Download or read book Overcoming Skin Rejection in Composite Tissue Allotransplantation written by B. Horner and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of composite tissue techniques is constrained by the susceptibility of skin to rejection. The aim of this thesis is to improve our understanding of skin rejection and find ways to avoid it, in order to enable expansion of the application of composite tissue transplantation techniques. The first part of the thesis explores the consequences and mechanism of skin rejection in rat models. These studies indicate that in the event of allograft failure, there is minimal damage to the vascular pedicle of a composite tissue allotransplant, even after full rejection, making retransplantation possible. Furthermore, there is only mild damage to the recipient tissues, indicating that the second transplant would not be limited in form or function by recipient tissue bed damage. Finally, the studies indicate that there are significant differences between the mechanism of rejection of skin in composite tissue transplants and conventional skin grafts. This means that much of the historical data relating to skin graft rejection is not necessarily relevant to composite tissue allotransplantation. The second part of the thesis uses swine models to explore ways to overcome skin rejection while avoiding the toxicity of chronic systemic immunosuppression, through tolerance induction, and site specific therapy. Previous experience in organ and composite tissue allotransplantation models are analysed to develop the hypothesis that high-level chimeras are tolerant to vascularised skin allotransplants. In utero and adult chimerism induction models are then used in an attempt to attain moderate-level chimeras. A vascularised skin allotransplant model is developed. Finally, the hypothesis is confirmed with the transplantation of a vascularised skin allotransplant on to moderate-level chimeras with the achievement of tolerance. In addition, site-specific therapy is used in an attempt to avoid the side-effects of chronic high-dose systemic immunosuppression. This led to prolongation of skin survival, but eventual skin rejection.

Download or read book Transplantation of Composite Tissue Allografts written by Charles W. Hewitt and published by Springer Science & Business Media. This book was released on 2007-12-20 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brilliant synthesis summarizes all of the recent accomplishments – as well as the ongoing research – in the field of composite tissue transplantation. It includes sections on hand transplantation and vascularized bone marrow transplantation. The volume focuses on immunology and the biotechnology/bioengineering aspects of transplantation surgery, as those two areas have demonstrated the most growth within the last five years in terms of current research.

Download or read book Composite Tissue Allograft written by Hakim Nadey S and published by World Scientific. This book was released on 2006-05-05 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first textbook of its kind dealing with composite tissue allograft and allograft transplantation, provides an excellent overview on the subject. It provides a clear description of the current status of the transplant of every composite tissue allograft already performed and others which are still at the basic experimental level.The editors of the book, who also contribute chapters in their expertise, are world renowned surgeons. This book opens with an introductory chapter on the history of this type of transplantation and then details the clinical experience in each graft such as hand, larynx, face, uterus and the related histopathology, immunosuppression and immunomodulation.A multidisciplinary and comprehensive presentation of the various aspects of this new area of transplantation will allow the reader to understand the complexity and the challenges of composite tissue transplantation. A number of important topics are analyzed and discussed in detail, such as the ethical, medicolegal, psychological and immunological implications. New rehabilitation techniques and strategies, together with innovative tools for the functional evaluation of the transplanted parts, are highlighted. A section on the experimental work underlines what lies ahead of us./a

Download or read book Composite Tissue Allografts written by Jean-Michel Dubernard and published by MIT Press. This book was released on 2002 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplanting hands -- a model of composite tissue grafting -- began in Lyons in November 1998 with the transplant of one hand and then, in January 2000, of two, both with the support of the Mérieux Foundation. Advances in immunosuppression made possible some unusual transplants of tissue, such as bones, knee-joints, femurs and larynx. From these stemmed the first attempts to transplant hands. This book looks at the long-term results of reattaching hands that have been accidentally amputated. It reviews all the problems -- technical, immunological, nervous, functional and psychological -- that surgeons encountered during and after the transplants. Surgeons, transplant experts, immunologists, dermatologists, psychiatrists, neurophysiologists, physiotherapists and re-education experts will also find here answers to their ethical and legal questions about removing tissue from donors, as well as information about composite tissue grafts in plastic and reconstructive surgery.

