Download or read book Osseoconductive Surface Engineering for Orthopedic Implants written by Amirhossein Goharian and published by Academic Press. This book was released on 2021-01-26 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osseoconductive Surface Engineering for Orthopedic Implants provides a comprehensive overview of the state of the art of osseointegration based on surface-mediated engineering. It offers a practical approach to the design and development of implant surface engineering, by reviewing and discussing the usability and efficacy of each processing technique. The reader can learn about the variety, characteristics, advantages, challenges, and optimum parameters for each process—enabling targeted selection of coatings and technologies to enhance long-term implant–bone integration. - Practical and engineering notions in the field of osseoconductive surface engineering are reviewed and discussed using scientific principles and concepts. - Engineering cases are analyzed in depth giving a thorough exploration and description of the engineering and scientific concepts for all osseoconductive surface engineering processes. - Chapters integrate topics and are organised in such a way as to build on themes and practice.

Download or read book Osseointegration of Orthopaedic Implants written by Amirhossein Goharian and published by Academic Press. This book was released on 2019-03-16 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osseointegration of Orthopaedic Implants helps product developers at orthopedic implant manufacturers enhance the effectiveness of orthopedic implants and reduce complications, particularly in patients with osteoporotic bones. The book's expert contributors provide cutting-edge information on the latest technologies and advances available. Biomaterial researchers can use the book for basic data in the further development of orthopedic implant materials with better osseointegration. Biomechanical researchers can review related challenges and concepts of osseointegration for use in the development of implants. The book is suitable for readers from academia and industry, bridging the knowledge gap between academic based researchers, industrial based engineers, and clinical based surgeons. - Reviews and discusses all aspects of orthopedic implant osseointegration - Provides conceptual implants for bone fracture fixation and joint replacement - Offers novel ideas for the development of orthopedic implants with superior osseointegration

Download or read book Surface Engineering and Technology for Biomedical Implants written by Yoshiki Oshida and published by Momentum Press. This book was released on 2014-04-15 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book synthesizes a wide range of interdisciplinary literature to provide the state-of-the art of biomedical implants. It discusses materials and explains the three basic requirements for implant success from a surface engineering perspective: biological compatibility, biomechanical compatibility, morphological compatibility. Biomedical, mechanical, and materials engineers will find this book indispensable for understanding proper treatment of implant surfaces in order to achieve clinical success. Highlights include: • Coverage of surface engineering of polymer, metallic, ceramic and composite implant materials; • Coverage of chemical, mechanical, physical, thermal, and combined surface modification technologies; • Explanations of interfacial reaction between vital tissue and non-vital implant surface; and • Methodologies and technologies for modification of surface layer/zone to promote the osteo-integration, the ultimate success for biomedical implants in both dental and medical practice.

Download or read book Interactions of Bone with Orthopedic Implants and Possible Failures written by Amirhossein Goharian and published by Academic Press. This book was released on 2022-07-20 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interactions of Bone with Orthopedic Implants and Possible Failures focuses on the mechanical and biological issues that may cause failure of the implant-bone construct. The book provides discussions on the effects of the design, process, surface and other engineering parameters of implants and their interaction with bone tissue. For implant designers, it is highly crucial to know the final effects of what they are designing or aiming to design, along with performance parameters. It is also crucial for orthopedic surgeons to be familiar with the background of the design and process parameters of the implant they will insert in a patient’s body. With the understanding brought forth in this book, surgeons can have better implant options and implant designers can create and develop new implant designs. This book can also help biomechanical and mechanical engineers who are normally dealing with testing and analysis of orthopedic implants examine the biomechanical behavior of the implants and their interaction with bone tissue. Explains interactions, along with possible complications of trauma, joint and spinal implants, and failures of the implant and bone tissue Focuses on issues such as bone loss, defects and resorption at the bone and implant interface Includes case studies of implant failures and discusses the mechanical and biological reasons that would cause failure of bone and implant integration

