Download or read book Parametric Contrast Enhanced Ultrasound Evaluation of Transarterial Chemoembolization written by Minakshi Mohanty and published by . This book was released on 2015 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work investigates quantitative contrast enhanced ultrasound (CEUS) derived blood flow parameters for evaluating chemoembolization of hepatocellular carcinoma. Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide and is becoming increasingly common. Liver transplant is the only cure with 70 percent 5 year survival rate. However, transplant requires the tumor to fall under the Milan criteria (less than 5cm or up to 3 nodules each less than 1cm) and the technique is limited by the availability of donors. Transarterial chemoembolization (TACE), currently, is a treatment option for non-resectable tumors. It involves the administration of drug eluting beads via catheter into the branch of the hepatic artery that feeds the tumor. These beads occlude the blood supply to the tumor and at the same time release chemotherapy, leading to necrosis of the tumor and reduction in its size. Presently, the effectiveness of TACE procedure is determined one month post embolization through the use of contrast enhanced magnetic resonance imaging (MRI) or computed tomography (CT) scans, by evaluating blood flow within the tumor. Early screening for effective chemoembolization with contrast-enhanced MRI has been proven ineffective due to an inability to adequately visualize the vasculature. An earlier estimation of treatment efficacy would provide clinicians more time and options for re-treatment. Additionally, a number of patients may have morbidities including renal insufficiency. These patients may develop nephrogenic systemic fibrosis, which is the necrosis of skin and the internal organs, on exposure to gadolinium (present in MRI contrast agents). This project proposes the use of contrast enhanced ultrasound (CEUS) for monitoring the effectiveness of transarterial chemoembolization. Ultrasound contrast agents are gas filled microbubbles, which are encapsulated within a thin elastic shell made of lipids. They have a diameter of 1-[mu]m. Due to their restriction to the vasculature, an absence of contrast within the tumor is expected in cases where complete embolization has been achieved. Earlier studies have shown that lack of detected agents as little as 2 days post procedure correlated with effective procedure. However, currently there is no established standard as to how many days post treatment should the follow up be conducted, or which contrast agent to use. Fourteen patients with 16 lesions scheduled for transarterial chemoembolization (TACE) of HCC using drug eluting beads provided informed consent to undergo CEUS exam prior to treatment, 2 weeks post treatment, and the morning of follow up (contrast enhanced MRI 1 month post TACE). Ultrasound was performed using a Sequoia 512 scanner with 4C1 probe (Siemens Medical Solutions, Mountain View, CA). CEUS data was acquired using Cadence Pulse Sequencing (Siemens) during bolus injection of 0.6-0.7 ml of Definity (Lantheus Medical Imaging, N. Billerica, MA). Motion compensation was performed and time intensity curves were generated on a pixel-by-pixel basis to create parametric images showing maximum signal intensity (MAX), time to peak intensity (TTP), perfusion (PER), and area under curve (AUC). These values were averaged over the tumor and expressed normalized relative to baseline. Results were then grouped by clinical diagnosis (fully treated (n=5), partially treated (n=5) or no change (n=6)) and compared at each time point. Parametric imaging was successfully performed on 10 lesions, while six were excluded due to inability to identify tumor. Significant difference was observed in the time to peak dataset 2 weeks post TACE between complete response and no response group (p=0.018). No significance was observed in maximum intensity, perfusion and area under curve dataset. In the time intensity parameters obtained 4 weeks post TACE, no significant difference was observed. In conclusion, time to peak currently appears to be a good quantitative CEUS parameter for evaluating the effectiveness of TACE treatment 2 weeks post treatment.
Download or read book Interventional Ultrasound written by Hans Henrik Holm and published by Springer. This book was released on 2013-11-11 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern sonography makes possible the detection of small and subtle changes in the normal echo pattern. These may represent significant pathological changes which can not al ways be fully revealed by the echo pattern alone. There is, therefore, an increasing need for the supplement of the ultra sonically guided percutaneous puncture, which can be per formed with great accuracy and with virtually no risk. Also, ultrasonically guided puncture has proven invaluable for a wide variety of therapeutic purposes. The first percutaneous puncture guided by ultrasonic scanning using a specifically designed transducer was per formed in 1969 at the ultrasonic laboratory in Gentofte, now Herlev, Hospital, Copenhagen. The idea was based on a punc ture transducer described and used by Kratochwill for punc ture under the guidance of the ultrasonic A-presentation tech nique. The development in the field formed the basis of the First International Conference on Ultrasonically Guided Puncture at Herlev Hospital in 1978 sponsored by The Danish Society of Diagnostic Ultrasound. The knowledge and experience of the speakers at that conference was compiled in the book "Ultrasonically Guided Puncture Technique" published in 1980. Since then the Society has sponsored a conference at the same place in 1980 and 1983, the latest conference being termed "Third International Conference on lnterventional Ultrasound".
Download or read book Quantification of Contrast Kinetics in Clinical Imaging written by Massimo Mischi and published by Springer. This book was released on 2018-11-02 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive survey of the pharmacokinetic models used for the quantitative interpretation of contrast-enhanced imaging. It discusses all the available imaging technologies and the problems related to the calibration of the imaging system and accuracy of the estimated physiological parameters. Enhancing imaging modalities using contrast agents has opened up new opportunities for going beyond morphological information and enabling minimally invasive assessment of tissue and organ functionality down to the molecular level. In combination with mathematical modeling of the contrast agent kinetics, contrast- enhanced imaging has the potential to provide clinically valuable additional information by estimating quantitative physiological parameters. The book presents the broad spectrum of diagnostic possibilities provided by quantitative contrast-enhanced imaging, with a particular focus on cardiology and oncology, as well as novel developments in the area of quantitative molecular imaging along with their potential clinical applications. Given the variety of available techniques, the choice of the appropriate imaging modality and the most suitable pharmacokinetic model is often challenging. As such, the book provides a valuable technical guide for researchers, clinical scientists, and experts in the field who wish to better understand and properly apply tracer-kinetic modeling for quantitative contrast-enhanced imaging.
Download or read book Contrast Enhanced Ultrasound Imaging of Hepatic Neoplasms written by Wen-Ping Wang and published by Springer Nature. This book was released on 2021-06-26 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide reader an overview of clinical applications of contrast-enhanced ultrasound in hepatic neoplasms diagnosis. Ultrasound images and pathological results of different hepatic neoplasms are introduced in the chapters, including benign liver tumors, malignant liver tumors, hepatic carcinoma, intrahepatic cholangiocarcinoma, rare liver benign and malignant neoplasms, regenerative nodules, inflammatory pseudotumor, parasite liver lesions, and hepatitis peliosis, etc. The combination of ultrasound findings with final histopathological results then discover the potential mechanical of contrast enhancement changes. With the development of ultrasound technology and widely application of ultrasound contrast agents (USCA) in recent decades, contrast-specific imaging modalities have been developed in combination with USCA and a low mechanical index (MI), allowing continuous real-time grey scale imaging. The updated contrast-specific software for liver diseases and hepatic tumors diagnosis has also been described described in detail. With high-resolution contrast ultrasound images during arterial phase, portal venous phase and late phase, author wants to show the whole dynamic wash-in and wash-out process of the different focal liver lesions.This book is an invaluable resource for radiologists, hepatologists and oncologists in their everyday clinical practice.
Download or read book Diagnostic Radiology Recent Advances and Applied Physics in Imaging written by Arun Kumar Gupta and published by JP Medical Ltd. This book was released on 2013-07-30 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition has been fully updated to provide radiologists with all the recent technological advances in diagnostic radiology. Divided into six sections, it covers all the key aspects of the imaging – ultrasound, computed tomography, magnetic resonance imaging, radiography and interventional radiography, and contrast media. The final section discusses miscellaneous topics including evidence based radiology, radiation protection, molecular imaging, planning a modern imaging department, and common drugs used. A separate chapter is dedicated to picture archiving and data management. This comprehensive new edition includes nearly 600 full colour radiological images and illustrations. Key points Fully updated, new edition presenting recent technological advances in diagnostic radiology Covers all key imaging techniques Includes nearly 600 radiological photographs and illustrations Previous edition published in 2007
Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.
