Download or read book Pathogenesis Diagnostics Treatments of Mycobacterium tuberculosis and Its co Infection with HIV or SARS CoV 2 written by Amit Singh and published by Frontiers Media SA. This book was released on 2024-01-30 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is the major cause of tuberculosis (TB) across the globe. Around one-fourth of the world’s population is infected with TB asymptomatically. Longer regimen of anti-TB drugs (longer treatment leading to poor adherence to treatment), interrupted anti-TB drugs treatment (long regimen with incomplete anti-TB treatment), and ineffectiveness of the anti-TB drugs due to the re-emergence of latent TB infections are just a few mechanisms that play a major hindrance to achieving the end of the global TB epidemic by 2035 as WHO plans. The emergence of drug-resistant in Mycobacterium tuberculosis and co-infections with HIV as well as SARS-CoV-2 poses a serious threat to global health agencies. It was reported that the TB cases in India and other endemic countries are two to three times higher than in the last few years. Different mechanisms were acquired by the bacteria to become multidrug-resistant such as an alternation in the target site, drug efflux by overexpression of efflux pumps, inactivation of drugs by enzymes and biofilms. Mechanisms adopted by bacteria and longer anti-tuberculosis treatment regimens are the greatest threat in TB control programs especially in malnourished, immune-compromised, M. tuberculosis co-infection with HIV and SARS-CoV-2 individuals in developing countries. There is a great need for shorter anti-TB regimens and novel drugs with a different mode of action to encounter the emergence of drug resistance in Mycobacterium tuberculosis. Combinatorial drug treatments by anti-TB drugs along with the repurposed drugs are also the novel choice against this deadly TB. The current issue will focus on different mechanisms adopted by mycobacterium to develop multidrug-resistant mycobacteria and the impact of SARS-CoV-2 pandemics in TB treatment and management. Furthermore, the modern techniques used for the early diagnosis and management of M. tuberculosis and its co-infection with HIV and SARS-CoV-2 are the point of innovative interest that shows the potential development in technologies and applications for the management of these co-infections.
Download or read book Disease Control Priorities Third Edition Volume 6 written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Download or read book Case Studies in Infectious Disease Mycobacterium Tuberculosis written by Peter Lydyard and published by Garland Science. This book was released on 2009-12 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Case Studies in Infectious Disease: Mycobacterium tuberculosis presents the natural history of this infection from point of entry of the pathogen through pathogenesis, clinical presentation, diagnosis, and treatment. A set of core questions explores the nature, causation, host response, manifestations, and management of this infectious process. This case also includes summary bullet points, questions and answers, and references.
Download or read book Global Infectious Disease Surveillance and Detection written by Institute of Medicine and published by National Academies Press. This book was released on 2007-11-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early detection is essential to the control of emerging, reemerging, and novel infectious diseases, whether naturally occurring or intentionally introduced. Containing the spread of such diseases in a profoundly interconnected world requires active vigilance for signs of an outbreak, rapid recognition of its presence, and diagnosis of its microbial cause, in addition to strategies and resources for an appropriate and efficient response. Although these actions are often viewed in terms of human public health, they also challenge the plant and animal health communities. Surveillance, defined as "the continual scrutiny of all aspects of occurrence and spread of a disease that are pertinent to effective control", involves the "systematic collection, analysis, interpretation, and dissemination of health data." Disease detection and diagnosis is the act of discovering a novel, emerging, or reemerging disease or disease event and identifying its cause. Diagnosis is "the cornerstone of effective disease control and prevention efforts, including surveillance." Disease surveillance and detection relies heavily on the astute individual: the clinician, veterinarian, plant pathologist, farmer, livestock manager, or agricultural extension agent who notices something unusual, atypical, or suspicious and brings this discovery in a timely way to the attention of an appropriate representative of human public health, veterinary medicine, or agriculture. Most developed countries have the ability to detect and diagnose human, animal, and plant diseases. Global Infectious Disease Surveillance and Detection: Assessing the Challenges-Finding Solutions, Workshop Summary is part of a 10 book series and summarizes the recommendations and presentations of the workshop.
Download or read book Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection written by Vishwanath Venketaraman and published by Springer. This book was released on 2018-09-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization, approximately one third of the world’s population is latently infected with Mycobacterium tuberculosis (M. tb [LTBI]), of whom about 9 million have active tuberculosis (TB). It is estimated that approximately 2 million individuals die each year from active TB. An estimated 14.4% of these individuals have HIV and M. tb co-infection. TB has long been known to be one of the leading causes of death in HIV-infected individuals. Recent evidence now indicates that individuals with type 2 diabetes, the elderly, and chronic smokers are also increasingly susceptible to TB infection, the ability of their immune system to fight off active TB infection having been compromised by their condition. This book therefore aims to provide a detailed review of recent advances in the research that involves characterizing the host’s immune responses against TB infection in conditions such as HIV, diabetes, chronic cigarette smoking and aging, and strategies to restore favorable immune responses against this deadly pathogen.
Download or read book WHO Consolidated Guidelines on Tuberculosis written by World Health Organization and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The WHO Consolidated Guidelines on Tuberculosis, Module 4: Treatment - Tuberculosis Care and Support informs health care professionals in Member States on how to improve treatment and care for patients with TB. These guidelines group all recommendations on TB care and support in one document and are complemented by an operational handbook. The guidelines are to be used primarily by national TB programmes, or their equivalents in Ministries of Health, stakeholders and technical organizations working on TB care in the public and private sectors and in the community.
Download or read book Tuberculosis and Co infection with HIV AIDS written by Pranveer Singh and published by Cambridge Scholars Publishing. This book was released on 2019-10-09 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with Tuberculosis in exhaustive detail. It incorporates the most recent research on the disease, and is divided into different sections highlighting the chronological history of its development, global spread, the current scenario in India with regards to the disease, seasonality, co-infection with HIV-AIDS, and the novel combinatorial-therapy with special reference to underprivileged and tribal populations. Avoiding lengthy and irrelevant descriptions, it will help the reader, particularly students, to grasp the facts. The book is supplemented with figures and ray diagrams to allow full visualisation of the concepts discussed.
Download or read book Concomitant Tuberculosis Infection in HIV positive Patients written by Hirdesh Kumari Gupta and published by . This book was released on 2022-11-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Document from the year 2015 in the subject Biology - Micro- and Molecular Biology, grade: A, course: Dept. of Microbiology, MLB Medical college, Jhansi, language: English, abstract: Mycobacterium tuberculosis (TB) and human immune deficiency virus (HIV) infections are two major public health problems in many parts of the world, particularly in many developing countries. TB is the most common opportunistic disease and cause of the death for those infected with HIV. Diagnosis of TB in HIV infected patients may be delayed because of atypical clinical presentation and involvement of inaccessible sites and low sputum smear positivity. Further, there has been an increase in rates of drug resistant tuberculosis, including multi-drug (MDR-TB) and extensively drug resistant TB (XDR-TB), which are difficult to treat and contribute to increased morbidity and mortality. TB is the most common serious opportunistic infection in HIV positive patients and is the manifestation of AIDS in more than 50% of cases in developing countries. TB shortens the survival of patients afflicted with HIV infection, may accelerate the progression of HIV, and is the cause of death in one third of people with AIDS worldwide. While HIV and TB can individually be the major causes for public health threats, the combination of the two has proven to have a far greater impact on the epidemiologic progression and consequently on the global health scene. Although the increased access to highly active antiretroviral therapy (HAART) has led to a reduction in HIV-associated opportunistic infections and hence mortality, but the concurrent management of HIV/TB co-infection remains a serious challenge to the health care delivery system. Discussion on the mechanisms produced by infectious cofactors with impact on disease pathology could shed light on how to design potential interventions that could decelerate disease progression. It is the need of the hour to design strategies against HIV-TB co-infection. Thi
Download or read book SARS MERS and other Viral Lung Infections written by David S. Hui and published by European Respiratory Society. This book was released on 2016-06-01 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Download or read book Re emergence of neglected tropical diseases amid the COVID 19 pandemic Epidemiology transmission mitigation strategies and recent advances in chemotherapy and vaccines written by Ranjan K. Mohapatra and published by Frontiers Media SA. This book was released on 2023-11-09 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mycobacterium Tuberculosis Pathogenesis Infection Prevention and Treatment written by Riccardo Miggiano and published by Mdpi AG. This book was released on 2020-10 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis (MTB) and it represents a persistent public health threat for a number of complex biological and sociological reasons. According to the most recent Global Tuberculosis Report (2019) edited by the World Health Organization (WHO), TB is considered the ninth cause of death worldwide and the leading cause of mortality by a single infectious agent, with the highest rate of infections and death toll rate mostly concentrated in developing and low-income countries. We present here the editorial section to the Special Issue entitled "Mycobacterium tuberculosis Pathogenesis, Infection Prevention and Treatment" that includes 7 research articles and a review. The scientific contributions included in the Special Issue mainly focus on the characterization of MTB strains emerging in TB endemic countries as well as on multiple mechanisms adopted by the bacteria to resist and to adapt to antitubercular therapies.
Download or read book Wildlife and Emerging Zoonotic Diseases The Biology Circumstances and Consequences of Cross Species Transmission written by James E. Childs and published by Springer. This book was released on 2010-11-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers an overview of the processes of zoonotic viral emergence, the intricacies of host/virus interactions, and the role of biological transitions and modifying factors. The themes introduced here are amplified and explored in detail by the contributing authors, who explore the mechanisms and unique circumstances by which evolution, biology, history, and current context have contrived to drive the emergence of different zoonotic agents by a series of related events.
Download or read book Innate and adaptive immunity against tuberculosis infection Diagnostics vaccines and therapeutics written by Zhidong Hu and published by Frontiers Media SA. This book was released on 2024-02-05 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Global Tuberculosis Report 2018 written by World Health Organization and published by World Health Organization. This book was released on 2018-11-20 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO has published a global TB report every year since 1997. The main aim of the report is to provide a comprehensive and up-to-date assessment of the TB epidemic and of progress in prevention diagnosis and treatment of the disease at global regional and country levels. This is done in the context of recommended global TB strategies and targets endorsed by WHO?s Member States and broader development goals set by the United Nations (UN). The 2018 edition of the global TB report was released on 18 September in the lead up to the first-ever UN High Level Meeting on TB on 26 September 2018.
Download or read book Impact of SARS CoV 2 and COVID 19 Pandemic in Pediatrics written by Hulya Bukulmez and published by Frontiers Media SA. This book was released on 2024-01-03 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Essential Tuberculosis written by Giovanni Battista Migliori and published by Springer Nature. This book was released on 2021-07-26 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook covers the full spectrum of tuberculosis-related topics in a comprehensive yet easy-to-follow, readily accessible format. Filling a significant gap in tuberculosis literature, it addresses tuberculosis sensu latu, mirroring the content of the London Queen Mary University tuberculosis Diploma. Covering all aspects related to this condition, from prevention, diagnosis and treatment to public and global health, the book provides a broad overview of tuberculosis management. Further, it includes a wealth of case studies and exercises, making it an essential guide for all staff involved in tuberculosis management. Written by an international and interdisciplinary panel of experts, the book appeals to a broad readership including students, postdoctoral fellows, clinicians, researchers, and nurses, as well as public health officers working in tuberculosis control programs.
Download or read book Guidelines for the Programmatic Management of Drug resistant Tuberculosis written by World Health Organization and published by World Health Organization. This book was released on 2008 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of extensively drug-resistant strains of tuberculosis, especially in countries with a high prevalence of human immunodeficiency virus, is a serious threat to global public health and jeopardizes efforts to effectively control the disease. This publication offers updated recommendations for the diagnosis and management of drug-resistant tuberculosis in a variety of geographical, economic and social settings, and the recording of data that enables the monitoring and evaluation of programs.--Publisher's description.
