Download or read book Polyphenol Oxidases written by Pradeep Verma and published by Walter de Gruyter GmbH & Co KG. This book was released on 2024-04-22 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, there are no books that cover all the dimensions of Polyphenol Oxidases (PPOs), which is why publication of the book is needed. The book focuses on its types, structure, distinctive aspects, applications, genetic engineering, and commercial status. PPOs have been used for wastewater remediation and in environmental biosensors. The role of PPOs in global sustainability along with challenges and future prospects is also discussed.

Download or read book Amine Oxidases in Clinical Research written by V. Z. Gorkin and published by Elsevier. This book was released on 2013-10-22 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amine Oxidases in Clinical Research discusses the functions of amine oxidases in the rapid development of medical and biological research. Composed of 13 chapters, the book focuses on amine oxidases, including their key role in the metabolism of biogenic amines and other nitrogenous compounds in diseases and human health. The book considers primarily the enzymes denoted as EC 1.4.3.4 (flavin amine oxidases or monoamine oxidases) and EC 1.4.3.6 (copper-containing amine oxidase or diamine oxidases). To measure the estimates of amine oxidase activity, several methods and a number of requirements are presented. A description of the distribution and intracellular localization of amine oxidase follows. The methods of isolation and purification of amine oxides from different sources and the results of these various methods are explained. The text also considers the properties of the purified amine oxidases: the different methods of isolation and purification; storage conditions; and analytical techniques. Care is given when examining amine oxidases, because these may exhibit considerable differences in substrate specificity even if their physicochemical properties are similar. Inhibition of amine oxidase activity by unspecific and specific inhibitions is further discussed, including the biological functions and known effects of hormones on the biosynthesis and catabolism of the amine oxidase. Finally, the possible pathogenetic and/or diagnostic significance of the amine oxidases, as well as the corrective approaches seen in pathological conditions and in clinical medicine, are explained. Written as a handbook for the medically oriented investigators, biologists, and medical and chemical researchers, this book will prove a handy reference.

Download or read book Copper Amine Oxidases written by Giovanni Floris and published by CRC Press. This book was released on 2009-06-01 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the amount of research on copper amine oxidases has grown rapidly and substantially in the past decade, the field unfortunately suffers from lack of cohesion and significant confusion surrounds aspects as simple as confirmation of enzyme identities. This book describes the structure of the enzymes, the role of copper, and of the unusual co

Download or read book Structure and Functions of Amine Oxidases written by Mondovi and published by CRC Press. This book was released on 2018-01-10 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: A good portion of this book has been devoted to the copper-dependent enzymes, these being the more numerous. The chapter dealing with serum amine oxidases also focuses attention on their catalytic mechanism, as these enzymes have been studied in greater depth.As the presentation of topics whose experimental basis is rapidly developing is likely to stimulate the reader‘s interest, many bibliographic references have been included.Readers could find this book poor, as far as many topics are dealt with in a relatively little space, but we believe it essential to trace the background of our present knowledge in the field of amine oxidases, stressing the future outlook of research on these enzymes, for they are becoming more and more important in general and medical biochemistry.

Download or read book Structure and Functions of Amine Oxidases written by Mondovi and published by CRC Press. This book was released on 2018-01-10 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: A good portion of this book has been devoted to the copper-dependent enzymes, these being the more numerous. The chapter dealing with serum amine oxidases also focuses attention on their catalytic mechanism, as these enzymes have been studied in greater depth.As the presentation of topics whose experimental basis is rapidly developing is likely to stimulate the reader‘s interest, many bibliographic references have been included.Readers could find this book poor, as far as many topics are dealt with in a relatively little space, but we believe it essential to trace the background of our present knowledge in the field of amine oxidases, stressing the future outlook of research on these enzymes, for they are becoming more and more important in general and medical biochemistry.

Download or read book Functions of Alternative Terminal Oxidases written by Hans Degn and published by Elsevier. This book was released on 2013-10-22 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functions of Alternative Terminal Oxidases is a collection of papers from the 11th meeting of the Federation of European Biochemical Societies in Copenhagen in 1977. The book opens with a review of the alternate electron transport mechanism to the main phosphorylating respiratory chain. One paper presents the respiration of mutant stains of Neurospora crassa treated with chloramphenicol that results in three distinct pathways distinguishable by the use of inhibitors. Another paper outlines the testing methods to determine the parameters controlling cyanide-insensitive respiration in Acanthamoeba castellanii and notes the physiological function of this insensitivity. The book then explains that this phenomenon of cyanide-insensitive respiration is common among yeasts, and such pathway of electron transport to oxygen that is insensitive to cyanide or antimycin is well founded in many higher plants and microorganisms. One paper then investigates the terminal oxidases found in two stages in the life cycle of trypanosomes, which cause African sleeping sickness. Another paper notes that a study of the energy metabolism of End. magnusii, a kind of yeast, showed no glucose repression, no alternative oxidation pathway, and no cyanide-insensitive pathway was normally present. The text will be of interest to those whose work involves these organisms, and to researchers, professors, and students whose disciplines are in developmental biology, micro-biology, or cellular biology.

