is controlled by the Hox homeotic gene family. Hence, the absence of Hox gene expression in the brain provides a logical explanation for the extended progenitor proliferation and lack of Type I->0 switch. The repression of Hox genes in the brain is mediated by the histonemodifying Polycomb Group complex (PcG), which thereby is responsible for the anterior expansion. With respect to the 4th issue, we found no effect of PCD on anterior expansion in Drosophila, while this cannot be asserted for the mouse embryonic neurodevelopment as there are no genetic tools to abolish PCD effectively in mammals. Taken together, the studies presented in this thesis identified global and evolutionarily-conserved genetic programs that promote anterior CNS expansion, and pave the way for understanding the evolution of size along the anterior-posterior CNS axis.
Download or read book The Embryonic Development of Drosophila melanogaster written by Jose A. Campos-Ortega and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: " . . . but our knowledge is so weak that no philosoph er will ever be able to completely explore the nature of even a fly . . . " * Thornas Aquinas "In Syrnbolurn Apostolorum" 079 RSV p/96 This is a monograph on embryogenesis of the fruit fly Drosophi la melanogaster conceived as a reference book on morphology of embryonie development. A monograph of this extent and con tent is not yet available in the literature of Drosophila embryolo gy, and we believe that there is areal need for it. Thanks to the progress achieved during the last ten years in the fields of devel opmental and molecular genetics, work on Drosophila develop ment has considerably expanded creating an even greater need for the information that we present here. Our own interest for wildtype embryonie development arose several years ago, when we began to study the development of mutants. While those studies were going on we repeatedly had occasion to state in sufficiencies in the existing literature about the embryology of the wildtype, so that we undertook investigating many of these problems by ourselves. Convinced that several of our colleagues will have encountered similar difficulties we decided to publish the present monograph. Although not expressely recorded, Thomas Aquinas probably referred to the domestic fly and not to the fruit fly. Irrespective of which fly he meant, however, we know that Thomas was right in any case.
Download or read book Transcriptional Regulation in the Embryonic Central Nervous System of Drosophila written by Robert Graham Franks and published by . This book was released on 1994 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genes and Mechanisms Underlying the Development of Dendrites in the Central Nervous System of the Drosophila Embryo written by Barbara Chwalla and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Determinants of Neuronal Identity written by Marty Shankland and published by Academic Press. This book was released on 2012-12-02 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Determinants of Neuronal Identity brings together studies of a wide range of vertebrate and invertebrate organisms that highlight the determinants of neuronal identity. Emphasis of this book is on how neurons are generated; how their developmental identities are specified; and to what degree those identities can be subsequently modified to meet the changing needs of the organism. This book also considers various techniques used in the analysis of different organisms. This volume is comprised of 15 chapters; the first of which introduces the reader to the specification of neuronal identity in Caenorhabditis elegans. The discussion then turns to neurogenesis and segmental homology in the leech, as well as intrinsic and extrinsic factors influencing the development of Retzius neurons in the leech nervous system. Drosophila is discussed next, with particular reference to neuronal diversity in the embryonic central nervous system, cell choice and patterning in the retina, and development of the peripheral nervous system. Other chapters explore endocrine influences on the postembryonic fates of neurons during insect metamorphosis; neuron determination in the nervous system of Hydra and in the mammalian cerebral cortex; and segregation of cell lineage in the vertebrate neural crest. This book will help scientists and active researchers in synthesizing a conceptual framework for further studies of neuronal specification.
