Download or read book Otitis Media Genomics and the Middle Ear Microbiome written by Regie Santos-Cortez and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Differences from Within written by Ari Gordon and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human-restricted bacterial species Moraxella catarrhalis and Haemophilus influenzae are common members of the healthy nasal microbiome, but they are also leading causes of ear infections in children (otitis media, or OM) and of lung exacerbations in adults with chronic obstructive pulmonary disease. Clinical outcomes of colonization are influenced by host and environmental factors, as well as the extensive genetically encoded differences in virulence among isolates of the same species. We performed comparative functional genomics on diverse M. catarrhalis isolated from children with OM to identify genetic and physiological differences associated with severe disease leading to tympanic membrane rupture. This work found that rupture-associated strains were phylogenetically distinct but shared a common global transcriptional pattern when co-cultured with human airway epithelial cells, distinguishing them from more typical strains. Additional analyses suggest that shared genetic differences in rupture-associated strains enhance invasion and survival in airway epithelial cells through their altered regulation of several metabolic pathways. These differences may enhance survival of M. catarrhalis in the middle ear, leading to more severe outcomes for OM patients. We also performed comparative genomic studies on collections of H. influenzae strains to identify genes whose presence or absence are associated with colonization persistence after OM treatment. Collectively, this thesis work has added to the growing evidence that pathogenicity varies among strains of M. catarrhalis and H. influenzae and has identified genes that may be driving these differences.
Download or read book Evidence based Otitis Media written by Richard M. Rosenfeld and published by PMPH-USA. This book was released on 2003 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence-Based Otitis Media offers one-stop shopping for the best current evidence to guide management decisions at the individual, organizational, and societal levels. This text details the importance of evidence-based data in interpreting the ever-enlarging body of literature on otitis media. The editors have assembled an impressive group of experts on all aspects of otitis media and addressed comprehensively many issues related to methodology, clinical management, and consequences of this disease. The eight chapters comprising the methodology section provide the necessary background and detail to allow physicians and other health professionals to understand and appreciate the value of evidence-based medicine. Updates include: the incorporation of new original research, systemic reviews, and evidence reports to existing chapters. New chapter topics include: evidence-based medicine, professional evidence reports, molecular and translational research, complementary and alternative medicine, bacteriologic efficacy of antimicrobials, vaccine prevention, international management perspectives, meta-analysis of speech and language sequelae, suppurative complications, host susceptibility to sequelae, and judicious use of systemic and topical antimicrobials. FEATURES: *Maturation of evidence-based medicine as a foundation for clinical care is reflected throughout the text. *Extensive evidence tables summarize study characteristics and quantitative outcomes for clinically relevant endpoints *Internationally distinguished contributors selected based on both their clinical expertise and their ability to write for an evidence-based text
Download or read book Textbook of Otitis Media written by Marcos V. Goycoolea and published by Springer Nature. This book was released on 2023-12-29 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents a broad approach to otitis media ranging from the basic to the advanced, and comprehensively reviews the diagnosis, treatment, management, and complications of patients with infections of the middle ear (OM). It has been proven that children whose hearing has been affected by otitis media suffer academically. Since their hearing is impaired, their scholastic performance deteriorates, leading to multiple health and social problems. This in turn has a cascading effect on the child's ability to perform and cope. Quite often these problems are silent and go unrecognized and misdiagnosed. The socioeconomic impact of otitis media is profound and can deeply and adversely impact a child's growth and development if not diagnosed correctly and in a timely manner. The textbook starts by covering the basics, including chapters on classification and terminology, anatomy and embryological development of the inner ear, the immune system and the inner ear, inflammation and infection, genetic predisposition, current treatment strategies including surgical and non-surgical approaches, and hearing devices. Following chapters review the current and future state of the art in OM, including chapters on tympanoplasty, temporal bone cholesteatomas, advanced hearing and balance evaluations, advanced imaging evaluations, and mastoidectomy. Textbook of Otitis Media will be a go-to resource for otorhinolaryngology residents and fellows, pediatricians, ENT surgeons, consultants, nurses, and audiologists.