Download or read book Amine Oxidases and Their Impact on Neurobiology written by Peter Riederer and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Amine Oxidase Workshop was the brain child of Brian Callingham and Keith Tipton. The present book is the proceedings of the fourth in the series and in the past we have dedicated our meeting to individuals who have made significant fundamental contributions to the biochemistry, physiology and pharmacology of this interesting group of enzymes. The present meeting is not an exception because we have gathered here in Wtirzburg to honour an individual whose outstanding work on the autonomic pharmacology has span ned more than 30 years and whose contribution has made a vast impact in our understanding of the kinetic relationship between amine metabolism (that uptake and enzymatic inactivation) and adrenergic neurotransmission. We speak of course of Professor Ullrich Trendelenburg, or Ulli as he likes to be known. Like the amine oxidases, he has a unique place in Pharmacology. Professor Trendelenburg was born on the eve of the new year of 1922 in the city of Rostock in northern Germany, where his father was Professor of Pharmacology at the Faculty of Medicine of Rostock. His father accepted the offer to take over the corresponding chair in Freiburg im Breisgrau (in Southern Germany). As the youngest of four children, Ulli grew up mainly in the garden of the department, in the animal quarters and in the workshop. Of the various coworkers of his father, one he liked especially was Otto Krayer, the young pharmacologist.

Download or read book NADPH Oxidases Revisited From Function to Structure written by Edgar Pick and published by Springer Nature. This book was released on 2023-06-22 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a unique, comprehensive, and up-to-date overview of the various NADPH oxidases and narrates the history of their discovery, biochemical characteristics, genetics, molecular structure, and multiple functions in health and disease. It covers the subject in a manner that serves both the expert and the novice researcher in the field. The book starts with an overview of the major milestones in the discovery of the archetypical NADPH oxidase, known as cytochrome b558, and its cytosolic regulators. This is followed by personal recollections by pioneers of the field, descriptions of the work of the major figures of the past by their followers, and a rendering of the history of the discovery of the Nox family. The central section of the book consists of chapters devoted specifically to an in depth description of the individual members of the Nox family, and is followed by chapters focused on the modulators of their function. A subsequent section comprises chapters dealing with methodologies of Nox research, interaction with other proteins, and Nox inhibitors. A distinct section of the book deals with non-mammalian Noxs, from amoeba to zebrafish. Subsequent chapters focus on Nox structure, a field in which extraordinary progress was made in recent years. The volume ends with chapters on Chronic Granulomatous Disease, the consequence of Nox loss-of-function, and its treatment by gene therapy. The coda is a crystal ball perspective of the hopes for the clinical translation of basic Nox research. Written for biochemists, cell biologists, molecular biologists, and clinicians, this book is aimed at both senior scientists and young investigators in the field.

Download or read book Amine Oxidases Function and Dysfunction written by K.F. Tipton and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoamine oxidase plays a major role in the pathogenesis of neuropsychiatric disorders including depressive illness, Parkinson ́s disease and Alzheimer ́s disease. The new generation of selective monoamine oxidase inhibitors, devoid of major side effects, has found a prominent place in the treatment of these diseases. Some of these drugs may have neuroprotective activity with prospects for treating progressive neurodegenerative diseases. The volume presents a collection of research papers on monoamine oxidase and its inhibitors. The topic is treated from the point of view of chemistry, biochemistry, pharmacology, physiology, neurology and psychiatry. The book serves as a quick and comprehensive reference source for obtaining the most up to date information.

Download or read book MAO The Mother of all Amine Oxidases written by John P.M. Finberg and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinson’s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and characterization of these phenotypes, as well as the structure of MAO genes, is explored. Advances in the biochemistry of MAO subtypes and their physiological function and localization in brain and periphery is included. Other sections of the book deal with the neuroprotective action of MAO inhibitors and their pharmacology, especially the pharmacology of new MAO-B inhibitors.

Download or read book Oxidases Dehydrogenases and Related Systems written by and published by Walter de Gruyter. This book was released on 2012-12-21 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dynamic field of flavin and flavoprotein biochemistry has seen rapid advancement in recent years. This comprehensive two volume set provides an overview of all aspects of contemporary research in this important class of enzymes. Topics treated include flavoproteins involved in energy generation, signal transduction and electron transfer (including respiration); oxygen activation by flavoproteins; the biology and biochemistry of complex flavoproteins; flavin and flavoprotein photochemistry/photophysics as well as biotechnological applications of flavoproteins. Recent developments in this field include new structures (including those of large membrane-integral electron transfer complexes containing FMN or FAD), elucidation of the role of flavoproteins in cell signalling pathways (including both phototaxis and the circadian cycle) and important new insights into the reaction mechanisms of flavin-containing enzymes. This volume focussing on oxidases, dehydrogenases and related systems is an essential reference for all researchers in biochemistry, chemistry, photochemistry and photophysics working on flavoenzymes.

