Download or read book Paediatric drug optimization for antibiotics written by World Health Organization and published by World Health Organization. This book was released on 2023-03-22 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Paediatric drug optimization standard procedure written by and published by World Health Organization. This book was released on 2021-11-19 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this document is to provide guidance on how to undertake a paediatric drug optimization (PADO) exercise and identify key priority products for research and development. This guidance is for all technical units undertaking a PADO exercise, all stakeholders involved in PADO processes as well as interested organizations and experts involved in the research and development of therapeutics in the public and private sectors.
Download or read book Towards investigation development and introduction of cefiderocol in children written by World Health Organization and published by World Health Organization. This book was released on 2023-11-16 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: In November-December 2022, WHO undertook a Paediatric Drug Optimization (PADO) exercise for antibiotics, to: identify antibiotics with an approved indication for children for which age-appropriate formulations are missing that need to be given priority for development (PADO priority list); and pipeline or approved antibiotics without an indication for children to be given priority for further investigation and development for children (PADO watch list). Cefiderocol was included in the PADO priority list considering its efficacy against multiple pathogens in the WHO Bacterial Priority Pathogens List, its favorable resistance and cross-resistance profile and considering that clinical trials involving children are ongoing. This information note aims to provide a summary of cefiderocol’s characteristics (regulatory approvals, current formulations, inclusion in the WHO EML etc), current and planned paediatric studies (including neonates) and initiatives to ensure prompt access for all people in need, as well as lay out interventions that should be prioritized by researchers and funders for cefiderocol development, as well as, more broadly for antibiotics that are much needed in children.
Download or read book Handbook Of Pediatric Drug Therapy And Immunization written by Suneja and published by Elsevier India. This book was released on 2008 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides comprehensive, up-to-date information about current guidelines for drug therapy in important diseases and emergencies in children; rational antimicrobial therapy; immunization and immunoprophylaxis. Besides others, the important topics covered include Blood Component Therapy and Antidotes for Common Poisoning . Separate sections deal with Drugs , Vaccines, Immunoglobulins and Antitoxins their indications, dosage, mode of use, precautions and other information. About the Author : - RK Suneja, former Head, Department of Pediatrics and Medical Superintendent, Hindu Rao Hospital is one of the leading pediatricians based at New Delhi, India.
Download or read book The Optimization of Drug Prescribing in Children written by Hugo Juárez Olguín and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatrics is the form of medical care that is concerned with children from birth to adolescence, specializing in a variety of characteristics and changes subjective to each patient. Undoubtedly, these changes influence drug distribution and response. The body composition and the processes of biological and physiological maturation constitute important variables worthy of consideration in the effort to adequately satisfy the therapeutic necessities of all the age groups, since different formulations are required to achieve optimum therapy. The technological advances in the last decades have endowed humanity with the facilities to painstakingly analyze biological samples and thus give way to potential progress in pharmacokinetics and pharmacodynamics. From this knowledge, it becomes clear that the body is a dynamic model and thus, brings to light the necessity to individualize treatment regimens based on parameters of each and every individual, which in the past was not as important. There are instruments that contribute to optimizing drug management and safety in the pediatric population as recommended by the World Health Organization that rotate on the application of drug monitoring strategies that would contribute to ensuring the safety of patients and improve treatment schemes with increasingly safe and effective drugs. Furthermore, recourses to the therapeutic monitoring of drugs would become available where a monitoring based principally on the drug plasma levels is carried out in order to make the pertinent dose adjustments. The need for this will arise, since the most effective therapeutic range of many drugs is still unknown; unnecessarily high concentrations with potential risks of producing toxicity in patients is something that must be avoided. With these factors in mind, the decision to compose this book for pediatric doctors as well as specialists in the health sector who are dedicated to childcare became apparent, with the hope of portraying an array of pharmacokinetic knowledge, based on new therapeutic strategies ensuing from information furnished by research. The authors are convinced that the consideration of these concepts would definitely permit the elaboration of optimum and specific treatment for each pediatric patients.
Download or read book Antibiotic Pharmacodynamics written by John C. Rotschafer and published by Humana. This book was released on 2016-03-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text offers state of the art contributions written by world renown experts which provide an extensive background on specific classes of antibiotics and summarize our understanding as to how these antibiotics might be optimally used in a clinical situation. The book explores pharmacodynamics methods for anti-infective agents, pharmacodynamics of antibacterial agents and non-antibacterial agents, as well as pharmacodynamic considerations and special populations. As part of the Methods in Pharmacology and Toxicology series, chapters include detailed insight and practical information for the lab. Comprehensive and cutting-edge, Antibiotic Pharmacodynamics serves as an ideal reference for scientists investigating advances in antibiotic pharmacodynamics now finding their way into the antibiotic development process used for licensing new antibiotics.
Download or read book Model Based Evaluation of Antimicrobial Agents in Children written by Wei Zhao and published by Frontiers Media SA. This book was released on 2021-10-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Johannes N. van den Anker is the Chief Medical Officer at Reveragen Biopharma, as well as holding his positions at academic institutions. The other Topic Editor declares no competing interests with regard to the Research Topic subject.