Download or read book Inflammatory Cells and Bacteria in Mucoid Middle Ear Effusion of Patients with Secretory Otitis Media written by Pekka Sipilä and published by . This book was released on 1982 with total page 55 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recent Advances in Otitis Media written by David J. Lim and published by Wiley-Blackwell. This book was released on 1988 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Otitis Media in Infants and Children written by Charles D. Bluestone and published by W.B. Saunders Company. This book was released on 1988 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this text is a guide to the diagnosis and management of otitis media, one of the most frequently encountered infectious diseases of infancy and childhood.
Download or read book Otitis Media written by Robyn Marsh and published by Frontiers Media SA. This book was released on 2022-12-07 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Skin Gut Breast Microbiota Axes written by Lorenzo Drago and published by MDPI. This book was released on 2021-06-10 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the latest research on microbiota axes, with a special focus on the gut-skin axis and the role of microbial breast bacteria on human health communication. This book also contains discussions of the microorganism-derived products that can directly or indirectly be signals for our organs and systems. Gut dysbiosis, representing a disruption of intestinal integrity, can create aberrant physiological conditions (including immunological disorders, intestinal stress, and anxiety-like behavior), as well as high serum levels of microbial metabolites increasing oxidative stress dysfunctions and generalized inflammation. Much research in this field has been carried out in animal models, and establishing whether those findings translate to humans will be crucial but challenging. On the other hand, several studies conducted on humans have evaluated the link between fecal microbiota composition and quality of life by recruiting thousands of participants. As well as identifying bacterial genera associated with higher quality of life, they carried out metagenomic analyses that indicated that the potential of microorganisms to synthesize certain active metabolites, and especially their interrelation, may also correlate with general wellbeing. It is clear that many axes can influence our lives; the most important include “the gut-brain axis” and the “skin-gut-breast axis”. Together, the studies presented in this book have laid the foundations for a better understanding of the effects of gut microbiota on skin and on our body in general. The mechanisms that underlie them may represent the ideal focus for the initial efforts to explore the relevance of these axes for human wellbeing.
Download or read book Gut brain Connection Myth Or Reality Role Of The Microbiome In Health And Diseases written by Adrien A Eshraghi and published by World Scientific. This book was released on 2021-11-03 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the recent advancements in understanding the gut-brain interaction as well as gut microbiome and how this interaction plays a vital role in human health and disease are discussed. Each chapter gives an analysis of questions, research directions, and methods within the field of gut-brain axis. The readers will benefit from the latest knowledge about our understanding about how gut-brain axis and modulation of gut microbiome determines predisposition to neurological disorders. The multidisciplinary book is essential reading for anyone interested in the field of gut-brain axis and gut microbiome: from undergraduates to graduate students as well as scientists and physicians having an interest in the new exciting field of gut microbiome and its relationship with brain function.
Download or read book Polymicrobial Diseases written by Kim A. Brogden and published by . This book was released on 2002 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymicrobial diseases, those involving more than one etiologic agent, are more common than is generally realized and include respiratory diseases, gastroenteritis, conjunctivitis, keratitis, hepatitis, periodontal diseases, multiple sclerosis, genital infections, intra -- abdominal infections, and pertussis.