Download or read book Specialty Imaging Fundamentals in Contrast Enhanced Ultrasound written by Andrej Lyshchik and published by Elsevier. This book was released on 2019-03-06 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cost-efficient, safe, and clinically effective, contrast-enhanced ultrasound is a nascent diagnostic imaging technique for use in both adults and children. Specialty Imaging: Fundamentals in CEUS provides first of its kind, authoritative coverage to help you make the most of this promising imaging tool in your practice. This one-stop resource is tailored to your decision support needs, offering guidance from global experts on everything from physics and safety to each of the commonly used clinical applications of CEUS. Covers CEUS applications for every relevant anatomic area including liver, kidney, bowel, pancreas, spleen, adrenal glands, gynecology, prostate, scrotum, breast, thyroid, parathyroid, and lymph nodes Discusses key related topics such as vascular CEUS, CEUS-guided interventions, CEUS in treatment response evaluation, CEUS of thorax, intracavitary CEUS, endoscopic CEUS, abdominal trauma, and pediatric applications Includes chapters covering each of the currently available contrast agents and contains a helpful CEUS technical recommendations and lexicon of imaging findings Features more than 1,000 high-quality images with captions and annotations for interpretive guidance Presents information consistently, using a highly templated format with bulleted text for quick, easy reference Helps you make the most of the unique advantages of CEUS, such as reaching a more specific, accurate diagnosis than when using regular ultrasound, and providing alternative imaging methods for younger patients where ionizing radiation poses greater risks Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Download or read book Quantification of Biophysical Parameters in Medical Imaging written by Ingolf Sack and published by Springer. This book was released on 2024-10-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this book offers six new chapters covering the latest developments in quantitative medical imaging, including artificial intelligence, MRI mapping, sonography, elastography and cardiac CT. All the other existing chapters have been updated and expanded, many with new text and figures, to reflect the rapid translation and advancement of technology in this exciting area of biomedical research. This updated edition presents fundamental knowledge on the imaging quantification of biophysical parameters for clinical diagnostic purposes. Clinical imaging scanners are considered by the authors as physical measurement systems capable of quantifying intrinsic parameters for the representation of the constitution and biophysical properties of tissues in vivo. In one respect, this approach fosters the development of new imaging methods for highly reproducible, system-independent, and quantitative biomarkers. These methods are greatly detailed in the book. Alternatively, this new edition equips the reader with a better understanding of how the physical properties of tissues interact with signal generation in medical imaging, opening up new insights into the complex and fascinating relationship between structure and function in living tissues. This updated edition is of interest to all those who recognize the limitations of clinical diagnosis based primarily on visual inspection of images, and who wish to learn more about the diagnostic potential of quantitative, biophysically-based medical imaging markers, as well as the challenges posed by the scarcity of such markers for next-generation imaging technologies.
Download or read book Atlas of Ultrasonography in Urology Andrology and Nephrology written by Pasquale Martino and published by Springer. This book was released on 2017-03-28 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the latest recommendations for ultrasound examination of the entire urogenital system, particularly in the male. The coverage encompasses the role of ultrasound in imaging of disorders of the kidneys, urinary tract, prostate, seminal vesicles, bladder, testes, and penis, including male infertility disorders. In addition, detailed consideration is given to intraoperative and interventional ultrasound and recently developed ultrasound techniques. Each chapter defines the purpose of and indications for ultrasound, identifies its benefits and limitations, specifies the technological standards for devices, outlines performance of the investigation, establishes the expected accuracy for differential diagnosis, and indicates the reporting method. Most of the recommendations are based on review of the literature, on previous recommendations, and on the opinions of the experts of the Imaging Working Group of the Italian Society of Urology (SIU) and the Italian Society of Ultrasound in Urology, Andrology, and Nephrology (SIEUN). The book will be of value for all physicians involved in the first-line evaluation of diseases of the renal/urinary system and male genital disorders.
Download or read book Gastrointestinal Imaging written by Angela D. Levy and published by Rotations in Radiology. This book was released on 2015 with total page 761 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a comprehensive review of gastrointestinal pathologies commonly encountered by practising radiologists and residents in training. The chapters are organised by organ system and include the pharynx and esophagus, stomach, small bowel, appendix, colon, anorectum, liver, gallbladder, bile ducts, pancreas, spleen, peritoneum, mesentery, and abdominal wall, and one on multisystem disorders. The book offers a guided approach to imaging diagnosis with examples of all imaging modalities complimented by the basics of technique and interpretation and the nuances necessary to reach the best diagnosis.
