Download or read book Particle particle Adhesion In Pharmaceutical Powder Handling written by Fridrun Podczeck and published by World Scientific. This book was released on 1998-07-31 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph describes the physical principles of adhesion between particles and surfaces. These principles are applied to pharmaceutical processes involved in the manufacture of solid dosage forms such as powders, granules, tablets and dry powder inhalations. To help in the understanding of these systems, physical properties of solid surfaces, and an introduction to the theory of friction is given. Techniques for measuring particle adhesion and fracture mechanical properties of powders are introduced, as far as these are relevant to the processes discussed. The philosophy of the book deviates from that of standard pharmaceutical textbooks, in that it focuses primarily on physical principles involved in the manufacture of dosage forms rather than describing these processes purely by observation.
Download or read book Adhesion of Dust and Powder written by Anatoliǐ Davydovich Zimon and published by Springer. This book was released on 2013-12-11 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Particle Adhesion and Removal written by K. L. Mittal and published by John Wiley & Sons. This book was released on 2015-01-06 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive and easily accessible reference source covering all important aspects of particle adhesion and removal. The core objective is to cover both fundamental and applied aspects of particle adhesion and removal with emphasis on recent developments. Among the topics to be covered include: 1. Fundamentals of surface forces in particle adhesion and removal. 2. Mechanisms of particle adhesion and removal. 3. Experimental methods (e.g. AFM, SFA,SFM,IFM, etc.) to understand particle-particle and particle-substrate interactions. 4. Mechanics of adhesion of micro- and nanoscale particles. 5. Various factors affecting particle adhesion to a variety of substrates. 6. Surface modification techniques to modulate particle adhesion. 7. Various cleaning methods (both wet & dry) for particle removal. 8. Relevance of particle adhesion in a host of technologies ranging from simple to ultra-sophisticated.
Download or read book Particulate Products written by Henk G. Merkus and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Particulate products make up around 80% of chemical products, from all industry sectors. Examples given in this book include the construction materials, fine ceramics and concrete; the delicacies, chocolate and ice cream; pharmaceutical, powders, medical inhalers and sun screen; liquid and powder paints. Size distribution and the shape of the particles provide for different functionalities in these products. Some functions are general, others specific. General functions are powder flow and require – at the typical particulate concentrations of these products – that the particles cause adequate rheological behavior during processing and/or for product performance. Therefore, this book addresses particle packing as well as its relation to powder flow and rheological behavior. Moreover, general relationships to particle size are discussed for e.g. color and sensorial aspects of particulate products. Product-specific functionalities are often relevant for comparable product groups. Particle size distribution and shape provide, for example, the following functionalities: - dense particle packing in relation to sufficient strength is required in concrete construction, ceramic objects and pharmaceutical tablets - good sensorial properties (mouthfeel) to chocolate and ice cream - effective dissolution, flow and compression properties for pharmaceutical powders - adequate hiding power and effective coloring of paints for protection and the desired esthetical appeal of the objects - adequate protection of our body against sun light by sunscreen - effective particle transport and deposition to desired locations for medical inhalers and powder paints. Adequate particle size distribution, shape and porosity of particulate products have to be achieved in order to reach optimum product performance. This requires adequate management of design and development as well as sufficient knowledge of the underlying principles of physics and chemistry. Moreover, flammability, explosivity and other health hazards from powders, during handling, are taken into account. This is necessary, since great risks may be involved. In all aspects, the most relevant parameters of the size distribution (and particle shape) have to be selected. In this book, experts in the different product fields have contributed to the product chapters. This provides optimum information on what particulate aspects are most relevant for behavior and performance within specified industrial products and how optimum results can be obtained. It differs from other books in the way that the critical aspects of different products are reported, so that similarities and differences can be identified. We trust that this approach will lead to improved optimization in design, development and quality of many particulate products.
Download or read book Pharmaceutical Inhalation Aerosol Technology Second Edition written by Anthony J. Hickey and published by CRC Press. This book was released on 2003-09-03 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors, influencing the efficacy and utilization of pharmaceutical aerosol. It analyzes the latest science and developments in the generation, administration and characterization of these compounds, showcasing current clinical applications, the efficiency and limitations of major aerosol products and emerging aerosol therapies impacting the field.
Download or read book Particles on Surfaces Detection Adhesion and Removal Volume 7 written by Kash L. Mittal and published by CRC Press. This book was released on 2023-01-06 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume documents the proceedings of the 7th International Symposium on Particles on Surfaces: Detection, Adhesion and Removal held in Newark, NJ, June 19-21, 2000. The study of particles on surfaces is extremely important in a host of diverse technological areas, ranging from microelectronics to optics to biomedical. This volume contains a total of 28 papers, which were all properly peer reviewed, revised and edited before inclusion. Therefore, this book is not merely a collection of unreviewed manuscripts, but rather represents information which has passed peer scrutiny. Furthermore, the authors were asked to update their manuscripts, so the information contained in this book should be current and fresh. This volume is divided into two parts: 1) Particle Analysis and General Cleaning-Related Topics; and 2) Particle Adhesion and Removal. The topics covered include: surface analysis techniques for particle identification; cleaning, rinsing and drying issues in post-CMP cleaning; fundamental forces involved in particle adhesion; factors affecting adhesion of small (nanosize) particles; factors important in particle detachment; particle adhesion measurement by AFM; various (wet and dry) techniques for particle removal, e.g., laser, ultrasonic, megasonic, use of surfactants; toner particles and pharmaceutical particles. This volume offers a wealth of information on the tremendously technologically important field of particles on surfaces and should provide a consolidated source of current R&D activity in this arena. Therefore, it will be of value and use to anyone interested in the topic of particles on surfaces.