Download or read book Microbial Biofilms in Chronic and Recurrent Infections written by Axel Cloeckaert and published by Frontiers Media SA. This book was released on 2022-01-19 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Probiotic Dairy Products written by Adnan Y. Tamime and published by John Wiley & Sons. This book was released on 2018-02-05 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probiotic Dairy Products, 2nd Edition The updated guide to the most current research and developments in probiotic dairy products The thoroughly revised and updated second edition of Probiotic Dairy Products reviews the recent advancements in the dairy industry and includes the latest scientific developments in regard to the 'functional' aspects of dairy and fermented milk products and their ingredients. Since the publication of the first edition of this text, there have been incredible advances in the knowledge and understanding of the human microbiota, mainly due to the development and use of new molecular analysis techniques. This new edition includes information on the newest developments in the field. It offers information on the new ‘omic’ technologies that have been used to detect and analyse all the genes, proteins and metabolites of individuals’ gut microbiota. The text also includes a description of the history of probiotics and explores the origins of probiotic products and the early pioneers in this field. Other chapters in this resource provide valuable updates on genomic analysis of probiotic strains and aspects of probiotic products’ production and quality control. This important resource: Offers a completely revised and updated edition to the text that covers the topic of probiotic dairy products Contains 4 brand new chapters on the following topics: the history of probiotics, prebiotic components, probiotic research, and the production of vitamins, exopolysaccharides (EPS), and bacteriocins Features a new co-editor and a host of new contributors, that offer the latest research findings and expertise Is the latest title in Wiley's Society of Dairy Technology Technical Series Probiotic Dairy Products is an essential resource for dairy scientists, dairy technologists and nutritionists. The text includes the results of the most reliable research in field and offers informed views on the future of, and barriers to, the progress for probiotic dairy products.
Download or read book The Hologenome Concept Human Animal and Plant Microbiota written by Eugene Rosenberg and published by Springer Science & Business Media. This book was released on 2014-01-31 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Groundbreaking research over the last 10 years has given rise to the hologenome concept of evolution. This concept posits that the holobiont (host plus all of its associated microorganisms) and its hologenome (sum of the genetic information of the host and its symbiotic microorganisms), acting in concert, function as a unique biological entity and therefore as a level of selection in evolution. All animals and plants harbor abundant and diverse microbiota, including viruses. Often the amount of symbiotic microorganisms and their combined genetic information far exceed that of their host. The microbiota with its microbiome, together with the host genome, can be transmitted from one generation to the next and thus propagate the unique properties of the holobiont. The microbial symbionts and the host interact in a cooperative way that affects the health of the holobiont within its environment. Beneficial microbiota protects against pathogens, provides essential nutrients, catabolizes complex polysaccharides, renders harmful chemicals inert, and contributes to the performance of the immune system. In humans and animals, the microbiota also plays a role in behavior. The sum of these cooperative interactions characterizes the holobiont as a unique biological entity. Genetic variation in the hologenome can be brought about by changes in either the host genome or the microbial population genomes (microbiome). Evolution by cooperation can occur by amplifying existing microbes, gaining novel microbiota and by acquiring microbial and viral genes. Under environmental stress, the microbiome can change more rapidly and in response to more processes than the host organism alone and thus influences the evolution of the holobiont. Prebiotics, probiotics, synbiotics and phage therapy are discussed as applied aspects of the hologenome concept.
Download or read book Pseudomonas aeruginosa as an Opportunistic Pathogen written by Mario Campa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling the latest research by an international group of contributors, this volume covers the epidemiology, pathogenesis, clinical features, and control measures of this elusive microorganism. It will provide a deeper understanding of the pathogen to physicians and surgeons caring for patients infected, or at risk of becoming infected, with Pseudomonas Aeruginosa.
Download or read book The Connections Between Ecology and Infectious Disease written by Christon J. Hurst and published by Springer. This book was released on 2018-08-30 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes current advances in our understanding of how infectious disease represents an ecological interaction between a pathogenic microorganism and the host species in which that microbe causes illness. The contributing authors explain that pathogenic microorganisms often also have broader ecological connections, which can include a natural environmental presence; possible transmission by vehicles such as air, water, and food; and interactions with other host species, including vectors for which the microbe either may or may not be pathogenic. This field of science has been dubbed disease ecology, and the chapters that examine it have been grouped into three sections. The first section introduces both the role of biological community interactions and the impact of biodiversity on infectious disease. In turn, the second section considers those diseases directly affecting humans, with a focus on waterborne and foodborne illnesses, while also examining the critical aspect of microbial biofilms. Lastly, the third section presents the ecology of infectious diseases from the perspective of their impact on mammalian livestock and wildlife as well as on humans. Given its breadth of coverage, the volume offers a valuable resource for microbial ecologists and biomedical scientists alike.
Download or read book The Global Impact of Respiratory Disease written by Darcy D. Marciniuk and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
