Download or read book Part I Total Synthesis of Azaspiracid 3 written by Eriketi Loizidou and published by . This book was released on 2006 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Part I Total Sysnthesis of Azaspiracid 3 Part II Molecular Recognition Studies in Aqueous Solutions Facilitated by a Receptor Modified Polymer written by and published by . This book was released on 2006 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part I. Azaspiracids are novel marine toxins produced by microalgae of the genus Protoperidinium . They were first identified in 1995 following an incident of food poisoning in the Netherlands. The major toxin azaspiracid-1 was isolated in 1998 and its structure was unambigously determined in 2004 after its first total synthesis by Nicolaou and others At least 11 analogues have been isolated and among them azaspiracid-1, -2 and -3 are the most potent toxins. Due to the difficulty of obtaining sufficient amount of toxin the studies towards their mechanism of action have been limited. The total synthesis of these toxins can provide sufficient material for biological studies as well as an opportunity to study structure activity relationships. Part I of this thesis reports the first total synthesis of azaspiracid-3. The synthetic strategy includes the same key reactions as those reported for the synthesis of azaspiracid-1; however, this synthetic route is shorter and more efficient. Part II. It is well established that therapeutic drugs are designed to bind substrates through various types of noncovalent interactions such as electrostatic, hydrogen bonding, [pi]-[pi] stacking and Van der Waals interactions. Hosts based on electrostatic, hydrophobic and [pi]-[pi] stacking interactions have been reported in the literature for potential applications in aqueous media to emulate functions in biological systems. However, to enable specific binding of hydrogen bonding based artificial receptors for aqueous solution applications such as in sensor and biomedicine technology, one must circumvent the competing effect of water. We introduce a general approach for applying hydrogen bonding based receptors in water, by covalently attaching a purely hydrogen bonding based barbiturate receptor to a water-soluble amphiphilic polymer. Amphiphilic polymers are known to self-associate in aqueous media forming micelle-like microdomains. The hydrophobic environment of the micelle allows hydrogen bonding based recognition to occur. The binding of barbiturates to the receptor-modified polymer is studied via UV spectroscopy and affinity capillary electrophoresis.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Download or read book Applied Cross Coupling Reactions written by Yasushi Nishihara and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.
Download or read book Molecules That Changed the World written by K. C. Nicolaou and published by Wiley-VCH. This book was released on 2008-03-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry Here, the best-selling author and renowned researcher, K. C. Nicolaou, presents around 40 natural products that all have an enormous impact on our everyday life. Printed in full color throughout with a host of pictures, this book is written in the author's very enjoyable and distinct style, such that each chapter is full of interesting and entertaining information on the facts, stories and people behind the scenes. Molecules covered span the healthy and useful, as well as the much-needed and extremely toxic, including Aspirin, urea, camphor, morphine, strychnine, penicillin, vitamin B12, Taxol, Brevetoxin and quinine. A veritable pleasure to read.
Download or read book Bad Bug Book written by Mark Walderhaug and published by Createspace Independent Publishing Platform. This book was released on 2014-01-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Bad Bug Book 2nd Edition, released in 2012, provides current information about the major known agents that cause foodborne illness.Each chapter in this book is about a pathogen—a bacterium, virus, or parasite—or a natural toxin that can contaminate food and cause illness. The book contains scientific and technical information about the major pathogens that cause these kinds of illnesses.A separate “consumer box” in each chapter provides non-technical information, in everyday language. The boxes describe plainly what can make you sick and, more important, how to prevent it.The information provided in this handbook is abbreviated and general in nature, and is intended for practical use. It is not intended to be a comprehensive scientific or clinical reference.The Bad Bug Book is published by the Center for Food Safety and Applied Nutrition (CFSAN) of the Food and Drug Administration (FDA), U.S. Department of Health and Human Services.