Download or read book Trauma Plating Systems written by Amirhossein Goharian and published by Elsevier. This book was released on 2017-03-15 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trauma Plating Systems is the first reference and systematic book in the topic of trauma plating system in view of biomechanical, material, biological, and clinical aspects. The effects of these aspects on effectiveness of trauma plating fixation are deeply reviewed, discussed, and challenged from which promising evaluation and development concepts are explored. This book is divided into five sections: Section I covers general concepts of biomechanical, material, biological, and clinical aspects. Then it provides fundamentals of trauma plating systems, principles of biomechanical evaluation methods, and biomechanics of plating fixation in Section II. Section III reviews current metallic materials with their advantages and disadvantages in plating fixation of bone fractures and new promising materials with their potential benefits to enhance the effectiveness of plating fixation. Section IV represents currently concerned biomechanical-clinical challenges of plating fixation for various bone fractures, and Section V presents current and new development concepts of this type of trauma implants. This book as an accessible and easy usable textbook for various disciplines of audiences who are dealing with trauma plating system and fixation such as orthopedic surgeons, trauma implant manufacturers, biomechanical researchers, biomaterial researchers, and all biomedical or medical students and residents in different levels of education. Author has been diligent in both engineering and research environments in terms of research, testing, analysis, validation, verification, clinical studies, and technical writing. His main interest and effort is to integrate biomechanical, material, biological, and clinical requirements of orthopedic implants for creation of novel design conception in this industry. He has developed the website http://orthoimplant-development.com/ for further communication in development of orthopedic implants. - Smooth writing style for effective following, fast reading, and easy accessibility of the content - Detailed and insight reviews, discussions, and new ideas in evaluation methods and design conception - Disclosing of a novel conceptual plating system (Advance Healing Fixation System—AHealFS) with advanced biomechanical and clinical benefits in various stages of healing period potential to bring an interesting science breakthrough in fixation of bone fractures

Download or read book Advances in Materials Science and Implant Orthopedic Surgery written by R. Kossowsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Materials Science and Implant Orthopedic Surgery brings together experts from major university hospitals, materials scientists specializing in bio-materials, and development engineers working for implant manufacturers to address such issues as: mechanisms of fixation; foreign-body immune response; generation and consequences of ionic and wear debris; materials selection, design and manufacturing schemes; and surgical techniques to maximize the safety and efficacy of the devices.

Download or read book Osseo Integrated Implants written by Gunther Heimke and published by CRC Press. This book was released on 1990-07-03 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this two-volume work is osseo integration. It discusses the use of glue to attach bony tissue as well as the use of the absence of biochemical interactions between some oxide ceramics (particularly pure A1203 ceramic) and the adjacent tissue. This book also demonstrates the possibility of controlling the interface remodelling by the stresses and strains created by the insertion of the implant. Written in a concise, easy-to-read format, this text covers the use of implants in orthopedics, maxillo-facial surgery, and dentistry. All those involved with bioengineering, orthopedics, maxillo-facial surgery, dentistry, and biomechanics will find this reference to be of particular interest.

Download or read book Surface Engineering of Biomaterials written by Ajit Behera and published by CRC Press. This book was released on 2024-03-20 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface engineering provides one of the most important means of engineering product differentiation in terms of quality, performance, and lifecycle cost. It is essential to achieve predetermined functional properties of materials such as mechanical strength, biocompatibility, corrosion resistance, wear resistance, and heat and oxidation resistance. Surface Engineering of Biomaterials addresses this topic across a diverse range of process technologies and healthcare applications. Introduces biomaterial surface science and surface engineering and includes criteria for biomaterial surface selection Focuses on a broad array of materials including metals, ceramics, polymers, alloys, and composites Discusses corrosion, degradation, and material release issues in implant materials Covers various processing routes to develop biomaterial surfaces, including for smart and energy applications Details techniques for post-modification of biomaterial surfaces This reference work helps researchers working at the intersection of materials science and biotechnology to engineer functional biomaterials for a variety of applications.

