Download or read book Characterization of Pharmaceutical Nano and Microsystems written by Leena Peltonen and published by John Wiley & Sons. This book was released on 2020-12-21 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn about the analytical tools used to characterize particulate drug delivery systems with this comprehensive overview Edited by a leading expert in the field, Characterization of Pharmaceutical Nano- and Microsystems provides a complete description of the analytical techniques used to characterize particulate drug systems on the micro- and nanoscale. The book offers readers a full understanding of the basic physicochemical characteristics, material properties and differences between micro- and nanosystems. It explains how and why greater experience and more reliable measurement techniques are required as particle size shrinks, and the measured phenomena grow weaker. Characterization of Pharmaceutical Nano- and Microsystems deals with a wide variety of topics relevant to chemical and solid-state analysis of drug delivery systems, including drug release, permeation, cell interaction, and safety. It is a complete resource for those interested in the development and manufacture of new medicines, the drug development process, and the translation of those drugs into life-enriching and lifesaving medicines. Characterization of Pharmaceutical Nano- and Microsystems covers all of the following topics: An introduction to the analytical tools applied to determine particle size, morphology, and shape Common chemical approaches to drug system characterization A description of solid-state characterization of drug systems Drug release and permeation studies Toxicity and safety issues The interaction of drug particles with cells Perfect for pharmaceutical chemists and engineers, as well as all other industry professionals and researchers who deal with drug delivery systems on a regular basis, Characterization of Pharmaceutical Nano- and Microsystems also belongs on bookshelves of interested students and faculty who interact with this topic.
Download or read book Particle Size Analysis In Pharmaceutics And Other Industries Theory And Practice written by Clive Washington and published by CRC Press. This book was released on 1992-06-30 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent major advances in particle size analysis, particularly with regard to its application in the pharmaceutical and related industries, provides justification for this title. It is a book for technicians and senior technicians, project and development managers, and formulation More...development scientists in a wide range of industries, pharmace
Download or read book Particle Size Measurements written by Henk G. Merkus and published by Springer Science & Business Media. This book was released on 2009-01-07 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the practical aspects of particle size measurement: a major difference with existing books, which have a more theoretical approach. Of course, the emphasis still lies on the measurement techniques. For optimum application, their theoretical background is accompanied by quantitative quality aspects, limitations and problem identification. In addition the book covers the phenomena of sampling and dispersion of powders, either of which may be dominant in the overall analysis error. Moreover, there are chapters on the general aspects of quality for particle size analysis, quality management, reference materials and written standards, in- and on-line measurement, definitions and multilingual terminology, and on the statistics required for adequate interpretation of results. Importantly, a relation is made to product performance, both during processing as well as in final application. In view of its set-up, this book is well suited to support particle size measurement courses.
Download or read book Solid State Development and Processing of Pharmaceutical Molecules written by Michael Gruss and published by John Wiley & Sons. This book was released on 2021-11-15 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid State Development and Processing of Pharmaceutical Molecules A guide to the lastest industry principles for optimizing the production of solid state active pharmaceutical ingredients Solid State Development and Processing of Pharmaceutical Molecules is an authoritative guide that covers the entire pharmaceutical value chain. The authors—noted experts on the topic—examine the importance of the solid state form of chemical and biological drugs and review the development, production, quality control, formulation, and stability of medicines. The book explores the most recent trends in the digitization and automation of the pharmaceutical production processes that reflect the need for consistent high quality. It also includes information on relevant regulatory and intellectual property considerations. This resource is aimed at professionals in the pharmaceutical industry and offers an in-depth examination of the commercially relevant issues facing developers, producers and distributors of drug substances. This important book: Provides a guide for the effective development of solid drug forms Compares different characterization methods for solid state APIs Offers a resource for understanding efficient production methods for solid state forms of chemical and biological drugs Includes information on automation, process control, and machine learning as an integral part of the development and production workflows Covers in detail the regulatory and quality control aspects of drug development Written for medicinal chemists, pharmaceutical industry professionals, pharma engineers, solid state chemists, chemical engineers, Solid State Development and Processing of Pharmaceutical Molecules reviews information on the solid state of active pharmaceutical ingredients for their efficient development and production.