Download or read book Polyphenol Oxidases PPOs in Plants written by Aravind Jukanti and published by Springer. This book was released on 2017-08-18 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is first of its kind exclusively dedicated to plant polyphenol oxidases (PPOs), highlighting their importance in the food processing industry. By reviewing the scientific developments of the past several decades, it offers a comprehensive overview of various aspects of plant PPOs, including chemistry, structure, functions, regulation, genetics/genomics and molecular aspects. PPOs are copper-containing proteins found in several plant species that catalyze the hydroxylation of o-monophenols to o-diphenols and oxidation of the o-dihydroxyphenols to o-quinones. Further, the quonines undergo self-polymerization or react with amines/thiol groups to produce brown/dark coloration of products. All the PPOs contain two Cu-binding sites (CuA and CuB) as their central domain, these interact with phenolic substrates and molecular oxygen. Several of the plant PPOs contain an N-terminal transit peptide (~80-100 amino acids ) necessary for plastid import. The PPOs occur in latent form that are activated by various treatments including acid and base shock, exposure to detergents or proteolytic degradation. The pH optimum of PPOs varies widely depending upon different plant species but is usually ~4.0 – 8.0. Similarly, the optimum temperature also varies as per the source and substrate involved ranging from 30 to 45 °C. Multiple PPO isoforms have been reported in several plant species, and the chromosomal location of PPOs has also been studied in some species. The physiological role (s) of PPOs is not entirely understood, but they could be involved in defense-related functions in plants. From an applied perspective, PPOs are implicated in enzymatic browning/darkening of cereal products, vegetables and fruits. Interestingly, browning is preferred in some instances like the processing of black tea, cocoa, and coffee as it enhances their quality by forming flavorful products. There have b een initiatives to specifically breed and develop cultivars with reasonably low PPO levels in the mature grain or fruit. Further, several types of inhibitors that reduce the PPO activity have also been identified. Despite their commercial/economic importance and the availability of literature on different aspects of PPOs in different plant species, this is the first book to provide basic information regarding PPOs. It is a valuable resource for researchers involved in quality-related research specifically in crops, vegetables and fruits. Further, as PPOs are also implicated in defense- or stress-related functions, the book is also useful to breeders, pathologists, molecular biologists, physiologists and entomologists.

Download or read book Monoamine Oxidase and its Inhibition written by G. E. W. Wolstenholme and published by John Wiley & Sons. This book was released on 2009-09-16 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Download or read book Flavin Dependent Enzymes Mechanisms Structures and Applications written by and published by Academic Press. This book was released on 2020-09-21 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Enzymes, Volume 47, highlights new advances in the field, with this new volume presenting interesting chapters on The Multipurpose Family of Oxidases, Vanillyl alcohol oxidase, Choline oxidases, Aryl alcohol oxidase, D- and L-amino acid oxidases, Sugar oxidases, Phenolic Compounds hydroxylases, Baeyer-Villiger Monooxygenases, Flavin-dependent halogenases, Flavin-dependent dehalogenases, Styrene Monooxygenases, Bacterial luciferases, Cellobiose Dehydrogenases, Prenylated flavoenzymes, Ene-reductases, Flavoenzymes in Biocatalysis. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

Download or read book The Oxidases and Other Oxygen catalysts Concerned in Biological Oxidations written by Joseph Hoeing Kastle and published by . This book was released on 1910 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Oxidases and Related Redox Systems written by Tsso E. King and published by Elsevier. This book was released on 2013-10-22 with total page 1295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidases and Related Redox Systems is a collection of papers from the Third International Symposium on Oxidases and Related Reduction Systems held in Albany, New York on July 3-7, 1979. This book deals with the oxygen and peroxide activating enzymes field. The book addresses electron transfer related to oxygen biochemistry by comparing quantum, semiclassical, and classical methods of electron transfer reactions. Several papers then discuss the active and toxic states of oxygen and superoxide as the discovery of superoxide dismutase activity of erythrocuprein can provide a means to studying oxygen reaction in biological systems. One paper then compares the active sites of molluskan and arthropodan hemocyanins, which are known as reversible oxygen-carriers. The result of this study is presented in a table. Other papers discuss the flavin catalyzed reactions of molecular oxygen and the implications of the physiological function of D-amino acid oxidase from inhibition studies. The book then explains the role of carbon monoxide in the reaction mechanism of oxygen with cytochrome oxidase. This collection will prove beneficial for research students and professors in the field of biochemistry and chemical physics.

Download or read book Biocatalysis in the Pharmaceutical and Biotechnology Industries written by Ramesh N. Patel and published by CRC Press. This book was released on 2006-09-26 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemic