Download or read book Principles of Osteoimmunology written by Peter Pietschmann and published by Springer. This book was released on 2016-08-18 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.
Download or read book Osteoimmunology written by Yongwon Choi and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has only recently been appreciated that the immune and skeletal systems have major interactions. It is now well documented that osteoclasts, which are important cellular mediators of skeletal homeostasis, are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines that were first shown to regulate immune cell function have also been demonstrated to regulate bone cells and influence skeletal health. Conversely, products of bone cells appear critical for the engraftment of marrow in bone, the normal development of the hematopoietic and immune systems and provide niche for long-term memory B and T cells. In the past scientists involved in immune and bone cell investigations have rarely interacted in a significant way as these disciplines have developed independently and, for the most part, remain separate. The conference will bring together leading international scientists from both fields to interact so that new collaboration can develop and more rapid progress in understanding the relationships between these fields can be achieved. Short talks will be selected from abstracts from the international community. This conference will have a format to provide an environment of maximum interaction and interchange through lectures, posters, and open discussion.
Download or read book Osteoimmunology written by Joseph Lorenzo and published by Academic Press. This book was released on 2015-09-23 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget's disease, the genetics of bone disease, and bone cancer metastasis. - Explains the intricate interaction between the immune system and bone - Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems - Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems
Download or read book Recent Advances in Basic and Translational Osteoimmunology written by Rupesh K. Srivastava and published by Frontiers Media SA. This book was released on 2022-01-10 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Updates on Osteoimmunology What s New on the Crosstalk Between Bone and Immune Cells written by Giacomina Brunetti and published by Frontiers Media SA. This book was released on 2020-03-24 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Innate Immunity in the Context of Osteoimmunology 2nd Edition written by Cristina Sobacchi and published by Frontiers Media SA. This book was released on 2021-07-01 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS. Part of the APCs for articles in this collection were financed by the Fondazione Beppe e Nuccy Angiolini ONLUS. Publisher’s note: In this 2nd edition, acknowledgment for the Fondazione Beppe e Nuccy Angiolini ONLUS has been added.
Download or read book Bone metastasis in the milieu of Osteoimmunology written by Jawed A. Siddiqui and published by Frontiers Media SA. This book was released on 2023-09-01 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone metastases are common in many cancers and associated with skeletal-related events such as spinal cord compression, fractures, pain, disability, and impaired quality of life. Bone metastasis is most prominent in breast, prostate, and lung cancer patients and is the leading cause of cancer-associated death. Osteoblasts and osteoclasts control each other’s functions to maintain normal bone homeostasis. In addition, bone remodeling is governed by the balanced activity of the bone and immune cells. Bone metastasis is a multistage process, and the bone microenvironment influences the seeding and colonization of the disseminated cancer cells. Disruption of bone homeostasis and immune population provides fertile soil to facilitate cancer cell seeding. Despite the advancement of our understanding to treat primary tumors, most of the treatments for bone metastasis are palliative. Proper understanding of the immune component of the bone and their involvement in bone metastasis niche formation will help to explore future directions of bone metastasis research.
Download or read book Advances in Osteoimmunology written by Claudine Blin-Wakkach and published by Frontiers Media SA. This book was released on 2020-01-21 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bone Regulators and Osteoporosis Therapy written by Paula H. Stern and published by Springer. This book was released on 2020-11-29 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is designed to provide an understanding of current and potential therapies for osteoporosis. The opening chapter introduces the cells of bone and their interactions. Several following chapters describe factors affecting bone including systemic hormones with significant effects on bone, and local mediators including growth factors, prostaglandins, cytokines and chemokines. Topics that have commanded particular attention recently are calcium, FGF-23, nervous system bone interactions. Drugs that cause bone loss provide important information on mechanism as well as therapeutic considerations. An overview of the genetics of bone disorders and a discussion of the pathophysiology of osteoporosis establish the clinical context. The final chapters discuss current and potential osteoporosis treatments.
Download or read book Osteosarcopenia written by Gustavo Duque and published by Elsevier. This book was released on 2022-03-04 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. - Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways, impacting the wellbeing of our older population - Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field - Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of osteosarcopenia
Download or read book Bone Toxicology written by Susan Y. Smith and published by Springer. This book was released on 2017-09-27 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.
Download or read book Advanced Techniques in Bone Regeneration written by Alessandro Rozim Zorzi and published by BoD – Books on Demand. This book was released on 2016-08-31 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Techniques in Bone Regeneration is a book that brings together over 15 chapters, written by leading practitioners and researchers, of the latest advances in the area, including surgical techniques, new discoveries, and promising methods involving biomaterials and tissue engineering. This book is intended for all who work in the treatment of disorders involving problems with the regeneration of bone tissue, are doctors or dentists, as well as are researchers and teachers involved in this exciting field of scientific knowledge.
Download or read book Osteoimmunopathology written by Francesco Chiappelli and published by Springer Science & Business Media. This book was released on 2011-05-30 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoimmunology pertains to the study of the relationship between the bones, particularly the bone marrow, and the immune system. This monograph pursues the best available evidence, by means of research synthesis, for the characterization of the physiological relevance and pathological implications of the inter-connectedness between the skeletal and the immune system. Research will be discussed that highlights the associated role of the circulatory, nervous and endocrine systems, as well as proteomic and genomic pathways and signatures. Emphasis is given that domain of medicine that relates to the oral cavity, its diseases and their systemic sequelae. This monograph arises from observations that have suggested that the skeletal system and the immune system are intimately intertwined. Chronic inflammatory reactions subsequent to an excessive immune reaction can damage the bones, as in rheumatoid arthritis (RA), osteoporosis, patients seropositive for the human immunodeficiency virus (HIV)-1 and with signs and symptoms of the acquired immune deficiency syndrome (AIDS), and bone cancer. Bones – in particular the bone marrow – are one of the primary locations in which cells of the immune system mature. In brief, this monograph begins to answer a range of questions, such as, what is osteoimmunology all about?, does the immune system and its components affect bone development?, how do stress hormones impact upon the pathophysiology of bone-immune interactions?, can the scientific process of research synthesis, obtain the best available evidence for treatment of diseases involving the bone-immune entity (i.e., osteo immunopathologies) means of evidence-based clinical decision-making directed at the treatment of osteoimmune pathologies?
Download or read book Biological Mechanisms of Tooth Movement written by Vinod Krishnan and published by John Wiley & Sons. This book was released on 2021-05-24 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Mechanisms of Tooth Movement This new edition continues to be an authoritative reference to the scientific foundations underpinning clinical orthodontics The newly and thoroughly revised Third Edition of Biological Mechanisms of Tooth Movement delivers a comprehensive reference for orthodontic trainees and specialists. It is fully updated to include new chapters on personalized orthodontics as well as the inflammatory process occurring in the dental and paradental tissues. It is heavily illustrated throughout, making it easier for readers to understand and retain the information discussed within. The topics covered range from bone biology, the effects of mechanical loading on tissues and cells, genetics, tissue remodeling, and the effects of diet, drugs, and systemic diseases. The Third Edition of Biological Mechanisms of Tooth Movement features seven sections that cover subjects such as: The development of biological concepts in orthodontics, including the cellular and molecular biology behind orthodontic tooth movement Mechanics meets biology, including the effects of mechanical loading on hard and soft tissues and cells, and biological reactions to temporary anchorage devices Inflammation and orthodontics, including markers for tissue remodeling in the gingival crevicular fluid and saliva Personalized diagnosis and treatment based on genomic criteria, including the genetic influences on orthodontic tooth movement Rapid orthodontics, including methods to accelerate or decelerate orthodontic tooth movement Perfect for residents and PhD students of orthodontic and periodontal programs, Biological Mechanisms of Tooth Movement is also useful to academics, clinicians, bone biologists, and researchers with an interest in the mechanics and biology of tooth movement.
Download or read book Rheumatology E Book written by Marc C. Hochberg and published by Elsevier Health Sciences. This book was released on 2022-07-29 with total page 2123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases. - Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases. - Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases. - Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference. - Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics. - Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis. - Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology. - Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. If you encounter issues with your eBook please contact Elsevier eBook+ support via [email protected].
Download or read book Osteoarthritis Biomarkers and Treatments written by and published by BoD – Books on Demand. This book was released on 2019-03-27 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents exclusive and comprehensive insight into the detailed molecular mechanisms of osteoarthritis (OA) initiation, progression and current advancements in the field. Inputs from clinician scientists, research and expertise offer a complete explanation of the current understanding of the pathogenesis of OA and practice in imaging and treatments strategies. Contributions from leading scientists provide a detailed introduction in the use of biomarkers in clinical research as well as in clinical practice and OA diagnosis. This book further discusses the potential of regenerative therapies and recent advances in cardiovascular and functional capacity on patients with OA.
Download or read book Editor s Pick 2021 Highlights in Signaling written by Ana Cuenda and published by Frontiers Media SA. This book was released on 2022-02-07 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt:
