Download or read book Oxy radicals in Molecular Biology and Pathology written by Upjohn Company and published by . This book was released on 1988 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxy Radicals in Molecular Biology and Pathology written by Peter A. Cerutti and published by Wiley-Liss. This book was released on 1988-09-22 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides in-depth coverage of recent advances in oxy-radical biology and medicine. Examines the deleterious effects of oxy-radicals at the tissue, cellular, and molecular levels; and application of ESR and spin-trapping to in vivo detection and identification of free radicals. Also covers biological sources of O2-, superoxide dismutases, the defensive role of glutathione peroxidase against oxygen toxicity, regulation of the GSHPx gene, and much more.
Download or read book Oxy radicals in Molecular Biology and Pathology written by and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxy radicals in Molecular Biology and Pathology written by UCLA SYMPOSIA ON MOLECULAR AND CELLULAR BIOLOGY and published by . This book was released on 1983 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxy radical in Molecular Biology and Pathology written by and published by . This book was released on 1988 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oxygen Radicals in Biology and Medicine written by Michael Simic and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 1064 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.
Download or read book Oxygen Free Radicals in Tissue Damage written by TARR,M. and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxygen free radicals and other reactive oxygen species are being postulated as causal agents in an increasing number of pathological conditions. Indeed, some investigators are suggesting that highly destructive reactive oxygen species are the final common path lead ing to tissue damage following a wide variety of insults including trauma, hypoxia, ischemia, hyperoxia, radiation, some toxins, and even strenuous athletic pursuits. But, as Robert Floyd points out, "Proof of the importance of oxygen free radicals and the oxidative damage they initiate depend on unequivocal evidence for the pres ence of free radicals and a clear association of their formation with the induction of the dysfunction of pathological conditions. " Since such proof does not come easily, there have been and will continue to be many controversies regarding the role played by reactive oxygen species in tissue damage. There have been many recent reviews of the chemistry and pos sible role of reactive oxygen species in many types of organ dys functions, tissue damage, degenerative diseases, and aging. This book is not such a review. Rather it presents for a diverse audience of physical-organic chemists, biochemists, medical researchers, and other investigators of pathophysiology, discussions of a variety of is sues important for understanding reactive oxygen species and their role in tissue damage.
Download or read book Oxygen Nitrogen Radicals Cell Injury and Disease written by Val Vallyathan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: A veritable mountain of literature has been published showing the causal relationship of reactive oxygen/nitrogen species in human disease conditions, and there has been an explosion in the understanding of oxidative stress, the protective role of antioxidants and molecular events involved in the regulation of transcription, editing, and translation of key events leading to disease processes. Strategies need to be developed for prevention of diseases by allowing scientists and clinicians to obtain information on new and emerging advances. The molecular mechanisms involved in several diseases including Alzheimer's disease, atherosclerosis, diabetes, arthritis, and Parkinson's disease, as well as disorders of the eye, skin, cardiac, and pulmonary systems are discussed in this volume, along with scientific evidence supporting the value of dietary supplementation with antioxidants in the prevention of cellular damage leading to chronic disease. Special in vivo techniques are also discussed at length, along with the role of molecular studies in human risk assessment.
Download or read book Free Radical Damage and its Control written by C.A. Rice-Evans and published by Elsevier. This book was released on 1994-02-09 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive treatise on the chemical and biochemical consequences of damaging free radical reactions, the implications for the pathogenesis of disease and how this might be controlled endogenously and by radical scavenging drugs. Oxidative stress may be influenced by exogenous agents of oxidative stress, radiation, trauma, drug activation, oxygen excess, or by exogenous oxidative stress which is associated with many pathological states including chronic inflammatory disorders, cardiovascular disease, injury to the central nervous system, and connective tissue damage. This and many other such aspects are presented clearly and in depth. The development of antioxidant drugs depends on the understanding of the mechanisms underlying the generation of excessive free radicals in vivo, the factors controlling their release and the site of their action. This excellent volume presents an up-to-date account of the current state of knowledge in these areas.
Download or read book Oxyradicals in Medical Biology written by J.M. McCord and published by Elsevier. This book was released on 1998-04-23 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid expansion of the area of free radical biology in the last 25 years has occurred within a framework of assumptions and preconceived notions that has at times directed the course of this movement. The most dominant of these notions has been the view that free radical production is without exception a bad thing, and that the more efficient our elimination of these toxic substances, the better off we will be. The very important observation by Bernard Babior and colleagues in 1973 that activated phagocytes produce superoxide in order to kill micro organisms, served to illustrate that constructive roles are possible for free radicals. For many in the field, however, this merely underscored the deadly nature of oxygen-derived radicals, both from the microbe's point of view and from the host's as well. (Phagocyte-produced superoxide is responsible in part for the tissue injury manifested as inflammation. See Harris and Granger, Chapter 5, and Leff, Hybertson and Repine, Chapter 6.) Mother Nature, however, has a penchant for being able to make a silk purse from a sow's ear. If one is dealt a bad hand, one must simply make the best of it. After two decades of focusing on the destructive side of free radicals, the last few years have begun to reveal a new and finer perspective on free radical metabolism - a role in regulation of cellular function (see Schulze-Osthoff and Baeuerle, Chapter 2). Evidence from a number of sources suggests that an increase in the oxidative status of cell encourages that cell to grow and divide. Increasing the expression of mangnese superoxide dismutase can suppress the malignant phenotype of melanon cells (see Oberley and Oberley, Chapter 3). Oxidative stress beyond a certain poitosis (from the Greek, literally "to fall apart"). Is this suicide response an evolutionary fail-safe device to curtail tumorogenesis? Does oxidative stress-induced apoptosis account for the loss of immune cells in AIDS (see Flores and McCor Chapter 4)? This volume attempts to present the spectrum of roles, both good and bad played by active oxygen species as understood at this point in the evolution of this field of free radical biology.
