Download or read book Oxygen Sensing in Tissues written by Helmut Acker and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a wide biological range of problems regarding oxygen sensing in tissues. Oxygen sensing is defined as a process in which 02 reacts with different cellular components to avoid hypoxic cell damages. Oxygen sensing contributes to auxiliary mechanisms which help bacteria, invertebrates, vertebrates, and mammalians to survive and withstand hypoxic sensations. For the first time, experts from different disciplines have cooperated in examining various biological systems exhibiting this phenomenon.
Download or read book Measuring Oxidants and Oxidative Stress in Biological Systems written by Lawrence J. Berliner and published by Springer Nature. This book was released on 2020-08-08 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Download or read book Oxygen Sensing written by Sukhamay Lahiri and published by Springer Science & Business Media. This book was released on 2006-03-06 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the XIVth International Symposium on Arterial Chemoreception, held June 24-28, 1999, in Philadelphia, Pennsylvania. This volume, containing the proceedings of the fourteenth biannual ISAC meeting presents a new departure from their traditional focus on arterial chemoreceptors and their functions, in the expansion to include the study and discussion of oxygen sensing in other tissues and cells, and the genes involved. Bringing together scientists from cellular and systemic boundaries of physiology, working at the interface of cellular and molecular biology, this book, containing new physiological and biochemical perspectives.
Download or read book Tissue Hypoxia and Ischemia written by Martin Reivich and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph contains the proceedings of a symposium entitled, "Tissue Hypoxia and Ischemia," which was held at the Annenberg Center of the University of Pennsylvania on August 13 and 14, 1976. The symposium was jointly sponsored by the following groups at the University of Pennsylvania: the Respiratory Physiology Group of the Department of Physio logy, the Cardiopulmonary Section of the Department of Medicine, the Johnson Research Foundation, the Cerebrovascular Research Center of the Department of Neurology, the Head Injury Center of the Department of Neurosurgery, the. Institute for Environ mental Medicine, and the International Society on Oxygen Transport to Tissues. Its purpose was to promote an interdisciplinary discussion of oxygen sensors in various tissues and their mechanism of action as well as to examine the deleterious effects of hypoxia and ischemia with special reference to the brain. There were four sessions, one on the biochemistry of physi ologic oxygen sensors, two on the mechanism of oxygen sensing in tissues and one on the circulatory and metabolic aspects of cerebral hypoxia and ischemia.
Download or read book Oxygen Sensing written by and published by Elsevier. This book was released on 2004-05-10 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.
Download or read book Regulation of Tissue Oxygenation Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.
Download or read book Oxygen Transport to Tissue III written by I. Silver and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the papers which were presented at the Third International Symposium on Oxygen Transport to Tissue together with the discussions at the end of each Session. The meeting was held at Churchill College, Cambridge from July 4th-7th 1977. Our special thanks are due to Mrs. Valerie Jeal and Mr. Charles Drown of the Department of Pathology, Bristol, who were invaluable in ensuring the smooth running of the meeting and the preparation of this book. We are very grateful to Dr. Marian Silver for proof-reading and helping to disentangle the "discussion". We would also express our thanks for the general help received from Janet and Fiona Silver and Steven James and our appreciation of the cheerful assistance of Miss Sadie Williams in putting the finishing touches to the manuscript. August, 1977 I. A. Silver M. Erecinska H. I. Bicher Contents Session 1 - OXYGEN ELECTRODES AND BLOOD MONITORING DEVICES The Bitumen P0 Electrode - A New Method to 2 Manufacture P0 Needle Electrodes 3 2 H. Acker, D. Sylvester, E. Dufau, and H. Durst A Working Equation for Oxygen Sensing Disk Electrodes • • • • • • 9 T. E. Tang, R. E. Barr, V. G. Murphy, and A. W. Hahn Variations on the Response Characteristics of Oxygen Electrodes •••• 17 R. E. Barr, T. E. Tang, and A. W. Hahn Directly Heated Transcutaneous Oxygen Sensor 25 H. P. Kimmich, J. G. Spaan, and F.
