Download or read book Part I Mechanistic Studies Optimization and Further Applications of the Organocatalytic alpha hydroxymethylation of Aldehydes Part II Studies Toward the Total Synthesis of FK 506 written by Kyle Francis Biegasiewicz and published by . This book was released on 2016 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Part I. Mechanistic Studies, Optimization, and Further Applications of the Organocatalytic [alpha]-Hydroxymethylation of Aldehydes: Further developments in studies of the direct [alpha]-hydroymethylation of aldehydes employing the [alpha],[alpha]-diarylprolinol trialkylsilyl ether class of organocatalysts are described. This synthetic transformation has proven effective in expedient access to [beta]-hydroxycarboxylic acids and [delta]-hydroxy-[alpha],[beta]-unsaturated esters from aldehydes in moderate to excellent yields, excellent enantioselectivity, and compatibility across a wide range of funtional groups in the starting aldehyde. These studies have also been successful in identifying the critical reaction variables that influence the yield and enantioselectivity in the [alpha]-hydroxymethylation process including catalyst structure, pH of the reaction medium, purity of the reagents employed, nature of the buffer, along with standard reaction variables including the solvent, time, temperature, and mixing efficiency. In addition, the previously identified lactol intermediate has been further characterized and examined. The culmination of these studies has translated directly into an improved substrate scope, reproducibility, enantioselectivity, and yields of the described method. Finally, the described [alpha]-hydroxymethylation protocol has been applied to a multi-gram scale synthesis of the southern hemisphere of the apoptosis inducer, (-)-rasfon. Part II. Studies Toward the Total Synthesis of FK-506: An approach to the total synthesis of the immunosuppressant FK-506 is described. The synthetic strategy features the division of the macrocycle into four subunits allowing for a maximum degree of convergence in the forward synthesis. Improvements to the synthesis of a key intermediate vinyl bromide are described that have allowed for the multi-gram throughput of the southern portion of the macrocycle. Improvements have been made to the synthesis of the northern hemisphere of the macrocyle synthesis, again allowing for better material throughput. Finally, several coupling strategies have been explored and the culmination of these efforts have led to promising preliminary results on the unification of the northern and southern hemispheres, bringing the molecules synthesis to near completion"--Pages vii-viii.
Download or read book Part I Direct Alkylation of alpha alpha disubstituted Aldehydes Part II Studies Directed Towards the Synthesis of Reiswigin A written by Santosa Setiadji and published by . This book was released on 1996 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Total Synthesis of Natural Products written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.
Download or read book Part I Asymmetric Alkylation of Aldehydes with Simple Olefins And Part II Enantioselective Total Synthesis of Polypyrroloindoline Natural Products written by Robert J. Comito and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Science of Synthesis Dual Catalysis in Organic Synthesis 1 written by G. A. Molander and published by Thieme. This book was released on 2020-05-22 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of dual catalysis has developed rapidly over the last decade, and these volumes define its impact on organic synthesis. The most important, basic concepts of synergistic, dual catalytic cycles are introduced, providing newcomers to the field with reliable information on this new approach to facilitating the synthesis of organic molecules. Background information and reliable procedures for challenging transformations in synthesis are presented, applying the concept of cooperative dual catalysis as a means of increasing molecular complexity in the most efficient manner. The most useful, practical, and reliable methods for dual catalysis combining metal catalysts, organocatalysts, photocatalysts, and biocatalysts are presented.
Download or read book Strained Hydrocarbons written by Helena Dodziuk and published by John Wiley & Sons. This book was released on 2009-03-30 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: In clearly structured chapters, this book covers the fascinating world of hydrocarbons, providing an insight into the fundamental principles of chemistry. The monograph covers modern aspects of the topic, such as carbon nanotubes, molecular flask inclusion, and fullerenes, with new synthetic procedures for the build up of the structural lattice included.
Download or read book Spectroscopy and Kinetics written by James S. Mattson and published by . This book was released on 1973 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbocyclic Cage Compounds written by Eiji Ōsawa and published by VCH Publishers. This book was released on 1992 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Natural Bioactive Molecules written by Goutam Brahmachari and published by Alpha Science International, Limited. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: NATURAL BIOACTIVE MOLECULES: Impacts and Prospects in Medicinal Chemistry is an endeavor to underline how natural product research continues to make significant contributions in the domain of discovery and development of new medicinal entities. Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. Bioactive natural products are proving to be a rich source of novel therapeutics. Search for bioactive molecules from nature (plants, animals, microflora) continues to play an important role in fashioning new medicinal agents. With the advent of modern techniques, very particularly the rapid improvements in spectroscopic as well as accompanying advances in high-throughput screening techniques, it has become possible to have an enormous repository of bioactive natural compounds, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.This book, which will comprise a variety of at least fifteen chapters written by active researchers and leading experts in natural products chemistry on biologically active natural products, brings together an overview of current discoveries and trends in this remarkable field. This definite volume is also an outstanding source of information with regard to the industrial application of natural products for medicinal purposes. The broad interdisciplinary approach dealt in this book would surely make the work much interesting to the scientists deeply engaged in the research and/or use of bioactive natural products. It will serve not only as a valuable resource for researchers in their own fields to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations, but also motivates young scientists to the dynamic field of bioactive natural products research.
Download or read book The Chemistry of Cyclobutanes written by Zvi Rappoport and published by . This book was released on 2005 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Elegant Total Synthesis written by Karl J. Hale and published by Wiley-VCH Verlag GmbH. This book was released on 2013-02-04 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to other books on this topic, the editor has chosen a top selection of target molecules not previously covered, many of them taken from chemical biology and including syntheses from bioorganic chemistry. Inspiration not only for organic chemists but also bioorganic chemists in industry and academia to develop their own synthesis routes.
Download or read book Advances in Strained and Interesting Organic Molecules written by Brian Halton and published by JAI Press(NY). This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A collection of essays on the facets of strained organic molecules. It covers topics such as applications of ring strain in natural product synthesis and uses of the vacuum gas-solid reaction procedure in synthesis.
Download or read book Challenges in Synthetic Organic Chemistry written by Teruaki Mukaiyama and published by Oxford University Press, USA. This book was released on 1994 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the life's work of Professor Teruaki Mukaiyama, one of Japan's most important and respected synthetic organic chemists. It includes information on his early research into a wide range of reactions, including dehydration reactions, the use of organosulfur compounds, and oxidation-reduction condensations in peptide and nucleotide synthesis reagents, as well as an account of Mukaiyama's important work on the applications of titanium compounds in organic synthesis. Three final chapters review Mukaiyama's work in synthetic control, stereoselective synthesis of carbohydrates, the stereoselective aldol, and Michael reactions. This unique book makes accessible much research that has only been available in Japanese, and provides a rare account of the contributions of one of the world's leading chemists.
Download or read book Chemistry and Toxicology of Diverse Classes of Alkaloids written by Murray Sheldon Blum and published by Alaken, Incorporated. This book was released on 1996 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