Download or read book Inhalation Drug Delivery written by Paolo Colombo and published by John Wiley & Sons. This book was released on 2013-02-11 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a rapid evolution in the field of inhalation drug therapy, including new drugs, increased regulation and quality control, and strong pressure from generics. Inhalation Drug Therapy brings together the most current inhalation drug research, as well as practical developments and processes, into one essential guide. Focusing on inhalation products and specific equipment and techniques used in manufacturing and quality control, the book balances research with the industrial aspects of creating the drugs, and features a highly regarded author team with both academic and industry experience.
Download or read book Handbook of Lung Targeted Drug Delivery Systems written by Yashwant Pathak and published by CRC Press. This book was released on 2021-10-17 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems
Download or read book Modern Pharmaceutics written by Gilbert S. Banker and published by CRC Press. This book was released on 2002-05-24 with total page 1255 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Completely revised and expanded throughout. Presents a comprehensive integrated, sequenced approach to drug dosage formulation, design, and evaluation. Indentifies the pharmacodynamic and physicochemical factors influencing drug action through various routes of administration."
Download or read book Handbook of Polymers for Pharmaceutical Technologies Processing and Applications written by Vijay Kumar Thakur and published by John Wiley & Sons. This book was released on 2015-07-27 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications. Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe. This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated. Volume 1: Structure and Chemistry Volume 2: Processing and Applications Volume 3: Biodegradable Polymers Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers
Download or read book Multiphase Flow with Solid Particles written by Pawel Kosinski and published by Cambridge University Press. This book was released on 2023-10-19 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the topic of multiphase flow in detail, providing clear explanations of the physics behind solid particles in fluids. It is illustrated with frequent worked examples and algorithms, enabling the reader to develop the required tools for simulating the flow of fluids with solid particles.
Download or read book Chemical Engineering in the Pharmaceutical Industry written by David J. am Ende and published by John Wiley & Sons. This book was released on 2011-03-10 with total page 1431 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.
Download or read book Pharmaceutical Powder and Particles written by Anthony J. Hickey and published by Springer. This book was released on 2018-08-13 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist. The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.
Download or read book Predictive Modeling of Pharmaceutical Unit Operations written by Preetanshu Pandey and published by Woodhead Publishing. This book was released on 2016-09-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of modeling and simulation tools is rapidly gaining prominence in the pharmaceutical industry covering a wide range of applications. This book focuses on modeling and simulation tools as they pertain to drug product manufacturing processes, although similar principles and tools may apply to many other areas. Modeling tools can improve fundamental process understanding and provide valuable insights into the manufacturing processes, which can result in significant process improvements and cost savings. With FDA mandating the use of Quality by Design (QbD) principles during manufacturing, reliable modeling techniques can help to alleviate the costs associated with such efforts, and be used to create in silico formulation and process design space. This book is geared toward detailing modeling techniques that are utilized for the various unit operations during drug product manufacturing. By way of examples that include case studies, various modeling principles are explained for the nonexpert end users. A discussion on the role of modeling in quality risk management for manufacturing and application of modeling for continuous manufacturing and biologics is also included. Explains the commonly used modeling and simulation tools Details the modeling of various unit operations commonly utilized in solid dosage drug product manufacturing Practical examples of the application of modeling tools through case studies Discussion of modeling techniques used for a risk-based approach to regulatory filings Explores the usage of modeling in upcoming areas such as continuous manufacturing and biologics manufacturingBullet points
Download or read book Molecular Adhesion and Its Applications written by Kevin Kendall and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the beginning of the twentieth century, engineers and technologists would have recognized the importance of adhesion in two main aspects: First, in the display of friction between surfaces — at the time a topic of growing importance to engineers; the second in crafts requiring the joining of materials — principally wood—to form engineering structures. While physical scientists would have admitted the adhesive properties of glues, gels, and certain pastes, they regarded them as materials of uncertain formulation, too impure to be amenable to precise experiment. Biological scientists were aware also of adhesive phenomena, but the science was supported by documentation rather than understanding. By the end of the century, adhesion and adhesives were playing a crucial and deliberate role in the formulation of materials, in the design and manufacture of engineering structures without weakening rivets or pins, and in the use of thin sections and intricate shapes. Miniaturization down to the micro- and now to the nano-level of mechanical, electrical, electronic, and optical devices relied heavily on the understanding and the technology of adhesion. For most of the century, physical scientists were aware that the states of matter, whether gas, liquid, or solid, were determined by the competition between thermal energy and int- molecular binding forces. Then the solid state had to be differentiated into crystals, amorphous glasses, metals, etc. , so the importance of the molecular attractions in determining stiffness and strength became clearer.
Download or read book Pharmaceutical Process Engineering written by Anthony J. Hickey and published by CRC Press. This book was released on 2016-03-09 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: With step-by-step methods of drug production and knowledge of major unit operations and key concepts of pharmaceutical engineering, this guide will help to improve communication among the varied professionals working in the pharmaceutical industry. Key features: REVISION OF A BESTSELLER - Updates include recent advances in the field to keep pharmac
Download or read book Pharmaceutical Capsules written by Fridrun Podczeck and published by Pharmaceutical Press. This book was released on 2004 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Updated and expanded second edition covers all aspects of capsule technology, including history, standards, methods and equipment used in manufacture, filling, printing, weighing, cleaning and inspecting of both hard and soft capsules.