Download or read book Sentinel Skin Allograft for Monitoring of Composite Tissue Transplants Rejection written by Zamfirescu DG and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Modelling and Characterisation of in Vivo Human Skin Graft Rejection for the Investigation of Regulatory T Cell Therapy in Vascularised Composite Allotransplantation written by Fadi Issa and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascularised composite allograft (VCA) transplantation is revolutionising the field of plastic surgery. It reconstructs the most complex tissue defects effectively, achieving a new functional and cosmetic gold standard. However, VCA transplantation is currently limited by high rates of acute rejection and the need for patients without life-threatening conditions to be maintained on immunosuppression for life. Skin is the most problematic component of VCA transplants. It stimulates a vigorous immune response and is highly susceptible to rejection, even in the presence of potent immunosuppression. In order to expand the field of VCA transplantation and improve outcomes, the morbidity and mortality associated with immunosuppression need to be minimised or eliminated. This would require manipulation of the immune response to allow long-term survival in the absence of immunosuppression, in other words tolerance. A particular focus on the immune response directed against skin is required. Tolerance to skin allografts may be achievable with the use of regulatory T cells (Treg). Due to relatively few clinical cases, human skin transplantation is a poorly investigated area. The studies in this thesis were therefore designed to elucidate the characteristics of human skin rejection using a novel humanised mouse model, testing the hypothesis that human Treg could prevent human skin rejection in vivo. In Chapters 3 and 4 we develop a system whereby human skin rejection may be modelled effectively in vivo. Subsequently we investigate the unique characteristics of human skin rejection using this model. In Chapter 5 we demonstrate the capacity for Treg to prevent human skin rejection and investigate the systemic and local cellular changes resulting from Treg therapy. These changes include a reduction in the number of circulating proliferating T cells, a preservation of skin microvasculature, and a reduction in skin-infiltrating CD8+ leukocytes. Treg migrate to the allograft-draining lymph node and into the skin allograft to regulate immune responses. We demonstrate the importance of expansion or activation of Treg for their suppressive activity and the requirement for these cells to be derived from the allograft recipient for efficient regulation to be achieved. Treg cellular therapy has already been trialed clinically for the prevention of graft- versus-host disease after haematopoietic stem cell transplantation. The use of Treg in transplantation is therefore on the horizon. The unique translational data from this study bridge a critical gap between laboratory observations and the clinic. These data therefore form the basis upon which future clinical trials of Treg in skin or VCA transplantation may be performed.

Download or read book Advances in Bioartificial Materials and Tissue Engineering Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Bioartificial Materials and Tissue Engineering Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Bioartificial Materials and Tissue Engineering. The editors have built Advances in Bioartificial Materials and Tissue Engineering Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bioartificial Materials and Tissue Engineering in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Bioartificial Materials and Tissue Engineering Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Download or read book Facial Trauma Surgery E Book written by Amir H Dorafshar and published by Elsevier Health Sciences. This book was released on 2019-02-18 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering authoritative guidance and a multitude of high-quality images, Facial Trauma Surgery: From Primary Repair to Reconstruction is the first comprehensive textbook of its kind on treating primary facial trauma and delayed reconstruction of both the soft tissues and craniofacial bony skeleton. This unique volume is a practical, complete reference for clinical presentation, fracture pattern, classification, and management of patients with traumatic facial injury, helping you provide the best possible outcomes for patients’ successful reintegration into work and society. Explains the basic principles and concepts of primary traumatic facial injury repair and secondary facial reconstruction. Offers expert, up-to-date guidance from global leaders in plastic and reconstructive surgery, otolaryngology and facial plastic surgery, oral maxillofacial surgery, neurosurgery, and oculoplastic surgery. Covers innovative topics such as virtual surgical planning, 3D printing, intraoperative surgical navigation, post-traumatic injury, treatment of facial pain, and the roles of microsurgery and facial transplantation in the treatment facial traumatic injuries. Includes an end commentary in every chapter provided by Dr. Paul Manson, former Chief of Plastic Surgery at Johns Hopkins Hospital and a pioneer in the field of acute treatment of traumatic facial injuries. Features superb photographs and illustrations throughout, as well as evidence-based summaries in current areas of controversy.

