Download or read book PAS Proteins Regulators and Sensors of Development and Physiology written by Stephen T. Crews and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status. Not surprising, given these roles, there is intense investigation of the roles of bHLH-PAS proteins in issues of human health including: (1) cancer induction, (2) cancer growth and vascularity, (3) birth defects, including Down syndrome, (4) appetite control and obesity, (5) sleep rhythm disorders, and (6) mental health disorders such as social interactions and learning. PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.
Download or read book Gene Duplication written by Felix Friedberg and published by BoD – Books on Demand. This book was released on 2011-10-21 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Gene Duplication consists of 21 chapters divided in 3 parts: General Aspects, A Look at Some Gene Families and Examining Bundles of Genes. The importance of the study of Gene Duplication stems from the realization that the dynamic process of duplication is the "sine qua non" underlying the evolution of all living matter. Genes may be altered before or after the duplication process thereby undergoing neofunctionalization, thus creating in time new organisms which populate the Earth.
Download or read book The British National Bibliography written by Arthur James Wells and published by . This book was released on 2003 with total page 2248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Gene Expression and Regulation in Mammalian Cells written by Fumiaki Uchiumi and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixty years after the "central dogma," great achievements have been developed in molecular biology. We have also learned the important functions of noncoding RNAs and epigenetic regulations. More importantly, whole genome sequencing and transcriptome analyses enabled us to diagnose specific diseases. This book is not only intended for students and researchers working in laboratory but also physicians and pharmacists. This volume consists of 14 chapters, divided into 4 parts. Each chapter is written by experts investigating biological stresses, epigenetic regulation, and functions of transcription factors in human diseases. All articles presented in this volume by excellent investigators provide new insights into the studies in transcriptional control in mammalian cells and will inspire us to develop or establish novel therapeutics against human diseases.
Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Download or read book Modeling Pas Sensors Through in Silico and Genetic Approaches written by Brenda Rojas (Ph.D.) and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PAS family of transcription factors play vital roles in important physiological processes. Within this family, PAS sensors, with their characteristic domain, are of interest because they modulate circadian rhythms, xenobiotic metabolism, and oxygen homeostasis, in addition to other functions. The PAS domain was named from the three founding members - Period, Aryl hydrocarbon nuclear translocator, and Sim. Structurally, the domain has been labeled in many ways, however we stick to the PAS A and B nomenclature Our central hypothesis is that PAS proteins are part of a network that coordinate physiological responses to stressors through obscure interactions. To test our hypothesis, we worked on the following aims: (1) To develop a lexicon for the structures partaking in PAS-PAS dimerization, we mined the Protein Data Bank for mammalian proteins. This information helped us refine the terminology and showcase differences between PAS A-PAS A and PAS B-PAS B repeat interactions. Moreover, it taught us that PAS proteins interact with other regions outside their PAS counterpart, thus PAS A-PAS B repeat interconnectivity is common. (2) To determine the ability of our yeast system, based on Saccharomyces cerevisiae strain L40, to accommodate steroid receptor signaling, we introduced and activated the mineralocorticoid, androgen, glucocorticoid, and estrogen Îł receptors individually and exposed them to various ligands. Results from these experiments argue for the possibility of turning our L40 system into a "one-cell system" that can accommodate multiple pathways for complex receptor mixtures. (3) To determine dimerization between PAS B repeats in the prototypical AhR:ARNT complex, we again used our L40 system. We found that PAS B repeats are necessary for successful interconnectivity. Additionally, we took advantage of the new AlphaFold and SwarmDock algorithms to predict PAS B interactions between the AhR and ARA9 and ARA3. This work is significant because it also has the potential to detect biomarkers of disease progression that can function as targets for therapeutic treatments and drugs
Download or read book Modeling Pas Sensors Through in Silico and Genetic Approaches written by Brenda Rojas (Ph.D.) and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PAS family of transcription factors play vital roles in important physiological processes. Within this family, PAS sensors, with their characteristic domain, are of interest because they modulate circadian rhythms, xenobiotic metabolism, and oxygen homeostasis, in addition to other functions. The PAS domain was named from the three founding members - Period, Aryl hydrocarbon nuclear translocator, and Sim. Structurally, the domain has been labeled in many ways, however we stick to the PAS A and B nomenclature Our central hypothesis is that PAS proteins are part of a network that coordinate physiological responses to stressors through obscure interactions. To test our hypothesis, we worked on the following aims: (1) To develop a lexicon for the structures partaking in PAS-PAS dimerization, we mined the Protein Data Bank for mammalian proteins. This information helped us refine the terminology and showcase differences between PAS A-PAS A and PAS B-PAS B repeat interactions. Moreover, it taught us that PAS proteins interact with other regions outside their PAS counterpart, thus PAS A-PAS B repeat interconnectivity is common. (2) To determine the ability of our yeast system, based on Saccharomyces cerevisiae strain L40, to accommodate steroid receptor signaling, we introduced and activated the mineralocorticoid, androgen, glucocorticoid, and estrogen Îł receptors individually and exposed them to various ligands. Results from these experiments argue for the possibility of turning our L40 system into a "one-cell system" that can accommodate multiple pathways for complex receptor mixtures. (3) To determine dimerization between PAS B repeats in the prototypical AhR:ARNT complex, we again used our L40 system. We found that PAS B repeats are necessary for successful interconnectivity. Additionally, we took advantage of the new AlphaFold and SwarmDock algorithms to predict PAS B interactions between the AhR and ARA9 and ARA3. This work is significant because it also has the potential to detect biomarkers of disease progression that can function as targets for therapeutic treatments and drugs
Download or read book The Role of the Aryl Hydrocarbon Receptor in Caridac Development and Homeostasis written by Evan A. Thackaberry and published by . This book was released on 2002 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Steroids and Secosteroids in the Modulation of Inflammation and Immunity written by Bidesh Mahata and published by Frontiers Media SA. This book was released on 2022-02-04 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Entomology Abstracts written by and published by . This book was released on 2000 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physiology of the Gastrointestinal Tract written by Hamid M. Said and published by Academic Press. This book was released on 2018-03-08 with total page 1752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal function Presents new information on the brain-gut axis and microbiome Edited by preeminent scientists in the field Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more
Download or read book Endogenous and Exogenous Induction of AHR ARNT Signal Transduction in Human Epidermal Cell Types written by Lisa M. Van Pay and published by . This book was released on 2006 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Function and Regulation of the Two PAS Proteins HIF 1 alpha and PASKIN written by and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genetics Abstracts written by and published by . This book was released on 2000 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Regulation and Function of Two PAS Domain containing Proteins written by Jared P. Rutter and published by . This book was released on 2001 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Function and Regulation of the Two PAS Proteins HIF 1 and PASKIN written by Katrin Eckhardt and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Function and Regulation of the Two PAS Proteins HIF 1 alpha and PASKIN written by Katrin Eckhardt and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