Download or read book Developing Non fouling and Lubricious Surface Coatings for Orthopedic Implants written by Prabhleen Kaur and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foreign body response (FBR) remains a persistent challenge limiting the longevity of medical devices. Upon implantation, non-specific protein adsorption on the implant surface can trigger FBR and result in fouling. This necessitates frequent replacements and surgical procedures. Biological host responses are influenced primarily by atomic-scale surface properties like wettability, roughness and cytotoxicity. This dissertation introduces robust and versatile surface modification techniques designed to suitably alter these properties to enhance biocompatibility, applicable to commercially available, industrial-strength materials used in orthopedic implants. Chemical modification via introduction of zwitterionic molecules is a proven strategy that greatly alters the thermodynamics of surface protein adsorption through strong interfacial hydration effects. This reduces non-specific protein adsorption and enhances surface lubricity through robust hydration layers and fluidity of adhered water. The techniques demonstrated herein use poly (sulfobetaine methacrylate) (pSBMA) due to its low cost and ease of synthesis relative to other zwitterionic molecules. In grafting these species on to implant surfaces, we leverage versatile chemical modification methods based on RFGD plasma and ARGET ATRP. The first part of this work thus focuses on surface modification protocols that involve surface activation using RFGD plasma deposition of HEMA, followed by macro-initiator covalent coupling and grafting pSBMA using ARGET ATRP (method 1). Next, we introduce a solvent free initiator for ARGET ATRP (method 2). A highly reactive bromoester, M3BP is deposited on the surface using RFGD plasma and used as initiator for synthesizing pSBMA coatings. Polyurethane and titanium are used as model substrates to demonstrate the versatility of these techniques. This dissertation also details the performance evaluation of the fabricated coatings, including quantification of surface composition, wettability, protein adsorption and lubricity, in addition to in vitro and in vivo studies. Surfaces prepared using methodology 1 achieve a 93% reduction in albumin adsorption and 95% reduction in the friction coefficients relative to bare surfaces. They are chemically robust, non-cytotoxic, and show good in vivo performance in mice and chicken models. Surfaces prepared using methodology 2 also exhibit comparable results for both protein adsorption and friction coefficients, while providing an alternative ARGET ATRP initiator chemistry that does not require harsh solvents and is compatible with various materials irrespective of surface chemistry or geometry. These results signify the potential of these techniques for substantially improving biocompatibility and represent a proof-of-concept for simple and reproducible surface modification techniques with applicability at scale, serving a critical complementary function in maximizing the longevity and performance of orthopedic implants.

Download or read book Orthopaedic Knowledge Update Trauma 5 written by William Ricci, MD and published by Lippincott Williams & Wilkins. This book was released on 2018-08-21 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Orthopaedic Knowledge Update: Trauma 5 brings together relevant knowledge and new breakthroughs in orthopaedic trauma treatment and management. Developed in partnership with the Orthopaedic Trauma Association (OTA), this new edition features chapters on computer-assisted surgery, new technologies, and the diagnosis and management of infection associated with fractures and nonunions.

Download or read book Mechanical Testing of Orthopaedic Implants written by Elizabeth Friis and published by Woodhead Publishing. This book was released on 2017-05-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanical Testing of Orthopaedic Implants provides readers with a thorough overview of the fundamentals of orthopedic implants and various methods of mechanical testing. Historical aspects are presented, along with case studies that are particularly useful for readers. - Presents information on a range of implants, from dental to spinal implants - Includes case studies throughout that help the reader understand how the content of the book is applied in practice - Provides coverage and guidance on FDA regulations and requirements - Focuses on application of mechanical testing methods

Download or read book Titanium Alloys written by Jan Sieniawski and published by BoD – Books on Demand. This book was released on 2013-05-15 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains six chapters and covers topics dealing with biomedical applications of titanium alloys, surface treatment, relationships between microstructure and mechanical and technological properties, and the effect of radiation on the structure of the titanium alloys.

Download or read book Aseptic Loosening of Orthopedic Implants written by Mehdi Amirhosseini and published by Linköping University Electronic Press. This book was released on 2019-05-24 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aseptic loosening is the main cause of failure of orthopedic prostheses. With no pharmaceuticals to prevent or mitigate periprosthetic bone degradation, a surgery to replace the loose implant with a new one is the only choice to restore patients’ function. Most studies on mechanisms for aseptic loosening investigate wear debris particle-induced osteolysis. However, pathological loading conditions around unstable implants can also trigger osteoclast differentiation and bone loss. In the first study, global gene expression changes induced by mechanical instability of implants, and by titanium particles were compared in a validated rat model for aseptic loosening. Microarray analysis showed that similar signaling pathways and gene expression patterns are involved in particle- and instability-induced periprosthetic osteolysis with an early onset innate immune response as a hallmark of osteolysis induced by mechanical instability. Further, effects of potential therapeutics on restriction of excessive osteoclast differentiation were evaluated. Wnt signaling pathway is known to regulate bone remodeling. In the second study, effects of inactivation of glycogen synthase kinase 3 beta (GSK-3?), a negative regulator of canonical Wnt signaling, on instability-induced periprosthetic osteolysis were examined using our rat model for aseptic loosening. Inhibition of GSK-3? led to a decrease in osteoclast numbers in the periprosthetic bone tissue exposed to mechanical instability while osteoblast perimeter showed an increase. This was accompanied by higher bone volume fraction (BV/TV) in animals treated with the GSK-3? inhibitor. In the third study, potential beneficial effects of two selective inhibitors of cyclindependent kinase 8/19 (CDK8/19) on bone tissue were evaluated. CDK8/19 is a Mediator complex-associated transcriptional regulator involved in several signaling pathways. CDK8/19 inhibitors, mainly under investigation as treatments for tumors, are reported to enhance osteoblast differentiation and bone formation. We show in this study, for the first time, that inhibition of CDK8/19 led to marked suppression of osteoclast differentiation from bone marrow macrophages in vitro through disruption of the RANK signaling. In mouse primary osteoblasts downregulation of osteopontin mRNA, a negative regulator of mineralization, together with increased alkaline phosphatase activity and calcium deposition indicated that osteoblast mineralization was promoted by CDK8/19 inhibition. Moreover, local administration of a CDK8/19 inhibitor promoted cancellous bone regeneration in a rat model for bone healing. These studies contribute to better understanding of mechanisms behind mechanical instability-induced periprosthetic osteolysis and propose potential therapeutics to restrict bone loss with effects on both osteoclasts and osteoblasts.

Download or read book Bone Response to Dental Implant Materials written by Adriano Piattelli and published by Woodhead Publishing. This book was released on 2016-10-27 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Response to Dental Implant Materials examines the oral environment and the challenges associated with dental biomaterials. Understanding different in vivo and in vitro responses is essential for engineers to successfully design and tailor implant materials which will withstand the different challenges of this unique environment. This comprehensive book reviews the fundamentals of bone responses in a variety of implant materials and presents strategies to tailor and control them. - Presents a specific focus on the development and use of biomaterials in the oral environment - Discusses the basic science of the dental interface and its clinical applications - Contains important coverage on the monitoring and analysis of the dental implant interface

Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t

Download or read book Biomaterials in Orthopedics written by Michael J. Yaszemski and published by CRC Press. This book was released on 2003-10-17 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by respected experts in the field, Biomaterials in Orthopedics discusses bioabsorbable biomaterials for bone repair, nondegradable materials in orthopaedics and delivery systems. Topics in this text include biocompatibility and the biomaterial/tissue interface; self-reinforced bioabsorbable devices and guided regeneration; bone substitutes,

Download or read book Handbook of Research on Green Engineering Techniques for Modern Manufacturing written by Uthayakumar, M. and published by IGI Global. This book was released on 2018-11-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green manufacturing has developed into an essential aspect of contemporary manufacturing practices, calling for environmentally friendly and sustainable techniques. Implementing successful green manufacturing processes not only improves business efficiency and competitiveness but also reduces harmful production in the environment. The Handbook of Research on Green Engineering Techniques for Modern Manufacturing provides emerging perspectives on the theoretical and practical aspects of green industrial concepts, such as green supply chain management and reverse logistics, for the sustainable utilization of resources and applications within manufacturing and engineering. Featuring coverage on a broad range of topics such as additive manufacturing, integrated manufacturing systems, and machine materials, this publication is ideally designed for engineers, environmental professionals, researchers, academicians, managers, policymakers, and graduate-level students seeking current research on recent and sustainable practices in manufacturing processes.