Download or read book Plastic Surgery Principles and Practice E Book written by Rostam Farhadieh and published by Elsevier Health Sciences. This book was released on 2021-04-22 with total page 924 pages. Available in PDF, EPUB and Kindle. Book excerpt: With detailed, expert guidance on each essential topic, Plastic Surgery: Principles and Practice offers single-volume convenience without sacrificing complete coverage of this multi-faceted field. Written by global leading authorities, it provides concise, easy-to-follow instruction with the clinical details and supportive data needed to achieve optimal patient outcomes. Offers thorough coverage of facelift procedures, rhinoplasty, otoplasty and more, along with clinical pearls from masters in the field. Features hundreds of high-quality images including anatomical line art, case photos, and procedural operative photos. I Includes a superb selection of procedural videos of global experts performing key techniques within operating room and close-up clinical pearls. An ideal resource for residents, fellows, and practitioners in plastic surgery, as well as those in otolaryngology, vascular surgery, and cosmetic dermatology.

Download or read book Scientific Principles of Adipose Stem Cells written by Lauren Kokai and published by Academic Press. This book was released on 2021-08-19 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Principles of Adipose Stem Cells provides readers with in-depth and expert knowledge on adipose stem cells, their developmental biologic origins, foundational research on ASC signaling mechanisms and immunomodulatory properties, and clinical insights into applications in regenerative medicine. Topics covered include basic adipose stem cell developmental biology and mechanisms of regulating self-renewal and activation in the stem cell niche, important methods for isolation and characterizing ASCs, and data on the impact on human demographics (age, sex, BMI) on ASC phenotype. A section devoted to ASC biology, ASCs for stem cell therapy and regenerative medicine, and ASCs in tissue engineering applications are also included. The book is written for scientists and clinicians who are broadly familiar with stem cells and basic cell biology principles and those seeking advanced information on adipose stem cells. Coverage of basic adipose stem cell developmental biology (maturation process during embryogenesis) and mechanisms of regulating self-renewal and activation in the stem cell niche Includes important methods for isolation and characterizing ASCs, as well as known data any impact of human demographics (age, sex, BMI) on ASC phenotype An entire section dedicated to ASC biology, additional sections will be devoted to ASCs for stem cell therapy and regenerative medicine, as well as ASCs in tissue engineering applications

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Download or read book Primer on Transplantation written by American Society of Transplantation and published by John Wiley & Sons. This book was released on 2011-03-07 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Produced in association with the American Society of Transplantation, this new edition is full of practical advice for the next generation of transplant professionals. In addition to 5 organ-specific chapters: kidney, pancreas, heart, lung and liver, the book includes essential information on: immunobiology pharmacology donor management infectious complications pediatric transplantation general principles of patient management Fully updated and redesigned to make it even more user-friendly, the book now contains clinical vignettes, key point boxes, and self-assessment multiple choice questions in each chapter. Primer on Transplantation, Third Edition is an invaluable resource for all health professionals in the transplant team including trainees, residents, fellows, physicians, surgeons, nurses and transplant co-ordinators. Purchasing this book entitles you to access to the companion website: www.astprimer.com The website includes: Interactive Multiple-Choice Questions for each chapter Figures from the book as Powerpoints for downloading All chapters online

Download or read book Advances in Regenerative Medicine Role of Nanotechnology and Engineering Principles written by Venkatram Prasad Shastri and published by Springer Science & Business Media. This book was released on 2010-08-14 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.