Download or read book Signalling Pathways in Acute Oxygen Sensing written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2006-03-30 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen sensing is a key physiological function of many tissues, but the identity of the sensor, the signalling pathways linking the sensor to the effector, and the endpoint effector mechanisms are all subjects of controversy. This book evaluates the various mediators that have been proposed, including the mitochondria, NAD(P)H oxidases, cytochrome p450 enzymes, and direct effects on enzymes and ion channels. There has been a resurgence of interest in the role of mitochondria, based partly on the ability of mitochondrial inhibitors to mimic hypoxia, but there is little consensus concerning mechanisms. Some favour the view that the primary signalling event is a reduction in cell redox state and reactive oxygen species (ROS) due to general inhibition of the electron transport chain (ETC); others support a key role for complex III of the ETC and an increase in ROS generation, while others doubt either of these components is the key intermediary. All these hypotheses are discussed in the book, together with conceptual problems concerning the ability of mitochondria to respond to physiological hypoxia. The other area of controversy covered in the book is the identity of the endpoint effector(s). Some authors favour K+ channel inhibition, followed by depolarization and Ca2+ entry via L-type channels, while others propose that release of Ca2+ from intracellular stores, or capacitative Ca2+ entry and other voltage-independent pathways may be more important. The book also describes evidence for an endothelium-dependent Ca2+-sensitizing pathway involving Rho and possibly other kinases. While some of these differences can be attributed to variation between tissues, many must be related to differences in interpretation or methodology. In this book, experts in the field of acute oxygen sensing working in different tissues address these controversies and their possible origins, and discuss possible approaches whereby these controversies might be resolved. The book will be of great interest to all those working in fields where oxygen sensing is important, particularly cancer and wound healing, as well as researchers in drug discovery and biotechnology.
Download or read book Oxygen Transport to Tissue III written by I. Silver and published by Springer. This book was released on 1978-03-01 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the papers which were presented at the Third International Symposium on Oxygen Transport to Tissue together with the discussions at the end of each Session. The meeting was held at Churchill College, Cambridge from July 4th-7th 1977. Our special thanks are due to Mrs. Valerie Jeal and Mr. Charles Drown of the Department of Pathology, Bristol, who were invaluable in ensuring the smooth running of the meeting and the preparation of this book. We are very grateful to Dr. Marian Silver for proof-reading and helping to disentangle the "discussion". We would also express our thanks for the general help received from Janet and Fiona Silver and Steven James and our appreciation of the cheerful assistance of Miss Sadie Williams in putting the finishing touches to the manuscript. August, 1977 I. A. Silver M. Erecinska H. I. Bicher Contents Session 1 - OXYGEN ELECTRODES AND BLOOD MONITORING DEVICES The Bitumen P0 Electrode - A New Method to 2 Manufacture P0 Needle Electrodes 3 2 H. Acker, D. Sylvester, E. Dufau, and H. Durst A Working Equation for Oxygen Sensing Disk Electrodes • • • • • • 9 T. E. Tang, R. E. Barr, V. G. Murphy, and A. W. Hahn Variations on the Response Characteristics of Oxygen Electrodes •••• 17 R. E. Barr, T. E. Tang, and A. W. Hahn Directly Heated Transcutaneous Oxygen Sensor 25 H. P. Kimmich, J. G. Spaan, and F.