Download or read book Determination of particle sizes in the pharmaceutical industry written by Karin Liltorp and published by BoD – Books on Demand. This book was released on 2014-03-03 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: At Particle Analytical, we have been working with determination of particle sizes for the pharmaceutical industry since 2000. Our customers have in general showed a large interest for an introduction to this area from a down-to-earth and practical perspective. The intended readers of this booklet are pharmacists and technicians working with determination of particles sizes. This booklet is not meant as a thorough introduction into theory behind determination of particle sizes, and only a limited number of references will be given: The booklet is primarily based on our own experiences and is a practical introduction to the area with a brief introduction to "why" and "how" in determination of particle sizes.
Download or read book Early Drug Development 2 Volume Set written by Fabrizio Giordanetto and published by John Wiley & Sons. This book was released on 2018-12-10 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: This one-stop reference systematically covers key aspects in early drug development that are directly relevant to the discovery phase and are required for first-in-human studies. Its broad scope brings together critical knowledge from many disciplines, ranging from process technology to pharmacology to intellectual property issues. After introducing the overall early development workflow, the critical steps of early drug development are described in a sequential and enabling order: the availability of the drug substance and that of the drug product, the prediction of pharmacokinetics and -dynamics, as well as that of drug safety. The final section focuses on intellectual property aspects during early clinical development. The emphasis throughout is on recent case studies to exemplify salient points, resulting in an abundance of practice-oriented information that is usually not available from other sources. Aimed at medicinal chemists in industry as well as academia, this invaluable reference enables readers to understand and navigate the challenges in developing clinical candidate molecules that can be successfully used in phase one clinical trials.
Download or read book Powder Sampling and Particle Size Determination written by Terence Allen and published by Elsevier Science Limited. This book was released on 2003 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Important new work in rapidly expanding field of powder technology.
Download or read book Chemical Engineering in the Pharmaceutical Industry written by Mary T. am Ende and published by John Wiley & Sons. This book was released on 2019-04-09 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the important chemical engineering concepts for the development of new drugs, revised second edition The revised and updated second edition of Chemical Engineering in the Pharmaceutical Industry offers a guide to the experimental and computational methods related to drug product design and development. The second edition has been greatly expanded and covers a range of topics related to formulation design and process development of drug products. The authors review basic analytics for quantitation of drug product quality attributes, such as potency, purity, content uniformity, and dissolution, that are addressed with consideration of the applied statistics, process analytical technology, and process control. The 2nd Edition is divided into two separate books: 1) Active Pharmaceutical Ingredients (API’s) and 2) Drug Product Design, Development and Modeling. The contributors explore technology transfer and scale-up of batch processes that are exemplified experimentally and computationally. Written for engineers working in the field, the book examines in-silico process modeling tools that streamline experimental screening approaches. In addition, the authors discuss the emerging field of continuous drug product manufacturing. This revised second edition: Contains 21 new or revised chapters, including chapters on quality by design, computational approaches for drug product modeling, process design with PAT and process control, engineering challenges and solutions Covers chemistry and engineering activities related to dosage form design, and process development, and scale-up Offers analytical methods and applied statistics that highlight drug product quality attributes as design features Presents updated and new example calculations and associated solutions Includes contributions from leading experts in the field Written for pharmaceutical engineers, chemical engineers, undergraduate and graduation students, and professionals in the field of pharmaceutical sciences and manufacturing, Chemical Engineering in the Pharmaceutical Industry, Second Edition contains information designed to be of use from the engineer's perspective and spans information from solid to semi-solid to lyophilized drug products.