Download or read book Classics in Total Synthesis written by K. C. Nicolaou and published by John Wiley & Sons. This book was released on 1996-04-11 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: K.C. Nicolaou - Winner of the Nemitsas Prize 2014 in Chemistry This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists. To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information. Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins. Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
Download or read book Bioremediation and Biotechnology written by Khalid Rehman Hakeem and published by Springer Nature. This book was released on 2020-01-26 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxic substances threatens aquatic and terrestrial ecosystems and ultimately human health. The book is a thoughtful effort in bringing forth the role of biotechnology for bioremediation and restoration of the ecosystems degraded by toxic and heavy metal pollution. The introductory chapters of the book deal with the understanding of the issues concerned with the pollution caused by toxic elements and heavy metals and their impacts on the different ecosystems followed by the techniques involved in monitoring of the pollution. These techniques include use of bio-indicators as well as modern techniques for the assessment and monitoring of toxicants in the environment. Detailed chapters discussing the role of microbial biota, aquatic plants, terrestrial plants to enhance the accumulation efficiency of these toxic and heavy metals are followed by remediation techniques involving myco-remediation, bio-pesticides, bio-fertilizers, phyto-remediation and rhizo-filtration. A sizable portion of the book has been dedicated to the advanced bio-remediation techniques which are finding their way from the laboratory to the field for revival of the degraded ecosystems. These involve bio-films, micro-algae, genetically modified plants and filter feeders. Furthermore, the book is a detailed comprehensive account for the treatment technologies from unsustainable to sustainable. We believe academicians, researchers and students will find this book informative as a complete reference for biotechnological intervention for sustainable treatment of pollution.
Download or read book Algal Chemical Ecology written by Charles D. Amsler and published by Springer Science & Business Media. This book was released on 2007-11-03 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Yet another Springer world-beater, this is the first ever book devoted to the chemical ecology of algae. It covers both marine and freshwater habitats and all types of algae, from seaweeds to phytoplankton. While the book emphasizes the ecological rather than chemical aspects of the field, it does include a unique introductory chapter that serves as a primer on algal natural products chemistry.
Download or read book Foodborne Microbial Pathogens written by Arun K. Bhunia and published by Springer. This book was released on 2018-05-21 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book primarily covers the general description of foodborne pathogens and their mechanisms of pathogenesis, control and prevention, and detection strategies, with easy-to-comprehend illustrations. The book is an essential resource for food microbiology graduate or undergraduate students, microbiology professionals, and academicians involved in food microbiology, food safety, and food defense-related research or teaching. This new edition covers the significant progress that has been made since 2008 in understanding the pathogenic mechanism of some common foodborne pathogens, and the host-pathogen interaction. Foodborne and food-associated zoonotic pathogens, responsible for high rates of mortality and morbidity, are discussed in detail. Chapters on foodborne viruses, parasites, molds and mycotoxins, and fish and shellfish are expanded. Additionally, chapters on opportunistic and emerging foodborne pathogens including Nipah virus, Ebola virus, Aeromonas hydrophila, Brucella abortus, Clostridium difficile, Cronobacter sakazakii, and Plesiomonas shigelloides have been added. The second edition contains more line drawings, color photographs, and hand-drawn illustrations.
Download or read book Chemical Analysis of Food Techniques and Applications written by Yolanda Pico and published by Academic Press. This book was released on 2012-09-01 with total page 813 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Analysis of Food: Techniques and Applications reviews new technology and challenges in food analysis from multiple perspectives: a review of novel technologies being used in food analysis, an in-depth analysis of several specific approaches, and an examination of the most innovative applications and future trends. This book won a 2012 PROSE Award Honorable Mention in Chemistry and Physics from the Association of American Publishers. The book is structured in two parts: the first describes the role of the latest developments in analytical and bio-analytical techniques and the second reviews the most innovative applications and issues in food analysis. Each chapter is written by experts on the subject and is extensively referenced in order to serve as an effective resource for more detailed information. The techniques discussed range from the non-invasive and non-destructive, such as infrared spectroscopy and ultrasound, to emerging areas such as nanotechnology, biosensors and electronic noses and tongues. Important tools for problem-solving in chemical and biological analysis are discussed in detail. Winner of a PROSE Award 2012, Book: Honorable Mention in Physical Sciences and Mathematics - Chemistry and Physics from the American Association of Publishers Provides researchers with a single source for up-to-date information in food analysis Single go-to reference for emerging techniques and technologies Over 20 renowned international contributors Broad coverage of many important techniques makes this reference useful for a range of food scientists
Download or read book Marine Algae written by Leonel Pereira and published by CRC Press. This book was released on 2014-09-26 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is divided into three thematic areas. The first covers a revision of the taxonomy of algae, based on the algae portal, as well as the general aspects of biology and the methodologies used in this branch of marine biology. The second subject area focuses on the use of algae in environmental assessment, with an intensive implementation in Western economies and some emerging economies. The third topic is the potential use of algae in various industries including food, pharmaceuticals, cosmetics, agricultural fertilizers, and the emerging biofuels industries.
