Download or read book P2 Purinoceptors written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
Download or read book Functional Expression of P2 Purinoceptors in a Primary Neuroglial Cell Culture of the Rat Arcuate Nucleus written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The P2 Nucleotide Receptors written by John T. Turner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: A state-of-the-art summary from leading laboratories around the world of our current knowledge of the molecular biology, the physiology, and the pharmacology of the P2 receptors. The authoritative contributions cover the major aspects of these receptors, describing the relationships between physiological and pharmacological effects of ATP and other nucleotides and the various cloned P2 receptors, as well as providing an historical perspective and discussing current issues of nomenclature. They also illuminate how P2 receptor structures contribute to their function, including the physical differences underlying the pharmacological and functional variations among P2 receptor subtypes.
Download or read book Structure and Function of P2 purinoceptors written by and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Investigations Into the Properties of Vascular P2 purinoceptors written by Barbara E. Crack and published by . This book was released on 1993 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purinergic Receptors written by G. Burnstock and published by Springer. This book was released on 1981-06-30 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fifty-odd years have elapsed since the first observation of the response of visceral smooth muscle to an adenine nucleotide was reported by Drury and Szent Gyorgi (1929). It is now known that purinergic receptors mediating responses to adenosine and the adenine nucleotides (AMP, ADP and ATP) are present in all types of visceral smooth muscle. Adenine itself and other endogenous purine derivatives appear to have no direct effects, or only minimal effects, on most visceral smooth muscles. Airway smooth muscle is an exception in this regard, and responds to purine bases and non-adenine nucleosides and nucleotides. Knowledge of the distribution of purinergic receptor sites on the plasma membrane of visceral musculature has grown particularly rapidly since Burnstock and his colleagues (1970) proposed that ATP, or a related adenine derivative, is the inhibitory transmitter released from non cholinergic non-adrenergic nerves present in the gut. Much evidence has been presented favoring the view that ATP is the inhibitory transmitter, and evidence to the contrary has also been put forward. The hypothesis remains controversial primarily because specific blockers of the postsynaptic purinergic site, with which the hypothesis might be tested, have not been found. Nevertheless, the numerous studies designed to investigate the purinergic nerve hypothesis have generated much information concerning the nature of the purinergic receptors in visceral smooth muscle.
Download or read book Pharmacological Properties of P2 X purinoceptors in Smooth Muscle and Autonomic Neurones written by B. S. Kakh and published by . This book was released on 1995 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterisation of P2 Purinoceptors on Vascular Endothelial Cells written by Graeme Francis Wilkinson and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies on P2 purinoceptors and Ectonucleotidases on Guinea pig Visceral Smooth Muscle written by Laurence Alexander Welford and published by . This book was released on 1987 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Purinergic Receptor Expression in Neuronal Bladder Smooth Muscle and Urothelial Cells written by J. L. Gever and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus, unraveling the functional role - and pharmacological potential - of any subtype is a complex task. Additionally limiting is the paucity of potent, selective antagonists, particularly those with suitable physicochemical and pharmacokinetic properties for animals models and clinical development. These studies address questions initially debated >10 years ago, following the successful cloning of purinoceptor families. First, given the large, polyanionic or nucleotide chemical probes available for pharmacology, are these receptors medicinally tractable? Secondly, given the admixture of purinoceptor expression in mammalian cells, would selective interference impact pathophysiology and disease burden; or would redundancy dominate? Through the current investigations some answers can be offered. First, a resounding "yes", second, a more equivocal "possibly". Importantly, in addressing these queries, our investigations - and others - have furnished both important data on biological relevance of P2 subtype expression and function, as well as excellent chemical and biological tools for future investigators, so that more answers can be found. Meanwhile, the pharmacological characteristics of two novel prototype antagonists have been detailed: for P2X1 (RO-1) and P2X3-containing receptors (RO-4). Additionally, the potential value of these compounds for the study of P2X signaling in vitro and in vivo, as well as templates for candidate medicines with a wide variety of potential therapeutic uses are demonstrated. It has also been possible to elucidate the potential of selective interference in certain target tissues - urological and sensory - and increasing the apparent therapeutic potential. We can indeed conclude that P2X channels of focus in this work, P2X1, P2X3 and P2X2/3, are druggable; the true therapeutic value of antagonists of these channels is awaited.
Download or read book Receptors P1 and P2 as Targets for Drug Therapy in Humans written by Robson Faria and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Download or read book An Investigation of the P1 P2 Purinoceptor Hypothesis written by Christine Mary McKillop and published by . This book was released on 1981 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Structure and Function of P 2 purinoceptors written by and published by . This book was released on 1995 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulatory Function of Adenosine written by Robert M. Berne and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: The principal objective of this symposium was to bring together investigators from all over the world who work in diverse areas of research but share a common interest in the physiologic and pathophysiologic funetions of the nueleoside adenosine. In 1978, the "International Conference on Physiological and Regulatory Funetions of Adenosine and Adenine Nueleotides," held in Banff, Canada, served as an effective catalyst in enabling scientists with differ ent points of view to exchange information and ideas on this subject. Since 1978, the amount of research on different as peets of adenosine metabolism, mechanism of action, transport, and function in various tissues (in both nor maI and abnormal states) has increased exponentially, and there was an urgent need for another meeting for updating information on this burgeoning subject. The focus of the meeting was extremely sharp, but the scope of the subject material was very broad. Scientists categorized as chemists, biochemists, physiologists, pharmacologists, and immunologists, working with cells and eelI fragments, with tissues such as heart, brain, musele, fat, kidney, and with human beings having immune deficiency diseases participated in the sym posium. They had an opportunity to air their differences, reinforce their areas of agreement, and, most important, they educated each other with respeet to research on adenosine; it is hoped that they also enriched their own research programs from the information they gained from their fellow participants.
Download or read book Expression Function and Modulation of Nicotinic ACh Receptors and P2 Purinoceptors in Rat Parasympathetic Neurons written by Dongmei Liu and published by . This book was released on 2001 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book P2 Purinoceptors written by CIBA Foundation Symposium and published by Wiley. This book was released on 1996-08-06 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
Download or read book Pharmacology of Purine and Pyrimidine Receptors written by and published by Academic Press. This book was released on 2011-07-13 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for understanding tissue protection Subject matter is of intense interest for new drug development