Download or read book Nasal Reconstruction written by Frederick J. Menick and published by Elsevier Health Sciences. This book was released on 2009 with total page 789 pages. Available in PDF, EPUB and Kindle. Book excerpt: A nasal reconstruction authority shows you how to obtain the best outcomes and repair unsatisfactory results from former surgeries. In addition to presenting the latest principles and techniques, this new resource also examines evolving concepts and methods, keeping you at the forefront of today's practice. The book emphasizes the restoration of nasal defects-from simple to complex-and achieving normal appearance and function. Comprehensive coverage of all nasal injuries and available surgical methods-both cutting edge as well as older, established approaches-help you choose the best approach for each patient and situation. Full-color clinical photos offer real-life clinical views of conditions and step-by-step surgical results, and a bonus DVD-featuring operative clips-shows techniques in action as well as providing hints and tips for obtaining optimal surgical outcomes. Offers detailed coverage of the principles of nasal reconstruction and application of the aesthetic principles as they apply to the whole face. Discusses design, planning, technique, and pitfalls to avoid for the full range of nasal reconstruction for complete surgical management guidance. Covers the latest topics in reconstruction including three-stage forehead flap . repair of the cocaine nose . advances in the use of free flaps for lining . forehead skin graft . microvascular reconstruction of the nose and face . and revision surgery to equip you to meet a wide range of surgical needs. Features guidance on reconstruction of nasal defects due to cancer, trauma, infection, congential deformity, drug abuse, and collagen vascular disease. Provides expert advice on revision surgery-as well as refinement/touch-up procedures-to effectively handle a previously repaired nose. Includes a DVD with 90 minutes of surgical footage-including cases with a complete 2 stage and a 3 stage folded forehead flap-as well as hints and tips for obtaining optimal surgical outcomes.

Download or read book Injectable Biomaterials written by Brent Vernon and published by Elsevier. This book was released on 2011-01-24 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Novel injectable materials for non-invasive surgical procedures are becoming increasingly popular. An advantage of these materials include easy deliverability into the body, however the suitability of their mechanical properties must also be carefully considered. Injectable biomaterials covers the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology.Part one focuses on materials and properties, with chapters covering the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites. Part two covers the clinical applications of injectable biomaterials, including chapters on drug delivery, tissue engineering and orthopaedic applications as well as injectable materials for gene delivery systems. In part three, existing and developing technologies are discussed. Chapters in this part cover such topics as environmentally responsive biomaterials, injectable nanotechnology, injectable biodegradable materials and biocompatibility. There are also chapters focusing on troubleshooting and potential future applications of injectable biomaterials.With its distinguished editor and international team of contributors, Injectable biomaterials is a standard reference for materials scientists and researchers working in the biomaterials industry, as well as those with an academic interest in the subject. It will also be beneficial to clinicians. Comprehensively examines the materials, properties and biomedical applications of injectable materials, as well as novel developments in the technology Reviews the design of injectable biomaterials as well as their rheological properties and the mechanical properties of injectable polymers and composites Explores clinical applications of injectable biomaterials, including drug delivery, tissue engineering, orthopaedic applications and injectable materials for gene delivery systems

Download or read book Pediatric Hand Therapy written by Joshua M. Abzug and published by Elsevier Health Sciences. This book was released on 2019-11-07 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of optimal therapeutic interventions for pediatric patients with musculoskeletal conditions of the hand. This concise resource by Drs. Joshua Abzug, Scott Kozin, and Rebecca Neiduski offers practical recommendations and guidelines along with key background information, for a well-rounded, concise perspective on hand therapy for children. You’ll benefit from the knowledge and experience of orthopaedic surgeons and other members of the rehabilitation care team who provide a real-world, multidisciplinary approach to this complex field. - Covers a range of musculoskeletal conditions, including: congenital disorders, joint disorders, neuromuscular disorders, sports-related injuries, and trauma. - Includes supporting background information, including an overview of embryology, intrauterine diagnosis, and physical functional development. - Covers complementary, practical, and clinical approaches, including orthotic intervention and prosthetics. - Editors and contributors represent orthopaedic surgeons and members of the rehabilitation care team for a well-rounded perspective.

Download or read book Hand transplantation written by Marco Lanzetta and published by Springer Science & Business Media. This book was released on 2007-03-20 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents international experimental and clinical experience on limb transplantation and other composite tissue allografts, representing the most complete and comprehensive review of this innovative and ground breaking procedure. This book is a milestone in medical literature and an asset for every scientific library.