Download or read book Algal Toxins Nature Occurrence Effect and Detection written by Valtere Evangelista and published by Springer Science & Business Media. This book was released on 2008-06-27 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the lectures and seminars given at the NATO Advanced Study Institute on “Sensor Systems for Biological Threads: The Algal Toxins Case”, held in Pisa, Italy in October, 2007. The Institute was sponsored and funded by the Scientific Affairs Division of NATO. It is my pleasant duty to thank this institution. This ASI offered updated information on how far the research on algal toxins has gone in the exploration of structures, biosynthesis and regulation of toxins, and the development of technology for bio-monitoring these c- pounds. Algae can form heavy growths in ponds, lakes, reservoirs and sl- moving rivers throughout the world; algae can house toxins which are - ually released into water when the cells rupture or die. Hundreds of toxins have been identified so far. Detection methods, including rapid screening, have been developed to help us learning more about them, especially to find out which toxins are a real threat for people and what conditions encourage their production and accumulation. Early detection of algal toxins is an - portant aspect for public safety and natural environment, and significant efforts are underway to develop effective and reliable tools that can be used for this purpose.
Download or read book Natural Products From Marine Algae written by Dagmar B. Stengel and published by Humana. This book was released on 2016-10-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a fundamental overview of the current state of the art in natural products from marine algae, linking the complex and diverse natural resource with recent developments in extraction, analytical and bioactivity testing methodologies. Natural Products from Marine Algae: Methods and Protocols guides readers through protocols and techniques on algal biotechnology, metabolites, Solid-Liquid Extraction (SLE), Microwave Assisted Extraction (MAE), Liquid Chromatography, Gas Chromatography, Nuclear Magnetic Resonance Spectroscopy, Infra-red spectroscopy and Raman Spectroscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Natural Products from Marine Algae: Methods and Protocols hopes to aid scientists unravel and quantify algal chemical diversity and support further marine biotechnological developments.
Download or read book Marine Biotoxins written by Hans P. Egmond and published by Food & Agriculture Org.. This book was released on 2004 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper provides an extensive review of different aspects of five shellfish-poisoning syndromes (paralytic, diarrhoeic, amnesic, neurologic and azapiracid), as well as one fish-poisoning syndrome (ciguatera fish poisoning), and discusses in detail the causative toxins produced by marine organisms, chemical structures and analytical methods of the toxins, habitat and occurrence of the toxin-producing organisms, case studies and existing regulations. Based on this analysis, risk assessments are carried out for each of the toxins, and recommendations are elaborated to improve the management of these risks in order to reduce the harmful effect of these toxins on public health.
Download or read book Biological Toxins and Bioterrorism written by P. Gopalakrishnakone and published by Springer. This book was released on 2015-01-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological toxins are an important part of our world, a reality with which we need to cope, so in parallel with understanding their mechanisms of action and thereby improving our fundamental knowledge, there are successful efforts to utilize them as therapeutics against some debilitating human and animal diseases. In view of the complexity of different types of biotoxins and the broad range of toxin structure, physiology, utility, and countermeasures including regulatory issues, it was thus aimed to compile a book on biotoxins and bioweapons. This reference work in the Toxinology handbook series gathers together knowledge from around the globe about naturally inspired and manufactured biological weapons. The authors describe how they work; how authorities may detect their presence, prevent their use, and diagnose their impacts; and the means by which medical and paramedical professionals may treat victims. Also described are how they have been used to further our knowledge and what insights they have given us into evolutionary and physiological processes. Finally, it is also discussed how these toxins can be used as therapeutics and what the implications of such therapeutics are to their use as biothreat agents. This volume provides a reference accessible to scientists, educators, and medical experts alike with an interest in biotoxins, focusing on the major toxins used as bioweapons. Regulatory agencies will also benefit from the information provided in this book. Some in the intended audience may need to understand how they elicit their effects and how we can defend ourselves against them. Others may be interested in the sometimes colorful histories that surround this subset of biotoxins that can be and, in some cases, have been used as weapons.