Download or read book Paediatric Clinical Pharmacology written by Evelyne Jacqz-Aigrain and published by CRC Press. This book was released on 2021-02-25 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of children with medicinal products is an important scientific area. It is recognized that many medicines that are used extensively in pediatric patients are either unlicensed or off-label. This textbook will help pediatric health professionals effectively treat children with the most appropriate medicine with minimal side effects.
Download or read book Paediatric Formulation written by Nunzio Denora and published by MDPI. This book was released on 2021-09-02 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of paediatric medicines can be challenging since this is a different patient population with specific needs. A medicine designed for use in paediatric patients must consider the following aspects: patient population variability; the need for dose flexibility; route of administration; patient compliance; excipient tolerability. For example, the toxicity of excipients may differ in children compared to adults and children have different taste preferences. Globally, about 75% of drugs do not carry regulatory approval for use in children; worldwide, many medications prescribed for the treatment of paediatric diseases are used off-label, and less than 20% of package inserts have sufficient information for treating children. This book provides an update on both state-of-the-art methodology and operational challenges in paediatric formulation design and development. It aims at re-evaluating what is needed for more progress in the design and development of age-appropriate treatments for paediatric diseases, focusing on: formulation development; drug delivery design; efficacy, safety, and tolerability of drugs and excipients.
Download or read book Manual of Childhood Infections written by Mike Sharland and published by Oxford University Press, USA. This book was released on 2011-04-07 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual gives information on the causative organisms, epidemiology and clinical features of all important childhood infections. It includes guidance on the clinical management of the infections and on steps to be taken to prevent future cases.
Download or read book Paediatric drug optimization for neglected tropical diseases written by World Health Organization and published by World Health Organization. This book was released on 2023-11-21 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Priority-setting is the first step to enable a targeted approach to research and development. Developing a prioritized drug portfolio of the most needed formulations for children is essential to streamline researchers’ and supplier’s efforts and resources around specific dosage forms and formulations that address most urgent needs for children. In general, due to limited financial incentives, few new drugs are being developed for Neglected Tropical Diseases (NTDs). Several NTDs disproportionately affect children compared to adults and, as is the case like for most diseases affecting adults and children, the burden to children is compounded by lack of inclusion of paediatric populations in clinical trials and/or lack of age-appropriate dosing regimens and formulations. The PADO-NTD exercise concluded with a final meeting organized in September 2023 with representatives from the four prioritized disease areas to reach consensus on a final PADO-NTD priority list, watch list and research questions and discuss transversal issues for the way forward. The meeting report will include summaries of the background, discussions and deliberations of all PADO exercises, and final conclusions and outputs of the overall PADO for NTD exercises.
Download or read book Addressing the Barriers to Pediatric Drug Development written by Institute of Medicine and published by National Academies Press. This book was released on 2008-08-12 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research have demonstrated that children do not respond to medications in the same way as adults. Differences between children and adults in the overall response to medications are due to profound anatomical, physiological, and developmental differences. Although few would argue that children should receive medications that have not been adequately tested for safety and efficacy, the majority of drugs prescribed for children-50 to 75 percent-have not been tested in pediatric populations. Without adequate data from such testing, prescribing drugs appropriately becomes challenging for clinicians treating children, from infancy through adolescence. Addressing the Barriers to Pediatric Drug Development is the summary of a workshop, held in Washington, D.C. on June 13, 2006, that was organized to identify barriers to the development and testing of drugs for pediatric populations, as well as ways in which the system can be improved to facilitate better treatments for children.
Download or read book Antimicrobial Stewardship written by Matthew Laundy and published by Oxford University Press. This book was released on 2016 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotic resistance threatens the effective prevention and treatment of infections. Antimicrobial Stewardship provides a practical guide on this growing area, supported by the review of the available evidence, including example case studies.
Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Download or read book Pocket Book of Hospital Care for Children written by World Health Organization and published by World Health Organization. This book was released on 2013 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pocket Book is for use by doctors nurses and other health workers who are responsible for the care of young children at the first level referral hospitals. This second edition is based on evidence from several WHO updated and published clinical guidelines. It is for use in both inpatient and outpatient care in small hospitals with basic laboratory facilities and essential medicines. In some settings these guidelines can be used in any facilities where sick children are admitted for inpatient care. The Pocket Book is one of a series of documents and tools that support the Integrated Managem.
Download or read book Neonatal perinatal Medicine written by Richard E. Behrman and published by Mosby. This book was released on 1977 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pediatric Board Study Guide written by Osama Naga and published by Springer. This book was released on 2015-03-27 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the most frequently asked and tested points on the pediatric board exam. Each chapter offers a quick review of specific diseases and conditions clinicians need to know during the patient encounter. Easy-to-use and comprehensive, clinicians will find this guide to be the ideal final resource needed before taking the pediatric board exam.