Download or read book Oxygen Transport to Tissue III written by I. Silver and published by Springer. This book was released on 1978-03-01 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the papers which were presented at the Third International Symposium on Oxygen Transport to Tissue together with the discussions at the end of each Session. The meeting was held at Churchill College, Cambridge from July 4th-7th 1977. Our special thanks are due to Mrs. Valerie Jeal and Mr. Charles Drown of the Department of Pathology, Bristol, who were invaluable in ensuring the smooth running of the meeting and the preparation of this book. We are very grateful to Dr. Marian Silver for proof-reading and helping to disentangle the "discussion". We would also express our thanks for the general help received from Janet and Fiona Silver and Steven James and our appreciation of the cheerful assistance of Miss Sadie Williams in putting the finishing touches to the manuscript. August, 1977 I. A. Silver M. Erecinska H. I. Bicher Contents Session 1 - OXYGEN ELECTRODES AND BLOOD MONITORING DEVICES The Bitumen P0 Electrode - A New Method to 2 Manufacture P0 Needle Electrodes 3 2 H. Acker, D. Sylvester, E. Dufau, and H. Durst A Working Equation for Oxygen Sensing Disk Electrodes • • • • • • 9 T. E. Tang, R. E. Barr, V. G. Murphy, and A. W. Hahn Variations on the Response Characteristics of Oxygen Electrodes •••• 17 R. E. Barr, T. E. Tang, and A. W. Hahn Directly Heated Transcutaneous Oxygen Sensor 25 H. P. Kimmich, J. G. Spaan, and F.
Download or read book Oxygen Transport to Tissue XX written by Antal G. Hudetz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: ''In addition to a wide variety of traditional oxygen transport topics, particular areas have been selected for emphasis at the 1997 meeting, which are: Molecular and genetic techniques to study oxygen transport in health and disease Angiogenesis during hypoxia, ischemia, and development Physiological mechanisms of oxygen sensing Physiological fluctuations of cerebral blood flow, metabolism and oxygenation Near infrared and phsophorescence techniques for the assessment of blood and tissue oxygenation Advances in biotechnology of anticoagulants and blood substitutes. '' (excerpted from the Preface).
Download or read book The Arterial Chemoreceptors written by Yoshiaki Hayashida and published by Springer Science & Business Media. This book was released on 2006-04-24 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents an updated review of the physiology of the carotid body chemoreceptors. It contains results in the topics at the frontiers of future developments in O2-sensing in chemoreceptor cells. Additionally, this volume provides data from studies carried out in other O2-sensing tissues including pulmonary vasculature and erythropoietin producing cells. It is a prime source of information and a guideline for arterial chemoreception researchers.
Download or read book Oxygen Transport to Tissue XXXIX written by Howard J. Halpern and published by Springer. This book was released on 2018-08-22 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents all aspects of delivery of oxygen to tissues and tumors in peer reviewed short articles. Both overview and the most recent, advanced techniques for oxygen measurement are presented. Articles and peer reviewers include those from leaders in their field. Topics such as molecular signaling in the organismal and tumor response to low levels of local oxygenation, hypoxia inducible factor (HIF) , cancer metabolism, individual human and animal response to oxygen changes monitored by optical/near infrared spectroscopy/ tomography to novel electron resonance spectroscopy and spectroscopic imaging, instrumentation, progress in blood substitute research, retinal physiology, cellular hypoxia, mitochondrial function; brain oxygenation and function; oxygen transport in sports, hypoxia in diseases and clinical care. Chapters 10 and 19 of this book are open access under a CC BY 4.0 license.
Download or read book Oxygen Sensing written by Sukhamay Lahiri and published by CRC Press. This book was released on 2003-04-15 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviewing research on the molecular basis of oxygen homeostasis, this text describes the changes in intracellular signalling and gene expression that lead to physiological responses to hypoxia in unicellular, invertebrate, and mammalian species. It examines O2 sensing systems in bacteria and archaea and demonstrates interrelationships among cell proliferation, energy metabolism, oxygen homeostasis, redox states, signal transduction and gene expression in humans and other organisms. The book describes the effect of hypoxia on carotid body structure and function and the effect of alterations in oxygen homeostasis on the pathophysiology of cardiac ischemia, cancer, stroke, and chronic lung disease.