Download or read book Solid State Characterization of Pharmaceuticals written by Richard A. Storey and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of solid state characterization is central to the pharmaceutical industry, as drug products are, in an overwhelming number of cases, produced as solid materials. Selection of the optimum solid form is a critical aspect of the development of pharmaceutical compounds, due to their ability to exist in more than one form or crystal structure (polymorphism). These polymorphs exhibit different physical properties which can affect their biopharmaceutical properties. This book provides an up-to-date review of the current techniques used to characterize pharmaceutical solids. Ensuring balanced, practical coverage with industrial relevance, it covers a range of key applications in the field. The following topics are included: Physical properties and processes Thermodynamics Intellectual guidance X-ray diffraction Spectroscopy Microscopy Particle sizing Mechanical properties Vapour sorption Thermal analysis & Calorimetry Polymorph prediction Form selection
Download or read book Pharmaceutical Microscopy written by Robert Allen Carlton and published by Springer Science & Business Media. This book was released on 2011-05-04 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microscopy plays an integral role in the research and development of new medicines. Pharmaceutical Microscopy describes a wide variety of techniques together with numerous practical applications of importance in drug development. The first section presents general methods and applications with an emphasis on the physical science aspects. Techniques covered include optical crystallography, thermal microscopy, scanning electron microscopy, energy dispersive x-ray spectrometry, microspectroscopy (infrared and Raman), and particle size and shape by image analysis. The second section presents applications of these techniques to specific topics of pharmaceutical interest, including studies of polymorphism, particle size and shape analysis, and contaminant identification. Pharmaceutical Microscopy is designed for those scientists who must use these techniques to solve pharmaceutical problems but do not need to become expert microscopists. Consequently, each section has exercises designed to teach the reader how to use and apply the techniques in the book. Although the focus is on pharmaceutical development, workers in other fields such as food science and organic chemistry will also benefit from the discussion of techniques and the exercises. Provides comprehensive coverage of key microscopy techniques used in pharmaceutical development Helps the reader to solve specific problems in pharmaceutical quality assurance Oriented and designed for pharmaceutical scientists who need to use microscopy but are not expert microscopists Includes a large number of practical exercises to give the reader hands-on experience with the techniques Written by an author with 21 years of experience in the pharmaceutical industry
Download or read book Automated Microbial Identification and Quantitation written by Wayne P. Olson and published by CRC Press. This book was released on 1996-01-31 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on practical, proven applications to automate the microbial identification process economically and with greater levels of safety and quality for patients. A diverse group of recognized experts survey the topic and present the latest techniques and technologies for microbial detection. They cover bacteria and yeasts, the technology of automation, equipment, methods, and the validation issues involved in "going automated." They also explore the challenges of detection and quantititation of contaminants in the increasing number of biologic injectable drugs and identify current trends in the industry. Features
Download or read book Integrated Pharmaceutics written by Antoine Al-Achi and published by John Wiley & Sons. This book was released on 2013-01-22 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the application of physical pharmacy, drug design, and drug regulations as they relate to produce effective dosage forms for drug delivery, Integrated Pharmaceutics provides a comprehensive picture of pharmaceutical product design, describing the science and art behind the concepts of dosage form development. Combining physical pharmacy, product design, and regulatory affairs issues in a single book, the authors address topics governing drug regulations of United States, European, and Japanese agencies and detail new regulatory guidelines, including quality by design, design space analysis, and blend sample uniformity.
Download or read book Pharmaceutical Powder and Particles written by Anthony J. Hickey and published by Springer. This book was released on 2019-09-06 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.
Download or read book Chemical Engineering in the Pharmaceutical Industry written by David J. am Ende and published by John Wiley & Sons. This book was released on 2011-03-10 with total page 1431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.
Download or read book Supercritical Fluid Technology for Drug Product Development written by Peter York and published by CRC Press. This book was released on 2004-03-23 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interconnecting the fundamentals of supercritical fluid (SCF) technologies, their current and anticipated utility in drug delivery, and process engineering advances from related methodological domains and pharmaceutical applications, this volume unlocks the potential of supercritical fluids to further the development of improved pharmaceutical prod
Download or read book Analysis of Aggregates and Particles in Protein Pharmaceuticals written by Hanns-Christian Mahler and published by John Wiley & Sons. This book was released on 2011-12-20 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.
Download or read book Particle Size Measurement written by Terence Allen and published by Springer Science & Business Media. This book was released on 1996-12-31 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the fifth edition of the highly successful work first published in 1968, comprising two definitive volumes on particle characterisation. The first volume is devoted to sampling and particle size measurement, while surface area and pore size determination are reviewed in volume 2. Particle size and characterisation are central to understanding powder properties and behaviour. This book describes numerous potential measuring devices, how they operate and their advantages and disadvantages. It comprise a fully comprehensive treatise on the wide range of available equipment with an extensive literature survey, and a list of manufacturers and suppliers. The author's blend of academic and industrial experience results in a readable technical book with information on how to analyse, present, and extract useful information from data. This is an essential reference book for both industrial and academic research workers in a variety of areas including: pharmaceuticals, food science, pollution analysis and control, electronic materials, agricultural products, polymers, pigments and chemicals.