Download or read book Hepato Pancreato Biliary and Transplant Surgery written by Quyen D Chu and published by Beaux Books Publishing, LLC. This book was released on 2018-01-08 with total page 1352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique textbook provides a concise and practical approach to clinical dilemmas involving the liver, pancreas, and biliary tree. Six major sections encompass (1) Hepatic, (2) Biliary, (3) Pancreas, (4) Transplantation, (5) Trauma, and (6) Innovative Technology. Each topic is written by recognized experts from an "e;experiential"e; viewpoint combined with evidence-based medicine. The book contains over 170 chapters and over 350 contributors. It is relevant to Surgical Oncologists, Hepato-Pancreato-Biliary (HPB) Surgeons, Transplant Surgeons, Traumatologists, HPB Interventionalists, General Surgeons, and trainees and students. The title of each chapter is in a form of a clinical scenario and each chapter begins with a Case Scenario and ends with Salient Points. Special debates are included in each section. There are numerous compelling images, detailed illustrations, comprehensive tables, thorough algorithms, and other adjunctive tools that enhance learning. The authors emanate from different corners of the world. The book is a valuable resource for faculty, students, surgical trainees, fellows, and all health care providers in the HPB/Trauma/Transplant/Oncology fields.
Download or read book Magnetic Resonance Elastography written by Sudhakar K. Venkatesh and published by Springer. This book was released on 2014-10-01 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.
Download or read book ALERT Adverse Late Effects of Cancer Treatment written by Philip Rubin and published by Springer Science & Business Media. This book was released on 2013-12-12 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt: The literature on the late effects of cancer treatment is widely scattered in different journals since all major organ systems are affected and management is based on a variety of medical and surgical treatments. The aim of "ALERT – Adverse Late Effects of Cancer Treatment" is to offer a coherent multidisciplinary approach to the care of cancer survivors. Volume 2 of this two-volume work comprehensively documents potential late effects in all the normal tissue anatomic sites in the human body. The detection, diagnosis, management and prevention of effects are all considered in detail, and prognostic outcomes are discussed. Radiation risk factors and interactions with chemotherapy effects are clearly presented. The text is accompanied by numerous supportive illustrations and tables. It is anticipated that this textbook will become the gold standard in providing information on the late effects of cancer treatment and that, in its digitized form, it will be referenced in cancer survivorship guidelines.
Download or read book Artificial Intelligence in Medical Imaging written by Erik R. Ranschaert and published by Springer. This book was released on 2019-01-29 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relating to the growing role of big data in radiology. Diverse real-life clinical applications of AI are then outlined for different body parts, demonstrating their ability to add value to daily radiology practices. The concluding section focuses on the impact of AI on radiology and the implications for radiologists, for example with respect to training. Written by radiologists and IT professionals, the book will be of high value for radiologists, medical/clinical physicists, IT specialists, and imaging informatics professionals.
Download or read book CT and MR Guided Interventions in Radiology written by Andreas H. Mahnken and published by Springer Science & Business Media. This book was released on 2013-05-14 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interventional radiology is an indispensable and still expanding area of modern medicine that encompasses numerous diagnostic and therapeutic procedures. The revised and extended second edition of this volume covers a broad range of non-vascular interventions guided by CT or MR imaging. Indications, materials, techniques, and results are all carefully discussed. A particularly comprehensive section is devoted to interventional oncology as the most rapidly growing branch of interventional radiology. In addition, detailed information is provided that will assist in establishing and developing an interventional service. This richly illustrated book will be a most valuable source of information and guidance for all radiologists who deal with non-vascular procedures.
Download or read book Radiofrequency Ablation for Small Hepatocellular Carcinoma written by Minshan Chen and published by Springer. This book was released on 2015-11-26 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive guide to the treatment of small hepatocellular carcinoma (sHCC) using a minimally invasive technique: radiofrequency ablation (RFA). RFA has emerged as a new treatment modality and become the main modality of locoregional therapy. Extensive clinical research indicates that RFA is as effective as surgical resection for sHCC, and it has the advantage of being less invasive. However, the outcomes after RFA are largely dependent on the operators’ experience- known as the “learning curve”. This book presents the characteristics of sHCC and discusses why sHCC is the best candidate for RFA. Then it introduces all the commercially available RFA systems, and their working principles, advantages, disadvantages and so on. It goes on to demonstrate how to perform RFA under the guidance of ultrasound, CT, laparoscopy, or during open operation. Finally, it discusses the radiologic assessment and follow‐up after RFA, as well as adjuvant therapies and clinical trials on RFA. The authors are experts from the fields of pathology, radiology, surgery, and gastroenterology, as well as manufacturers. With this book, readers gain have a clear idea of when and how to do RFA. It aims to standardize and generalize the procedure of RFA, which will be very helpful in improving the outcome of RFA for sHCC.
Download or read book Ultrasound in Gastroenterology written by Paul A. Dubbins and published by . This book was released on 1994 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the series reflects the rapid advances that have occurred in the use of ultrasound in the investigation of gastroenterology diseases.