Download or read book Oxygen Transport to Tissue XXXI written by Eiji Takahashi and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Society on Oxygen Transport to Tissue (ISOTT, www. isott. info) is an interdisciplinary society comprising about 250 members worldwide. Its purpose is to further the understanding of all aspects of the processes involved in the transport of oxygen from the air to its ultimate consumption in the cells of the various organs of the body. The annual meeting brings together scientists, engineers, clinicians and mathematicians in a unique int- national forum for the exchange of information and knowledge, the updating of participants on latest developments and techniques, and the discussion of controversial issues within the field of oxygen transport to tissue. Founded in 1973, the society has been the leading platform for the presentation of many of the technological and conceptual developments within the field both at the meetings themselves and in the proceedings of the society. These have been published first by Plenum Publishing (1973), then by Kluwer Academic/Plenum Publishers and presently by Springer Publishing, all in the Advances In Expe- mental Medicine and Biology Series. The 36th Annual ISOTT conference was held in Sapporo, Japan during August 3–7, 2008. It was the second occasion that the ISOTT meeting was held in Japan; the first one was held in the same place in 1987 organized by Professor Masaji Mochizuki.
Download or read book Gas Sensing in Cells written by Shigetoshi Aono and published by Royal Society of Chemistry. This book was released on 2017-10-31 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas molecules such as O2, NO, CO and ethylene are present in the environment and are endogenously (enzymatically) produced to act as signalling molecules in biological systems, including the regulation of metabolic networks, chemotaxis, circadian rhythms, mammalian hypoxia responses, and plant ethylene responses by transcriptional, translational, or post translational control. Sensing these gas molecules is the first step in their acting as signalling molecules. When a sensor domain/protein senses an external signal, intra- and inter-molecular signal transductions take place to regulate the biological function of a regulatory domain/protein such as DNA-binding, enzymatic activity, or protein–protein interaction. Interaction between gas molecules and sensor proteins is essential for recognition of gas molecules. Metal-containing prosthetic groups such as haem, iron–sulfur clusters, and non-haem iron centres are widely used. As these metal-containing centres are good spectroscopic probes, detail characterizations have utilized spectroscopic techniques along with X-ray crystallography. Covering both the signalling and sensing of gaseous molecules, this book provides the first comprehensive overview of gas sensor proteins in both prokaryotic and eukaryotic cells. This book will be particularly interesting to postgraduates and researchers in biochemistry, molecular biology and metallobiology.
Download or read book Stress Signaling in Plants Genomics and Proteomics Perspective Volume 1 written by Maryam Sarwat and published by Springer Science & Business Media. This book was released on 2013-06-21 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant diseases, extreme weather caused by climate change, drought and an increase in metals in soil are amongst the major limiting factors of crop production worldwide. They devastate not only food supply but also the economy of a nation. Keeping in view of the global food scarcity, there is, an urgent need to develop crop plants with increased stress tolerance so as to meet the global food demands and to preserve the quality of our planet. In order to do this, it is necessary to understand how plants react and adapt to stress from the genomic and proteomic perspective. Plants adapt to stress conditions by activation of cascades of molecular mechanisms, which result in alterations in gene expression and synthesis of protective proteins/compounds. From the perception of the stimulus to transduction of the signal, followed by an appropriate response, the plants employ a complex network of primary and secondary messenger molecules. Cell signaling is the component of a complex system of communication that directs basic cellular activities and synchronizes cell actions. Cells exercise a large number of noticeably distinct signaling pathways to regulate their activity. In order to contend with different environmental adversities plants have developed a series of mechanisms at the physiological, cellular and molecular level. This two volume set takes an in-depth look at the Stress Signaling in Plants from a uniquely genomic and proteomics perspective. Stress Signaling in Plants offers a comprehensive treatise on the Chapter, covering all of the signaling pathways and mechanisms that have been researched so far. Each chapter provides in-depth explanation of what we currently know of a particular aspect of stress signaling and where we are headed. All authors have currently agreed and abstracts have been complied for the first volume, due out midway through 2012. We aim to have the second volume out at the beginning of 2013.