Download or read book Oxygen Radicals written by Kunio Yagi and published by . This book was released on 1992 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an increasing number of reports that suggest that oxygen radicals play a role in a wide variety of pathological conditions such as atherosclerosis, cancer, ischemia, inflammation, radiation injury, and environmental stress and that they may be important in the aging process. This publication comprises of poster presentations given at the 5th International Congress on Oxygen Radicals which was held on November 17-21, in Kyoto, Japan. Contributions to this volume describe the generation and reaction of oxygen radicals and lipid peroxides, and the pathophysiological effects of various radical species. Furthermore, presentations on the effect of antioxidants in preventing free radical injury were given. A summarized version of the contents is provided hereunder.
Download or read book Oxygen Radicals in Chemistry and Biology written by Wolf Bors and published by de Gruyter. This book was released on 1984 with total page 1060 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Oxygen Radicals in Chemistry and Biology".
Download or read book Calcium Oxygen Radicals and Cellular Damage written by C. J. Duncan and published by Cambridge University Press. This book was released on 1991-11-21 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cellular events underlying rapid cellular damage in different organs are potentially of great medical importance, for example muscular dystrophy, liver damage and the preservation of kidneys for transplantation. Many hypotheses exist for the biochemical pathways involved in these damage processes. The roles of calcium and active oxygen metabolites are of particular interest. There is considerable literature on both these triggering agents and good evidence for their involvement in the genesis of damage, although little agreement on their precise roles. This volume records the proceedings of a meeting held by the Society for Experimental Biology that attempted to determine whether there are common mechanisms of cellular damage and to explore the ways in which calcium and oxygen radicals may interact to generate damage. The questions addressed, in particular, are whether there are any common biochemical pathways, and the specific and possibly interacting roles of calcium and active oxygen metabolites.
Download or read book Free Radicals in Molecular Biology Aging and Disease written by Donald Armstrong and published by Lippincott Williams & Wilkins. This book was released on 1984 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Signaling Mechanisms of Oxygen and Nitrogen Free Radicals written by Igor B Afanas'ev and published by CRC Press. This book was released on 2019-08-30 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Once the existence of free radicals was proven, an avalanche of studies on free radical-mediated biological processes ensued. The study of reactive oxygen and nitrogen species (ROS and RNS) is center stage in biological free radical investigations. Written by a biochemist, Signaling Mechanisms of Oxygen and Nitrogen Free Radicals discusses the regulatory functions of ROS and RNS in physiological and pathophysiological states. An exploration of the main questions of signaling mechanisms of reactive oxygen and nitrogen species in enzymatic processes, this book draws attention to the chemical mechanisms of these reactions. It elucidates the differences between signaling functions and damaging effects of ROS and RNS in biological systems. The text also covers free radical signaling processes catalyzed by enzymes, producers of superoxide and nitric oxide that are able to use produced ROS and RNS as signaling species in their own catalytic processes. It then examines ROS and RNS signaling produced by mitochondrial enzymes. The author explores signaling functions of ROS and RNS in enzymatic heterolytic reactions, supplying important data on ROS and RNS signaling in the catalysis by the enzymes which do not produce free radicals by themselves. He provides information on signaling by reactive oxygen and nitrogen species in apoptosis and aging/senescence and concludes with coverage of mechanisms of free radical signaling in enzymatic processes. The book provides new understanding of signaling functions in living organisms related to cardiovascular processes, cancer, inflammation, hereditary diseases, and their regulation of physiological functions such as development, aging, and senescence. This information can support the development of new drugs and novel treatment methods.
Download or read book Free Radicals and Antioxidant Protocols written by Rao M. Uppu and published by Humana Press. This book was released on 2010-05-03 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cutting-edge and updated book offers methods for the rapid detection of RONs and redox stress. It includes in-depth analysis of natural and synthetic antioxidants, and also of DNA oxidation, oxidative lipidomics, and biomarkers.
Download or read book Oxygen Radicals in Chemistry and Biology written by Wolf Bors and published by . This book was released on 1984-03-01 with total page 1029 pages. Available in PDF, EPUB and Kindle. Book excerpt:
